Secrétariat : Isabelle DIJOUX
Tel. 04 92 03 38 12
Mail dijoux.i@chu-nice.fr
Titres
• Ancienne interne des hôpitaux de Toulouse
• Chef de clinique universitaire, Assistants des hôpitaux de Nice
Année de recherche
- Novembre 2019 – Novembre 2021 : MASTER 2 à l’étranger (USA)
- Stage de recherche : Vascularized Composite Allotransplantation laboratory. Boston, USA – Massachusetts General Hospital (MGH).
- Sujet d’étude : Vascularized Composite Allotransplantation/Tissue Engineering (directeurs de recherche : Dr. Curtis L. Cetrulo, MD)
- Institution d’affilation : Harvard Medical School Boston, MA
- https://connects.catalyst.harvard.edu/Profiles/display/Person/184947
- Théorique : Paris Créteil – UPEC – Science chirurgicale (Novembre 2020 à Novembre 2021)
Double cursus chirurgien / chercheur
- « Research Fellow » au MGH 2021 – Janvier 2026 dans le cadre d’une thèse de science et pour la mise en place d’essais cliniques au MGH. Voyage à Boston 1 semaine tous les 3 mois jusque fin 2024.
- Chercheur au laboratoire PhysioMedicine (LP2M), UMR 7370 CNRS, dans l’équipe du Pr Antoine Sicard depuis le 02/11/2024. Soumission d’une ANR retenue en phase 2. Décision finale en attente.
Mobilités académique (hors année recherche)
- Mobilité universitaire d’un an : 3 fois 4 mois
- Novembre 2024 – Mars 2025 : Laboratoire LP2M du CNRS : Pr Antoine Sicard. Élaboration de projets de recherche et demande de grants (PMID:41428681) / Ouverture d’une branche chirurgie reconstructrice au LP2M / Certification à l’expérimentation animale niveau Applicateur / Création d’une plateforme de supermicrochirurgie au PEMED.
- Juillet 2025 – Octobre 2025 : New York Langone Health, USA : Service de chirurgie plastique du Pr Eduardo Rodriguez (4 articles publiés : PMID:42044141, PMID: 41789363, PMID: 41554000, PMID: 2 en cours)
- Juillet 2026 – Octobre 2026 : Service de chirurgie plastique et esthétique. Melanoma Institute Australia / Pr Ch’ng. (3 articles en cours)
- Stage d’observation 2 semaines à l’Asan Medical Center – Séoul, Corée du Sud. Septembre 2022. (Publié PMID: 42583665)
- Mission humanitaire microchirurgicale au Children’s Surgical Centre – Phnom Pen, Cambodge. Juin 2023. Médecin du monde. (publié PMID: 39260035)
Thèse de Science
- 2021 – 2024 : École Doctorale 85 Sciences et vie et de la Santé. Nice. Université Côte d’Azur. Directeur de thèse : Pr Olivier Camuzard et Dr Alexandre Lellouch (codirection)
- Projet de thèse : Ingénierie tissulaire et induction de tolérance pour la réparation des pertes de substances complexes
- Cotutelle entre les laboratoires: UR2CA – Côte d’Azur en collaboration avec VCA laboratory – Massachusetts General Hospital. Boston
- Soutenance : 29 Novembre 2024 (Faculté de Nice UCA). Proposition au prix de thèse de l’Université Côte d’Azur UCA.
Diplômes complémentaires
-
- MASTER1 « Biologie-Santé » – Débuté à Université Rennes 1, finalisée à Université Paul Sabatier :
- UE 4A « Bases fondamentales de la toxicologie » (2011 – 2012)
- UE 12 « Santé et Environnement » (2012 – 2013)
- UE Recherche : Stage de recherche en médecine régénératrice au laboratoire STROMALab – Toulouse. (Septembre-Octobre 2018)
Mémoire de stage : « Caractérisation des mécanismes de communication entre les cellules stromales mésenchymateuses du tissu adipeux et les macrophages » présenté Juin 2019, mention « très bien ».
- DU « Cicatrisation des plaies aigues et chroniques » Université Paul Sabatier, Pr Grolleau – Raoux (lauréate)
- DU « Microchirurgie » – Université Paul Sabatier, Pr Mansat
- DU « Anatomie appliquée à la chirurgie plastique » Laboratoire d’anatomie de l’UFR Biomédicale des Saints-Pères, Pr Revol – Paris Descartes.
- DU « Anglais pour la santé » Université Paul Sabatier.
- DIU « Chirurgie du visage » 2020-2021 (DESIU – Les ateliers du Visage)
- DIU « Chirurgie de la main » 2019-2021 (Faculté de Montpellier).
- Titulaire du DES de chirurgie générale 2022 (Faculté de Toulouse, 14 Octobre 2022)
- DIU « Diagnostic et prise en charge des sarcomes et des tumeurs mésenchymateuses » 2022 – 2023 (Université Paris Cité).
- DESC de chirurgie plastique, reconstructrice et esthétique, 29 Septembre 2023, Toulouse (coordinateur : Pr Chaput Benoît)
- DIU de Simulation en pédagogie 2024 – 2025. Université Côte d’Azur
- Titre en chirurgie de la main – Janvier 2025
- MASTER1 « Biologie-Santé » – Débuté à Université Rennes 1, finalisée à Université Paul Sabatier :
Prix et honneurs
-
- Lauréate Prix du Public « soirée recherche et Innovation ». CHU Pasteur 2 le 9.12.2025.
- Lauréate Prix d’Excellence d’Université Côte d’Azur 2025
- “Top 100 reviewer of the year” 2025 – PRS Global Open
- Lauréate de la bourse de mobilité des amis de la faculté de Nice (8000 euros)
- Lauréate de la bourse de mobilité Zagamé Novembre 2024 (10 000 euros)
- “Best Presentation” de la session reconstruction 7 – Plastic Surgery The Meeting 2023, Austin, Texas
- Thèse de Médecine le 15.04.2022. Faculté Purpan – Toulouse. Mention « Très honorable avec les Félicitations du Jury ». Proposée au prix de thèse.
- Lauréate du Prix des Chirurgiens de l’Avenir 2021 (Parcours 3R UPEC)
- Nominée dans les finalistes du concours de présentation de poster MGH SAC 2021
- Approbation d’un Visa 0-1A par le service d’immigration des Etats-Unis (USCIS) 2021 – 2026 (« Individual with extraordinary ability – Science »)
- Nominée au prix du forum de la recherche chirurgicale – Académie de chirurgie. 4 Décembre 2020
- Lauréate du prix de la vocation « Fondation Marcel Bleustein-Blanchet » 2019-2020 (10 000 euros)
- Lauréate Bourse BNP Paribas Upec 2020
- Obtention Bourse « année recherche » 2019-2020 (subdivision de Toulouse) (24 685 euros)
Financements de projets
- Lauréate de l’aide financière à projet 2022 de la « Fondation Gueules Cassées » (51 200 euros) (Agrément NO. 75-2022).
- Bourse AAP Scientifique UFR Médecine 2025 (9786 euros) (étude microchirurgicale à l’animalerie PEMED). UCA.
- Réinvestissement des fonds des DU en charge pour achat de 2 microscopes microchirurgicaux au PEMED et pour le fonctionnement du module P4P Simlife cadavre reperfusé au laboratoire d’anatomie (30 000 euros environ depuis 2024). UCA.
- Obtention d’une bourse de projet en tant que principal-investigateur (entreprise Orthonose ) (328 541 dollars US). Étude au Massachusetts General Hospital. (Financement du Visa 0-1 et thèse de science)
- Obtention d’une bourse de projet en tant que principal-investigateur (entreprise KCI) (10 000 dollars US). Étude au Massachusetts General Hospital.
Responsabilité académique
- Responsabilités pédagogiques et coordination de formations universitaires
- Co-création et responsable / coordinatrice du centre de Nice du DIU « Lambeaux perforants », formation interuniversitaire associant les Universités de Toulouse, Nice et Montpellier, depuis 2023
- Responsable / coordinatrice de la formation à Nice du DU « Plaies et cicatrisation », Université Côte d’Azur, depuis 2025
- Responsable de l’organisation et de la modération de la journée annuelle «Tumeurs cutanées» du DIU Européen de pratiques chirurgicales en Cancérologie, depuis mars 2024
- Membre du département « IA et pédagogie » du CHU de Nice, depuis sa création en 2025 ; implication dans l’axe « Intelligence artificielle et ECOS » (PMID: 42662474)
- Reconnaissance académique et expertise par les pairs
- International Visiting Professor, American Society of Plastic Surgeons / Plastic Surgery Foundation, programme 2025–2026
- Membre du jury du Prix de thèse 2023 de la Société Française du Cancer
- Experte pour le recrutement de chercheurs postdoctoraux, Université Libre de Bruxelles, programme IF@ULB COFUND – Marie Skłodowska-Curie Actions, H2020
- Responsabilités institutionnelles et scientifiques
- Co-organisatrice du Congrès de la Société Française de Chirurgie Oncologique (SFCO), Nice, mai 2027
- Co-organisatrice du Vidéoforum de chirurgie plastique, reconstructrice et esthétique, Toulouse, juin 2026
- Membre élue de la Commission Médicale d’Établissement (CME) du CHU de Nice depuis 2025
- Secrétaire générale du Bureau de l’internat de Toulouse, 2021–2022
Publications avec comité de lecture
Publications 2026 du Dr LUPON Élise
The emerging role of mixed reality and artificial intelligence in sarcoma care: A systematic review
The emerging role of mixed reality and artificial intelligence in sarcoma care: A systematic review
Surbhi Joshi, Pharel Njessi, Olivier Camuzard, Marc-Olivier Gauci, Sylvie Bonvalot, Elise Lupon
https://doi.org/10.1016/j.ejso.2026.111447
Abstract
Background: Sarcomas are a heterogeneous group of cancers requiring cautious monitoring and expert management. The emerging role of Artificial Intelligence (AI) and Mixed Reality (MR) may represent a turning point in sarcoma care. This systematic review evaluates their application in sarcoma management.
Methods: A comprehensive search of PubMed/MEDLINE, Embase, Scopus, and Web of Science up to June 2025 was conducted following PRISMA guidelines. Eligible studies included case series, cohort studies, multicenter studies, diagnostic accuracy studies and prediction model studies reporting on AI or MR use in sarcoma. Review articles and non-English studies were excluded. Data extracted included design, population, modality, sarcoma subtype, and reported outcomes.
Results: Twenty-three studies met inclusion criteria: 1 case series, 1 case report, 2 cohort studies, 8 diagnostic accuracy studies and 11 prediction model studies with a cumulative sample size of 8478 patients. The most frequently investigated tumors were osteosarcoma (n = 6), soft tissue sarcoma (STS) (n = 5), and chondrosarcoma (n = 4). AI was primarily applied in imaging-based diagnosis (n = 12, reported accuracy 78-95 %), histopathological grading (n = 5), and radiogenomic models (n = 4). MR was used in preoperative planning (n = 3), intraoperative navigation (n = 2), and surgical training (n = 2). No integrated AI/MR platforms were reported.
Conclusion: AI and MR show strong potential in improving sarcoma management, particularly for diagnostic accuracy and surgical planning. However, the literature remains heterogeneous, consisting mostly of preliminary studies with limited statistical power. Large-scale multicenter studies are required to validate the impact of AI and MR on outcomes and safely integrate these technologies into routine care.
Keywords: Artificial intelligence; Machine learning; Mixed reality; Oncology; Sarcoma; Surgery.
Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.
Conflict of interest statement
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The author Sylvie Bonvalot is an Associate Editor for this journal and was not involved in the editorial review or the decision to publish this article.
Outcomes of All-Dorsal Augmented Intercarpal Ligament Reconstruction
Outcomes of All-Dorsal Augmented Intercarpal Ligament Reconstruction
Jean-Baptiste de Villeneuve Bargemon, Silvia Gandolfi, Elise Lupon
https://doi.org/10.1097/prs.0000000000012447
Heterotopic Hindlimb-to-Neck Transplantation in the Mouse: A Supermicrosurgical Model of Vascularized Composite Allotransplantation
Heterotopic Hindlimb-to-Neck Transplantation in the Mouse: A Supermicrosurgical Model of Vascularized Composite Allotransplantation
Haruyuki Hirayama, Lisa Polak, Marisa Delliturri, Jebrane Bouaoud, Daniel J Ceradini, Piul S Rabbani, Eduardo D Rodriguez, Elise Lupon, Catherine Pei-Ju Lu
Abstract
Vascularized composite allotransplantation (VCA) is increasingly recognized as a reconstructive option that offers substantial benefits for patients with severe tissue loss, including injuries affecting the face and hand. Despite its clinical promise, VCA remains limited by surgical complexity, the need for long-term immunosuppression, and associated morbidity. Preclinical models are therefore essential for refining surgical techniques, testing novel immunomodulatory approaches, and investigating ischemia/reperfusion injury. Compared with large-animal models, rodent models offer advantages in accessibility and cost while adhering more closely to the 3Rs principles of Replacement, Reduction, and Refinement. Among them, the mouse offers unique advantages, including the availability of humanized strains, a broad panel of well-characterized antibodies, and compatibility with advanced immunological assays. These features make the mouse particularly valuable for translational VCA research. Murine VCA, however, requires demanding supermicrosurgical skills, as vascular anastomoses are performed on vessels measuring approximately 0.3-0.5 mm in diameter. To enhance reproducibility, we provide technical tips that have proven critical to the success of these procedures. These include the insertion of a nylon filament into the vessel lumen to stabilize the anastomosis, careful separation of the artery and vein over a sufficient distance along the pedicle, precise anesthetic dosing, and specific maneuvers to prevent pedicle twisting. We also highlight common pitfalls and errors, offering practical guidance to improve outcomes. Here, we describe a comprehensive, stepwise protocol for mouse heterotopic hindlimb-to-neck transplantation, accompanied by instructional video material. This non-functional model minimizes postoperative morbidity compared with orthotopic transplantation while providing robust and reproducible results. It is ideally suited for training in supermicrosurgery and for addressing key experimental questions in VCA, including immune tolerance, graft preservation, and ischemia/reperfusion mechanisms. This methodology provides investigators with a reliable murine platform to advance translational VCA research and to develop innovative strategies aimed at improving outcomes in reconstructive transplantation.
Response to the letter from Shigeki Matsubara
Response to the letter from Shigeki Matsubara
Bernard de Geofroy, Elise Lupon, Grégoire Micicoi
https://doi.org/10.1016/j.otsr.2026.104743
Conflict of interest statement
Declaration of competing interest G. Micicoi is Associate editor of Orthopedics & Traumatology: Surgery & Research. The other authors declare no conflict of interest.
Vascular anatomy of the hand and therapeutic applications
Vascular anatomy of the hand and therapeutic applications
Rémy Lavigne, Tanguy Perraudin, Pharel Njessi, Olivier Camuzard, Elise Lupon
https://doi.org/10.1016/j.hansur.2026.102737
Abstract
This article provides a detailed analysis of the complexity of hand vascularization and its anatomical relationships. It examines the main arteries of the hand (radial, ulnar, and interosseous) and their networks of branches and anastomoses in relation to the structures of the hand. The therapeutic applications derived from this vascular anatomy are also described, particularly the various types of flaps used in reconstructive surgery to address soft tissue defects of the hand. The article also discusses the venous and lymphatic vascularization of the hand.
Keywords: Anatomical snuffbox; Finger flap; Hand vascularization; Perforator flap.
Copyright © 2026 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
Conflict of interest statement
Declaration of competing interest The authors declare having no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Response to the comment on: Morphometric, curvature CT-based study of the distal radius watershed line. Valerio T, Lupon E, Quemener-Tanguy A, Masse E, Brenac C, de Villeneuve Bargemon J-B. Hand Surg Rehabil. 2025, 44:102168. by Aphale P et al
Response to the comment on: Morphometric, curvature CT-based study of the distal radius watershed line. Valerio T, Lupon E, Quemener-Tanguy A, Masse E, Brenac C, de Villeneuve Bargemon J-B. Hand Surg Rehabil. 2025, 44:102168. by Aphale P et al
Elise Lupon, Thomas Valério, Pharel Njessi, J B De Villeneuve Bargemon
https://doi.org/10.1016/j.hansur.2026.102570
Conflict of interest statement
Declaration of competing interest The authors declare having no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
The 50 most-cited publications in lymphatic surgery: A bibliometric analysis
The 50 most-cited publications in lymphatic surgery: A bibliometric analysis
Abdullah A Al Qurashi, Pharel Njessi, Hatan Mortada, Olivier Camuzard, Joon Pio Hong, Elise Lupon
https://doi.org/10.1016/j.jpra.2026.03.032
Abstract
Background: Lymphatic surgery has evolved from palliative debulking procedures to physiologic reconstruction using microsurgical and supermicrosurgical techniques. Despite this progress, the publications that have most influenced this evolution have not been systematically examined. This study aimed to analyze the 50 most-cited publications in lymphatic surgery, assessing their bibliometric characteristics, study designs, levels of evidence, and thematic contributions to lymphedema surgical management.
Methods: The Web of Science Core Collection was searched for articles on surgical treatment of lymphedema from inception to November 7, 2025. The 50 most-cited articles were identified and analyzed for citation count, citation density (citations per year), authorship, geographic origin, journal distribution, and keyword frequency. Studies were categorized by design and evaluated according to the Oxford Centre for Evidence-Based Medicine levels of evidence. Concise summaries were generated to facilitate access to key findings.
Results: Published between 2004 and 2023, the top 50 articles accumulated 4612 citations (mean 92.2, median 75.5). Citation density ranged from 3.9 to 32.5 citations per year. Plastic and Reconstructive Surgery was the most represented journal (n = 14). Asian institutions predominated, with Japan (n = 16) and Taiwan (n = 11) accounting for 54% of publications. Case series were the most common study design (n = 24). Most studies provided Level 4 or 5 evidence (74%), although two Level 2 randomized controlled trials were identified. Keyword analysis identified supermicrosurgery, lymphaticovenular anastomosis, and indocyanine green lymphography as the most recurring technical concepts.
Conclusions: This bibliometric analysis highlights seminal publications underlying the development of supermicrosurgical techniques such as lymphaticovenous anastomosis and vascularized lymph node transfer. The results demonstrate a strong Eastern contribution to innovation. While observational studies predominate, the near-total absence of Level 1 evidence and the presence of only two Level 2 trials underscore the need for well-designed prospective comparative studies to establish standardized treatment algorithms. Level of evidence: IV.
Keywords: Bibliometric analysis; Lymphatic surgery; Lymphaticovenous anastomosis; Lymphedema; Supermicrosurgery; Vascularized lymph node transfer.
© 2026 The Author(s).
Conflict of interest statement
The authors declare that they have no conflicts of interest.
Carpal ligamentous injury in children and adolescents: a systematic review
Carpal ligamentous injury in children and adolescents: a systematic review
Pauline Mathon, Pharel Njessi, Camille Brenac, Rémy Dubian, Elise Lupon, Jean-Baptiste de Villeneuve Bargemon
https://doi.org/10.1016/j.hansur.2026.102646
Abstract
Purpose: Carpal ligamentous injuries in children and adolescents are uncommon yet often underappreciated. This systematic review aims to consolidate existing evidence regarding scapholunate (SL), lunotriquetral (LT), and perilunate injuries in patients aged 16 years and younger while exploring potential management strategies.
Methods: We conducted a PRISMA-compliant systematic review, sourcing data from PubMed/MEDLINE, Embase, Scopus, and Web of Science from inception to October 2025. Studies focusing on SL, LT, or perilunate injuries in pediatric patients that documented treatment and included at least three months of follow-up were selected. Two reviewers independently screened the studies. Due to diversity in the data, results were synthesized narratively. A good clinical outcome was defined as minimal pain (VAS<2), flexion-extension ≥50 °, and grip strength >80% of the contralateral side.
Results: Twenty-two studies were identified, detailing 62 SL injuries, 13 perilunate injuries, and 2 isolated LT injuries. The majority were case reports, with only two retrospective cohort studies on SL injuries. SL injuries often co-occurred with distal radius fractures and usually necessitated arthroscopy for accurate diagnosis. While case reports indicated favorable outcomes, cohort studies exhibited greater variability in recovery, particularly with delayed interventions. For unstable SL lesions, arthroscopic debridement combined with scapholunate pinning showed promising functional outcomes. Concerning perilunate injuries, both surgical and non-surgical treatments were documented, with closed reduction and subsequent immobilization yielding satisfactory results in approximately 87.5% of cases. Notably, only one instance of long-term growth disturbance was reported. Isolated LT injuries were managed with arthroscopic debridement and pinning, allowing athletes to safely return to sports.
Conclusion: Current evidence regarding carpal ligamentous injuries in the pediatric population is limited and primarily derived from small, heterogeneous case series. Early intervention appears to correlate with improved functional outcomes in SL injuries, with arthroscopy being crucial for accurate diagnosis. In select cases of perilunate injury, closed reduction followed by immobilization may offer satisfactory results. Given the limitations, these findings warrant cautious interpretation, emphasizing the need for higher-quality prospective studies in this area.
Level of evidence: Systematic Review, Level IV.
Keywords: Carpal ligaments; Immature skeletal; Pediatric; Wrist.
Copyright © 2026 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.
Conflict of interest statement
Declaration of competing interest No conflict.
Regulatory T-cells technology and vascularized composite allotransplantation: A scoping review
Regulatory T-cells technology and vascularized composite allotransplantation: A scoping review
Amina Oyuntogos, Pharel Njessi, Olivier Camuzard, Marion Cremoni, Antoine Sicard, Elise Lupon
https://doi.org/10.1016/j.trim.2026.102417
Abstract
Background: Vascularized composite allotransplantation (VCA) offers life changing reconstructive options for patients with traumatic injuries or congenital defects, restoring function and appearance. Its success is limited by strong immune responses, and long-term immunosuppression carries significant risks. Emerging cellular therapies, particularly regulatory T cells (Tregs) offer promising strategies to mitigate rejection and reduce immunosuppression dependence. Preclinical studies in animal models suggest that Treg-based approaches may improve graft survival and potentially reduce the need for conventional immunosuppression in VCA.
Methods: An all-time literature search of Regulatory T cell therapy in Vascularized Composite Allotransplantation in animal models was performed on the following electronic databases: PubMed, EMBASE, Cochrane Library, Scopus, Web of Science, and TRIP Database until August 2025. Data was analyzed for graft survival, regulatory T cell activity, chimerism, and tolerance mechanisms.
Results: A total of 2182 studies were screened across six databases, of which 13 met eligibility criteria and 5 were selected focusing on Treg therapy in VCA animal models. Treg therapy consistently prolonged graft survival (>200 days), promoted chimerism, reduced inflammation, and induced donor specific tolerance. CAR-Tregs demonstrated antigen-specific tolerance, while mesenchymal stem cells (MSCs) enhanced immunomodulation, particularly under hypoxic preconditioning. Other cellular therapies, including hematopoietic stem cells (HSC), also improved graft acceptance, demonstrating their potential as adjuncts or alternatives to long term immunosuppression.
Conclusion: Cellular therapies, especially Treg based approaches such as adoptive transfer and local enrichment or induction of Tregs, consistently promote immune tolerance, suppress graft rejection, and extend allograft survival in VCA animal models. These approaches reduce the need for long term immunosuppression and create a pro-tolerogenic environment, supporting their translational potential. However, further clinical validation is required to optimize dosing, persistence and safety for application in human VCA recipients.
Keywords: Cellular therapy; Chimerism; Immune tolerance; Regulatory T cells (Tregs); Vascularized composite allotransplantation.
Copyright © 2026. Published by Elsevier B.V.
Conflict of interest statement
Declaration of competing interest The authors declare no conflicts of interest.
Scapholunate Injuries in the Context of Acute Scaphoid Fractures: A Systematic Literature Review
Scapholunate Injuries in the Context of Acute Scaphoid Fractures: A Systematic Literature Review
Laure Glévarec, Pharel Njessi, Marie-Anne Poumellec, Thierry Balaguer, Olivier Camuzard, Elise Lupon
https://doi.org/10.1177/15589447261430936
Abstract
The association between acute scaphoid fractures and concomitant scapholunate ligament (SLL) injuries has historically been underestimated, yet failure to recognize these lesions may lead to carpal instability, scaphoid nonunion, and long-term degenerative changes. This systematic review synthesizes current evidence on the incidence, diagnostic methods, and management of SLL injuries occurring with acute scaphoid fractures. A comprehensive search of PubMed/MEDLINE, Embase, Scopus, and Web of Science from inception to April 2025 was conducted in accordance with Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, including original articles in English or French reporting on SLL injuries associated with acute scaphoid fractures. Eleven studies met inclusion criteria, comprising prospective and retrospective cohorts, case-control studies, series, and case reports. Reported incidence of SLL injuries ranged from 0% to 71%, with arthroscopy detecting higher rates than radiography or magnetic resonance imaging. Most lesions were Geissler grades I to III, while complete tears were rare. Management was predominantly limited to scaphoid fixation, with only a minority of cases undergoing concomitant SLL repair or pinning. Outcomes were inconsistent, with some studies showing persistent pain and lower Mayo Wrist Scores, whereas others reported no significant differences. Overall methodological quality was low to moderate. These findings suggest that SLL injuries may complicate acute scaphoid fractures more frequently than previously recognized. Routine arthroscopy is not universally recommended, but selective use based on clinical suspicion and imaging may improve detection. Treatment should be tailored to the grade of injury, and further prospective studies with standardized diagnostic protocols and long-term follow-up are required to clarify prognostic impact and optimize management strategies.
Keywords: arthroscopy; associated ligament injury; carpal instability; scaphoid fracture; scapholunate advanced collapse wrist; scapholunate ligament.
Conflict of interest statement
The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: The authors (LG, PN, M-AP, TB, OC, EL) declare that they have no conflicts of interest related to this work.
Preservation Strategies for Vascularized Composite Allotransplantation: An Updated Systematic Review of a Rapidly Expanding Field
Preservation Strategies for Vascularized Composite Allotransplantation: An Updated Systematic Review of a Rapidly Expanding Field
Pharel Njessi, Pierre Barbat, Rabbani S Piul, Didier F Pisani, Olivier Camuzard, Antoine Sicard, Eduardo Rodriguez, Elise Lupon
https://doi.org/10.1097/sap.0000000000004677
Abstract
Background: Composite allotransplantation has become a viable reconstructive option for selected patients, but preservation remains a major barrier to broader clinical application. Static cold storage is the current gold standard, yet ischemia reperfusion injury and limited preservation times restrict its effectiveness. Recent advances in machine perfusion and subzero nonfreezing storage (or supercooling) have prompted renewed interest in optimizing graft viability.
Methods: Following PRISMA guidelines, we systematically searched PubMed, EMBASE, and Cochrane, covering studies published from June 2022 to August 2025 for studies on ex vivo preservation of vascularized composite allotransplantations. Eligible articles included original studies in English evaluating postharvest, pretransplant preservation strategies. Data extracted were study design, preservation methods, perfusates, and primary outcomes. Risk of bias was assessed using SYRCLE for animal studies and Joanna Briggs Institute for human/cadaver studies.
Results: Seventeen studies met the inclusion criteria: 1 on static cold storage, 13 on machine perfusion, and 3 on supercooling. Static cold storage research has declined, with the only recent study investigating subnormothermic machine perfusion as a recovery adjunct. Machine perfusion studies focused on the optimization of perfusion parameters, perfusate composition, and circuit design. Red blood cell-based perfusates remained common, but alternative oxygen carriers such as polymerized hemoglobin-based oxygen carrier-201 and dextran oxygen microcarriers showed promise despite edema-related challenges. Supercooling studies demonstrated the feasibility of multiday preservation in rodent and porcine models. Overall, risk of bias was high or unclear across animal studies, mainly due to selection and performance bias, whereas the single human ex vivo study showed low risk of bias.
Conclusions: The field of vascularized composite allograft preservation is expanding rapidly, with a combination of static and dynamic techniques emerging as a promising option to extend graft viability beyond the current limits. However, translation to clinical setting remains limited by small preclinical studies, methodological heterogeneity, and the paucity of functional endpoints. Standardized protocols, robust large-animal models, and eventual human feasibility trials are needed to establish clinically applicable preservation strategies.
Keywords: VCA preservation; ex vivo preservation; ischemia-reperfusion injury; machine perfusion; supercooling; translational research; vascularized composite allotransplantation.
Copyright © 2026 Wolters Kluwer Health, Inc. All rights reserved.
Conflict of interest statement
Conflicts of interest and sources of funding: The authors declare that they have no conflicts of interest.
A Model for Malpractice Preparedness for Plastic Surgery Residents
A Model for Malpractice Preparedness for Plastic Surgery Residents
Silvia Gandolfi, Abdulaziz Asiry, Benoît Chaput, Elise Lupon
https://doi.org/10.1097/gox.0000000000007622
Conflict of interest statement
The authors have no financial interest to declare in relation to the content of this article.
Asan Medical Center Plastic Surgery Visit: Insights from France
Asan Medical Center Plastic Surgery Visit: Insights from France
Elise Lupon
https://doi.org/10.1055/a-2726-3307
Conflict of interest statement
Conflict of Interest The authors declare that they have no conflict of interest.
Autoclosing Excision Design for Dermatofibrosarcoma Protuberans in Slow Mohs Surgery
Autoclosing Excision Design for Dermatofibrosarcoma Protuberans in Slow Mohs Surgery
Elise Lupon, Ioana Ivan, Olivier Camuzard, Silvia Gandolfi, Dimitri Gangloff
https://doi.org/10.1002/ccr3.73472
Abstract
In DFSP treated with slow Mohs surgery, first-stage planning is critical given delayed histologic results. The pinch test allows intraoperative assessment of skin mobility, enabling margin tailoring beyond the standard 1-1.3 cm when laxity permits, while preserving primary closure. This integrates oncologic and reconstructive planning in a single surgical step.
Keywords: dermatology; inguinal lymph node dissection; melanoma; oncology; surgery.
© 2026 The Author(s). Clinical Case Reports published by John Wiley & Sons Ltd.
Conflict of interest statement
The authors declare no conflicts of interest.
Saphenous Vein-Preserving Inguinal Lymph Node Dissection: A Stepwise Technical Approach
Saphenous Vein-Preserving Inguinal Lymph Node Dissection: A Stepwise Technical Approach
Elise Lupon, Ioana Ivan, Olivier Camuzard, Dimitri Gangloff
https://doi.org/10.1002/ccr3.71712
Abstract
Preserving the great saphenous vein during inguinal lymph node dissection maintains venous outflow and skin drainage while allowing complete oncologic clearance.
Keywords: dermatology; inguinal lymph node dissection; melanoma; oncology; surgery.
© 2025 The Author(s). Clinical Case Reports published by John Wiley & Sons Ltd.
Conflict of interest statement
The authors declare no conflicts of interest.
Refining the SCIP flap: Technical nuances and insights from osteocutaneous and chimeric applications
Refining the SCIP flap: Technical nuances and insights from osteocutaneous and chimeric applications
Paul Girard , Yanis Berkane, Pharel Njessi, Nicolas Bertheuil, Elise Lupon
https://doi.org/10.1016/j.jham.2025.100397
Conflict of interest statement
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Can large language models provide high-quality desk review decisions in an orthopaedic surgery journal? A concordance study comparing three AI models to human editorial decisions
Can large language models provide high-quality desk review decisions in an orthopaedic surgery journal? A concordance study comparing three AI models to human editorial decisions
Elise Lupon, Quentin Bérard, Henri Migaud, Philippe Clavert, Grégoire Micicoi
https://doi.org/10.1016/j.otsr.2026.104801
Abstract
Background: Artificial intelligence (AI) is increasingly integrated into scientific publishing workflows, yet no study has formally evaluated the ability of large language models (LLMs) to reproduce human editorial desk-review (R0) decisions in a general orthopaedic surgery journal. We investigated whether three commercially available LLMs could accurately replicate the editorial decisions of the Editorial Board of Orthopaedics & Traumatology: Surgery & Research (OTSR). The study addressed four questions: (1) Is the concordance between LLM and human R0 decisions satisfactory for editorial use? (2) Do LLMs exhibit a severity bias? (3) Do LLMs generate decision letters of acceptable quality, and do they reproduce the specific critiques of human reviewers? (4) Does prompt complexity influence LLM decision-making?
Hypothesis: LLMs used without task-specific fine-tuning or prior exposure to the study corpus would demonstrate at least moderate concordance (κ ≥ 0.40) with human editorial decisions.
Material and methods: A corpus of 32 manuscripts randomly selected from submissions to OTSR between 2025 and 2026 (n = 10 outright rejected at R0: 3 out of scope, 3 plagiarism/dual submission, 4 direct desk rejection; n = 11 accepted for peer review; n = 11 rejected after full peer review) was anonymised and independently evaluated, without task-specific fine-tuning or prior exposure to the study corpus, by ChatGPT (GPT-5.5, OpenAI), Gemini (3.1, Google), and Claude (Sonnet 4.6, Anthropic) using a structured prompt incorporating the OTSR guidelines. The primary outcome was assessed using Cohen’s kappa between LLM and human binary decisions. Secondary outcomes included accuracy, inter-LLM agreement, domain-specific scoring, ARCADIA quality scoring of 115 eligible decision letters by two blinded raters with ICC, human-performed content concordance analysis, sensitivity analysis (structured vs. minimal prompt), and test-retest reproducibility at 24 h.
Results: Overall accuracy (i.e. the decision was similar for LLM and editorial decision) was 59.4% for ChatGPT (19/32) and Claude (19/32), and 62.5% for Gemini (20/32). Cohen’s kappa was near-zero for ChatGPT (κ = -0.05) and Gemini (κ = 0.00), and low for Claude (κ = 0.15). All LLMs showed systematic over-rejection of accepted manuscripts. No LLM identified plagiarism or simultaneous dual submission as a rejection motive. Test-retest concordance was 84.4-90.6 % across models. ARCADIA quality scoring (n = 115 scorable letters, inter-rater ICC = 0.86, 95% CI 0.80-0.90) showed Claude achieved the highest scores (4.46 ± 0.32 /5), significantly above the human OTSR letters (4.01 ± 0.44, p < 0.001), ChatGPT (3.81 ± 0.49, p = 0.002), and Gemini (3.28 ± 0.49, p < 0.001). LLMs reproduced 30-41 % of human reviewer-specific critiques, with Claude achieving the highest match (40.5%) without hallucinations. Switching to a minimal prompt markedly increased acceptance rates for Gemini (87.5%) and Claude (75%), while ChatGPT remained largely insensitive to prompt simplification (15.6%).
Conclusion: The principal finding of this study is the dissociation between formal review quality and true editorial reliability. Although modern LLMs generated persuasive and methodologically structured decision letters, they failed to achieve meaningful concordance with real editorial decisions and displayed stable architecture-specific biases that were highly sensitive to prompt design. These results indicate that current LLMs reproduce the surface features of peer review more successfully than its underlying scientific and contextual reasoning. Consequently, LLMs may represent valuable supervised assistants for editorial workflows, but not reliable autonomous substitutes for human editorial expertise in orthopaedic scientific publishing.
Level of evidence: IV; Observational pilot study, concordance analysis.
Keywords: AI editorial workflow limits (plagiarism-dual submission detection/contextual reasoning/human supervision).; Content concordance (human critiques reproduced/additional valid critiques/hallucinations); Editorial concordance (Cohen’s kappa/accuracy/sensitivity-specificity/over-rejection bias); LLM desk-review decisions (ChatGPT/Gemini/Claude/human editorial R0); Prompt sensitivity (structured vs minimal prompt/test-retest reproducibility); Review-letter quality (ARCADIA score/formal quality/synthetic peer review).
Copyright © 2026. Published by Elsevier Masson SAS.
Conflict of interest statement
Declaration of competing interest Henri Migaud declares being Editor-in-Chief of OTSR and has received fees from Zimmer-Biomet and Corin. Grégoire Micicoi declares being Associate Editor of OTSR and has received financial support and non-financial benefits from Johnson & Johnson, United Orthopaedics, and Adler Ortho. Élise Lupon and Quentin Bérard declare no conflict of interest. Philippe Clavert is paid consultant for Stryker-Tornier and Médartis and perceives royalties from Médartis.
Trapeziectomy With Hemi-Abductor Pollicis Longus and SutureTape InternalBrace: A Technical Note and Case Series
Trapeziectomy With Hemi-Abductor Pollicis Longus and SutureTape InternalBrace: A Technical Note and Case Series
Richard Lachaux, Marie-Anne Poumellec, André-Pierre Uzel, Thierry Balaguer, Olivier Camuzard, Elise Lupon
https://doi.org/10.1097/gox.0000000000007538
Abstract
Background: Trapeziometacarpal osteoarthritis (rhizarthrosis) is a common cause of thumb pain and functional impairment. Although trapeziectomy remains the gold standard for pain relief, postoperative first metacarpal migration and scaphometacarpal impingement have led to the development of stabilization techniques. These procedures, however, are often technically demanding and lack consensus.
Methods: We describe a simplified suspensionplasty technique combining trapeziectomy with a hemi-abductor pollicis longus tendon and SutureTape InternalBrace reinforcement. A single-center retrospective study included 6 patients with Dell stage II-IV rhizarthrosis treated between January 2018 and March 2025 by a single experienced level IV surgeon (Tang and Giddins classification). Outcomes included pain (visual analog scale), function using the Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) questionnaire, key and grip pinch strength, Kapandji opposition score, and radiographic trapezial index. Pre- and postoperative values were compared.
Results: At a mean follow-up of 36 months, pain significantly decreased from 8.0 ± 0.89 to 1.83 ± 1.47. The QuickDASH score improved from 67.0 ± 15.08 to 17.83 ± 8.80. Key pinch strength increased from 4.07 ± 1.86 to 5.02 ± 2.37 kg, and grip strength increased from 18.0 ± 5.93 to 23.67 ± 6.38 kg. The Kapandji score improved from 7.67 ± 0.82 to 9.67 ± 0.52. The trapezial index decreased from 0.407 ± 0.053 to 0.311 ± 0.078. No major subluxations were observed, and no revision procedures were required.
Conclusions: This simplified InternalBrace-reinforced suspensionplasty seems safe, reproducible, and effective for pain relief and functional improvement in trapeziometacarpal osteoarthritis. Larger prospective studies are needed to confirm long-term outcomes.
Copyright © 2026 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.
Comparison of Radiographic and Ultrasound Imaging Techniques for Assessing the Scapholunate Interval in Healthy Individuals
Comparison of Radiographic and Ultrasound Imaging Techniques for Assessing the Scapholunate Interval in Healthy Individuals
Grégoire Micicoi, Jean Baptiste De Villeneuve Bargemon, Pharel Njessi, Thomas Apard, Nicolas Dréant, Elise Lupon
https://doi.org/10.3390/jcm15114250
Abstract
Background/Objectives: Ultrasound (US) is a valuable tool in hand surgery because of its portability, low cost, and ability to provide noninvasive, real-time evaluation of soft tissue structures. However, it has not been widely assessed for measuring the scapholunate (SL) interval using dynamic stress views. This study aimed to determine whether ultrasound provides comparable measurements to radiography when evaluating the SL interval in healthy subjects. Methods: We analyzed 29 wrists from 29 individuals. Each wrist underwent dynamic stress maneuvers while the SL interval was measured with both radiography and US. The following views were obtained: neutral rotation, ulnar deviation, clenched fist, and a modified dynamic clenched fist view. The latter was performed by applying pressure on the head of the third metacarpal from distal to proximal. Results: The SL interval could be visualized in the clenched fist and ulnar deviation radiographic views, as well as in the modified dynamic clenched fist US view. Ultrasound in the neutral position produced measurements similar to those of traditional stress radiographs. The most pronounced changes in the SL interval occurred between neutral and dynamic views, whether assessed by radiography or US. There was no significant difference in the magnitude of interval change between the two imaging modalities. Conclusions: Ultrasound with dynamic stress maneuvers provided similar dynamic SL interval changes to stress radiographs in healthy individuals. A modified stress view using a slightly clenched fist and manual pressure on the third metacarpal head may offer hand surgeons a simple, real-time tool to noninvasively evaluate SL instability.
Keywords: radiographic stress view; scapholunate gap; scapholunate instability; scapholunate noninvasive assessment; ultrasound; wrist examination; wrist ultrasonic examination.
Conflict of interest statement
The authors declare no conflicts of interest.
Artificial Intelligence in Plastic and Reconstructive Surgery: A Bibliometric Study of the 50 Most-cited Articles
Artificial Intelligence in Plastic and Reconstructive Surgery: A Bibliometric Study of the 50 Most-cited Articles
Pharel Njessi, Olivier Camuzard, Elise Lupon
https://doi.org/10.1097/gox.0000000000008120
Abstract
Background: Artificial intelligence (AI) has gained increasing attention in the surgical literature, including plastic and reconstructive surgery (PRS). However, the characteristics and trends of the most influential publications on AI in PRS remain poorly defined.
Methods: The online Web of Science Core Collection was searched on November 18, 2025, to identify articles on AI applications in PRS. Title, authorship information, publication year, journal, funding, and citation count were recorded. Studies were further classified based on application domain and PRS subspecialty.
Results: The 50 most-cited articles on AI in PRS were published between 2001 and 2024, with citation counts ranging from 45 to 124. Most articles originated from the United States (n = 18; 1166 citations) and were published by plastic surgeons (n = 17; 1332 citations). Imaging assessment (n = 21; 1564 citations) represented the most common application of AI, whereas the predominant PRS subspecialty was craniofacial surgery (n = 32; 2364 citations).
Conclusions: This bibliometric analysis highlights the most influential publications and emerging applications of AI in plastic surgery, revealing that image-based approaches predominate, particularly in craniofacial surgery, whereas adoption remains uneven across PRS subspecialties. These findings underscore current research priorities and identify areas where AI development remains limited, offering a foundation to guide future work in this rapidly evolving field.
Copyright © 2026 The Authors. Published by Wolters Kluwer Health, LLC. on behalf of The American Society of Plastic Surgeons.
Conflict of interest statement
The authors have no financial interest to declare in relation to the content of this article.
Preserving Function in Sternal Reconstruction: Complementary Roles of Pectoralis Major and Internal Mammary Artery Perforator Flaps
Preserving Function in Sternal Reconstruction: Complementary Roles of Pectoralis Major and Internal Mammary Artery Perforator Flaps
Elise Lupon, Pharel Njessi, Olivier Camuzard, Benoît Chaput, Silvia Gandolfi
https://doi.org/10.1097/sap.0000000000004618
Conflict of interest statement
Conflicts of interest and sources of funding: none declared.
Correspondence on: The management of sternal mediastinitis in heart and lung transplant patients: An 8-year experience and application of reconstructive algorithm
Correspondence on: The management of sternal mediastinitis in heart and lung transplant patients: An 8-year experience and application of reconstructive algorithm
Elise Lupon, Christian Herlin, Pharel Njessi, Benoît Chaput, Silvia Gandolfi
https://doi.org/10.1016/j.bjps.2026.07.042
Conflict of interest statement
Declaration of Competing Interest The authors have no conflicts of interests to declare.
Comment to ``Current evidence on arthroscopic capsuloligamentoplasty plications as treatment for chronic dynamic scapholunate instability`` by Goorens et al., J Hand Microsurg 2026
Comment to « Current evidence on arthroscopic capsuloligamentoplasty plications as treatment for chronic dynamic scapholunate instability » by Goorens et al., J Hand Microsurg 2026
Jean-Baptiste de Villeneuve Bargemon, Élise Lupon , Camille Brenac
https://doi.org/10.1016/j.jham.2025.100388
No abstract available
Keywords: Capsuloplasty; Dorsal intercarpal; Scapholunate.
Conflict of interest statement
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Large Language Models as Simulated Candidates in Objective Structured Clinical Examinations: A Rubric-Mapping Proof-of-Concept Study
Large Language Models as Simulated Candidates in Objective Structured Clinical Examinations: A Rubric-Mapping Proof-of-Concept Study
Elise Lupon, Alexandre O Gérard, Alexandre Destere, Romain Lombardi , Axel Maurice-Szamburski, Grégoire Micicoi
https://doi.org/10.1016/j.hansur.2026.102570
Abstract
Background: Large language models (LLMs) perform well on knowledge-based medical examinations, but evidence on their utility for performance-based assessments such as Objective Structured Clinical Examinations (OSCEs) remains limited. Beyond simulating candidate answers, LLMs could support quality assurance of OSCE stations by auditing the completeness and internal consistency of analytic scoring rubrics.
Methods: In this exploratory, single-run study, GPT-4 Turbo (OpenAI, accessed via the ChatGPT Plus consumer interface, May 2025) simulated a final-year medical student (DFASM3) across 10 validated French national OSCE stations covering all 11 nationally defined competency domains, using a fixed system prompt applied identically across stations. Each station was run once in a baseline condition and once in a reference-augmented (RAG) condition, in which official LiSA learning objectives and Starting Clinical Situation (SCS) documents were additionally provided. Outputs were scored against official analytic rubrics by two clinical educators through independent review (Cohen’s κ=0.84), with disagreements resolved by consensus; off-checklist content was similarly adjudicated.
Results: Mean baseline checklist coverage was 81% (SD 10.2), with A-level item omission averaging 10% (SD 7.2). RAG coverage increased to 95% (SD 5.1; Wilcoxon signed-rank test, p=0.002), recovering 1-4 previously missed items per station. Off-checklist additions averaged 22% of checklist items per station, nearly all clinically relevant; one incorrect addition was identified. Coverage was higher in structured, action-oriented stations (91.6% ± 4.1) than dialogue-heavy stations (73.7% ± 7.4). Given the single-run design and absence of a human comparator, results are exploratory and hypothesis-generating rather than robust performance estimates.
Conclusion: This proof-of-concept study shows that an LLM can generate structured, rubric-mappable OSCE responses and may help educators flag missing, ambiguous, or inconsistent checklist elements for expert review. These exploratory findings support further investigation of LLMs as decision-support tools for OSCE station pre-validation, pending replication with multiple runs, larger station banks, and human comparators.
Keywords: OSCE; artificial intelligence; assessment validation; large language models; medical education; proof-of-concept.
Plain language summary
Medical schools use Objective Structured Clinical Examinations (OSCEs) to test students’ clinical skills in standardized scenarios. Building these exams takes time, and teachers must carefully check that the scoring checklists are complete and consistent. In this study, we tested whether an artificial intelligence tool called a large language model (GPT-4 Turbo, the technology behind ChatGPT) could answer OSCE scenarios the way a medical student would. We then compared its answers with the official scoring checklists to see whether this could help teachers spot missing or unclear items. We tested 10 nationally validated French OSCE stations. The AI covered about 81% of the expected checklist items on average. When we gave it the official learning references, its coverage rose to 95%. The AI also gave extra, clinically appropriate answers that were not on the scoring checklist, suggesting some checklists may be incomplete. We found only one incorrect answer across all 10 stations. These findings suggest that AI tools could help teachers review and improve OSCE checklists before exams, as a quality-control support rather than a replacement for human examiners. This was a small, preliminary study with important limitations. We need larger studies that repeat the test multiple times before using this approach in practice.
© 2026 Lupon et al.
Corrigendum to ``Utility of the caprini risk assessment model in guiding venous thromboembolism prophylaxis after abdominoplasty`` `{`JPRAS Open 46 (2025) 305-315`}`
Corrigendum to « Utility of the caprini risk assessment model in guiding venous thromboembolism prophylaxis after abdominoplasty » [JPRAS Open 46 (2025) 305-315]
Abdulaziz Asiry, Anas Sayegh, Dimitri Gangloff, Hatan Mortada, Silvia Gandolfi, Elise Lupon
https://doi.org/10.1016/j.jpra.2026.01.001
Hypothenar Hammer Syndrome: Management of Acute Thromboembolic Complications From an Ulnar Artery Aneurysm
Hypothenar Hammer Syndrome: Management of Acute Thromboembolic Complications From an Ulnar Artery Aneurysm
Hani Al Shehhi, Tanguy Perraudin, Lilian Pimont, Thierry Balaguer, Olivier Camuzard, Elise Lupon
https://doi.org/10.1097/gox.0000000000007428
Abstract
Hypothenar hammer syndrome is a rare vascular disorder resulting from repetitive trauma to the hypothenar region of the hand, leading to ulnar artery injury and potential aneurysm formation. The aneurysm can eventually release distal emboli and lead to acute digital ischemia. Hypothenar hammer syndrome is often underdiagnosed, particularly in the plastic surgery setting. Management strategies are not standardized, and literature offering detailed surgical techniques, particularly involving palmar arch aneurysms, is sparse. We present the case of a 63-year-old manual laborer with a known ulnar artery aneurysm responsible for recurrent episodes of transient digital ischemia. The condition was initially managed conservatively; however, due to a worsening of symptoms, an elective surgical intervention was scheduled. Three months before the planned procedure, the patient presented to the emergency department with persistent acute ischemia of the third, fourth, and fifth fingers of the left hand. The imaging confirmed complete occlusion of the ulnar artery at the level of the aneurysm. Emergency intervention included aneurysm resection, ulnar artery anastomosis, and thromboembolectomy of the digital arteries. Multiple revascularization techniques were used, including intra-arterial heparinization, thrombolysis with urokinase, and Fogarty catheterization via different surgical approaches to the superficial palmar arch and digital arteries. Revascularization was successfully achieved in the ischemic digits. At the 2-year follow-up, the patient showed no recurrence and no sequelae. This case underscores the risks associated with delayed treatment of large digital aneurysms (>2 cm), called for prompt intervention upon diagnosis, and highlighted surgical tips that may improve outcomes in cases of embolic complications.
Copyright © 2026 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.
Assessing ChatGPT and Gemini Responses to Common Patient Questions Regarding Augmentation Mammaplasty
Assessing ChatGPT and Gemini Responses to Common Patient Questions Regarding Augmentation Mammaplasty
Pharel Njessi, Axel Maurice-Szamburski, Chris Amro, Carter J Boyd, Jérôme Laloze, Elise Lupon
https://doi.org/10.1007/s00266-026-05766-7
Abstract
Background: Large language models (LLMs) are becoming a common source of medical information for patients.
Objective: This study aimed to evaluate and compare the quality and readability of ChatGPT and Google’s Gemini in answering frequently asked questions (FAQs) about augmentation mammaplasty (AM).
Methods: Ten AM FAQs were submitted to ChatGPT (GPT-4.1 mini) and Gemini (2.5 Flash). Responses were de-identified and independently rated by two board-certified plastic surgeons and one senior resident using the Global Quality Score (GQS). Readability was assessed using the Flesch Reading Ease (FRE) and Flesch-Kincaid Grade Level (FKGL). Paired comparisons used the Wilcoxon signed-rank test for per-question median GQS, inter-rater agreement used Kendall’s W, and readability used paired tests as appropriate.
Results: Across 60 individual ratings (3 raters × 10 items × 2 models), per-question median GQS was 5 for 9/10 ChatGPT answers and 10/10 Gemini answers; the paired comparison showed no significant difference (Wilcoxon Z = -1.00; p = 0.317; effect size r = 0.32). Inter-rater agreement was W = 0.24 (ChatGPT, p = 0.091) and W = 0.60 (Gemini, p = 0.002). ChatGPT produced more readable outputs (FRE: 46.53 vs 43.70, p = 0.243; FKGL: 9.71 vs 11.43, p = 0.002), indicating approximately two US grade levels of easier reading.
Conclusion: ChatGPT and Gemini both generated high-quality answers to common AM FAQs, with no difference in quality based on GQS. ChatGPT’s responses were significantly easier to read according to FKGL. LLMs may support patient education when implemented with clinician oversight to mitigate limitations and prevent misinformation.
Level of evidence iv: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Keywords: Artificial intelligence; Augmentation mammaplasty; ChatGPT; Gemini; Large language models; Patient education; Plastic surgery.
© 2026. Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery.
Adoption and perception of artificial intelligence by corresponding authors in orthopaedic research: A global cross-sectional study
Adoption and perception of artificial intelligence by corresponding authors in orthopaedic research: A global cross-sectional study
Bernard de Geofroy, Alexandre Gérard, Élise Lupon, Chloé Desrayaud, Camille Choufani, Grégoire Micicoi
https://doi.org/10.1016/j.otsr.2026.104653
Abstract
Background: Generative artificial intelligence (AI) is increasingly integrated into scientific research, particularly in tasks related to academic writing and knowledge synthesis. However, empirical data on how orthopaedic researchers perceive, use, and regulate these tools remain limited. The purpose of this study was to: 1) assess attitudes, perceptions, and patterns of generative AI use among corresponding authors in orthopaedic research; 2) evaluate whether academic career stage influences perceptions, training, familiarity, and intended future use of AI; 3) identify individual and professional factors associated with positive perceptions of future AI use; and 4) examine disclosure practices, transparency issues, and perceived benefits and limitations of AI across the research and scientific publishing process.
Hypothesis: We hypothesized that generative IA tools are already widely adopted by orthopaedic researchers, but that this adoption is heterogeneous and associated with variable perceptions, training levels, and disclosure practices.
Material and methods: An international, anonymous web-based survey was conducted among corresponding authors of orthopaedic research articles published between January 2024 and June 2025. The questionnaire evaluated demographics, AI familiarity, patterns of past and intended AI use throughout the research process, perceived benefits and limitations, training needs, and disclosure practices. Associations with a positive perception of future AI use were analyzed according to career stage using univariate and multivariate logistic regression analyses.
Results: Among 216 respondents, 175 (81.0%) had previously used an AI-based chatbot and 96 (44.4%) had used AI in at least one of their last five publications, mainly for manuscript writing or editing (71/216; 32.9%), translation (64/216; 29.6%), and literature searching (56/216; 25.9%). Career stage did not influence intention to use AI in future research (non-senior: 79/95; 83.2% vs senior: 73/91; 80.2%; p = 0.123), and no significant differences were observed in perceived benefits, including manuscript writing support (3.83 ± 1.20 vs 3.63 ± 1.22; p = 0.275), literature search support (3.64 ± 1.20 vs 3.61 ± 1.20; p = 0.852), and overcoming language barriers (4.08 ± 1.13 vs 4.07 ± 0.99; p = 0.952), although senior researchers reported slightly greater concern about AI-related bias (4.30 ± 0.81 vs 4.01 ± 0.94; p = 0.032). In univariate analysis, male respondents were more likely to report a positive perception of future AI use than female respondents (133/157; 84.7% vs 18/28; 64.3%; p = 0.032), and in multivariate analysis, male gender was the only independent predictor (aOR = 2.85; 95% CI, 1.12-7.29; p = 0.029). Regarding transparency, 93 respondents (43.1%) consistently disclosed AI use, 144 (66.7%) feared negative perception when doing so, and 163 (75.4%) considered AI important or very important for future scientific production.
Conclusion: Generative AI is widely used among orthopaedic researchers but remains underreported, likely due to concerns about negative journal perceptions. Despite this, most researchers consider AI important for future scientific production, highlighting the need for clearer and harmonized guidelines on its use and disclosure among corresponding authors in orthopaedics.
Level of evidence: IV; cross-sectional survey study.
Keywords: Artificial intelligence chatbots; Artificial intelligence in medical research; Orthopaedic surgeons; Publishing ethics; Research ethics; Scientific integrity.
Copyright © 2026 Elsevier Masson SAS. All rights reserved.
100 most-cited publications in vascularized composite allotransplantation
Pharel Njessi, Carter J Boyd, Palmina Petruzzo, Olivier Camuzard, Antoine Sicard, Rami Kantar, Eduardo Rodriguez, Elise Lupon
https://doi.org/10.3389/frtra.2026.1745991
Abstract
Background: Citation analysis is a useful bibliometric tool to identify impactful publications and trace the evolution of a specialty or a technique. In the past three decades, the research on vascularized composite allotransplantation (VCA) has grown exponentially but very few studies have examined the most influential papers in this field.
Methods: The Web of Science Core Collection database was searched for articles published from inception to August 4th, 2025. Titles, full authors’ names, years of publication, source journals, regions of origin, and numbers of citations were recorded. VCA anatomical location, main topics, and citation density were determined. Articles were ranked based on number of citations and citation density; they were then categorized based on methodology, study design, and main topic.
Results: The 100 most-cited articles on VCA were published between 1996 and 2018 with the number of citations per article ranging from 61 to 604 citations. There were 53 non-clinical studies, the most prevalent topics were outcomes and rehabilitation (n = 48 articles) and immunology (n = 37). Of the 75 studies evaluated using the Oxford Centre for Evidence-Based Medicine levels of evidence, most (n = 51) were classified as level 4.
Discussion: This list of the top 100 most-cited articles highlights seminal and influential papers in VCA. It also demonstrates the relative novelty of this field with ongoing efforts in immunological research to allow its further expansion. The present study provides an understanding of VCA evolution while directing future clinical and preclinical studies.
Keywords: bibliometric; citation analysis; face transplant; hand transplant; upper extremity transplantation; vascularized composite allograft (VCA).
© 2026 Njessi, Boyd, Petruzzo, Camuzard, Sicard, Kantar, Rodriguez and Lupon.
Publications 2025 du Dr LUPON Élise
Comment to ``Current evidence on arthroscopic capsuloligamentoplasty plications as treatment for chronic dynamic scapholunate instability`` by Goorens et al., J Hand Microsurg 2026
Comment to « Current evidence on arthroscopic capsuloligamentoplasty plications as treatment for chronic dynamic scapholunate instability » by Goorens et al., J Hand Microsurg 2026
Jean-Baptiste de Villeneuve Bargemon, Élise Lupon, Camille Brenac
https://doi.org/10.1016/j.jham.2025.100388
Preserving Function in Sternal Reconstruction: Complementary Roles of Pectoralis Major and Internal Mammary Artery Perforator Flaps
Preserving Function in Sternal Reconstruction: Complementary Roles of Pectoralis Major and Internal Mammary Artery Perforator Flaps
Elise Lupon, Pharel Njessi, Olivier Camuzard, Benoît Chaput, Silvia Gandolfi
https://doi.org/10.1097/sap.0000000000004618
Reconstruction of a thumb metacarpophalangeal bone defect using the Masquelet technique: A case report
Reconstruction of a thumb metacarpophalangeal bone defect using the Masquelet technique: A case report
Gauthier Lagarde, Omar Alawadhi, Olivier Camuzard, Thierry Balaguer, Brieuc Monin, Elise Lupon
https://doi.org/10.1016/j.ijscr.2025.111425
Abstract
Introduction: Bone defects of the thumb secondary to trauma or infection pose a significant challenge for surgeons. The limited therapeutic options in such cases may, in the most severe scenarios, necessitate amputation, which has devastating functional consequences. The induced membrane technique, described by Masquelet, has proven effective in reconstructing bone loss in the lower limbs, particularly in septic contexts. However, its application in hand surgery remains underreported.
Case presentation: In this case, we describe a bone and joint defect of the thumb’s metacarpophalangeal joint, complicated by osteoarthritis following a dog bite injury. After failure of initial osteosynthesis, resulting in bone and joint destruction, we performed a two-stage metacarpophalangeal arthrodesis using an iliac bone graft and Masquelet’s technique.
Discussion: The permanent use of a cement spacer is often employed in clinical practice, but it frequently leads to complications, including spacer fractures, pain, and dislocations. Our proposed method is simple, reproductible, and applicable in both emergency and non-emergency settings.
Conclusion: Our findings suggest that the Masquelet technique represents a promising reconstructive option for managing bone loss in osteitis with a high risk of amputation. This approach enables the preservation of sufficient thumb length to maintain pollici-digital function, allowing for satisfactory gripping ability. Further long-term studies are necessary to confirm these preliminary results.
Keywords: Bone defect; Bone graft; Case report; Induced membrane; Osteoarthritis; Thumb reconstruction.
Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.
Reconstruction of a Complex Foot Defect with a Chimeric Triple-Component Osteocutaneous SCIP-SIEA Free Flap: A Case Report and Literature Review
Reconstruction of a Complex Foot Defect with a Chimeric Triple-Component Osteocutaneous SCIP-SIEA Free Flap: A Case Report and Literature Review
Yanis Berkane, Elise Lupon, Pierre Muret, Jérôme Laloze, Nicolas Bertheuil, Christian Herlin, Paul Girard, Hadrien Paol
https://doi.org/10.1055/a-2635-26802
Abstract
Complex defects resulting from infected bone or joints with or without osteosynthesis or prosthetic material lead to significant challenges that need to be addressed through orthoplastic approaches. Foot and ankle reconstruction is particularly difficult due to the lack of local or regional flap solutions in this highly mobile joint, which often necessitates microsurgical flaps in extended defects. In addition, rigorous bone reconstruction is critical to acute bone infection to minimize the risks of functional impairments. We present a novel approach using a chimeric osteocutaneous flap to address a complex calcaneus fracture with extended postoperative skin necrosis and septic pseudoarthrosis. A dual skin paddle (16 × 6.5 cm and 14 × 4.5 cm) was created using a superficial inferior epigastric artery (SIEA)-to-superficial circumflex iliac artery (SCIA) anastomosis, while the 7-cm pedicle was increased using a deep inferior epigastric artery graft, which was anastomosed to the tibial anterior vessels. The vascularized iliac crest component enabled optimal reconstruction of the bone defect with rapid healing, while the combined SCIP (superficial circumflex iliac artery perforator)-SIEA skin flap was used to cover the bone reconstruction and skin defect. This microsurgical reconstruction allowed optimal functional recovery at 12 months with successful bone integration and soft tissue coverage. The step-by-step intraoperative technique is described through Video 1 and Supplementary Video 2 .
Keywords: SCIP flap; SIEA flap; ankle reconstruction; chimeric flap; foot reconstruction.
An Experimental Human DIEP Flap Model to Investigate Preservation Strategies for Vascularized Composite Allografts and Free Flaps
An Experimental Human DIEP Flap Model to Investigate Preservation Strategies for Vascularized Composite Allografts and Free Flaps
Elise Lupon, Tanguy Perraudin, Pierre Barbat, Styliani Stergiadou, Pharel Njessi, Cassilia Dei, Amina Oyuntogos, Olivier Camuzard, Didier F Pisani, Antoine Sicard
Abstract
Recently, preservation approaches such as cytoprotective agents injection, ex vivo machine perfusion, and supercooling have emerged as strategies to enhance long-term preservation of both standard and marginal organs by mitigating ischemic and hypoxic injury. Although encouraging, its application in the field of vascularized composite allotransplantation (VCA) remains largely confined to preclinical research. To date, most studies investigating VCA perfusion strategies have relied on animal models, particularly swine or rodent composites. While these models provide valuable mechanistic insights, their anatomical, immunological, and physiological differences limit reproducibility and translational relevance to human applications. In this protocol, each surgical step required for the procurement of a human deep inferior epigastric perforator (DIEP) flap for preservation studies is described in detail. The perforator is transected above the fascia without any subfascial dissection, yielding a short yet sufficient pedicle for catheterization. This model takes advantage of discarded tissue from standard abdominoplasty procedures, posing no additional risk to the patient. Critical steps are outlined to ensure a functional flap is harvested without prolonging operative time or compromising patient safety. Functional imaging is subsequently performed to confirm flap viability prior to experimental use, and sequential biopsies may be performed to follow tissue integrity. This model is particularly suited for research involving muscle-sparing VCA procedures — such as partial facial transplantation — and may also have relevance for the study of autologous free flap preservation.
Extemporaneous histological analysis according to slow-Mohs combined with Full-Field Optical Coherence Tomography evaluation (FFOCT) in cutaneous tumor pathology: Toward a digital extemporaneous analysis?
Extemporaneous histological analysis according to slow-Mohs combined with Full-Field Optical Coherence Tomography evaluation (FFOCT) in cutaneous tumor pathology: Toward a digital extemporaneous analysis?
Sarah Hendriks, Eugénie Dalimier, Bernard Gasser, Olivier Camuzard, Thérèse Adawa, Elise Lupon
https://doi.org/10.1016/j.bjps.2025.03.025
Abstract
Background: Slow-Mohs micrographic surgery use is limited by the logistic constraints it imposes. Full-field optical coherence tomography (FFOCT) is an emerging non-invasive imaging technique that provides skin tissue imaging at the cellular level without tissue preparation.
Objective: Evaluating the FFOCT technology’s diagnostic possibilities in examining surgical sections in micrographic surgery for basal cell carcinomas compared to slow-Mohs.
Materials and methods: Two plastic surgeons provided 24 Mohs sections from 20 patients with basal cell carcinomas from a single-center. Each section was scanned using FFOCT, and a diagnosis-blinded pathologist reviewed the digital images for malignancy. The FFOCT images were compared with the standard histologic analysis of the sample sections.
Results: The agreement between FFOCT imaging results and slide histology included 17 true positives (VP) and 4 true negatives (TN) for debulking and 19 TN and 2 VP for Mohs peripheral cuts. The positive predictive value (PPV) was 85% for debulking, and the negative predictive value (NPV) was 100%. For recuts, the PPV was 50% and NPV was 95%.
Conclusion: We developed a protocol for analyzing skin tumors ex vivo using FFOCT, providing digital images that can be transmitted remotely. This study serves as a proof of concept. The visualization of peripheral margins in a single image and the predictive values need to be improved before clinical use can be considered.
Keywords: Cutaneous tumor; Full-Field Optical Coherence Tomography; Histology; Mohs; Slow Mohs.
Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.
Reconstruction after wide excision of the nail apparatus for in situ or minimally invasive subungual melanoma: A retrospective case series
Reconstruction after wide excision of the nail apparatus for in situ or minimally invasive subungual melanoma: A retrospective case series
Luc Chouquet, Feriel Boukari, Thierry Balaguer, Henri Montaudié, Olivier Camuzard, Elise Lupon
https://doi.org/10.1016/j.jpra.2025.10.027
Abstract
Introduction: Historically, subungual melanoma (SUM) was treated by amputation of the affected digit. Wide local excision (WLE) of the nail apparatus has since become a conservative alternative for in situ or minimally invasive lesions. While several reconstructive techniques have been described after WLE, few centers have reported their outcomes objectively. This study presents our series of reconstructions following WLE of the nail apparatus.
Methods: We conducted a retrospective study at a university hospital, including patients referred by dermatologists for WLE and nail apparatus reconstruction between 2021 and 2024. Clinical, surgical, functional, and aesthetic outcomes were evaluated using validated scores (QuickDASH, Modified Mayo Wrist Score, AOFAS).
Results: Ten patients were included. Reconstructions were performed with full-thickness skin grafts (n = 6), with or without dermal matrix (n = 4), and local flaps (n = 4). Five patients underwent immediate definitive reconstruction. Two recurrences occurred: one requiring dermal matrix removal, and the other necessitated amputation forinvasive SUM. Functional and aesthetic outcomes were satisfactory, with a mean follow-up of 19 months and no local recurrence in the remaining patients. The mean QuickDASH score was 25.5 ± 16.4 (range: 2.3-41). For the three foot cases, the mean AOFAS score was 86 ± 4.1 (range: 80-90).
Conclusion: Nail apparatus reconstruction is feasible for in situ or minimally invasive SUM, particularly when the Breslow thickness is ≤0.5 mm. In invasive cases, immediate reconstruction risks being performed over residual tumor, supporting a two-stage approach, especially when donor site morbidity is expected. Techniques such as full-thickness skin grafts combined with a dermal matrix provide reliable functional and aesthetic outcomes. A two-stage approach is particularly valuable when oncologic margins are uncertain, as it reduces the risk of reconstructing over residual disease while preserving options with lower donor-site morbidity.
Keywords: Flap; Microsurgery; Nail apparatus; Nail reconstruction; Oncology; Subungual melanoma; Wide local excision.
© 2025 The Author(s).
Balancing secondary intention and reconstruction in nail apparatus melanoma: Plastic surgery insight from a case serie
Balancing secondary intention and reconstruction in nail apparatus melanoma: Plastic surgery insight from a case serie
Elise Lupon, Luc Chouquet, Olivier Camuzard
https://doi.org/10.1016/j.ijscr.2025.112030
Abstract
- •Secondary intention healing remains an option for nail apparatus melanoma.
- •Healing time is long and cosmetic results can be unpredictable.
- •Local flaps or dermal substitutes allow faster healing and better outcomes.
- •Perforator flaps can improve comfort and long-term functional results.
Keywords: Dermal substitute; Nail apparatus melanoma; Perforator flap; Reconstructive surgery; Secondary intention healing.
Influence of the Teaching Hospital Environment on Plastic Surgery Residents' Academic Interest and Career Aspirations: Insights from France
Influence of the Teaching Hospital Environment on Plastic Surgery Residents’ Academic Interest and Career Aspirations: Insights from France
Yanis Berkane, Haizam Oubari, Jonathan Cornacchini, Olivier Camuzard, Nicolas Bertheuil, Elise Lupon
https://doi.org/10.1097/gox.0000000000006652
Abstract
Background: Plastic surgery residency training in France presents unique challenges and opportunities, with a highly competitive environment and a growing demand for academic plastic surgeons. Understanding the factors influencing residents’ career decisions is essential for optimizing training programs and fostering academic interest.
Methods: A cross-sectional study was conducted using a self-administered questionnaire comprising 14 questions distributed via RedCAP between January and June 2023. The study included all residents and young attendings in all 21 French University Hospital Centers nationwide, from year 1 to postgraduate year 2.
Results: Among 204 contacted participants, 106 responses were obtained. All responses were complete. First-year residents represented 9.4% of respondents, whereas residents in the « deepening » and « consolidation phases » represented 41.5% and 25.6%, respectively. Senior residents such as « junior doctors » and young attendings represented 25.5% of survey respondents. Although most residents expressed interest in private practice, mentorship from academic surgeons emerged as a significant influencer toward academic pursuits. Despite the prevalence of academic mentors (38% of identified mentors), a discrepancy was found between perceived academic orientation and actual research opportunities, indicating a need for improved awareness and exposure to academic possibilities during residency. Financial considerations, including salary differentials and job security, also seemed to play a substantial role in career decision-making.
Conclusions: Cultivating a deeper understanding of academic careers’ multifaceted nature and enhancing the appeal of academic pursuits are essential for nurturing the next generation of academic plastic surgeons. It is hoped that this study will help enhance the appeal of academic vocations in plastic surgery residents.
Copyright © 2025 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.
Morphometric and curvature CT-based study of the distal radius watershed line
Morphometric and curvature CT-based study of the distal radius watershed line
Thomas Valerio, Elise Lupon, Alexandre Quemener-Tanguy, Eloïse Masse, Camille Brenac, Jean-Baptiste de Villeneuve Bargemon
https://doi.org/10.1016/j.hansur.2025.102168
Abstract
Purpose: Fixation of distal radius fractures involving the volar rim is technically demanding and often complex. In most cases, it requires the use of so-called « specific » plates. Although these plates have been developed using morphometric databases, proper application can still be imperfect-even when the plate appears to be correctly positioned. This mismatch may result in secondary displacement of the fragment, tendon irritation, or even tendon rupture. We hypothesized that anatomical variations in the radius, particularly in the shape of the watershed line, may explain the difficulty in achieving optimal plate adaptation in some patients.
Methods: Nineteen distal radius were analyzed using Computed Tomography-scan segmentation and curvature analysis to assess the shape of the watershed line. K-means clustering was then performed to identify distinct groups based on volar rim curvature patterns.
Results: Clustering analysis revealed two distinct anatomical groups based on volar rim curvature. The first group exhibited a mean curvature of 0.07 ± 0.03 mm–¹, while the second group had a significantly higher curvature of 0.23 ± 0.06 mm–¹ (mean ± SD). A Student’s t-test confirmed a statistically significant difference between the two groups (p < 0.001).
Conclusions: Our findings suggest the existence of at least two anatomical variations in volar rim shape at the watershed line, forming a spectrum between flatter and more sharply curved forms. These anatomical differences may explain inconsistencies in plate adaptation and should be taken into account by surgeons when selecting and positioning fixation hardware.
Level of evidence: Diagnostic study (IIIb).
Keywords: Anatomical variability; Distal radius fracture; Plate fixation; Volar rim; Watershed line.
Copyright © 2025 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.
Coverage of elbow and forearm soft tissue defects with the posterior ulnar recurrent artery perforator flap (PURAP): an anatomical study
Coverage of elbow and forearm soft tissue defects with the posterior ulnar recurrent artery perforator flap (PURAP): an anatomical study
Elise Lupon, Hadrien Paoli, Yanis Berkane, Nicolas Bertheuil, Jean Baptiste De Villeneuve Bargemon, Olivier Camuzard, Isabelle Pluvy, Benoît Chaput
https://doi.org/10.1007/s00276-025-03616-w
Abstract
Introduction: Covering soft tissue defects from the elbow and forearm is challenging for the plastic surgeon. The posterior ulnar recurrent artery perforator flap is a fasciocutaneous perforator flap vascularized by the perforators emerging from the posterior ulnar recurrent artery. It has multiple functional and aesthetic advantages but has not yet been well studied. This work aimed to examine the number, caliber, and topography of the posterior ulnar recurrent artery’s perforators.
Methods: Perforator mapping was performed by blue latex injection on 20 fresh cadavers’ upper extremities. Thermal mapping by TIRD was used to identify the « hot spots » of these perforators, and the 4D vascular network of the ulnar recurrent artery was scanned. The preoperative design and dissection of the flap were adapted based on the results of this anatomical study. A case study was performed to illustrate the clinical application.
Results: On average, we located 7.7 ± 1.7 perforators per upper extremity with an average caliber of 0.77 ± 0.19 mm (3.5 ± 1.2 in the forearm and 4.2 ± 1.5 in the arm). On average, the arm perforators were located 3.2 ± 1.6 cm proximally from the medial epicondyle. Thermal mapping showed three perforator « hot spots, » two in the forearm (directly at the artery origin level and one more posteriorly) and one in the arm. The 4D CT reconstructions allowed us to estimate the vascular territory at the level of the medial epicondyle and the distal half of the medial aspect of the arm, as well as the ascending course of the artery.
Conclusion: The posterior ulnar recurrent artery perforator flap can be harvested efficiently and reliably, as the posterior ulnar recurrent artery has constant perforators, especially around 3 cm proximal to the medial epicondyle. This reinforces this flap’s status as a potential elbow and forearm tissue defect coverage alternative.
Keywords: Anatomical study; Elbow defect coverage; Forearm defect coverage; Perforator flap; Posterior ulnar recurrent artery; Propeller flap.
© 2025. The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature.
Comment on: ``Objectifying aesthetic outcomes following face transplantation - the AI research metrics model``
Comment on: « Objectifying aesthetic outcomes following face transplantation – the AI research metrics model »
Elise Lupon
A New Method for Preparation of Decellularized Human Scaffolds for Facial Reconstruction
A New Method for Preparation of Decellularized Human Scaffolds for Facial Reconstruction
Elise Lupon, Aylin Acun, Alec R Andrews, Ruben Oganesyan, Hyshem H Lancia, Laurent Lantieri, Mark A Randolph, Curtis L Cetrulo Jr, Alexandre G Lellouch, Basak E Uygun
https://doi.org/10.3390/cimb47040275
Abstract
Vascularized composite allotransplantation (VCA) has emerged as a robust alternative for addressing anatomically complex defects but requires a toxic lifelong immunosuppressive regimen. Tissue engineering offers the promise of creating recipient-specific alternative grafts using a decellularization and recellularization approach. In this article, we establish a reliable protocol for human face decellularization by immersion as a new tool in the development of engineered graft alternatives for reconstructive surgery. Three cadaveric face grafts were immersed in 1% sodium dodecyl sulfate for 216 h followed by 1% Triton X-100 for 48 h, without perfusion through the pedicle. We determined that decellularization was successfully accomplished for three facial specimens as confirmed by histological evaluation and quantification of DNA content. The extracellular components including collagen, glycosaminoglycans, elastin, and matrix-bound growth factors were preserved. Vascular architecture did not show significant differences between native and decellularized grafts as imaged by X-ray angiography. The mechanical strength of the grafts was not altered after decellularization. We also showed that the decellularized grafts were biocompatible in vitro and in vivo allowing cell engraftment. As a result, we have successfully developed a protocol to yield a clinical size decellularized graft suitable for generating a recellularized, potentially non-immunogenic graft for facial reconstruction.
Keywords: decellularization; facial reconstruction; recellularization; regenerative medicine; scaffold; tissue engineering; vascularized composite allotransplantation.
Management of a large abdominal dermatofibrosarcoma protuberans requiring a life-threatening excision: A case report
Management of a large abdominal dermatofibrosarcoma protuberans requiring a life-threatening excision: A case report
Rawan Albadia, Perrine Rousset, Damien Massalou, Olivier Camuzard, Henri Montaudié, Elise Lupon
https://doi.org/10.1016/j.ijscr.2025.111579
Introduction and importance: Dermatofibrosarcoma protuberans (DFSP) is a rare malignant tumor of the dermis and subcutaneous tissue, characterized by local aggressiveness and a high recurrence rate. The gold standard treatment is wide excision with negative margins, sometimes using Mohs surgery, with careful planning for reconstruction. In challenging cases, neoadjuvant imatinib therapy and adjuvant radiotherapy may help optimize outcomes. We report a case of extensive abdominal DFSP requiring a multidisciplinary approach after resection exposed the liver and the last three right ribs.
Case presentation: Neoadjuvant imatinib was administered to reduce tumor size, followed by radical resection and immediate reconstruction using prosthetic mesh and three pedicled flaps: a deep inferior epigastric perforator flap, an anterior intercostal artery perforator flap, and a pedicled latissimus dorsi flap. The reconstruction was performed as a single-stage procedure. Postoperative ischemia due to hematoma required conversion of the latissimus dorsi flap into a free flap and remobilization of the remaining flap. A split-thickness skin graft was applied on postoperative day ten. Histology confirmed negative margins. At six months, the patient showed complete healing, no recurrence, and a satisfactory reconstructive outcome.
Clinical discussion: In such extensive DFSP cases, immediate flap reconstruction helps prevent complications related to exposed bone or viscera and preserves functional and aesthetic outcomes. It does not hinder oncologic follow-up and may reduce morbidity.
Conclusion: This case highlights the surgical and reconstructive challenges of large DFSPs and the vital role of a plastic surgery team in planning tailored, multidisciplinary management within an oncodermatology center.
Keywords: DFSP; Dermatofibrosarcoma protuberans; Imatinib; Perforators flaps.
Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.
Saphenous Vein-Preserving Inguinal Lymph Node Dissection: A Stepwise Technical Approach
Saphenous Vein-Preserving Inguinal Lymph Node Dissection: A Stepwise Technical Approach
Elise Lupon, Ioana Ivan, Olivier Camuzard, Dimitri Gangloff
https://doi.org/10.1002/ccr3.71712
Abstract
Preserving the great saphenous vein during inguinal lymph node dissection maintains venous outflow and skin drainage while allowing complete oncologic clearance.
Keywords: dermatology; inguinal lymph node dissection; melanoma; oncology; surgery.
Perforator identification for propeller flap harvest: Technical insights from a case serie
Perforator identification for propeller flap harvest: Technical insights from a case serie
Elise Lupon
InternalBrace™ for intercarpal ligament reconstruction: An ``All-dorsal`` variant technique with capsular preservation
InternalBrace™ for intercarpal ligament reconstruction: An « All-dorsal » variant technique with capsular preservation
Jean Baptiste de Villeneuve Bargemon, Antoine Martins, Brieuc Monin, Elise Lupon
The First Dorsal Metatarsal Artery Perforator Flap: A Description and Anatomical Study
The First Dorsal Metatarsal Artery Perforator Flap: A Description and Anatomical Study
Mathilde Saboye, Alexis Majchrzak, Grégoire d’Andréa, Nicolas Bronsard, Olivier Camuzard, Elise Lupo
https://doi.org/10.3390/jcm14124136
Abstract
Background/Objectives: Soft-tissue defects surrounding the big toe can be a challenging problem for reconstructive surgeons. The first dorsal metatarsal artery (FDMtA) arises from the dorsalis pedis artery, which itself arises in front of the ankle joint from the anterior tibial artery. This study aimed to characterize the FDMtA cutaneous perforators (FDMtAPs) and evaluate the potential of a local pedicled perforator flap to cover a hallux soft-tissue defect. Methods: Nine feet from fresh cadavers were dissected to describe the FDMtAP anatomy. For each artery, we recorded the origin’s position from the FDMtA, the proximal and distal diameters, and the artery’s course, length, number, and type. We described the FDMtA perforator flap harvest and its application through a clinical case. Results: A mean of 3.67 ± 1.23 FDMtAPs were found from the nine dissected feet, with at least 2 perforators per foot. Around 88% were located between 0 and 4 cm along the axis at their origin from the FDMtA, with an area of around 8 cm2 and a mean of 2.35 ± 0.36 cm long. The proximal diameter had a mean of 0.178 ± 0.037 mm and 0.110 ± 0.008 mm at the distal diameter. A pedicled flap was readily feasible for all dissections. The case described had satisfactory healing, correct functional, and aesthetic recovery at two months. Conclusions: The first dorsal metatarsal artery perforator flap seems to be a reliable and valuable solution for the hallux soft-tissue reconstruction, notably after the excision of acral melanoma.
Keywords: acral melanoma reconstruction; anatomical study; first dorsal metatarsal artery perforator flap; greater toe coverage; hallux soft-tissue reconstruction; perforator flap.
Letter to the Editor regarding ``Brachial plexus compression following a laterjet procedure``
Letter to the Editor regarding « Brachial plexus compression following a laterjet procedure »
Olivier Camuzard, Tanguy Perraudin, Lucas Lo Cunsolo, Elise Lupon
RE: How Artificial Intelligence Differs From Humans in Peer Review
RE: How Artificial Intelligence Differs From Humans in Peer Review
Gauthier Largarde, Grégoire Micicoi, Elise Lupon
Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach
Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach
Tanguy Perraudin, Yanis Berkane, Antoine Sicard, Nicolas Bronsard, Olivier Camuzard, Elise Lupon
Abstract
Upper limb amputations represent a real medical and surgical challenge. The ideal treatment should restore function, sensation, and body image. At present, neither traditional reconstructions nor prostheses meet all these criteria. However, vascularized composite allografts offer a unique option for restoring form and function satisfactorily despite harmful immunosuppression. Ideally, donor tissue is procured in excess to repair without tension. The donor upper limb is procured through a fish-mouth incision at the mid-arm level. Then, the brachial artery and vein, median, ulnar, and radial nerve are located and dissected. The biceps, brachioradialis, and triceps muscles are sectioned, and then an osteotomy of the humerus is performed above the elbow. For distal forearm transplantation, the donor upper limb can also be procured below the elbow by disarticulating through the joint. The brachial artery is cannulated, and the graft is irrigated with a preservative solution. Preparation of the graft then begins with two incisions, anterior and posterior, to raise two lateral skin flaps. A medial skin flap exposes the basilic vein, medial antebrachial cutaneous nerve, medial epicondylar muscles, ulnar nerve, median nerve, brachial artery, and vein. A lateral skin flap, including the cephalic vein, the lateral antebrachial cutaneous nerve, the radial nerve up to its division, the brachioradialis, and the lateral epicondylar muscles, completes graft preparation. In the case of transplantation, cutting guides are attached to the posterior surface of the two forearm bones to perform the osteotomies. This protocol presents a systematized procedure for procuring and preparing a vascularized forearm composite allograft to ensure optimal results and minimize tissue damage during procurement.
Evolution of cell therapies derived from adipose tissue: historical perspectives, current development trends and future directions
Evolution of cell therapies derived from adipose tissue: historical perspectives, current development trends and future directions
Silvia Gandolfi, Elise Lupon, Audrey Varin, Agnes Coste, Brigitte Sallerin, Carla Boyer, Yanis Berkane, Benoit Chaput
https://doi.org/10.1186/s13062-025-00682-3
Abstract
Over the last few decades, adipose tissue has attracted increasing attention in the field of regenerative medicine, thanks to discoveries related to its regenerative, anti-inflammatory, and pro-angiogenic properties. Over the years, with the advancement of sophisticated research around adipose tissue, there has been a shift from tissue transfer to cell transfer, and then to the application of cell-free derivatives and bioengineering. Understanding the evolution of this scientific revolution around adipose tissue not only helps clarify potential therapeutic products and indications but also allows us to discuss its limitations and future directions.
Keywords: Adipose tissue; Cell therapy; Regenerative medicine.
© 2025. The Author(s).
Utility of the Caprini risk assessment model in guiding venous thromboembolism prophylaxis after abdominoplasty
Utility of the Caprini risk assessment model in guiding venous thromboembolism prophylaxis after abdominoplasty
Abdulaziz Asiry, Anas Sayegh, Dimitri Gangloff, Hatan Mortada, Silvia Gandolfi, Elise Lupon
https://doi.org/10.1016/j.jpra.2025.09.01722
Abstract
Introduction: Abdominoplasty carries a significant risk of venous thromboembolism (VTE). Two main strategies have been described for prophylaxis: systematic administration of low molecular weight heparin (LMWH) and risk-stratified management using the Caprini score. This study aimed to assess thromboembolic risk in abdominoplasty patients and compare the cost-effectiveness of a Caprini-based strategy with routine prophylaxis.
Methods: A retrospective review was performed on 219 patients who underwent abdominoplasty at a university plastic surgery unit where systematic LMWH prophylaxis was standard. Demographic data, Caprini score components, complications, and costs were analyzed, and a cost-effectiveness comparison between systematic LMWH and a Caprini-based approach was performed.
Results: The mean Caprini score was 3.3 ± 1.1 (range 1-10). All patients received LMWH for a mean of 14.9 ± 1.5 days. One patient (0.45 %) developed pulmonary embolism, and 13 (5.9 %) developed hematomas. Cost analysis indicated that a risk-stratified approach could reduce LMWH expenditure by 44.5 %.
Conclusions: Applying the Caprini score for VTE prophylaxis in abdominoplasty may reduce unnecessary anticoagulation and associated complications, while generating substantial cost savings for centers that do not currently use this model.
Keywords: Abdominoplasty; Body contouring; Caprini risk assessment model; Low molecular weight heparin; Venous thromboembolism.
© 2025 The Author(s).
Trapeziectomy with an innovative suspensionplasty technique for trapeziometacarpal osteoarthritis
Trapeziectomy with an innovative suspensionplasty technique for trapeziometacarpal osteoarthritis
Richard Lachaux, André-Pierre Uzel, Marie-Anne Poumellec, Thierry Balaguer, Olivier Camuzard, Elise Lupon
Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation
Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation
Elise Lupon, Sergio A Segrera, Tanguy Perraudin, Anandhini D Narayanan, Alexis K Gursky, Hailey P Wyatt, Eduardo D Rodriguez
Abstract
Full facial vascularized composite allotransplantation (VCA) offers a reconstructive option for patients with severe facial disfigurement who cannot be treated with conventional methods. This article details a surgical protocol for donor procurement of a full facial allograft, focusing on soft tissue with limited bony harvest restricted to the nasal framework, and emphasizes key anatomical landmarks and technical considerations for safe and efficient harvest. The procedure involves dissection of the entire facial soft tissues while preserving the external carotid artery, internal jugular veins and subsequent thyro-linguofacial, and branches of the facial and maxillary nerves to maximize pedicle length for later neurorrhaphy. The protocol describes systematic exposure of the vascular pedicles at their origin in the neck, subperiosteal elevation of the scalp, identification and division of the supraorbital and infraorbital nerves, and preparation of the facial nerve at its root to achieve optimal length. Strategies to minimize ischemia time and ensure allograft integrity are highlighted. This article provides a comprehensive visual guide to the procurement phase of a full soft tissue face allograft and aims to standardize the technique for research application and surgical training in advanced vascularized composite allotransplantation.
Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation
Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation
Tanguy Perraudin, Selma Lahlali, Nicolas Bronsard, Antoine Sicard, Olivier Camuzard, Elise Lupon
Abstract
In vascularized composite allograft (VCA) for upper limb reconstruction, upper arm-level or transhumeral transplantations are performed less frequently than forearm and hand transplantations. Transplantation is technically more feasible at this proximal level, largely owing to the use of macrovascular anastomoses. Despite these challenges, the outlook for arm allotransplantation remains encouraging, and this protocol provides a standardized technique for harvesting a vascularized upper arm composite allograft, ensuring both optimal outcomes and minimal tissue trauma. In the case of upper arm transplant, the technique varies according to the level of transplantation: supracondylar, transhumeral at a proximal arm level, or through the shoulder with the donor humeral head. A circumferential skin incision at mid-arm, or depending on the level at the origin of the upper limb, is made. A skin flap, such as a deltoid flap, can be harvested from the donor for skin closure at proximal levels. Dissection of the cephalic vein and deeper the brachial or axillary artery and veins is required. Then, the surgeon must identify the nerves depending on the level (terminal branches of brachial plexus or anteromedial and anterolateral cords for proximal transplantation) and transect the biceps, brachialis, and triceps muscles. The coracobrachialis and the deltoid muscles may also be dissected depending on the amputation level. Finally, the surgeon must make a transhumeral osteotomy or, if needed, harvest the donor humeral head for shoulder reconstruction. In this case, a peroneus longus graft for the suspension ligamentoplasty can also be harvested. The goal of this protocol is to standardize the procedure of harvesting and preparing an upper arm allotransplant.
Reconstruction After Wide Excision of the Nail Apparatus in the Treatment of Melanoma: A Systematic Literature Review
Reconstruction After Wide Excision of the Nail Apparatus in the Treatment of Melanoma: A Systematic Literature Review
Luc Chouquet, Feriel Boukari, Thierry Balaguer, Henri Montaudié, Olivier Camuzard, Elise Lupon
https://doi.org/10.3390/jcm14175932
Abstract
Background/Objectives: Historically, the treatment of subungual melanoma was based on amputation of the affected digit. However, extended wide local excision of the nail apparatus is now considered the conservative gold standard for in situ or minimally invasive forms. There are many after wide local excision reconstruction techniques, but few studies have objectively compared their results. The objectives were to carry out a systematic review of reconstruction after wide local excision reconstructions in the treatment of subungual melanoma. Methods: This systematic review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. An exhaustive search was conducted in the PubMed (Medline), Embase, and Cochrane Library databases, up to July 2025. Articles reporting reconstructions after wide local excision for subungual melanoma of the fingers or toes were included. Clinical, technical, and outcome data were analyzed. Results: The literature review comprised 24 articles on 373 patients, primarily those with in situ subungual melanoma. Reconstruction was most often performed using total skin grafts, sometimes combined with dermal matrices. Some authors used local or free flaps. Few studies used validated functional scores. Local recurrences were significant, affecting 18% of patients and requiring secondary amputation. Conclusions: Nail apparatus reconstructions are primarily indicated for in situ or minimally invasive subungual melanomas. Immediate reconstruction carries a risk of performing the reconstruction over residual tumor tissue, particularly in the case of invasive melanomas. Reconstructive techniques, such as full-thickness skin grafts and the use of dermal matrices, can provide satisfactory functional and aesthetic outcomes. However, objective evaluations of these results remain limited, and better standardization of clinical practice, along with prospective studies, is needed to refine long-term outcome assessment.
Keywords: nail apparatus; nail melanoma; nail reconstruction; subungual melanoma; wide local excision.
Outcomes of All-Dorsal Augmented Intercarpal Ligament Reconstruction
Outcomes of All-Dorsal Augmented Intercarpal Ligament Reconstruction
Jean-Baptiste de Villeneuve Bargemon, Silvia Gandolfi, Elise Lupon
Procurement for a Vascularized and Reinnervated Abdominal Wall Allotransplantation
Procurement for a Vascularized and Reinnervated Abdominal Wall Allotransplantation
Pierre Barbat, Antoine Sicard, Yanis Berkane, Nicolas Bronsard, Olivier Camuzard, Elise Lupon
Abstract
Abstract
Extensive and complex abdominal wall defects, particularly those associated with intestinal or visceral organ damage, pose significant medical and surgical challenges. An ideal reconstruction must restore anatomy, function, sensation, and body image. Currently, no conventional reconstruction method fulfills all these criteria in such complex scenarios. However, vascularized composite allotransplantation (VCA) offers a unique solution, providing satisfactory anatomical and functional outcomes — albeit at the cost of lifelong immunosuppression. Since the first reported human case in 2003, approximately 40 abdominal wall transplants have been performed worldwide, all in conjunction with intestinal or multivisceral transplantation. While various technical adaptations have been described, the procedure has proven to be both safe and effective for patients with complex abdominal wall defects. To date, no reinnervated abdominal wall allograft has been attempted in humans. However, reinnervation appears to be the next frontier, with the potential to enhance functional outcomes and reduce complications. This protocol outlines a standardized procedure for harvesting and preparing a vascularized abdominal wall composite allograft, designed to ensure optimal results and minimize tissue damage. The graft, vascularized via the deep inferior epigastric vessels, is harvested with generous margins to enable tension-free reconstruction. We also detail the specific steps required to collect an innervated specimen. At the end of the procedure, the two deep inferior epigastric arteries are cannulated, and the graft is perfused with preservation solution for transport. Ultimately, this protocol aims to standardize abdominal wall graft procurement. It is intended as a valuable resource for both translational research and clinical applications, particularly as interest in abdominal wall transplantation continues to grow.
Application of Microgravity Experiments in Plastic Surgery: A Literature Review
Application of Microgravity Experiments in Plastic Surgery: A Literature Review
Jonathan Cornacchini, Yanis Berkane, Vlad Tereshenko, Olivier Camuzard, Alexandre G Lellouch, Elise Lupon
https://doi.org/10.1097/gox.0000000000006802
Abstract
Background: Interest in microgravity is growing in the medical and surgical fields. This literature review aims to synthesize existing evidence on microgravity applications in plastic surgery, focusing on experimental methods, outcomes, and prospects.
Methods: All reported articles up to October 2023, including publications and news reports, were screened for inclusion using Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The PubMed keywords and Boolean operators were « plastic surgery AND microgravity, » « plastic surgery AND spaceflight, » « wound healing AND microgravity, » « skin aging AND microgravity, » « skin cancer AND microgravity, » and « melanoma AND microgravity. »
Results: A total of 201 articles were identified, and 14 studies were included. Plastic surgery procedures can be performed under microgravity, resulting in a delayed wound healing process. Four studies demonstrated that microgravity could reduce skin thickness and modify cell metabolism. In 2 studies, neoplastic melanoma cells have shown behavioral modifications under microgravity with induced apoptosis but increased potential for metastasis.
Conclusions: Microgravity represents a unique environment with potential implications in plastic surgery, although further rigorous studies need to be conducted in humans. The anticipated rise and development of spaceflights render the study of biological changes in space an impactful and significant topic.
Copyright © 2025 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.
Publications 2024 du Dr LUPON Élise
Superior Pedicle Breast Reduction: Multivariate Analysis of Complication Risk Factors and Building a Predictive Score in 1306 Patients
Superior Pedicle Breast Reduction: Multivariate Analysis of Complication Risk Factors and Building a Predictive Score in 1306 Patients
Paul Girard, Yanis Berkane, Jérôme Laloze, Chloé Rousseau, Elise Lupon, Sacha Schutz, Eric Watier, Nicolas Bertheuil
https://doi.org/10.1097/prs.0000000000010828
Abstract
Background: Breast reduction surgery for hypertrophy is one of the most commonly performed procedures in plastic surgery. This surgery exposes patients to complications that are well-documented in the literature. The objective of this study is to identify risk factors to establish an estimate of the risk of developing complications. The authors propose the first predictive score of postoperative complications, including continuous preoperative variables such as body mass index (BMI) and suprasternal notch-to-nipple distance (SSN:N).
Methods: An analytic observational retrospective cohort study was conducted including 1306 patients who underwent superior pedicle reduction mammaplasty at the Rennes University Hospital (France) between January 1, 2011, and December 31, 2016. The primary endpoint was to study the association between known preoperative risk factors and occurrence of any complications using multivariable logistic regression to identify independent risk factors. A secondary endpoint was to establish a score to estimate a probability of occurrence of complications.
Results: A total of 1306 patients were analyzed. Multivariable logistic regression showed three independent risk factors: active smoking [OR, 6.10 (95% CI: 4.23, 8.78); P < 0.0001], BMI [OR, 1.16 (95% CI: 1.11, 1.22); P < 0.0001], and SSN:N [OR, 1.14 (95% CI: 1.08, 1.21); P < 0.0001]. The Rennes Plastic Surgery Score estimating the occurrence of postoperative complications was determined, integrating regression coefficients of each risk factor.
Conclusions: Active smoking, BMI, and SSN:N distance are independent preoperative risk factors for the occurrence of breast reduction complications. The Rennes Plastic Surgery Score including the continuous values of BMI and SSN:N allows us to provide our patients with a reliable estimation of the risk of occurrence of these complications.
Clinical question/level of evidence: Risk, III.
Copyright © 2023 by the American Society of Plastic Surgeons.
Regarding ``Adjuvant Arthroscopy Does Not Improve the Functional Outcome of Volar Locking Plate for Distal Radius Fractures: A Randomized Clinical Trial``
Regarding « Adjuvant Arthroscopy Does Not Improve the Functional Outcome of Volar Locking Plate for Distal Radius Fractures: A Randomized Clinical Trial »
Jean-Baptiste de Villeneuve Bargemon, Elise Lupon, Marie Witters, Camille Brenac
Abdominoplasty and Lower Body Lift Surgery Improves the Quality of Life after Massive Weight Loss: A Prospective Multicenter Study
Abdominoplasty and Lower Body Lift Surgery Improves the Quality of Life after Massive Weight Loss: A Prospective Multicenter Study
Yanis Berkane, François Saget, Elise Lupon, Camille Mocquard, Isabelle Pluvy, Eric Watier, Alexandre G Lellouch, Jérôme Duisit, Benoit Chaput, Nicolas Bertheuil
https://doi.org/10.1097/prs.0000000000010683
Abstract
Background: This study was conducted to assess the impact of abdominoplasty and lower body lift surgery following massive weight loss on both the general quality of life and the sexual life of patients.
Methods: The authors performed a multicenter prospective study on the quality of life after massive weight loss using three scoring questionnaires: The Short-Form 36 questionnaire, the Female Sexual Function Index questionnaire, and the Moorehead-Ardelt Quality of Life Questionnaire. Seventy-two patients who underwent lower body lift and 57 patients who underwent abdominoplasty in three centers with preoperative and postoperative evaluation were included.
Results: The mean age of the patients was 43.2 ± 13.2 years. All categories of the Medical Outcomes Study Short-Form 36 Health Status Survey questionnaire were statistically significant at 6 months, and all categories except health change were significantly improved at 12 months postoperatively. Overall, the Moorehead-Ardelt questionnaire showed a higher quality of life in general (1.78 ± 0.92 and 1.64 ± 1.03 at 6 and 12 months, respectively) and in all domains (ie, self-esteem, physical activity, social relationships, work performance, and sexual activity). Interestingly, global sexual activity improved at 6 months but not at 12 months. Some domains of sexual life improved at 6 months (ie, desire, arousal, lubrication, satisfaction), but only desire remained improved at 12 months.
Conclusions: Abdominoplasty and lower body lift improve the quality of life of patients after massive weight loss and the sexual quality of life. This should be an additional valid reason for promoting reconstructive surgery for massive weight loss patients.
Clinical question/level of evidence: Therapeutic, IV.
Copyright © 2023 by the American Society of Plastic Surgeons.
Intrafocal Pinning in Distal Extraarticular Radius Fracture: A Retrospective Study Based on Patient Age
Intrafocal Pinning in Distal Extraarticular Radius Fracture: A Retrospective Study Based on Patient Age
Abdulaziz Asiry, Jean Baptiste De Villeneuve Bargemon, Stéphanie Delclaux, Pierre Mansat, Silvia Gandolfi, Elise Lupon
https://doi.org/10.1097/gox.0000000000006229
Abstract
Background: Percutaneous intrafocal pinning is one of the many surgical options for extraarticular distal radius fracture with minimal comminution. This study aims to describe the role and indications of intrafocal pinning.
Methods: This monocentric, retrospective study included 49 patients who underwent intrafocal pinning for distal radius fractures in 2013 in our French hand surgery department. All the patients underwent posteroanterior and lateral x-ray on days 2 and 45 to measure radial inclination, distal radioulnar index, and volar tilt.
Results: The mean age of the patients was 45.4 years, with women representing approximately 61.2% of the sample (n = 30). The patients were divided into three groups: group A (17-50 y), 26 patients; group B (50-70 y), 15 patients; and group C (>70 y), eight patients. We documented on x-ray images, 21 secondary displacements, including seven in group C. There were three displacements (all in group C) and one surgical revision within 15 days for a previous displacement. The distal radioulnar index increased in all three groups.
Conclusions: The percutaneous intrafocal pinning fixation technique exposes a high risk of complications, especially for those older than 50 years, for whom this technique should be avoided. Overall, due to the frequency of secondary displacements encountered, our first-line treatment favors plate osteosynthesis for all patients. Pinning fixation should only be considered with caution in younger patients if plate osteosynthesis is not possible, but it requires a strict 6-week immobilization. The fracture morphology must also be considered.
Copyright © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.
Vascularized posterior interosseous nerve graft for digital neurovascular bundle reconstruction
Vascularized posterior interosseous nerve graft for digital neurovascular bundle reconstruction
George Paleu, Tanguy Perraudin, Alexis Majchrzak, Mihai Grigore, Elise Lupon, Olivier Camuzard
https://doi.org/10.1016/j.hansur.2024.101761
Abstract
Introduction: Despite the progress in microsurgery in recent decades, neurovascular bundle defects during ring finger injuries still pose challenges for the surgeon. Usually, a reversed venous graft and a non-vascularized nerve graft are utilized to reconstruct this defect. One of the most common challenges encountered when using a venous graft is the caliber mismatch between the graft and the digital arterial ends. The use of an arterialized nerve graft (neurovascular graft) is poorly described and could represent an attractive reconstructive option.
Case presentation: We present the case of a 36-year-old manual worker, a non-smoker, with no significant medical or surgical comorbidities, who presented a ring avulsion type trauma, leading to the amputation of the third left finger at the distal interphalangeal joint and avulsion of the circumferential skin at the level of the middle and proximal phalanges (Urbaniak III). The patient presented a neurovascular bundle defect of 3 cm, reconstructed by the vascularized posterior interosseous nerve graft along the distal perforator of the dorsal branch of the anterior interosseous artery serving both as an interpositional arterial conduit and as a nerve graft. The results of postoperative nerve regeneration at three years are satisfactory, with the patient demonstrating a two-point discrimination measured at 6 mm.
Conclusion: Simultaneous digital artery and nerve reconstruction using a neurovascular flap is very appealing to the hand surgeon as it offers several advantages over traditional methods, particularly the ideal diameter match between the digital arteries and the distal perforator of the dorsal branch of the anterior interosseous artery.
Keywords: Branch of the anterior interosseous artery; Digit amputation; Digital neurovascular bundle reconstruction; Posterior interosseous nerve; Ring finger; Vascularized nerve graft.
Copyright © 2024 SFCM. Published by Elsevier Masson SAS. All rights reserved.
Exploring Iodide and Hydrogen Sulfide as ROS Scavengers to Delay Acute Rejection in MHC-Defined Vascularized Composite Allografts
Exploring Iodide and Hydrogen Sulfide as ROS Scavengers to Delay Acute Rejection in MHC-Defined Vascularized Composite Allografts
Philipp Tratnig-Frankl, Alec R Andrews, Yanis Berkane, Claire Guinier, Marion Goutard, Elise Lupon, Hyshem H Lancia, Michael L Morrison, Mark B Roth, Mark A Randolph, Curtis L Cetrulo Jr, Alexandre G Lellouch
https://doi.org/10.3390/antiox13050531
Abstract
Vascularized composite allografts (VCA) face ischemic challenges due to their limited availability. Reperfusion following ischemia triggers oxidative stress and immune reactions, and scavenger molecules could mitigate ischemia-reperfusion injuries and, therefore, immune rejection. We compared two scavengers in a myocutaneous flap VCA model. In total, 18 myocutaneous flap transplants were performed in Major histocompatibility complex (MHC)-defined miniature swine. In the MATCH group (n = 9), donors and recipients had minor antigen mismatch, while the animals were fully mismatched in the MISMATCH group (n = 9). Grafts were pretreated with saline, sodium iodide (NaI), or hydrogen sulfide (H2S), stored at 4 °C for 3 h, and then transplanted. Flaps were monitored until clinical rejection without immunosuppression. In the MATCH group, flap survival did not significantly differ between the saline and hydrogen sulfide treatments (p = 0.483) but was reduced with the sodium iodide treatment (p = 0.007). In the MISMATCH group, survival was similar between the saline and hydrogen sulfide treatments (p = 0.483) but decreased with the sodium iodide treatment (p = 0.007). Rhabdomyolysis markers showed lower but non-significant levels in the experimental subgroups for both the MATCH and MISMATCH animals. This study provides insightful data for the field of antioxidant-based approaches in VCA and transplantation.
Keywords: VCA; acute rejection; free radical scavengers; ischemia–reperfusion injury; transplantation; vascularized composite allotransplantation.
Immunosuppressant drug monitor: A non-invasive device to measure tacrolimus level in the saliva of transplanted patients
Immunosuppressant drug monitor: A non-invasive device to measure tacrolimus level in the saliva of transplanted patients
Laura Charlès, Elise Lupon, Tia Sheth, Olivier Camuzard, Alexandre G Lellouch, Chetan Shende, Stuart Farquharson, Kassem Safa, Curtis L Cetrulo Jr
https://doi.org/10.1016/j.ijpharm.2024.123858
Abstract
Solid organ and vascularized composite allograft transplantation are pivotal in enhancing both life expectancy and quality of life. However, the significant risk of donor tissue rejection requires lifelong immunosuppressive therapy. Tacrolimus, a common component of immunosuppressive regimens, offers effectiveness in preventing organ rejection but poses challenges due to its narrow therapeutic window and toxicity, making it essential to carefully monitor its concentration. Tacrolimus trough levels are currently measured in blood, requiring frequent blood draws from patients, and results are available after 3 to 6 h. To address the need for a fast, minimally-invasive, and simple method to monitor tacrolimus concentrations, we have assessed a new device for at-home analysis, the Immunosuppressant Drug Monitor (IDM) that can extract, identify and quantify tacrolimus in saliva within 15 min. We included males and females hospitalized at Massachusetts General Hospital Transplant Unit, between the ages of 21 and 65 years, and treated with Tacrolimus. Informed consent, demographic and treatment data were collected. Each subject was asked to provide a 5 mL saliva sample that was de-identified and processed by the IDM, while a 5 mL blood sample was drawn and supplied to the MGH clinical lab for analysis by the current standard, immunoassays. The predicted tacrolimus concentration found in saliva was compared to the blood trough level results. 62 samples from 31 different patients were obtained. The male to female ratio and ethnicity distribution were well balanced. The majority of patients were within 30 days of initiating tacrolimus treatment. After IDM calibration and exclusion, 21 samples were measured by the IDM. Using an exponential function fit, the IDM showed a correlation of R2 = 0.39 between the saliva Test Line absorption and the measured tacrolimus concentration in blood, with an average absolute error of 1.8 ng/mL. Our results demonstrate a clear correlation between blood and saliva measurements. The IDM provided promising results to monitor immunosuppressant drug concentrations in patients after transplantation. Future larger studies will further develop the correlation, and the IDM’s potential impact on patient outcomes.
Keywords: Absorption spectroscopy; At-home; Saliva analysis; Tacrolimus; Toxicity; Transplant.
Copyright © 2024 Elsevier B.V. All rights reserved.
Optimized Decellularization of a Porcine Fasciocutaneaous Flap
Optimized Decellularization of a Porcine Fasciocutaneaous Flap
Elise Lupon, Aylin Acun, Corentin B Taveau, Ruben Oganesyan, Hyshem H Lancia, Alec R Andrews, Mark A Randolph, Curtis L Cetrulo Jr, Alexandre G Lellouch, Basak E Uygun
https://doi.org/10.3390/bioengineering11040321
Abstract
Reconstructive techniques to repair severe tissue defects include the use of autologous fasciocutaneous flaps, which may be limited due to donor site availability or lead to complications such as donor site morbidity. A number of synthetic or natural dermal substitutes are in use clinically, but none have the architectural complexity needed to reconstruct deep tissue defects. The perfusion decellularization of fasciocutaneous flaps is an emerging technique that yields a scaffold with the necessary composition and vascular microarchitecture and serves as an alternative to autologous flaps. In this study, we show the perfusion decellularization of porcine fasciocutaneous flaps using sodium dodecyl sulfate (SDS) at three different concentrations, and identify that 0.2% SDS results in a decellularized flap that is efficiently cleared of its cellular material at 86%, has maintained its collagen and glycosaminoglycan content, and preserved its microvasculature architecture. We further demonstrate that the decellularized graft has the porous structure and growth factors that would facilitate repopulation with cells. Finally, we show the biocompatibility of the decellularized flap using human dermal fibroblasts, with cells migrating as deep as 150 µm into the tissue over a 7-day culture period. Overall, our results demonstrate the promise of decellularized porcine flaps as an interesting alternative for reconstructing complex soft tissue defects, circumventing the limitations of autologous skin flaps.
Keywords: decellularization; recellularization; soft tissue reconstruction; tissue engineering; vascularized composite allotransplantation.
Tissue engineering strategies for breast reconstruction: a literature review of current advances and future directions
Tissue engineering strategies for breast reconstruction: a literature review of current advances and future directions
Yanis Berkane, Haizam Oubari, Loïc van Dieren, Laura Charlès, Elise Lupon, Michelle McCarthy, Curtis L Cetrulo Jr, Nicolas Bertheuil, Basak E Uygun, David M Smadja, Alexandre G Lellouch
https://doi.org/10.21037/atm-23-1724
Abstract
Background and objective: Mastectomy is a primary treatment for breast cancer patients, and both autologous and implant-based reconstructive techniques have shown excellent results. In recent years, advancements in bioengineering have led to a proliferation of innovative approaches to breast reconstruction. This article comprehensively explores the promising perspectives offered by bioengineering and tissue engineering in the field of breast reconstruction.
Methods: A literature review was conducted between April and June 2023 on PubMed and Google Scholar Databases. All English and French articles related to bioengineering applied to the field of breast reconstruction were included. We used the Evidence-Based Veterinary Medicine Association (EBVM) Toolkit 14 checklist for narrative reviews as a quality assurance measure and the Scale for the Assessment of Narrative Review Articles (SANRA) tool to self-assess our methodology.
Key content and findings: Over 130 references related to breast bioengineering were included. The analysis revealed four key applications: enhancing the quality of the skin envelope, improving the viability of fat grafting, creating breast shape and volume via bio-printing, and optimizing nipple reconstruction through engineering techniques. The primary identified approaches revolved around establishing structural support and enhancing cellular viability. Structural techniques predominantly involved the implementation of 3D printed, decellularized, or biocompatible material scaffolds. Meanwhile, promoting cellular content trophicity primarily focused on harnessing the regenerative potential of adipose-derived stem cells (ADSCs) and increasing the tissue’s survivability and cell trophicity.
Conclusions: Tissue and bioengineering hold immense promise in the field of breast reconstruction, offering a diverse array of approaches. By combining existing techniques with novel advancements, they have the potential to significantly enhance the therapeutic options available to plastic and reconstructive surgeons.
Keywords: Breast surgery; acellular matrix; breast reconstruction; scaffold; tissue engineering.
2024 Annals of Translational Medicine. All rights reserved.
Update/Refinement of Targeted Muscle Reinnervation Indication: A Scoping Review of Applications for Non-Amputees
Update/Refinement of Targeted Muscle Reinnervation Indication: A Scoping Review of Applications for Non-Amputees
Jonathan Cornacchini, Haïzam Oubari, Vlad Tereshenko, Maria Bejar-Chapa, Yanis Berkane, Anna Scarabosio, Alexandre G Lellouch, Olivier Camuzard, Kyle R Eberlin, Elise Lupon
https://doi.org/10.3390/jcm13206107
Abstract
Background: Targeted muscle reinnervation (TMR) was originally developed to enhance prosthetic control in amputees. However, it has also serendipitously demonstrated benefits in reducing phantom pain and neuromas. As a result, it has emerged as a secondary treatment for chronic neuromas in amputees and holds promise for managing neuropathic pain in non-amputee patients, particularly those with neuromas. This review synthesizes the current literature on TMR indications for non-amputee patients, highlighting its potential to address chronic peripheral nerve pain and neuromas beyond its original application in amputation. Methods: A thorough search of the PubMed and Cochrane databases up to January 2024 was conducted following the PRISMA guidelines. Inclusion criteria comprised case series, cohort studies, and randomized controlled trials reporting TMR outcomes in non-amputees. Results: Of 263 articles initially identified, 8 met the inclusion criteria after screening and full-text assessment. The articles were all case series with varied sample sizes and mainly focused on neuroma treatment (n = 6) and neuropathic pain management (n = 2) for both upper and lower extremities. Clinical studies included TMR efficacy for sural nerve neuromas in the lower extremities and hand neuromas, showing pain relief and improved function. Key findings were encouraging, showing successful pain relief, patient satisfaction, and psychosocial improvement, with only rare occurrences of complications such as motor deficits. Conclusions: In non-amputee patients, TMR appears to be a promising option for the surgical management of neuropathic pain, demonstrating favorable patient satisfaction and psychosocial outcomes along with low morbidity rates. Although functional improvements in gait recovery and range of motion are encouraging, further research will be important to confirm and expand upon these findings.
Keywords: TMR; complex regional pain syndrome; neuroma; neuropathic pain; non-amputee; post-mastectomy pain syndrome.
Microsurgery in low- and middle-income countries: Results of 20 years of experience in Cambodia
Microsurgery in low- and middle-income countries: Results of 20 years of experience in Cambodia
Elise Lupon, Benoît Chaput, Yong-June Kim, Sopheap Pogn, Aymeric Andre, Frédéric Lauwers
https://doi.org/10.1016/j.bjps.2024.08.073
Abstract
Background: Microsurgical free tissue transfer is the gold standard for reconstructing major bone or soft tissue defects but requires complex training, and specific resources. Therefore, some authors have stated that microsurgery is impossible in low- and middle-income countries.
Methods: Patients from Khmer underwent free flap surgery at the Children’s Surgical Centre in Phnom Penh between 2004 and 2023. Two non-governmental organizations facilitated the program: Rose Charities Cambodia provided the facilities, patients and local staff, and Doctors of the World provided the surgeons, and anesthetists. At least one Khmer surgeon was trained during these operations. Digital data were collected retrospectively, and analyzed in June 2023.
Results: Fifty-six free flaps in 54 patients have been performed since 2004. The most frequent sites requiring reconstruction were the head and neck (35.7%), lower limbs (30.4%), and upper limbs (21.4%). The most frequent free flaps were free fibula (44.6%), gracilis (19.6%), and anterolateral thigh (16.1%). Among the 56 flaps, 41 (= 73.2%) were viable long-term and 15 (26.7%) were microsurgical failures. Sixteen flaps underwent revision in the operating room. Twenty-three flap-related complications were reported in 21 patients with mostly vascular thrombosis (n = 12), hematoma (n = 3) and infections (3). However, 83.3% had improved or were cured of their initial pathology after final surgical management.
Conclusions: Free flaps performed in our series as part of international surgical collaborations in a low-income country are feasible, but we experienced higher failure rates, and later revisions compared to the results in high-income countries. We identified several solutions to improve the microsurgery outcomes in low-income settings.
Keywords: Free flap; Free tissue transfer; International surgical collaborations; Low- and middle-income countries; Microsurgery; Surgical missions.
Copyright © 2024 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
Nonsurgical Treatment of Postburn Hypopigmentation: A Literature Review
Nonsurgical Treatment of Postburn Hypopigmentation: A Literature Review
Elise Lupon, Yanis Berkane, Nicolas Bertheuil, Curtis L Cetrulo, Camille Vaillant, Benoît Chaput, Olivier Camuzard, Alexandre G Lellouch
https://doi.org/10.1093/jbcr/irae030
Abstract
The treatment of postburn hypopigmentation was primarily surgical before the advent of new technologies. Medical devices and therapies are emerging to manage scar sequelae that can be disfiguring and associated with severe psychosocial impact. These innovations have been poorly investigated for hypopigmentation, but they represent a real hope. We reviewed all articles published on Pubmed up to June 2022. Included studies had to specifically focus on treating postburn hypopigmented scars. All articles evaluating transient solutions such as make-up, and articles describing inflammation-linked hypopigmentation with no etiological details or no burn injury history were excluded. Through this review, we have highlighted 6 different types of nonsurgical treatments reported in postburn leukoderma potentially allowing definitive results. Electrophoto-biomodulation or E light (combining intensive pulsed light, radiofrequency, and cooling), topical daylight psoralen UVA therapy, and lasers (fractional lasers using pulse energies or CO2FL devices, lasers-assisted drug delivery as local bimatoprost and tretinoin or pimecrolimus) have been explored with encouraging results in hypopigmented burns. Finally, other promising medical strategies include using FK506, a nonsteroidal anti-inflammatory drug, to induce melanogenesis or using melanocyte-stimulating hormones with fractional laser-assisted drug deliveries, which are expected to emerge soon.
Keywords: dyschromia; hypopigmentation; leukoderma; postburn sequelae; skin burn.
`{`Advances and perspectives in vascularized composite allotransplantation preservation`}`
A[Advances and perspectives in vascularized composite allotransplantation preservation]
Yanis Berkane, Haizam Oubari, Elise Lupon, Marion Goutard, Pierre Tawa, Mark A Randolph, Curtis L Cetrulo Jr, Nicolas Bertheuil, Alexandre G Lellouch, Korkut Uygun
https://doi.org/10.1016/j.banm.2024.09.001
Abstract
Les allotransplantations de tissus composites (ATC) concernent les transplantations de face, de membre supérieur, de trachée, de pénis, de paroi abdominale et, plus récemment, d’utérus. Ces greffons ont la particularité de comporter de nombreux tissus spécialisés dérivant de plusieurs feuillets embryonnaires, chacun présentant des contraintes spécifiques. Là où la composante cutanée, en tant que barrière immunologique, est un véritable challenge sur le plan de la tolérance immunitaire, le muscle est très sensible à l’ischémie, et les lésions d’ischémiereperfusion peuvent mener à un relargage antigénique favorisant les épisodes de rejet. Si le gold standard de la préservation de ces greffons demeure la préservation froide statique (4 °C), l’émergence des techniques dynamiques de perfusion en transplantation d’organes solides permet d’envisager leur adaptation aux ATC. Par cette revue, nous exposons les défis posés par l’allotransplantation de tissus composites, et discutons les dernières avancées en matière de préservation d’ATC basées sur machine de perfusion mais également sur les techniques statiques à températures négatives. Une attention particulière est portée à la préservation par perfusion subnormothermique et aux techniques de supercooling (surfusion), développées par notre équipe, tentant d’importer ces techniques optimisées en préservation d’organes solides. © 2024 l’Academie nationale de médecine. Publié par Elsevier Masson SAS. Tous droits réservés, y compris ceux relatifs à la fouille de textes et de données, à l’entraînement de l’intelligence artificielle et aux technologies similaires.
Keywords: Composite tissue allografts; Cryopreservation/methods; Organ preservation; Organ preservation/methods; Perfusion/methods; Vascularized composite allotransplantation.
Publications 2023 du Dr LUPON Élise
Superior Pedicle Breast Reduction: Multivariate Analysis of Complication Risk Factors and Building a Predictive Score in 1306 Patients
Abdominoplasty and Lower Body Lift Surgery Improves the Quality of Life after Massive Weight Loss: A Prospective Multicenter Study/strong>
Paul Girard, Yanis Berkane, Jérôme Laloze, Chloé Rousseau, Elise Lupon, Sacha Schutz, Eric Watier, Nicolas Bertheuil
https://doi.org/10.1097/prs.0000000000010828
Regarding ``Clinical Outcomes of Arthroscopic One-Tunnel Triangular Fibrocartilage Complex Transosseous Suture Repair Are Not Diminished in Cases of Ulnar Styloid Process Fracture Nonunion``
Abdominoplasty and Lower Body Lift Surgery Improves the Quality of Life after Massive Weight Loss: A Prospective Multicenter Study/strong>
Jean-Baptiste de Villeneuve Bargemon, Elise Lupon, Brieuc Monin, Christophe Mathoulin
https://doi.org/10.1016/j.arthro.2023.01.095
Comment to: Dorsal bridge plating versus bridging external fixation for management of complex distal radius fracture
Abdominoplasty and Lower Body Lift Surgery Improves the Quality of Life after Massive Weight Loss: A Prospective Multicenter Study/strong>
Jean-Baptiste de Villeneuve Bargemon, Romain Mari, Christophe Mathoulin, Elise Lupon
https://doi.org/10.1016/j.injury.2023.01.0113
Abdominoplasty and Lower Body Lift Surgery Improves the Quality of Life after Massive Weight Loss: A Prospective Multicenter Study
Abdominoplasty and Lower Body Lift Surgery Improves the Quality of Life after Massive Weight Loss: A Prospective Multicenter Study/strong>
Yanis Berkane, François Saget, Elise Lupon, Camille Mocquard, Isabelle Pluvy, Eric Watier, Alexandre G Lellouch, Jérôme Duisit, Benoit Chaput, Nicolas Bertheuil
Targeted partial arthroscopic trapeziectomy with temporary distraction: a retrospective study with 5-year follow-up
Targeted partial arthroscopic trapeziectomy with temporary distraction: a retrospective study with 5-year follow-up
Jean-Baptiste de Villeneuve Bargemon, Elise Lupon, Guillaume Soudé, Charlotte Jaloux, Paul Levet, Michel Levadoux
Fencing wrist: a 10-year retrospective study of wrist injuries in fencers
Fencing wrist: a 10-year retrospective study of wrist injuries in fencers
Jean-Baptiste de Villeneuve Bargemon, Christophe Mathoulin, Elise Lupon
Outcomes of Autologous Fat Graft Injection(s) in Treating Sequelae of Digital Trauma: A Case Series
Outcomes of Autologous Fat Graft Injection(s) in Treating Sequelae of Digital Trauma: A Case Series
Elise Lupon, Hadrien Paoli, Jean Baptiste De Villeneuve Bargemon, François Loisel, Olivier Camuzard, Isabelle Pluvy
Response to: Parasacral Perforator Flaps for Buttock Enhancement
Response to: Parasacral Perforator Flaps for Buttock Enhancement
Elise Lupon, Gilles Claro, Olivier Camuzard, Benoit Chaput
Practical Strategies in Reconstruction of Soft-Tissue Sarcoma
Practical Strategies in Reconstruction of Soft-Tissue Sarcoma
Elise Lupon, Alessander D’Ascoli, Olivier Camuzar
Tissue engineering strategies for breast reconstruction: a literature review of current advances and future directions
Tissue engineering strategies for breast reconstruction: a literature review of current advances and future directions
Yanis Berkane, Haizam Oubari, Loïc van Dieren, Laura Charlès, Elise Lupon, Michelle McCarthy, Curtis L. Cetrulo Jr, Nicolas Bertheuil, Basak E. Uygun, David M. Smadja, Alexandre G. Lelloucht
Response to: Parasacral Perforator Flaps for Buttock Enhancement
Response to: Parasacral Perforator Flaps for Buttock Enhancement
Elise Lupon, Gilles Claro, Olivier Camuzard, Benoit Chaput
Publications 2022 du Dr LUPON Élise
Acellular Nipple Scaffold Development, Characterization, and Preliminary Biocompatibility Assessment in a Swine Model
Ruben V Oganesyan, Alexandre G Lellouch, Aylin Acun, Elise Lupon, Corentin B Taveau, Laura C Burlage, Laurent A Lantieri, Mark A Randolph, Curtis L Cetrulo Jr, Basak E Uygun
https://pubmed.ncbi.nlm.nih.gov/36472499/
Abstract
Background: The standard in nipple reconstruction remains the autologous skin flap. Unfortunately, the results are not satisfying, with up to 75% loss of nipple projection over time. Existing studies investigated the use of primates as a source of implants. The authors hypothesized that the porcine nipple can serve as a perfect shape-supporting implant because of functional similarities to the human nipple. A decellularization protocol was developed to obtain an acellular nipple scaffold (ANS) for nipple reconstruction.
Methods: Tissue samples were collected from eight disease-free female Yorkshire pigs (60 to 70 kg) and then decellularized. The decellularization efficiency and extracellular matrix characterization was performed histologically and quantitatively (DNA, total collagen, elastin, and glycosaminoglycan content). In vitro and in vivo biocompatibility was determined by human dermal fibroblast culture and subcutaneous implantation of six ANSs in a single Yorkshire pig (60 to 70 kg), respectively. Inflammation and adverse events were monitored daily based on local clinical signs.
Results: The authors showed that all cellular structures and 96% of DNA [321.7 ± 57.6 ng DNA/mg wet tissue versus 11.7 ± 10.9 ng DNA/mg wet tissue, in native and ANS, respectively ( P < 0.001)] can be successfully removed. However, this was associated with a decrease in collagen [89.0 ± 11.4 and 58.8 ± 9.6 μg collagen/mg ( P < 0.001)] and elastin [14.2 ± 1.6 and 7.9 ± 2.4 μg elastin/mg ( P < 0.05)] and an increase in glycosaminoglycan content [5.0 ± 0.7 and 6.0 ± 0.8 ng/mg ( P < 0.05)]. ANS can support continuous cell growth in vitro and during preliminary biocompatibility tests in vivo.
Conclusion: This is a preliminary report of a novel promising ANS for nipple reconstruction, but more research is needed to validate results.
Clinical relevance statement: Breast cancer is very common among women. Treatment involves mastectomy, but its consequences affect patient mental well-being, and can lead to depression. Nipple-areola complex reconstruction is critical, and existing methods lead to unsatisfactory outcomes.
Copyright © 2022 by the American Society of Plastic Surgeons.
A Dynamic Anatomic Study of Parasacral Perforators: Mapping, Perforasome, and Applications for Buttock Enhancement
Gilles Claro, Elise Lupon, Farouk Dargai, Farid Bekara, Fatima Zohra Mokrane, Benoit Chaput
https://pubmed.ncbi.nlm.nih.gov/35665801/
Abstract
Background: Due to the lack of knowledge about parasacral artery perforators, flaps from this region cannot be used with complete confidence in their security and effectiveness. Knowledge of the clusters and perforasome of these perforators could help in the design of more reliable flaps and extend the range of applications.
Objectives: This study aimed to identify the location, number, and density of perforators, and to subsequently analyze the perfusion flow and linking vessel distribution.
Methods: Five fresh cadavers were harvested and dissected. For the mapping, after injecting lateral sacral arteries with colored latex, perforators with a diameter of >0.5 cm were examined in 5 sacral regions. All data were collected on the suprafascial plane, with an orthonormal coordinate system placed on iliac crests and median lines. For perforasome analysis, 5 perforators and 3 three sacral flaps were injected with radiopaque dye. A dynamic (4-dimensional) computed tomographic angiography completed the analysis.
Results: A mean [standard deviation] of 8.4 [1.36] perforators per corpse, with a mean diameter of 0.72 [0.14] mm, were identified. There was a higher density of parasacral perforators close to the median line and 7.6 cm above the iliac crests. This pattern was not a random distribution (P < 0.05). The perfusion area was preferentially in the superior gluteal region. Perfusion flow was permitted by the dominant direct-linking vessels towards adjacent lumbar perforators, oriented diagonally upward and outward to the midline.
Conclusions: Parasacral perforator flaps appear to be a useful procedure in reconstruction and in aesthetic surgery, especially in gluteal augmentation. Their reliability depends on sound anatomic knowledge, with accurate preoperative perforator mapping.
© The Author(s) 2022. Published by Oxford University Press on behalf of The Aesthetic Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
A Reliable Porcine Fascio-Cutaneous Flap Model for Vascularized Composite Allografts Bioengineering Studies
Victor Pozzo, Golda Romano, Marion Goutard, Elise Lupon, Pierre Tawa, Aylin Acun, Alec R Andrews, Corentin B Taveau, Basak E Uygun, Mark A Randolph, Curtis L Cetrul, Alexandre G Lellouch
https://pubmed.ncbi.nlm.nih.gov/35435906/
Abstract
Vascularized Composite Allografts (VCA) such as hand, face, or penile transplant represents the cutting-edge treatment for devastating skin defects, failed by the first steps of the reconstructive ladder. Despite promising aesthetic and functional outcomes, the main limiting factor remains the need for a drastically applied lifelong immunosuppression and its well-known medical risks, preventing broader indications. Therefore, lifting the immune barrier in VCA is essential to tip the ethical scale and improve patients’ quality of life using the most advanced surgical techniques. De novo creation of a patient-specific graft is the upcoming breakthrough in reconstructive transplantation. Using tissue engineering techniques, VCAs can be freed of donor cells and customized for the recipient through perfusion-decellularization-recellularization. To develop these new technologies, a large-scale animal VCA model is necessary. Hence, swine fascio-cutaneous flaps, composed of skin, fat, fascia, and vessels, represent an ideal model for preliminary studies in VCA. Nevertheless, most VCA models described in the literature include muscle and bone. This work reports a reliable and reproducible technique for saphenous fascio-cutaneous flap harvest in swine, a practical tool for various research fields, especially vascularized composite tissue engineering.
Breasts and congenital chest-wall deformities: Surgical strategy with 3D implants
Breasts and congenital chest-wall deformities: Surgical strategy with 3D implants
J-P Chavoin, S Gandolfi, P Leyx, F Facchini, C Schirmer, J-L Grolleau, E Lupon, B Chaput
https://pubmed.ncbi.nlm.nih.gov/35931576/
Abstract
Computer-aided design and manufacturing of custom-made elastomer implants leads from a CT scan to fill in with precision, a congenital chest wall congenital deformity, both bone (pectus excavatum) and muscle (Poland Syndrome), resulting in a natural repositioning of the breasts. We report our 25 years’ experience in 301 women (234 Pectus+64 Poland). Parietal correction must always be done in first intention. It is common to have to carry out a second stage in women with an additional mammaplasty especially in the presence of insufficient glandular volume or a fairly frequently associated tuberous breast.
Keywords: Asymétrie mammaire; Breast asymmetry; Computer-aided design; Computer-aided manufacturing; Conception assistée par ordinateur; Custom-made implants; Fabrication assistée par ordinateur; Implants de silicone; Implants sur mesure; Pectus excavatum; Poland syndrome; Seins tubéreux; Silicone Implants; Tuberous breasts.
Copyright © 2022 Elsevier Masson SAS. All rights reserved.
Combinatorial Use of Therapeutic ELP-Based Micelle Particles in Tissue Engineering
Combinatorial Use of Therapeutic ELP-Based Micelle Particles in Tissue Engineering
Beyza Bulutoglu, Aylin Acun, Sarah L Deng, Safak Mert, Elise Lupon, Alexandre G Lellouch, Curtis L Cetrulo Jr, Basak E Uygun, Martin L Yarmush
https://pubmed.ncbi.nlm.nih.gov/35373501/
Abstract
Elastin-like peptides (ELPs) are a versatile platform for tissue engineering and drug delivery. Here, micelle forming ELP chains are genetically fused to three therapeutic molecules, keratinocyte growth factor (KGF), stromal cell-derived growth factor 1 (SDF1), and cathelicidin (LL37), to be used in wound healing. Chronic wounds represent a growing problem worldwide. A combinatorial therapy approach targeting different aspects of wound healing would be beneficial, providing a controlled and sustained release of active molecules, while simultaneously protecting these therapeutics from the surrounding harsh wound environment. The results of this study demonstrate that the conjugation of the growth factors KGF and SDF1 and the antimicrobial peptide LL37 to ELPs does not affect the micelle structure and that all three therapeutic moieties retain their bioactivity in vitro. Importantly, when the combination of these micelle ELP nanoparticles are applied to wounds in diabetic mice, over 90 % wound closure is observed, which is significantly higher than when the therapeutics are applied in their naked forms. The application of the nanoparticles designed here is the first report of targeting different aspect of wound healing synergistically.
Keywords: cathelicidin; elastin-like peptides; keratinocyte growth factor; micelle particles; protein engineering; stromal cell-derived growth factor 1; wound healing.
© 2022 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.
Complications and quality of life after bodylift: About 143 patients
Complications and quality of life after bodylift: About 143 patients
J Heranney, E Lupon, D Guillier, D Feuvrier, I Pluvy
https://pubmed.ncbi.nlm.nih.gov/36028411/
Abstract
Introduction: The rise of bariatric surgery has led to a considerable increase in the demand for weight loss surgery. The lower body lift consists of removing the residual abdominal fat and skin excess and re-tensioning the surfaces. The objective of our study was to evaluate the associated complications, as well as the consequences of this surgery on the quality of life of the patients.
Materials and methods: A retrospective monocentric study was conducted in patients operated on for lower body lift between 2010 and 2019 at the University Hospital of Besançon. We collected postoperative complications and studied the satisfaction and quality of life of the operated patients using the Body-QoL and SF-36 questionnaires.
Results: One hundred forty-three patients were included with a mean age of 41.2 years. The mean body mass index was 26.6kg/m2 with a mean weight of 73.8kg and a mean weight loss of 54.4kg. Forty-one patients (29.7%) had at least one complication. Most complications were minor, with 16.8% of scar disunions, and 7% of complications were major, requiring revision surgery. Ninety-three patients (65%) responded to the satisfaction questionnaires with improvement mostly in physical symptoms and social life.
Conclusion: The lower body lift is an effective, safe procedure with mostly minor complications that do not influence quality of life. Patient satisfaction is high, and it is therefore justified to continue offering this procedure to correct the sequelae of massive weight loss.
Keywords: Amaigrissement massif; Bodylift; Complications; Massive weight loss; Quality of life; Qualité de vie.
Copyright © 2022 Elsevier Masson SAS. All rights reserved.
Engineering Vascularized Composite Allografts Using Natural Scaffolds: A Systematic Review
Engineering Vascularized Composite Allografts Using Natural Scaffolds: A Systematic Review
Elise Lupon, Alexandre G Lellouch, Aylin Acun, Alec R Andrews, Ruben Oganesyan, Marion Goutard, Corentin B Taveau, Laurent A Lantieri, Curtis L Cetrulo, Basak E Uygun
https://pubmed.ncbi.nlm.nih.gov/34238047/
Abstract
Vascularized composite allotransplantation (VCA) refers to the transplantation of multiple tissues as a functional unit from a deceased donor to a recipient with a severe injury. These grafts serve as potential replacements for traumatic tissue losses. The main problems are the consequences of the long immunosuppressive drugs and the lack of compatible donor. To avoid these limitations, decellularization/recellularization constitutes an attractive approach. The aim of decellularization/recellularization technology is to develop immunogenic free biological substitutes that will restore, maintain, or improve tissue and organ’s function. A PubMed search was performed for articles on decellularization and recellularization of composite tissue allografts between February and March 2021, with no restrictions in publication year. The selected reports were evaluated in terms of decellularization protocols, assessment of decellularized grafts, and evaluation of their biocompatibility and repopulation with cells both in vitro and in vivo. The search resulted in a total of 88 articles. Each article was reviewed, 77 were excluded, and the remaining 11 articles reported decellularization of 12 different vascular composite allografts in humans (4), large animals (3), and small animals (rodents; 5). The decellularization protocol for VCA varies slightly between studies, but majority of the reports employ 1% sodium dodecyl sulfate as the main reagent for decellularization. The immunological response of the decellularized scaffolds remain poorly evaluated. Few authors have been able to attempt the recellularization and transplantation of these scaffolds. Successful transplantation seems to require prior recellularization. Decellularization/recellularization is a promising, growing, and emerging developing research field in vascular composite allotransplantation. Impact statement Tissue engineering for vascular composite allotransplantation using decellularization and recellularization approach is a fast-growing area of interest in the reconstructive surgery field. This review will be a very useful tool to get a clear overview for researchers interested in this field.
Keywords: decellularization; recellularization; vascularized composite allotransplantation.
Juvenile and tuberous breast hypertrophy
Juvenile and tuberous breast hypertrophy
J L Grolleau, E Lupon, S Gandolfi
https://pubmed.ncbi.nlm.nih.gov/35902286/
Abstract
Adolescence is defined as the period extending from puberty to adulthood, the limit of which is difficult to determine. It is a delicate period, in which the distancing from one’s own body image can have deleterious consequences on psychological development and social-emotional life. Breast hypertrophy and the correction of hypertrophic tuberous breasts in adolescents raise some questions that we will attempt to answer in this article. There are specificities to manage, in relation to surgical indications, resection volume, postoperative follow-up and cutaneous healing.
Keywords: Adolescence; Breast Hypertrophy; Hypertrophie mammaire; Juvenile breast; Sein; Sein tubéreux; Tuberous breast.
Copyright © 2022 Elsevier Masson SAS. All rights reserved.
Modified nanofat grafting: Stromal vascular fraction simple and efficient mechanical isolation technique and perspectives in clinical recellularization applications
Paul Girard, Joelle Dulong, Jerome Duisit, Camille Mocquard, Simon Le Gallou, Benoit Chaput, Elise Lupon, Eric Watier, Audrey Varin, Karin Tarte, Nicolas Bertheuil
https://pubmed.ncbi.nlm.nih.gov/36177178/
Abstract
Background: Nanofat grafting (NG) is a simple and cost-effective method of lipoaspirates with inter-syringe passages, to produce stromal vascular fraction (SVF) and isolate adipose-derived stem cells (ASCs). This represents a tremendous interest in the future clinical needs of tissue engineering. In this study, we optimized the NG technique to increase the yield of ASC extractions.
Methods: We analyzed three groups of SVF obtained by 20, 30, and 40 inter-syringe passages. The control group was an SVF obtained by enzymatic digestion with Celase. We studied their cell composition by flow cytometry, observed their architecture by confocal microscopy, and observed immunomodulatory properties of the ASCs from each of the SVFs by measuring inflammatory markers of macrophages obtained by an ASC monocyte co-culture. Results: We have established the first cell mapping of the stromal vascular fraction of adipose tissue. The results showed that SVF obtained by 20 inter-syringe passages contains more statistically significant total cells, more cells expressing the ASC phenotype, more endothelial cells, and produces more CFU-F than the SVF obtained by 30 and 40 passages and by enzymatic digestion. Confocal microscopy showed the presence of residual adipocytes in SVF obtained by inter-syringe passages but not by enzymatic digestion. The functional study indicates an orientation toward a more anti-inflammatory profile and homogenization of their immunomodulatory properties.
Conclusion: This study places mechanically dissociated SVF in the center of approaches to easily extract ASCs and a wide variety and number of other progenitor cells, immediately available in a clinical setting to provide both the amount and quality of cells required for decellularized tissues.
Keywords: SVF; adipose derived stem cells; adipose tissue; clinical applicability; immunomodulatory properties; mechanical isolation; nanofat; recellularization.
Copyright © 2022 Girard, Dulong, Duisit, Mocquard, Le Gallou, Chaput, Lupon, Watier, Varin, Tarte and Bertheuil.
Outcomes and Reliability of Perforator Flaps in the Reconstruction of Hidradenitis Suppurativa Defects: A Systemic Review and Meta-Analysis
Camille Vaillant, Yanis Berkane, Elise Lupon, Michael Atlan, Pascal Rousseau, Alexandre G Lellouch, Jérôme Duisit, Nicolas Bertheuil
https://pubmed.ncbi.nlm.nih.gov/36233681/
Abstract
Introduction: Hidradenitis suppurativa (HS) is a common and debilitating disease, in which the only effective treatment involves a wide excision of the affected skin. Secondary wound healing and skin grafting are two well-known options for managing these defects, but perforator flaps provide a new therapeutic alternative by ensuring reconstructions of large defects, reducing donor site morbidity, and enhancing functional recovery. The aim of this study was to achieve a systematic review of perforator flaps use in HS.
Patients and methods: PubMed and Cochrane databases were searched from 1989 to 2021. The PRISMA statement was used in the study selection process and the review was registered on PROSPERO. Furthermore, patient characteristics, operative technique, complications, and recurrences were searched.
Results: Thirty-six articles were selected including 286 patients and 387 flaps. Axillary localization was mostly represented (83.2%). Direct donor site closure was achieved in 99.1% of cases. In total, 15.1% of the flaps presented at least one of the following complications: wound dehiscence (5.5%), partial necrosis (2.9%), hematoma or seroma (2.1%), infection (2.1%), venous congestion (1.8%), and nerve injury (0.3%). Two cases of total necrosis were recorded. Recurrence of the disease was observed in 2.7% of the defects.
Conclusions: Pedicled perforator flaps are a reliable and reproducible technique in the reconstruction of HS defects. They are associated with a low recurrence rate while ensuring an effective reconstruction with reduced morbidity and faster recovery compared to the techniques classically used in this indication.
Keywords: complications; hidradenitis suppurativa; island flap; perforator flap; propeller flap; recovery; recurrence; verneuil disease.
Spotlight in Plastic Surgery: January 2022
Spotlight in Plastic Surgery: January 2022
Brett T Phillips, Daniel Boczar, Carter J Boyd, Joseph M Escandón, Sameer H Halani, Efstathios Karamanos, Karen B Lu, Elise Lupon, Maciej J Mazurek, Amanda R Sergesketter, Harsh R Shah, Amiteshwar Singh, Arun K Gosain
Stent migration in the distal ulnar artery: A case report
Stent migration in the distal ulnar artery: A case report
H Paoli, E Lupon, S Gandolfi, I Pluvy, D Feuvrier
https://pubmed.ncbi.nlm.nih.gov/35077909/
Abstract
Angioplasty has taken an important place in treating cardiovascular ischemic lesions, and stenting has become a widespread routine practice. Stent loss is a complication that, although rare, can result in stent migration into a vessel with dramatic complications due to occlusion. We report the case of a 77-year-old woman who underwent surgery to remove a loose stent that had migrated into the right distal ulnar artery just before the superficial palmar arch following coronary angioplasty. The stent could be removed with the help of fluoroscopy and microscope while preserving vascular integrity. Different therapeutic strategies can be discussed in front of a stent lost in the general circulation, and those must be approached on a case by case basis.
Keywords: Angioplasty complication; Arcade palmaire; Complication de l’angioplastie; Hand; Main; Microchirurgie; Microsurgery; Migration de stent; Palmar arch; Perte de stent; Stent lost; Stent migration.
Copyright © 2022. Published by Elsevier Masson SAS.
Surgical management of slightly or non-displaced corporal scaphoid fractures by retrograde percutaneous screw fixation through the anterior trapezium horn: A single-center retrospective French study of 33 patients between January 2015 and January 2019
E Lupon, J B De Villeneuve Bargemon, Y Dalmas, S Gandolfi, B Chaput, O Camuzard, P Mansat, S Delclaux
https://pubmed.ncbi.nlm.nih.gov/36216645/
Abstract
Introduction: Percutaneous screw fixation has recently gained popularity as an alternative to conservative treatment to avoid prolonged immobilization. The placement of a screw in the central axis of the scaphoid has been shown to be biomechanically superior to its eccentricity. Still, it poses difficulties in performing percutaneous screw fixation via both palmar and dorsal approaches.
Objective: We describe a palmar percutaneous screwing of corporal fractures of the scaphoid by a simple palmar transtrapezial approach allowing an optimal centering of the screw.
Method: We selected patients operated on by the same surgeon using the palmar transtrapezial approach between January 2015 and January 2019 based on the coding used for these fractures and the operative reports. In addition, pre- and postoperative data were collected from the patient’s computer and paper records and by telephone contact with the patients.
Results: Thirty-three patients were included. Percutaneous screw fixation of the scaphoid was performed under locoregional anesthesia in the operating room with one arm in the supine position on the arm table. No hyper-extension of the wrist was performed. The Kirchner guidewire passed through the anterior horn of the trapezium and then into the trapezium-scaphoid joint. A screw replaced it after satisfactory centering in the axis of the scaphoid. Management took place on average within 12 days after the trauma. 75.8% were A2 fractures, according to Herbert’s classification. The average operating time was 16.63minutes, and in 91% of the cases, the patient was hospitalized for one day. The variation of the scapholunate angle on the preoperative profile radiographs with the angle defined by the axis of the scaphoid screw and the lunate postoperatively was on average 2.94°. One patient presented nonunion, and four showed an undersized screw with a screw overhang requiring revision surgery.
Conclusion: The transtrapezial approach to fixation of acute scaphoid fractures facilitates precise percutaneous screw placement in the central axis of the scaphoid. A study of long-term complications, including the degenerative impact on the scaphotrapezial joint, is needed to assess the safety of passage through the anterior horn of the trapezium.
Keywords: Corporal fracture; Fracture corporéale; Fracture scaphoïde; Percutaneous screw fixation; Retrograde screw fixation; Scaphoid; Scaphoid fracture; Scaphoïde; Transtrapezium; Transtrapézien; Vissage percutané; Vissage rétrograde.
Copyright © 2022 Elsevier Masson SAS. All rights reserved.
Total Denervation of the Elbow: Cadaveric Feasibility Study
Total Denervation of the Elbow: Cadaveric Feasibility Study
Pierre Laumonerie, Suzanne Robert, Meagan E Tibbo, Elise Lupon, Patrick Chaynes, Nicolas Bonnevialle, Pierre Mansat
https://pubmed.ncbi.nlm.nih.gov/34074568/
Abstract
Purpose: Total elbow arthroplasty for the treatment of patients with severe elbow osteoarthritis is associated with postoperative activity limitations and risk of midterm complications. Elbow denervation could be an attractive therapeutic option for young, active patients. The aim of our study was to assess the feasibility of selective total elbow denervation via 2 anteriorly based approaches.
Methods: Selective total elbow denervation was performed in 14 cadaver elbows by 2 fellowship-trained elbow surgeons. Lateral and medial approaches to the elbow were used. The length of skin incisions and the minimum distance between them were noted. The number of articular branches identified and their respective distances from the lateral or medial epicondyle of the humerus were recorded.
Results: The anterolateral and anteromedial approaches allowed for the identification of all mixed and sensory nerves in all 14 cases. The mean number of resultant articular branches per cadaver was 1 for the musculocutaneous nerve, 2 (range, 1-3) for the radial nerve, 1 (range, 1-3) for the posterior cutaneous nerve of the forearm, 2 (range, 1-3) for the ulnar nerve, and 2 (range, 1-3) for the medial antebrachial cutaneous nerve; the collateral ulnar nerve was connected directly to the capsule. The length of the medial and lateral incisions was 15 cm (range, 12-18 cm) and 12 cm (range, 10-16 cm), respectively. The mean minimum distance between the incisions was 7.5 cm (range, 6.7-8.5 cm).
Conclusions: The findings suggest that selective elbow denervation via 2 approaches is feasible.
Clinical relevance: Selective elbow denervation via 2 approaches is feasible. Surgeons should target the articular branches of the musculocutaneous, radial, ulnar, and collateral ulnar nerves, posterior cutaneous nerve of the forearm, as well as medial antebrachial cutaneous nerves when carrying out this procedure.
Keywords: Anatomy; denervation; elbow; microsurgery; nerve; osteoarthritis.
Copyright © 2022 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.
Treatment of hyperpigmentation after burn: A literature review
Treatment of hyperpigmentation after burn: A literature review
Elise Lupon, Jérôme Laloze, Benoit Chaput, Paul Girard, Curtis L Cetrulo, Laurent A Lantieri, Jean Louis Grolleau, Olivier Camuzard, Alexandre G Lellouch
https://pubmed.ncbi.nlm.nih.gov/35537921/
Abstract
Objectify: Skin pigmentation disorders are one of the most frequent sequelae after burn injury. While these conditions often improve over time, some are permanent and cause severe psychological disorders (especially on the face). Given the frequency of these disorders and their benign nature, the scientific community has great difficulty postponing these patient follow-ups. Publications on their management are rare, and there is no consensus on the gold standard treatment for skin dyschromia. Herein, we performed a literature review including the various treatments currently proposed to manage these hyperpigmentations.
Methods: All reported articles up to February 2021 were reviewed on Pubmed. Studies on the treatment of hyperpigmented scars were included if they were secondary to burn injuries. Excluded articles evaluated transient treatments, such as makeup, and articles on inflammatory hyperpigmentation without etiological details or not secondary to burns.
Results: 201 articles were identified, and 13 studies were included. Topical creams used in inflammatory hyperpigmented lesions such as hydroquinone and first-line retinoids are controversial due to their inconstant efficacy. Various types of laser and pulsed light treatments have shown their effectiveness but can also aggravate pigmentation.
Conclusion: Dyschromia after burn remains a therapeutic challenge. Hyperpigmentations after burn should be treated on a case-by-case basis, using data from the literature, clinical experience and measuring the risk/benefit ratio.
Keywords: Dyschromia; Hydroquinone; Hyperpigmentation; Post-burn sequelae; Skin burn.
Copyright © 2022. Published by Elsevier Ltd.
Publications 2021 du Dr LUPON Élise
Augmentation mammaplasty by superolateral thoracic flap: a case report
Augmentation mammaplasty by superolateral thoracic flap: a case report
Elise Lupon, Benoit Chaput, Thomas Meresse
https://pubmed.ncbi.nlm.nih.gov/34784968/
Abstract
Background: The lateral chest wall is intimately associated with the esthetics of the breast. Patients with massive weight loss often have excess skin and fat in the lateral thoracic region causing functional, esthetic, and psychological discomfort. In addition, the breasts exhibit extreme ptosis after weight loss due to a reduction in volume and projection that is exacerbated by qualitative changes in the skin, with loss of its natural elasticity. This article describes a reliable new technique for simultaneous autologous breast augmentation and lateral thoracic dermolipectomy to provide autologous tissue for breast augmentation and simultaneous rejuvenation of the chest wall.
Case presentation: A 30-year-old Caucasian woman who had lost 58 kg after bariatric surgery had major skin excess sequelae combined with major breast ptosis. She wanted to correct her brachial and lateral thoracic skin and fat excess, as well as rejuvenate her breasts. The lateral thoracic panicle present was harvested and transposed in the retroglandular plane to perform autologous breast augmentation with lateral thoracic dermolipectomy.
Results: The patient was totally healed and complication-free at day 15. Both esthetic results and patient satisfaction were good at 6 months post-surgery.
Conclusions: Superolateral thoracic flap augmentation mammaplasty during thoracic dermolipectomy is a simple and safe procedure for selected patients. Durable and natural autologous breast augmentation may be achieved in a single step without the need for a breast implant, while rejuvenating the thoracic region.
Keywords: Autologous breast augmentation; Bariatric surgery; Fat compartment; Lateral chest wall; Superolateral thoracic flap.
© 2021. The Author(s).
Comment on “The Impact of Microsurgery on the Treatment of Ring Avulsion Injuries ”
Comment on “The Impact of Microsurgery on the Treatment of Ring Avulsion Injuries ”
Elise Lupon, Marion Goutard, Benoit Chaput, Jean Louis Grolleau, Curtis L Cetrulo Jr, Pierre Laumonerie, Alexandre Gaston Lellouch
Complications after Ravitch versus Nuss repair of pectus excavatum: What if none of these techniques are the right one?
Elise Lupon, Jérôme Laloze, Benoit Chaput, Jean-Louis Grolleau, Jean-Pierre Chavoin
Correction of Calf Atrophy With a Custom-Made Silicone Implant for Reconstruction: An Update
Correction of Calf Atrophy With a Custom-Made Silicone Implant for Reconstruction: An Update
Elise Lupon, Benoit Chaput, Benjamin Moreno, Jean-Louis Grolleau, Jean-Pierre Chavoin
Local FK506 implants in non-human primates to prevent early acute rejection in vascularized composite allografts
Alexandre G Lellouch, Corentin B Taveau, Alec R Andrews, Joseph Molde, Zhi Yang Ng, Philipp Tratnig-Frankl, Ivy A Rosales, Marion Goutard, Elise Lupon, Laurent A Lantieri, Robert B Colvin, Mark A Randolph, Joachim Kohn, Curtis L Cetrulo Jr
https://pubmed.ncbi.nlm.nih.gov/34422982/
Abstract
Background: Previous vascularized composite allograft (VCA) studies from our laboratory have shown that topical FK506 delivery in non-human primates (NHPs) was limited by inadequate dermal penetration and rejection persisted. Herein, we report the first utilization of FK506 via subcutaneously implanted discs to mitigate VCA rejection in NHPs.
Methods: Full major histocompatibility complex (MHC)-mismatched NHP pairs underwent partial-face VCA and FK506 disc implantation along the suture line. All allotransplants were maintained post-operatively for two months on the FK506 discs, methylprednisolone, mycophenolate mofetil, and supplemented with intramuscular FK506 if necessary. Group 1 (n=4) was used for optimization of the implant, while Group 2 (n=3) underwent delayed bone marrow transplantation (DBMT) after two months. VCA skin biopsies and peripheral blood samples were obtained for serial assessment of rejection and mixed chimerism by histopathology and flow cytometry respectively.
Results: In Group 1, two technical failures occurred. Of the remaining two NHPs, one developed supratherapeutic levels of FK506 (50-120 ng/mL) and had to be euthanized on postoperative day (POD) 12. Reformulation of the implant resulted in stable FK506 levels (20-30 ng/mL) up to POD12 when further intramuscular (IM) FK506 injections were necessitated. In Group 2, two NHPs survived to undergo conditioning and one successfully developed chimerism at 2-3 weeks post-DBMT (96-97% granulocytes and 7-11% lymphocytes of recipient-origin). However, all three NHPs had to be terminated from study at POD64, 77 and 86 due to underlying post-transplant lymphoproliferative disorder. All VCAs remained rejection-free up to study endpoint otherwise.
Conclusions: This study shows preliminary results of local FK506 implants in potentially mitigating VCA acute rejection for tolerance protocols based on mixed chimerism approach.
Keywords: Immunosuppression; tacrolimus; vascularized composite allograft (VCA).
2021 Annals of Translational Medicine. All rights reserved.
Measured Level of Human Adipose Tissue-Derived Stem Cells in Adipose Tissue is Strongly Dependent on Harvesting Method and Stem Cell Isolation Technique
Jérôme Laloze, Elise Lupon, Julie Usseglio, Paul Girard, Alexis Desmoulière, Loïc Fiévet
Partial Heterotopic Hindlimb Transplantation Model in Rats
Partial Heterotopic Hindlimb Transplantation Model in Rats
Marion Goutard, Mark A Randolph, Corentin B Taveau, Elise Lupon, Laurent Lantieri, Korkut Uygun, Curtis L Cetrulo Jr, Alexandre G Lellouch
https://pubmed.ncbi.nlm.nih.gov/34180905/
Abstract
Vascularized composite allotransplantations (VCA) represent the most advanced reconstruction option for patients without autologous surgical possibilities after a complex tissue defect. Face and hand transplantations have changed disfigured patients’ lives, giving them a new aesthetic and functional social organ. Despite promising outcomes, VCA is still underperformed due to life-long immunosuppression comorbidities and infectious complications. The rat is an ideal animal model for in vivo studies investigating immunological pathways and graft rejection mechanisms. Rats are also widely used in novel composite tissue graft preservation techniques, including perfusion and cryopreservation studies. Models used for VCA in rats must be reproducible, reliable, and efficient with low postoperative morbidity and mortality. Heterotopic limb transplantation procedures fulfill these criteria and are easier to perform than orthotopic limb transplants. Mastering rodent microsurgical models requires solid experience in microsurgery and animal care. Herein is reported a reliable and reproducible model of partial heterotopic osteomyocutaneous flap transplantation in rats, the postoperative outcomes, and the means of prevention of potential complications.
Supplementation with Extracellular Vesicles Derived from Adipose-Derived Stem Cells Increases Fat Graft Survival and Browning in Mice: A Cell-Free Approach to Construct Beige Fat from White Fat Grafting
Jérôme Laloze, Elise Lupon, Paul Girard, Silvia Gandolfi, Loïc Fiévet, Alexis Desmoulière
Surgery, the neglected child of the world's health systems
The Perception of Plastic Surgery by Community-Based, Private Practice Nurses: A French National Descriptive Study
Elise Lupon, Paul Girard, Amélie Lupon, Loriane Jacques, Ludivine Jung, Zhi Yang Ng, Laurent Alexandre Lantieri, Jérôme Laloze, Alexandre Gaston Lellouch
https://pubmed.ncbi.nlm.nih.gov/33626557/
Abstract
Plastic surgery is a dynamic field but remains poorly understood by general practitioners, medical students, health professionals, and the public. The main health care professionals in the community who are involved in the follow-up of plastic surgery patients are nurses; they help to facilitate wound healing and rehabilitation in the postoperative period. In this study, the authors assessed the medical knowledge and perceptions of plastic surgery by nurses working in the community setting and explored their understanding of classical scenarios commonly encountered in reconstructive surgery. An online survey was designed to assess the demographics of nurses working in the community in France and their knowledge of plastic surgery. This was disseminated to all practicing nurses working outside of hospitals by means of an online social network from the period of April 2019 to June 2019. The survey was completed by 318 nurses. Specific training in plastic surgical nursing will be required to optimize the management of these patients following discharge from hospital. This gap in knowledge may affect patient recovery negatively.
Copyright © 2021 International Society of Plastic and Aesthetic Nurses. All rights reserved.
Vascularized Composite Allotransplantation in a Post-COVID-19 Pandemic World
Vascularized Composite Allotransplantation in a Post-COVID-19 Pandemic World
Elise Lupon, Curtis L Cetrulo Jr, Laurent A Lantieri, Alexandre G Lellouch
Publications 2020 du Dr LUPON Élise
BCGitis of the wrist after intravesical BCG therapy: A case report
BCGitis of the wrist after intravesical BCG therapy: A case report
E Lupon, G Martin-Blondel, T Pollon, C Berthier, A G Lellouch, P Mansat
https://pubmed.ncbi.nlm.nih.gov/32659383/
Abstract
Septic arthritis of the wrist can result in joint destruction, making timely diagnosis crucial for initiating empiric antibiotics and surgical intervention. Mycobacterium is a rare cause of this disorder. A 47-year-old man with bladder cancer was treated surgically and received BCG intravesical therapy. Eleven months later, this patient developed severe carpal BCGitis requiring total carpal resection. The first step was addition of a cement spacer and radiometacarpal stabilisation (Masquelet technique). Secondary infections occurred aggravating the prognosis. This case emphasises the importance of taking into account the patient’s medical history. Tuberculosis of the wrist is a rare etiology for septic arthritis; delayed treatment leads to severe complications and functional sequelae.
Keywords: BCGite; BCGitis; Carpectomie; Carpectomy; Infection du poignet; Osteoarthritis of the wrist; Ostéite du poignet; Ostéoarthrite du poignet; Ostéomyélite du poignet; Tuberculose; Tuberculosis; Wrist infection; Wrist osteitis; Wrist osteomyelitis.
Copyright © 2020 SFCM. Published by Elsevier Masson SAS. All rights reserved.
Combating hypoxemia in COVID-19 patients with a natural oxygen carrier, HEMO2Life® (M101)
Combating hypoxemia in COVID-19 patients with a natural oxygen carrier, HEMO2Life® (M101)
Elise Lupon, Alexandre G Lellouch, Franck Zal, Curtis L Cetrulo Jr, Laurent A Lantieri
https://pubmed.ncbi.nlm.nih.gov/33308935/
Abstract
Background: Infection with SARS-CoV-2 is responsible for the COVID-19 crisis affecting the whole world. This virus can provoke acute respiratory distress syndrome (ARDS) leading to overcrowed the intensive care unit (ICU). Over the last months, worldwide experience demonstrated that the ARDS in COVID-19 patients are in many ways « atypical ». The mortality rate in ventilated patients is high despite the application of the gold standard treatment (protective ventilation, curare, prone position, inhaled NO). Several studies suggested that the SARS-CoV-2 could interact negatively on red blood cell homeostasis. Furthermore, SarsCov2 creates Reactive Oxygen Species (ROS), which are toxic and generate endothelial dysfunction. Hypothesis/objective(s) We hypothesis that HEMO2Life® administrated intravenously is safe and could help symptomatically the patient condition. It would increase arterial oxygen content despite lung failure and allow better tissue oxygenation control. The use of HEMO2Life® is also interesting due to its anti-oxidative effect preventing cytokine storm induced by the SARS-CoV-2. Evaluation of the hypothesis: Hemarina is based on the properties of the hemoglobin of the Arenicola marina sea-worm (HEMO2Life®). This extracellular hemoglobin has an oxygen capacity 40 times greater than the hemoglobin of vertebrates. Furthermore, the size of this molecule is 250 times smaller than a human red blood cell, allowing it to diffuse in all areas of the microcirculation, without diffusing outside the vascular sector. It possesses an antioxidative property du a Superoxide Dismutase Activity. This technology has been the subject of numerous publications and HEMO2Life® was found to be well-tolerated and did not induce toxicity. It was administered intravenously to hamsters and rats, and showed no acute effect on heart rate and blood pressure and did not cause microvascular vasoconstriction. In preclinical in vivo models (mice, rats, and dogs), HEMO2Life® has enabled better tissue oxygenation, especially in the brain. This molecule has already been used in humans in organ preservation solutions and the patients showed no abnormal clinical signs.
Consequences of the hypothesis: The expected benefits of HEMO2Life® for COVID-19 patients are improved survival, avoidance of tracheal intubation, shorter oxygen supplementation, and the possibility of treating a larger number of patients as molecular respirator without to use an invasive machine.
Keywords: COVID-19; HEMO2Life; Hypoxemia; M101; Oxygen Carrier; SARS-CoV-2.
Copyright © 2020 Elsevier Ltd. All rights reserved.
Comments on ``Combined Non-Ablative Laser and Microfat Grafting for Burn Scar Treatment``
Comments on « Combined Non-Ablative Laser and Microfat Grafting for Burn Scar Treatment »
Elise Lupon, Jérôme Laloze, Jean Louis Grolleau, Laurent Alexandre Lantieri, Alexandre Gaston Lellouch
Comment on ``First Russian Experience of Composite Facial Tissue Allotransplantation``
Comment on « First Russian Experience of Composite Facial Tissue Allotransplantation »
Elise Lupon, Curtis L Cetrulo Jr, Marion Goutard, Corentin B Taveau, Jean-Louis Grolleau, Laurent A Lantieri, Alexandre G Lellouch
Correcting of Calf Atrophy With a Custom-Made Silicone Implant: Contribution of Three-Dimensional Computer-Aided Design Reconstruction: A Pilot Study
Jean-Pierre Chavoin, Elise Lupon, Benjamin Moreno, Pierre Leyx, Jean-Louis Grolleau, Benoit Chaput
https://pubmed.ncbi.nlm.nih.gov/32593168/
Abstract
Background: Calf shape is an essential aesthetic parameter of the leg, and calf atrophy can lead to complex problems. The functional consequences of calf atrophy are generally moderate. Prefilled silicone gel implants represent the vast majority of currently placed prostheses, but this technique does not ensure optimal adaptation of the implant shape due to loss of volume.
Objectives: The aim of this study was to describe an innovative procedure for correcting acquired calf atrophy based on 3-dimensional (3D) modeling.
Methods: The study involved 22 patients treated for calf atrophy caused by illness. Implants were made with solid rubber silicone, and 3D reconstructions were created by computer-aided design based on computed tomography scans. The implants were introduced through a horizontal popliteal incision.
Results: Forty-one implants were placed. No cases of infection, hematoma, or compartment syndrome were encountered. We experienced 1 case of skin necrosis and 1 case of periprosthetic seroma. In addition, lipofilling was performed in 5 cases. Two patients sought to benefit from a surgical reduction in implant size.
Conclusions: Our innovative procedure to correct calf atrophy with custom solid rubber silicone implants produces a calf shape that better adapts to volume loss than prefilled silicone gel implants. The material maintains its shape and facilitates retrofitting of the prosthesis. There is no risk of hull formation or breakage, and the life span of the implants is limitless. This 3D computer-aided design approach has optimized our reconstructions.
© 2020 The Aesthetic Society. Reprints and permission: journals.permissions@oup.com.
Elbow flexion reconstruction after arm-sparing excision for high-grade triton sarcoma: a case report
Elbow flexion reconstruction after arm-sparing excision for high-grade triton sarcoma: a case report
Elise Lupon, Christine Chevreau, Alexandre Gaston Lellouch, Dimitry Gangloff, Thomas Meresse
https://pubmed.ncbi.nlm.nih.gov/32620140/
Abstract
Background: Soft tissue sarcomas affecting the root of an upper extremity raise the question of limb amputation depending on their location, size, and malignancy. Malignant triton tumors are a rare subtype of neurofibrosarcomas that have been poorly reported in the literature. We report the case of a challenging reconstruction of the upper extremity using a pedicled latissimus dorsal flap.
Case presentation: A 25-year-old Occidental man was referred to our sarcoma unit for the management of a large, high-grade malignant peripheral nerve sheath tumor with no regional or distant extension and very fast progression. He was treated first by concomitant neoadjuvant radiotherapy and chemotherapy. Carcinologic excision was performed « en bloc » including the skin, the tumor, and the flexor muscles of our patient’s elbow. Coverage of the skin defect and elbow flexion restoration were achieved by using a homolateral pedicled musculocutaneous latissimus dorsi flap. Histological analysis showed an R0 resection. The reconstruction process recovered a complete bending of his elbow. He is still in remission at 26 months follow-up.
Conclusions: A malignant triton tumor is a rare, aggressive, and high-grade sarcoma. It was successfully treated and this case report describes an effective treatment modality. Reconstructive surgery, allowing large, complete tumor removal, is indispensable after neoadjuvant chemotherapy and radiotherapy.
Keywords: Malignant peripheral nerve sheath tumor; Malignant triton tumor; Neurofibrosarcoma; Rhabdomyoblastic differentiation.
Muscle-Derived Stem Cell-Enriched Scaffolds Are Capable of Enhanced Healing of a Murine Volumetric Muscle Loss Defect
Jérôme Laloze, Benoit Chaput, Elise Lupon, Audrey Varin, Charlotte Vaysse, Charline Berthier
https://pubmed.ncbi.nlm.nih.gov/31834231/
Prospective study of 80 volar wounds of the hand and wrist: Correlations between clinical examination and intraoperative findings
T Baron-Trocellier, M Rongières, O Mericq, E Lupon, P Mansat
https://pubmed.ncbi.nlm.nih.gov/32376508/
Abstract
Hand and wrist volar wounds are a common cause of emergency room (ER) visits. These wounds are explored surgically in the operating room at most hospitals. The main objective of our study was to prospectively assess the correlation between clinical examination in the ER performed by a surgical resident and the tendon, vascular and/or nerve damage found during surgery in hand and wrist volar wounds. The second objective was to describe the lesions based on their mechanism, as well as their topography. Eighty patients from two hand surgery referral centers were included. Patients’ past medical history was obtained, as well as records of their physical examination in the ER and description of lesions found during surgery. In 28% of wounds with a normal clinical examination, tendon, vascular or nerve damage was found on surgical exploration. Out of the cases that tested negative for tendon injury in the ER, 16% had partial tendon injury or digital tunnel wound discovered during surgery. Nerve damage was found during surgery in 12% of cases that had not been detected clinically preoperatively. Based on our findings, we recommend performing surgical exploration for all volar hand and wrist wounds in the operating room, as physical examination does not detect all tendons, vascular or nerve injuries.
Keywords: Clinical examination; Examen clinique; Hand lacerations; Pedicles; Plaies de main; Pédicules; Tendon.
Copyright © 2020 SFCM. Published by Elsevier Masson SAS. All rights reserved.
Surgical treatment of a digital metastasis of a large cell lung neuroendocrine carcinoma: A rare secondary anatomical localization
The perception of plastic surgery by physiotherapists: a French national descriptive study
The perception of plastic surgery by physiotherapists: a French national descriptive study
Elise Lupon, Arthur Bedet, Paul Girard, Jerome Laloze, Jean L Grolleau, Laurent Lantieri, Alexandre G Lellouch
https://pubmed.ncbi.nlm.nih.gov/32309331/
Abstract
Background: Plastic surgery is a transversal discipline that many people misunderstand, including general practitioners, medical students, paramedics and the public. Plastic surgeons often collaborate with physiotherapists for post-acute care and rehabilitation. They ensure optimal post-operative recovery of the patient. Herein, the authors assessed the medical knowledge and perceptions of plastic surgery by physiotherapists working outside health centers and explored their attitudes towards classic reconstructive surgery scenarios.
Methods: To assess physiotherapists’ medical knowledge and perceptions of plastic surgery, the authors conducted an online questionnaire survey. A total of 1,262 physiotherapists responded.
Results: The physiotherapists confirmed the suspected lack of knowledge regarding the plastic surgery field. Although they were generally aware that plastic surgeons perform cosmetic procedures and treat burns, they were largely unaware that plastic surgeons perform hand surgeries and microsurgical operations. More than 70% of them stated that they did not have the necessary knowledge to properly manage patients in this specialty. This lack of knowledge can sometimes have a negative impact on patients’ recovery, particularly for fear of making a mistake.
Conclusions: Physiotherapists, outside the hospital, have an incomplete conception of plastic surgery. They would need a specific plastic surgery training in order to manage these patients in an optimal way.
Keywords: Physiotherapists; perception; plastic surgery; rehabilitation; surgical physiotherapy.
2020 Annals of Translational Medicine. All rights reserved.
Want to Regain Motivation? Five Essential Publications You Should Read
Publications 2019 du Dr LUPON Élise
Comments on: An Open, Prospective Study to Evaluate the Effectiveness and Safety of Hyaluronic Acid for Pectus Excavatum Treatment
Jean Pierre Chavoin, Elise Lupon, Benoit Chaput, Jean Louis Grolleau
Hirschsprung disease in an adult with intestinal malrotation and volvulus: an exceptional association
Elise Lupon, François Labbe, Emile Nini, Sixte Sondji
https://pubmed.ncbi.nlm.nih.gov/31030669/
Abstract
Background: Hirschsprung disease is a neonatal discovery in almost all cases, and the association of Hirschsprung disease in adults with symptomatic intestinal malrotation is unusual. This combination delays diagnosis and can lead to mistake in surgical strategy.
Case presentation: A 43-year-old patient with a history of colectomy for colonic inertia and megadolichocolon was admitted to the Carcassonne Hospital emergency room for a volvulus of small bowel obstruction in a chronic intestinal obstruction context with episodes of acute, variable-looking occlusive syndromes. Intestinal malrotation was discovered during surgical small bowel detorsion. The acute occlusion syndrome recurred after the procedure. In view of the unfavorable evolution, an emptying of the dilated small bowel and a discharge ileostomy upstream of the rectum were performed. In the face of postoperative improvement, rectal manometry and deep full parietal rectal biopsies made it possible to highlight the diagnosis of Hirschsprung disease. The patient thus had functional acute occlusive syndromes and chronic occlusion due to Hirschsprung disease of attenuated form and acute organic occlusive syndromes related to her incomplete common mesentery.
Conclusions: This rare association, which may be responsible for delayed diagnostic and therapeutic wandering, highlights the importance of performing manometry and deep full parietal biopsies before a colectomy for colonic inertia, as well as the possibility of suggesting a common Hirschsprung disease and/or mesentery in an adult with multiple occlusive syndromes of variable appearance.
Keywords: Adult Hirschsprung disease; Chronic occlusion; Constipation; Malrotation intestinal; Multiple occlusive syndrome; Small bowel volvulus.
Internes en médecine et cicatrisation des plaies : une étude descriptive multicentrique entre Février et Avril 2018
E Lupon, U Turrian, J Malloizel-Delaunay, A Bura-Rivière, J L Grolleau
https://pubmed.ncbi.nlm.nih.gov/31474342/
Abstract
Objectives: Around 2.5 million wounds are recorded in France, representing, in terms of cost and quality of life, a real problem of public health issue. In France, residents are among the first line personnel having to manage wounds and their complications: this study is carried out to identify the view and feelings of residents concerning their preparation and training in this field.
Materials and methods: A questionnaire was distributed to residents throughout France. Residents’ characteristics, interests and training in wound healing, training courses and opinions concerning their training were recorded.
Results: Seven hundred and eleven French residents answered the questionnaire, the majority of whom (79 %) had not experienced training in wound healing. The majority of residents (69 %) believe that all physicians are concerned. Training in wound management and wound healing is considered insufficient (94 %) and most (79 %) had never received any training in wound management and wound healing. Ninety-eight percent stated they needed additional training courses in wound management.
Conclusions: Wound management and healing is a topic of interest to residents. Residents need more training in wound management in their curriculum to improve their practice.
Keywords: Cicatrisation; Dressing; Etudes médicales; Healing; Internes; Medical studies; Pansement; Plaie; Residents; Wound.
Copyright © 2019 Elsevier Masson SAS. All rights reserved.
Reconstruction of a dorsal thoracic wall defect by the intercostal artery perforator flap after removal of a bulky cutaneaous squamous cell carcinoma
E Lupon, A G Lellouch, F Deilhes, B Chaput, C Berthier
https://pubmed.ncbi.nlm.nih.gov/31526388/
Abstract
Introduction: Surgical reconstruction of large soft tissue defects of the upper back is challenging. Although the usefulness of free perforator flaps has been demonstrated, local options remain limited. The dorsal intercostal artery perforator flap was recently described but its use is still uncommon.
Case report: An 88-year-old Causasian woman presented with a large, ulcerated, left prescapular cutaneous squamous cell carcinoma (T3N0M0). Complete excision was performed, and the resulting defect was reconstructed with a dorsal intercostal artery perforator flap based on two perforators. Postoperative recovery was uncomplicated and adjuvant radiotherapy commenced 10 weeks later.
Conclusion: Compared to conventional muscle flaps, the dorsal intercostal artery perforator flap offers greater protection of muscle function, is less invasive, and lowers donor site morbidity. Based on these advantages, this flap should be considered a useful local option for reconstructing large cutaneous defects of the upper back.
Keywords: Carcinoma; Perforator flap; Squamous cell; Surgical flaps.
The palatal mucosal graft: The adequate posterior lamellar reconstruction in extensive full-thickness eyelid defects
S Hendriks, C Bruant-Rodier, E Lupon, S Zink, F Bodin, C Dissaux
https://pubmed.ncbi.nlm.nih.gov/30795932/
Abstract
Introduction: Full-thickness eyelid defects exceeding 25% of the eyelid width should benefit from a skillful, immediate and simultaneous reconstruction of two layers; anterior and posterior lamella. In this article, we recall, through an original series of cases, the possibility of using a palatal fibromucosal graft during the reconstruction of the posterior lamella as well as the modalities of its optimal use.
Patients and methods: Retrospective study, including 8 patients with an extensive full-thickness eyelid defect affecting more than half of the upper and/or lower eyelid, after tumor excisions. 4 cases were involved in lower eyelid reconstruction, 2 in upper one and 2 in both. Posterior lamella was reconstructed using a palatal mucosal graft. Anterior lamella was reconstructed using different flaps: Esser-Mustardé flap, medially and laterally based orbicularis oculi myocutaneous flap, Tripier and orbitonasolabial flaps. Mean follow-up was 12.75 months.
Results: The survival rate of grafts and flaps was excellent with only one flap border necrosis. The donor site healed in an average time of 3 weeks. Functional recovery, complete eye closure and opening, was obtained in all cases. Lining, texture and color was considered satisfactory in all cases.
Conclusion: The palatal mucosal graft provides a good and lasting structural support to the eyelid, which is essential for the inferior eyelid, especially when combined with a flap. Slight overcorrection is recommended.
Keywords: Eyelid reconstruction; Full-thickness eyelid reconstruction; Greffe fibromuqueuse; Greffe palatine; Lambeau musculocutané palpébral supérieur; Mucosal graft; Orbicularis myocutaneous flap; Palatal graft; Reconstruction de paupières; Reconstruction des paupières pleine épaisseur.
Copyright © 2019 Elsevier Masson SAS. All rights reserved.
Publications 2018 du Dr LUPON Élise
Surgical antegrade transcatheter valve implantation and heavily calcified heart
Surgical antegrade transcatheter valve implantation and heavily calcified heart
Elise Lupon, Anais Lemaire, Christophe Cron, Bertrand Marcheix
https://doi.org/10.1177/0218492318783306
Abstract
It is well known that a heavily calcified mitral valve significantly increases the perioperative and postoperative risks of mitral valve surgery. A 71-year-old woman was referred to our department with severe mitral valve disease. Cardiac imaging revealed extremely severe calcification of the entire left heart. Surgery was performed through a median sternotomy with standard cardiopulmonary bypass. After dilating the mitral orifice with a balloon, we replaced the valve with a transcatheter Edwards Sapiens 3 aortic valve under direct vision. Seven months after the procedure, the patient was doing well and no longer suffered from dyspnea.
Keywords: Calcinosis; Coronary artery bypass; Heart valve prosthesis implantation; Mitral valve insufficiency; Mitral valve stenosis.
- E. Lupon, AG. Lellouch, M. Goutard, C.L.Cetrulo. Chapitre de livre intitulé « Decellularization and Recellularization of Composite Tissue Allografts” Book: « Two Decades of Experience in Clinical Reconstructive Transplantation – Lessons Learned” Taylor and Francis Special Edition: Reconstructive Transplantation and Regenerative Medicine – The Emerging Interface. 2020.
- E. Lupon, J. Saboye, JL. Grolleau, B. Chaput. “Chirurgie esthétique des paupières”. EMC (Encyclopédie Médico-Chirurgicale Elsevier Masson).(EMC Chirurgie Plastique et EMC Chirurgie Maxillo-faciale). http://dx.doi.org/10.1016/S1286-9325(20)85633-7
- E. Lupon, AG. Lellouch, P.Girard, P. Mansat, JL. Grolleau, J. Laloze, S. Riot. Total thumb reconstruction by an original groin Pocket Flap-Graft design. Journal of Clinical Images & Medical Case reports http://jcimcr.org/articles.php. ISSN 2766-7820. Mars 2021.
- Alexandre Bourcier, Anudari Zorigtbaatar, Elise Lupon, Daniel S. Nteranya, Arsène D. Nyalundja, Jean W. Lartigue, David Masheka, Ulrick S. Kanmounye. Qu’est-ce la chirurgie globale en 2020 ? Pan African Medical Journal Clinical Medicine. DOI: 10.11604/pamj-cm.2020.3.172.24474
Publications sans comité de lecture
- Alexandre G. Lellouch, Corentin Taveau, Alec R. Andrews, Marion Goutard, Philipp Tratnig-Frankl, Elise Lupon, Joseph Molde, Zhi Yang Ng, Mark A. Randolph, Joachim Kohn, Curtis L. Cetrulo. Local delivery of FK506 to prevent VCA early acute rejection in a delayed mixed chimerism protocol. Transplantation. DOI: 10.1097/01.tp.0000702016.20235.b7.
- Philipp Tratnig-Frankl, Alec R. Andrews, Corentin Taveau, Alexandre G. Lellouch, Michael M. Jonczyk, Marion Goutard, Elise Lupon, Joseph Molde, Zhi Yang Ng, Mark A. Randolph, Michael L. Morrison, Mark B. Roth, Curtis L. Cetrulo. The impact of oxygen free radical scavenger on acute rejection in a histocompatible miniature swine model. Transplantation. DOI: 10.1097/01.tp.0000699276.73135.b0.
- E. Lupon, A. Acun, Corentin Taveau, Alexandre G. Lellouch, Marion Goutard, Elise Lupon, L. Lantieri, Curtis L. Cetrulo, B.Uygun. VCA. Decellularization Protocol for porcine Fasciocutaneaous flap: An update. The American Society for Reconstructive Transplantation. DOI:10.17.7/20503121103534
- E. Lupon, A. Acun, R. Oganesyan, AG. Lellouch, C. Taveau, Marion Goutard, B. Uygun, Curtis L. Cetrulo. Decellularization of vascularized engineered scaffolds for face and ear reconstruction. VCA – The American Society for Reconstructive Transplantation. DOI:10.17.7/20503121103534
Chapitre / Livre
- Chronique dans le journal PRS et Plastic Surgery Resident Magazine :
* E.Lupon. Covid-19: A great Opportunity to Improve Our Surgical Residency Training. PRS.
* E.Lupon. COVID-19 and plastic surgery residency training: A French experience. Plastic Surgery Resident Magazine. Winter 2020.
https://imirus.com/tmp/13491/19121/-1/pm13491.pdf
* E.Lupon. Time Management. Plastic Surgery Resident Magazine. Spring 2021. https://view.imirus.com/1006/document/13537/page/12
Abstracts publiés
-
- E. Lupon, D. Gangloff, T.Meresse. Couverture et reconstruction de la flexion du coude par un lambeau de grand dorsal après exérèse d’un volumineux sarcome du bras dominant. SFCO Montpellier. (vidéo disponible sur « Oncostream »). 16 Mai 2019.
- E.Lupon. « Mon master 2 en 180 secondes ». SFCO Montpellier. 16 Mai 2019.
- E. Lupon, B. Chaput, JL.Grolleau, LA. Lantieri, AG Lellouch. Traitement permanent des dyschromies cutanées post brûlures. Société Française de Brûlologie- Cap d’agde. 6 Juin 2019.
- P. Girard, E. Lupon, J. Laloze, E. Watier, J. Duisit, B. Chaput, N. Bertheuil. Technique de couverture de perte de substance péri vulvaire par lambeau perforant de type IGAP (Inferior Gluteal Artery Perforator), Videocorner SOFCPRE 2019, Paris, 21 Novembre 2019.
- Berthier C, Lupon E, Gangloff D, Meresse T. Lambeau musculocutané de grand dorsal pédiculé dans la chirurgie du sarcome, Vidéocorner SOFCPRE 2019, Paris, 22 Novembre 2019
- E. Lupon. Vascularized Composite Allotransplantation. Decellularization/Revascularization project. Science Slam. Massachusetts General Hospital Research Institute. Boston, 14 Janvier 2020.
- Elise Lupon, Aylin Acun, Marion Goutard, Ruben Oganesyan, Alexandre Lellouch, Laurent Lantieri, Jean louis Grolleau, Basak Uygun, Curtis Cetrulo Decellularization of vascularized engineered scaffolds for facial reconstruction. Virtual Plastic Surgery (the meeting). 89th Annual meeting. Présenté le 16 Octobre 2020 (5 minutes).
- Associate Editor on the Editorial Board of Plastic and Reconstructive Surgery – Janvier 2025 (journal international #1 en chirurgie plastique et réparatrice)
- Membre du PRS & PRS Global open Resident Advisory Board 2020 – 2024
- Peer review PRS & PRSGlobal Open (voir Web of Science ID ABA-5705-2020) >130 peer-review
- Guest Editor Jove “Protocols for Graft Procurement: Preservation, Organ Engineering, and Educational Training” (8 articles de pédagogie chirurgicale publiés en collaboration avec le laboratoire d’anatomie de Nice dans cette collection)
- Relecture nationale de l’Outil pour la pratique des médecins généralistes sur les mélanomes cutanés / Institut Nationale du Cancer (2024)
- Reviewer occasionnel pour Frontiers, Hand Surgery & Rehabilitation Journal, Annales de chirurgie plastique depuis 2021
- Membre élu au VCA board de l’European Society for Organ transplantation (ESOT) 2026/2027.
- Membre de la société internationale de microchirurgie « The World Society of reconstructive Microsurgery » depuis 2024
- Secrétaire (élue) du chapitre « Main et microchirurgie » de la Société Française de chirurgie plastique, reconstructrice et Esthétique (SOFCPRE) depuis 2025
- Membre élu du chapitre « Recherche, Idées & Innovations » de la SOFCPRE depuis 2025
- Membre élu du chapitre « Oncologie » de la SOFCPRE depuis 2025
- Membre du comité d’administration de la Société Francophone de chirurgie Oncologique (SFCO) depuis 2020
- Membre du comité scientifique du congrès de la SFCO depuis 2022
- Membre de l’ASPS (American Society of Plastic Surgeon), ID 166840 depuis 2020, élue International membership en 2026
- Présidente de l’Association Jeune Chirurgiens Oncologues (AJCO) de Octobre 2020 à Mai 2024
- Référente chirurgie plastique de l’AJCO – (Association Jeunes Chirurgiens Oncologues), depuis Mai 2019.
Diplôme universitaire (DU) et inter-universitaire (DIU)
- Enseignement au DIU des lambeaux perforants depuis 2023 (3*3 jours de cours annuellement)
- Membre enseignant / Modératrice auDIU Européen de pratiques chirurgicales en Cancérologie depuis 2024 (5 heures annuellement)
- Membre enseignant et évaluateur du DU plaie et cicatrisation de Nice depuis 2024
- Membre enseignant au DU de Pédagogie (thématique IA, prévu 24/03/ 2027)
- Membre enseignant du DU du SUD de Nice (Sport, Urgence, Dégénératif) (prévu en Janvier 2027)
- Membre enseignant du DIU de la verge et des reconstructions uro-génitales (session Nice, Juin 2024 )
- Membre enseignant du DIU de la main nationale tous les 2 ans (session couverture cutané, Nice, Avril 2024 et Mai 2026)
- Membre enseignant et évaluateur du DU plaie et cicatrisation de Nice, UCA, depuis 2024
- Enseignement au DU « plaies et cicatrisation » à Toulouse , Université Rangueil, (2018 – 2019)
Troisième cycle
- Enseignement Parage et cicatrisation aux néo-internes de chirurgie de Nice « BootCamp » annuellement depuis 2024
- Cours de DESC du collège de Chirurgie Plastique, Réparatrice et Esthétique (CPRE) « Les nouveautés dans la chirurgie des lambeaux » 23.03.2024 et « reconstructions thoraciques » le 27 Juin 2026. 30 minutes.
Premier et Deuxième cycle
- Cours en présentiel aux 6-ème année. « Sémiologie en chirurgie de la main et infections ». Le 28 Octobre 2026. Faculté de Médecine de Nice. « UE Professionnalisante – M3 ».
- Responsable de l’atelier « suture et stérilité » aux étudiants en médecine de Nice « UE Professionnalisante – M3 ». Séances de préparation aux stations procédurales ECOS nationaux. Formation de tuteurs pour former des TP de petits groupes (environ 250 étudiants répartis sur 3 jours annuellement depuis 2024)
- Responsable de parcours – ECOS nationaux Juin 2026.
- Groupe de suivi scénarios ECOS /Banque ECOS (2026) : Relecture des ECOS et constitution d’une banque locale de scénarios ECOS (coordination Dr J. Bernardor)
- Vidéo de calibrage ECOS (2025 – 2026) (coordination Dr J. Bernardor)
- Séance de révisions EDN 2024/2025 « Anatomie et chirurgie de la main » : 4 août 2025 pour la promotion de M2 (2 heures), 2026
- Participation au concours blanc M1 2025 (rédaction 30 QCM et correction)
- Examinateur des ECOS formatives, validantes, nationale, Université Côte d’Azur de Nice depuis 2022
- Surveillance des examens LAS 1, L2, L3, M1, M2 ; Université Côte d’Azur de Nice (2022 – présent)
- Tutorat de la faculté de médecine de Rennes 1 : Tutrice des étudiants de Première Année Commune aux études de santé (année scolaire 2014-2015)
Paramédicaux
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- Membre enseignant aux kinésithérapeutes de Nice (prévu 28/01/2027)
- Enseignement à l’IFSI de Nice annuellement depuis 2022 (4 heures)
- Enseignements aux kinésithérapeutes de Toulouse (2022)
- Enseignement aux éducateurs de la CAMI Sport & Cancer (2022 – 2023).
Directrice de thèse de Médecine (8):
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- Mathilde Saboye (UVic/soutenance Espagne, 31 Mai 2024)
- Luc Chouquet (soutenance Nice, 16 Mai 2025). Prix de thèse UCA.
- Richard Lachaux (soutenance Nice, 19 Juin 2025).
- Steven Roussihles (co-encadrement Toulouse, 15 Octobre 2025)
- Tanguy Perraudin (soutenance Nice, 7 Novembre 2025).
- En cours :
- Thibault Guillermin (soutenance Nice, prévu 2028).
- Thibault Caudemont (soutenance Nice, prévu 2029).
- Paul Le Trepuec (soutenance Nice, prévu 2029)
Directrice de Master 2 (9):
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- Jonathan Cornacchini (UPEC/Paris, VCA Lab Boston, 2023 – 2024)
- Pierre Barbat (Marseille, LP2M Nice, 2024 – 2025)
- Benjamin Hertzog (CRT Nice, LP2M Nice, 2025 – 2026)
- Ioana Ivan (CRT Nice, LP2M Nice, 2025 – 2026)
- Pharel Ulrich Njessi (CRT Nice, LP2M Nice, 2025 – 2026)
- Abdullah Al Quarshi (Sorbonne, LP2M Nice, 2025 – 2026)
- Joseph Sfeir (Sorbonne, LP2M Nice, 2026 – 2027)
- Alexandru Mihalache (Sorbonne, LP2M Nice, 2026 – 2027)
- Tanguy Perraudin (Sorbonne, LP2M Nice, 2026 – 2027)
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(Co)-Directrice de Doctorant en Science (1) :
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- Amina Oyuntogos (ED Nice/ LP2M) -> Encadrement pour l’obtention de la Bourse Campus France 2026/2029. Inscrite le 24 Septembre 2026.
- Pharel Njessi (ED Nice / LP2M) prévu en début année 2027
- Abdullah AL Qurashi (ED Sorbonne / LP2M) prévu en début année 2027
Membre de jury de thèse de médecine extérieur à l’UCA (3):
- Benjamin Hertozg (7 Octobre 2025)
- Yanis Berkane (24 Octobre 2025)
- Nicolas Cavadore (5 Juin 2026)
Membre de jury de thèse de science extérieur à l’UCA (1) :
- Lolita Micicoi (Marseilles, 26 Novembre 2026)
Mémoire DIU de la main > 15 étudiants, tous publiés<
Communications orales des étudiants en congrès (études supervisées en dernier auteur et présenté par l’encadré) :
- Luc Chouquet (SFCM, 2024 et ASPLD, 2025, sofcpre 2025).
- Jonathan Cornacchini (TMR, sofcpre 2024)
- Tanguy Perraudin (Lambeaux perforants IMAP, Sofcpre 2024 et poster WSRM 2025, vidéoforum 2026)
- Yanis Berkane (Activité universitaire en France, Sofcpre 2024 et VCA en France, ASPLD 2025)
- Pharel Njessi (Sofcep 2026)
- Thibaut Caudemont (*2 vidéoforum 2026)
- Abdullah AL Qrashi (*2 vidéoforum 2026)
- Salman Shaaban (vidéoforum 2026)
- Omer Al Balushi (*2 vidéoforum 2026)
Communications écrites (poster)
- Lupon, U.Turrian, J. Malloizel-Delaunay, A. Bura-Rivière. « Internes en médecine et cicatrisation des plaies : que pensent les internes de leur formation ? » Société française de Médecine vasculaire. Congrès du 25-28/09/2019.
- Philipp Tratnig-Frank, Alec R. Andrews, Corentin B. Taveau, Alexandre G. Lellouch, Michael M. Jonczyk, Marion Goutard, Elise Lupon, Mark A. Randolph, Michael L. Morrison, Mark B. Roth, Curtis L. Cetrulo, Jr. The Impact of oxygen free radical scavenger on acute rejection in a histocompatible miniature swine model. 28th congress of The Transplantation Society, 2020 virtual (e-poster)
- Alexandre Lellouch, Corentin Taveau, Alec Andrews, Marion Goutard, Philipp Tratnig-Frankl,
- Lupon E, Acun, M. Goutard, R. Oganesyan, A.G. Lellouch, L.A. Lantieri, Alec R. Andrews, M. Randolph, C.L. Cetrulo Jr, B. Uygun. Decellularization of Vascularized Engineered Scaffolds for Facial Reconstruction. MGH SAC Poster 2021. virtual (e-poster)
- Elise LUPON, Hadrien PAOLI, Yanis BERKANE, Nicolas BERTHEUIL, Jean Baptiste DE VILLENEUVE DE BARGEMON, Isabelle PLUVY, Olivier CAMUZARD, Benoît CHAPUT. Coverage of elbow and forearm soft tissue defects with the posterior ulnar artery perforator flap (PURAP): anatomical study and surgical description. World Society for Reconstructive Microsurgery (WSRM 2023), Singapour. Poster diffusé du 16 au 19 Août 2023.
- Elise LUPON. Vascularized Composite Allotransplantation in the past decade: What’s hot and What’s not?. World Society for Reconstructive Microsurgery (WSRM 2025), Barcelone. Poster diffusé du 24 au 26 Avril 2025.
- Vascularized Composite allotransplantation in France: overview and update. Helsinski. Juin 2025. Abstract publié dans Transplantation.
- A New Method for Preparation of Decellularized Human Scaffolds for Facial Reconstruction. Helsinski. Juin 2025. Abstract publié dans Transplantation.
Communications orales
- E. Lupon, D. Gangloff, T.Meresse. Couverture et reconstruction de la flexion du coude par un lambeau de grand dorsal après exérèse d’un volumineux sarcome du bras dominant. SFCO Montpellier. (vidéo disponible sur « Oncostream »). 16 Mai 2019.
- E.Lupon. « Mon master 2 en 180 secondes ». SFCO Montpellier. 16 Mai 2019.
- E. Lupon, B. Chaput, JL.Grolleau, LA. Lantieri, AG Lellouch. Traitement permanent des dyschromies cutanées post brûlures. Société Française de Brûlologie- Cap d’agde. 6 Juin 2019.
- P. Girard, E. Lupon, J. Laloze, E. Watier, J. Duisit, B. Chaput, N. Bertheuil. Technique de couverture de perte de substance péri vulvaire par lambeau perforant de type IGAP (Inferior Gluteal Artery Perforator), Videocorner SOFCPRE 2019, Paris, 21 Novembre 2019.
- Berthier C, Lupon E, Gangloff D, Meresse T. Lambeau musculocutané de grand dorsal pédiculé dans la chirurgie du sarcome, Vidéocorner SOFCPRE 2019, Paris, 22 Novembre 2019
- E. Lupon. Vascularized Composite Allotransplantation. Decellularization/Revascularization project. Science Slam. Massachusetts General Hospital Research Institute. Boston, 14 Janvier 2020.
- Elise Lupon, Aylin Acun, Marion Goutard, Ruben Oganesyan, Alexandre Lellouch, Laurent Lantieri, Jean louis Grolleau, Basak Uygun, Curtis Cetrulo Decellularization of vascularized engineered scaffolds for facial reconstruction. Virtual Plastic Surgery (the meeting). 89th Annual meeting. Présenté le 16 Octobre 2020 (5 minutes).
- Elise Lupon, Aylin Acun, Marion Goutard, Ruben Oganesyan, Alexandre Lellouch, Laurent Lantieri, Jean louis Grolleau, Basak Uygun, Curtis Cetrulo Decellularization protocol for porcine Fasciocutaneaousflap : an update. The Virtual Virginia Society of Plastic Surgeron « VASPS » (virtuel). Présenté le 24 Octobre 2020 (8 minutes).
- Elise Lupon, Aylin Acun, Alexandre Lellouch, Corentin Taveau, Ruben Oganesyan, Marion Goutard, Laurent Lantieri, Curtis Cetrulo Basak Uygun. Decellularisation/Recellularisation des Allogreffes de tissus Composites. Académie de chirurgie (virtuel). Présentation orale 10 minutes, 4 Décembre 2020.
- Marion Goutard, R.J. de Vries, A.G. Lellouch, E. Lupon, C. Pendexter, S. N. Tessier, M.A. Randolph, L. Lantieri, C.L. Cetrulo, K. Uygun. Recovery After extended Static Cold Storage Preservation Using Subnoormothermic Machine Perfusion In VCA. ATC 5 Juin 2021.
- E.Lupon. « Mon master 2 en 180 secondes ». e-congrès. SFCO. 6 Mai 2021. (Oratrice et modératrice).
- Elise Lupon, Aylin Acun, Marion Goutard, Alexandre G. Lellouch, Ruben Oganesyan, Alec R. Andrews, Laurent Lantieri, Mark A. Randolph, Curtis L. Cetrulo, Jr., Basak Uygun. Decellularization Of Vascularized Composite Allografts In The Rat. PSRC virtual. Pentathon. June 9 2021.https://ps-rc.org/meeting/abstracts/2021/QS29.cgi
- Marion Goutard, Alexandre Lellouch, Elise Lupon, Casie Pendexter, Mark A. Randolph, Laurent Lantieri, Curtis L. Cetrulo, Jr., Korkut Uygun. Effect Of Static Cold Storage On Vascularized Composite Allotransplantation On Rodent. PSRC virtual. Pentathon. June 9 2021. https://ps-rc.org/meeting/abstracts/2021/QS37.cgi
- Victor pozzo, Aylin Acun, Elise Lupon, Alexandre G. Lellouch, Ruben Oganesyan, Alec R. Andrews, Laurent Lantieri, Mark A. Randolph, Curtis L. Cetrulo, Jr., Basak Uygun. Reendothelialization of decellularized swine fasciocutaneous flap: a proof-of-concept study. IXA-CTRMS 2021 (Septembre 2021)
- Lupon E, Acun A, Ruben Oganesyan, Lantieri L, Uygun B, Cetrulo L. C, Lellouch A.G. Protocole d’immersion/décellularisation d’Allotransplantation de Face, 8 min, SOFCPRE, 18 Novembre 2021.
- E.Lupon. « Présentation des travaux de Master 2 / Lauréate parcours 3R ». UPEC. 8 Avril 2022.
- E.Lupon. « Mon master 2 en 180 secondes ». e-congrès. SFCO. 12 Mai 2022. (Organisatrice et modératrice).
- E. Lupon, A. Bizos, P. Marek, A. Ciron, D. T.Meresse, J.Segal, D.Gangloff. SFCO Toulouse. 12 Mai 2022. Couverture et reconstruction vasculaire et tissulaire du scarpa gauche après exérèse d’un myxosarcome récidivant.
- E. Lupon, T.Meresse, Benoit Chaput. SFCO Toulouse. 12 Mai 2022. Reconstruction mammaire par gracilis prélevé́ selon un schéma de cruroplastie interne.
- E. Lupon, D. Gangloff. SFCO Toulouse. 13 Mai 2022. Comment je fais : curage inguinal dans le cadre du mélanome avec envahissement ganglionnaire. (Également présenté au vidéoforum le 02/07/2022)
- Elise Lupon, Yoann Dalmas, Benoit Chaput, Pierre Mansat, Stéphanie Delclaux. « Prise en charge chirurgicale des fractures corporéales peu ou non déplacées du scaphoïde par vissage percutané rétrograde en passant par la corne antérieure du trapèze : Une étude Française rétrospective uni-centrique auprès de 33 patients”. # 27694 DOI: 10.1016/j.hansur.2021.10.099. GEM 57eme Congrès de la Société Française de Chirurgie de la Main. 2021, 6 minutes, 16 Décembre 2021.
- Elise Lupon « Évaluation fonctionnelle de la prise en charge chirurgicale de l’arthrose scapho-trapézo-trapézoïdienne isolée : série rétrospective monocentrique de 24 patients”. Lafaye Gregory, Rongieres Michel, Lupon Elise, Grolleau Jean-Louis, Riot Samuel, Mansat Pierre. TABLE RONDE. GEM 57eme Congrès de la Société Française de Chirurgie de la Main. 2021, 8 minutes, 18 Décembre 2021. (Également présentée au vidéoforum le 1/07/2022)
- E. Lupon, T. Meresse, D. Gangloff. VidéoForum Toulouse. 02 Juillet 2022. Comment je fais : Actualisation dans la prise en charge du Dermatofibrosarcome de Darrier-Ferrand. (également modératrice de la session)
- E. Lupon, I. Ongenda, A. Bourcier, A. Zorigtbaatar, U. Kanmounye, F. Lauwers. Journée des jeunes plasticiens, Toulouse. 30 Juin 2022. Introduction à la chirurgie Mondiale « Global Surgery ».
- E. Lupon. Medial sural artery perforator flap for leg and knee coverage: Extended skin paddle with a two perforator harvesting. Octobre 2022. Plastic Surgery The Meeting. Boston. Abstract #: 2845
- E. Lupon. Formation du jeune chirurgien oncologue au sarcome. SFCO Paris. 11 Mai 2023.
- Organisation et modération de la session « Prise en charge du lymphœdème » avec intervenants internationaux (JP Hong, Jaume Masia). SFCO Paris. 11 Mai 2023
- Session work shop. Orateur du “Speed mentoring” – Conseillère aux chirurgiens oncologues en formation. SFCO Paris. 12 Mai 2023 (également organisatrice et modératrice de session).
- Elise Lupon, Sarah Hendriks, Eugénie Dalamier, Bernard Gasser, Thérèse Adawa. Analyse histologique extemporanée selon Mohs en pathologie tumorale cutanée : possibilités et limites de l’évaluation tomographique par cohérence optique plein champ FFOCT (Full-Field Optical Coherence Tomography). SFCO Paris. 12 Mai 2023 et présenté le 28 Octobre au PSTM Texas 2023 (5 minutes).
- Elise Lupon, Inès Ongenda, Olivier Camuzard, Jacques Saboye, Frédéric Lauwers. La chirurgie oncologique mondiale. SFCO Paris. 12 Mai 2023 (également modératrice de session).
- Elise LUPON, Aylin Acun, Alexandre G. Lellouch, Ruben Oganesyan, Hyshem Lancia, Olivier Camuzard, Alec R. Andrews, Mark Randolph, Curtis L. Cetrulo Jr, Basak E. Uygun. Decellularization and recellularization of Vascularized Composite tissue Allografts: current status and new concepts. World Society for Reconstructive Microsurgery (WSRM 2023), Singapour. 17 Août 2023 (5 minutes).
- Elise LUPON, Gilles CLARO, Farid BEKARA, Fatima Zohra MOKRANE, Olivier CAMUZARD, Benoit CHAPUT. A dynamic anatomical study of parasacral perforators: mapping, perforasome and applications for buttock enhancement. WSRM 2023, Singapour. 17 Août 2023 (5 minutes).
- Elise LUPON, Hadrien PAOLI, Yanis BERKANE, Nicolas BERTHEUIL, Jean Baptiste DE VILLENEUVE DE BARGEMON, Isabelle PLUVY, Olivier CAMUZARD, Benoît CHAPUT. Coverage of elbow and forearm soft tissue defects with the posterior ulnar artery perforator flap (PURAP): anatomical study and surgical description. Plastic Surgery The meeting (PSTM 2023), Austin, Texas. 28 Octobre 2023 (5 minutes).
- Elise Lupon, Benoît Chaput, yong-June kim, Aymeric André, Frédéric « Microsurgery without border: Result of 20 years’ experience in Cambodia, 6 min, SOFCPRE, 16 Novembre 2023.
- Elise Lupon. Association des jeunes chirurgiens oncologues : pourquoi vous y intéresser ? 20 min, SOFCPRE/Table ronde, 18 Novembre 2023.
- Présentation des travaux de thèse de Science. JEDNs 85. Valrose, Université Côte d’Azur 21 Mai 2024 (8 minutes).
- Elise Lupon, Benoît Chaput, yong-June kim, Aymeric André, Frédéric Lauwers. Reconstructions tumorales microchirurgicales « sans frontières » : Résultat de 9 ans d’expérience au Cambodge, 8 min, SFCO Nantes, 24 Mai 2024. (également modératrice de session).
- Elise Lupon, Roxane Elaldi, Olivier Malard. Modération de la table ronde ORL. SFCO Nantes, 24 Mai 2024
- Elise Lupon « Quoi de neuf en chirurgie oncologique ? ». (25 minutes). SOFCPRE. Novembre 2024.
- Elise Lupon, Laura Charlès, Tia Sheth, Kassem Saffa, Alexandre G. Lellouch, Curtis Cetrulo. “Monitorage de médicaments immunosuppresseurs : Un dispositif non invasif pour une mesure salivaire du tacrolimus ».(8 minutes).
SOFCPRE. Novembre 2024. - Elise Lupon « Place des lambeaux perforant en chirurgie de la main ».(10 minutes). Table ronde. SOFCPRE. Novembre 2024. (également modératrice et organisatrice de session).
- Elise Lupon, Inès Ongenda, Alexandre Bourcier, Anudari Zorigtbaatar, Jacques Saboye, Ulrick Sidney Kanmounye, Fréderic Lauwers. La chirurgie mondiale : clarification et état des lieux dans la population francophone (8 minutes). SOFCPRE. Novembre 2024.
- Modératrice de session au congrès M.I.S.S (Mini Invasive Spine and Skeletal meeting) Galet, Nice (Session Squelette périphérique)
- Présidente, Modératrice et présentatrice (20 minutes). 5ème réunion d’échange sur la réparation tissulaire. Galet. Nice*
- Avancées dans le traitements chirurgical du lymphoedeme. Journée de medecine vasculaire nicoise 20 minutes. E-webinar.
- Webinar CNCEM. “Enseigner en Santé à l’Heure de l’IA Générative”. IA et santé. Évaluation du rôle des grands modèles de langage dans la simulation et la génération d’ECOS. 3 Juin 2025. CNEM.
- Organisation et modération table ronde Microchirurgie et main – Sofcpre 20 Novembre 2025. Oratrice présnetation “IA et microchirurgie”.
- Oratrice table ronde Oncologie – Sofcpre 21 Novembre 2025. “IA et Oncologie en chirurgie plastique”.
- Oratrice table ronde Innovation – Sofcpre 20 Novembre 2025. “IA en chirurgie plastique”.
- MedIntechs 10 mars 2026. Innovation chirurgicale. Simlife pour la chirurgie avancée des lambeaux. Parc Floral, Paris.
- Académie nationale de chirurgie. Impact des traitements systémiques sur la chirurgie en oncodermatologie. 15 minutes. 20 Mai 2026.
- « Expanding the role of perforator flaps in oncologic dermatologic reconstruction “ – Cours aux chirurgiens du Pakistan 7 Mai 2026 – ASPF / International visiting professor ( 1 heure)
- Prélèvement d’une allogreffe faciale complète de tissus mous pour la transplantation composite vascularisée. Vidéoforum le 26 Juin 2026.
- Un modèle expérimental humain de lambeau DIEP pour l’étude des stratégies de préservation des allogreffes composites vascularisées et des lambeaux libres. Vidéoforum. Le 27 Juin 2026.
- Le modèle cadavérique humain reperfusé SIMLife® comme plateforme translationnelle pour la chirurgie avancée des lambeaux. Vidéoforum. Le 27 Juin 2026.
- Transplantation hétérotopique de membre postérieur au cou chez la souris : un modèle de supermicrochirurgie appliqué à la transplantation composite vascularisée. Vidéoforum. Le 27 Juin 2026.
- Session 2. Modération Journée jeunes plasticiens. Vidéoforum. Toulouse. Le 25 Juin 2026.
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Publications
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Publications avec comité de lecture
Publications 2026 du Dr LUPON Élise
The emerging role of mixed reality and artificial intelligence in sarcoma care: A systematic reviewThe emerging role of mixed reality and artificial intelligence in sarcoma care: A systematic review
The emerging role of mixed reality and artificial intelligence in sarcoma care: A systematic review
Surbhi Joshi, Pharel Njessi, Olivier Camuzard, Marc-Olivier Gauci, Sylvie Bonvalot, Elise Lupon
https://doi.org/10.1016/j.ejso.2026.111447
Abstract
Background: Sarcomas are a heterogeneous group of cancers requiring cautious monitoring and expert management. The emerging role of Artificial Intelligence (AI) and Mixed Reality (MR) may represent a turning point in sarcoma care. This systematic review evaluates their application in sarcoma management.
Methods: A comprehensive search of PubMed/MEDLINE, Embase, Scopus, and Web of Science up to June 2025 was conducted following PRISMA guidelines. Eligible studies included case series, cohort studies, multicenter studies, diagnostic accuracy studies and prediction model studies reporting on AI or MR use in sarcoma. Review articles and non-English studies were excluded. Data extracted included design, population, modality, sarcoma subtype, and reported outcomes.
Results: Twenty-three studies met inclusion criteria: 1 case series, 1 case report, 2 cohort studies, 8 diagnostic accuracy studies and 11 prediction model studies with a cumulative sample size of 8478 patients. The most frequently investigated tumors were osteosarcoma (n = 6), soft tissue sarcoma (STS) (n = 5), and chondrosarcoma (n = 4). AI was primarily applied in imaging-based diagnosis (n = 12, reported accuracy 78-95 %), histopathological grading (n = 5), and radiogenomic models (n = 4). MR was used in preoperative planning (n = 3), intraoperative navigation (n = 2), and surgical training (n = 2). No integrated AI/MR platforms were reported.
Conclusion: AI and MR show strong potential in improving sarcoma management, particularly for diagnostic accuracy and surgical planning. However, the literature remains heterogeneous, consisting mostly of preliminary studies with limited statistical power. Large-scale multicenter studies are required to validate the impact of AI and MR on outcomes and safely integrate these technologies into routine care.
Keywords: Artificial intelligence; Machine learning; Mixed reality; Oncology; Sarcoma; Surgery.
Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.
Conflict of interest statement
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The author Sylvie Bonvalot is an Associate Editor for this journal and was not involved in the editorial review or the decision to publish this article.
CloseOutcomes of All-Dorsal Augmented Intercarpal Ligament ReconstructionOutcomes of All-Dorsal Augmented Intercarpal Ligament Reconstruction
Outcomes of All-Dorsal Augmented Intercarpal Ligament Reconstruction
Jean-Baptiste de Villeneuve Bargemon, Silvia Gandolfi, Elise Lupon
https://doi.org/10.1097/prs.0000000000012447
No abstract availableCloseHeterotopic Hindlimb-to-Neck Transplantation in the Mouse: A Supermicrosurgical Model of Vascularized Composite AllotransplantationHeterotopic Hindlimb-to-Neck Transplantation in the Mouse: A Supermicrosurgical Model of Vascularized Composite Allotransplantation
Heterotopic Hindlimb-to-Neck Transplantation in the Mouse: A Supermicrosurgical Model of Vascularized Composite Allotransplantation
Haruyuki Hirayama, Lisa Polak, Marisa Delliturri, Jebrane Bouaoud, Daniel J Ceradini, Piul S Rabbani, Eduardo D Rodriguez, Elise Lupon, Catherine Pei-Ju Lu
Abstract
Vascularized composite allotransplantation (VCA) is increasingly recognized as a reconstructive option that offers substantial benefits for patients with severe tissue loss, including injuries affecting the face and hand. Despite its clinical promise, VCA remains limited by surgical complexity, the need for long-term immunosuppression, and associated morbidity. Preclinical models are therefore essential for refining surgical techniques, testing novel immunomodulatory approaches, and investigating ischemia/reperfusion injury. Compared with large-animal models, rodent models offer advantages in accessibility and cost while adhering more closely to the 3Rs principles of Replacement, Reduction, and Refinement. Among them, the mouse offers unique advantages, including the availability of humanized strains, a broad panel of well-characterized antibodies, and compatibility with advanced immunological assays. These features make the mouse particularly valuable for translational VCA research. Murine VCA, however, requires demanding supermicrosurgical skills, as vascular anastomoses are performed on vessels measuring approximately 0.3-0.5 mm in diameter. To enhance reproducibility, we provide technical tips that have proven critical to the success of these procedures. These include the insertion of a nylon filament into the vessel lumen to stabilize the anastomosis, careful separation of the artery and vein over a sufficient distance along the pedicle, precise anesthetic dosing, and specific maneuvers to prevent pedicle twisting. We also highlight common pitfalls and errors, offering practical guidance to improve outcomes. Here, we describe a comprehensive, stepwise protocol for mouse heterotopic hindlimb-to-neck transplantation, accompanied by instructional video material. This non-functional model minimizes postoperative morbidity compared with orthotopic transplantation while providing robust and reproducible results. It is ideally suited for training in supermicrosurgery and for addressing key experimental questions in VCA, including immune tolerance, graft preservation, and ischemia/reperfusion mechanisms. This methodology provides investigators with a reliable murine platform to advance translational VCA research and to develop innovative strategies aimed at improving outcomes in reconstructive transplantation.
CloseResponse to the letter from Shigeki MatsubaraResponse to the letter from Shigeki Matsubara
Response to the letter from Shigeki Matsubara
Bernard de Geofroy, Elise Lupon, Grégoire Micicoi
https://doi.org/10.1016/j.otsr.2026.104743
No abstract availableConflict of interest statement
Declaration of competing interest G. Micicoi is Associate editor of Orthopedics & Traumatology: Surgery & Research. The other authors declare no conflict of interest.
CloseVascular anatomy of the hand and therapeutic applicationsVascular anatomy of the hand and therapeutic applications
Vascular anatomy of the hand and therapeutic applications
Rémy Lavigne, Tanguy Perraudin, Pharel Njessi, Olivier Camuzard, Elise Lupon
https://doi.org/10.1016/j.hansur.2026.102737
Abstract
This article provides a detailed analysis of the complexity of hand vascularization and its anatomical relationships. It examines the main arteries of the hand (radial, ulnar, and interosseous) and their networks of branches and anastomoses in relation to the structures of the hand. The therapeutic applications derived from this vascular anatomy are also described, particularly the various types of flaps used in reconstructive surgery to address soft tissue defects of the hand. The article also discusses the venous and lymphatic vascularization of the hand.
Keywords: Anatomical snuffbox; Finger flap; Hand vascularization; Perforator flap.
Copyright © 2026 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
Conflict of interest statement
Declaration of competing interest The authors declare having no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
CloseResponse to the comment on: Morphometric, curvature CT-based study of the distal radius watershed line. Valerio T, Lupon E, Quemener-Tanguy A, Masse E, Brenac C, de Villeneuve Bargemon J-B. Hand Surg Rehabil. 2025, 44:102168. by Aphale P et alResponse to the comment on: Morphometric, curvature CT-based study of the distal radius watershed line. Valerio T, Lupon E, Quemener-Tanguy A, Masse E, Brenac C, de Villeneuve Bargemon J-B. Hand Surg Rehabil. 2025, 44:102168. by Aphale P et al
Response to the comment on: Morphometric, curvature CT-based study of the distal radius watershed line. Valerio T, Lupon E, Quemener-Tanguy A, Masse E, Brenac C, de Villeneuve Bargemon J-B. Hand Surg Rehabil. 2025, 44:102168. by Aphale P et al
Elise Lupon, Thomas Valério, Pharel Njessi, J B De Villeneuve Bargemon
https://doi.org/10.1016/j.hansur.2026.102570
No abstract availableConflict of interest statement
Declaration of competing interest The authors declare having no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
CloseThe 50 most-cited publications in lymphatic surgery: A bibliometric analysisThe 50 most-cited publications in lymphatic surgery: A bibliometric analysis
The 50 most-cited publications in lymphatic surgery: A bibliometric analysis
Abdullah A Al Qurashi, Pharel Njessi, Hatan Mortada, Olivier Camuzard, Joon Pio Hong, Elise Lupon
https://doi.org/10.1016/j.jpra.2026.03.032
Abstract
Background: Lymphatic surgery has evolved from palliative debulking procedures to physiologic reconstruction using microsurgical and supermicrosurgical techniques. Despite this progress, the publications that have most influenced this evolution have not been systematically examined. This study aimed to analyze the 50 most-cited publications in lymphatic surgery, assessing their bibliometric characteristics, study designs, levels of evidence, and thematic contributions to lymphedema surgical management.
Methods: The Web of Science Core Collection was searched for articles on surgical treatment of lymphedema from inception to November 7, 2025. The 50 most-cited articles were identified and analyzed for citation count, citation density (citations per year), authorship, geographic origin, journal distribution, and keyword frequency. Studies were categorized by design and evaluated according to the Oxford Centre for Evidence-Based Medicine levels of evidence. Concise summaries were generated to facilitate access to key findings.
Results: Published between 2004 and 2023, the top 50 articles accumulated 4612 citations (mean 92.2, median 75.5). Citation density ranged from 3.9 to 32.5 citations per year. Plastic and Reconstructive Surgery was the most represented journal (n = 14). Asian institutions predominated, with Japan (n = 16) and Taiwan (n = 11) accounting for 54% of publications. Case series were the most common study design (n = 24). Most studies provided Level 4 or 5 evidence (74%), although two Level 2 randomized controlled trials were identified. Keyword analysis identified supermicrosurgery, lymphaticovenular anastomosis, and indocyanine green lymphography as the most recurring technical concepts.
Conclusions: This bibliometric analysis highlights seminal publications underlying the development of supermicrosurgical techniques such as lymphaticovenous anastomosis and vascularized lymph node transfer. The results demonstrate a strong Eastern contribution to innovation. While observational studies predominate, the near-total absence of Level 1 evidence and the presence of only two Level 2 trials underscore the need for well-designed prospective comparative studies to establish standardized treatment algorithms. Level of evidence: IV.
Keywords: Bibliometric analysis; Lymphatic surgery; Lymphaticovenous anastomosis; Lymphedema; Supermicrosurgery; Vascularized lymph node transfer.
© 2026 The Author(s).
Conflict of interest statement
The authors declare that they have no conflicts of interest.
CloseCarpal ligamentous injury in children and adolescents: a systematic reviewCarpal ligamentous injury in children and adolescents: a systematic review
Carpal ligamentous injury in children and adolescents: a systematic review
Pauline Mathon, Pharel Njessi, Camille Brenac, Rémy Dubian, Elise Lupon, Jean-Baptiste de Villeneuve Bargemon
https://doi.org/10.1016/j.hansur.2026.102646
Abstract
Purpose: Carpal ligamentous injuries in children and adolescents are uncommon yet often underappreciated. This systematic review aims to consolidate existing evidence regarding scapholunate (SL), lunotriquetral (LT), and perilunate injuries in patients aged 16 years and younger while exploring potential management strategies.
Methods: We conducted a PRISMA-compliant systematic review, sourcing data from PubMed/MEDLINE, Embase, Scopus, and Web of Science from inception to October 2025. Studies focusing on SL, LT, or perilunate injuries in pediatric patients that documented treatment and included at least three months of follow-up were selected. Two reviewers independently screened the studies. Due to diversity in the data, results were synthesized narratively. A good clinical outcome was defined as minimal pain (VAS<2), flexion-extension ≥50 °, and grip strength >80% of the contralateral side.
Results: Twenty-two studies were identified, detailing 62 SL injuries, 13 perilunate injuries, and 2 isolated LT injuries. The majority were case reports, with only two retrospective cohort studies on SL injuries. SL injuries often co-occurred with distal radius fractures and usually necessitated arthroscopy for accurate diagnosis. While case reports indicated favorable outcomes, cohort studies exhibited greater variability in recovery, particularly with delayed interventions. For unstable SL lesions, arthroscopic debridement combined with scapholunate pinning showed promising functional outcomes. Concerning perilunate injuries, both surgical and non-surgical treatments were documented, with closed reduction and subsequent immobilization yielding satisfactory results in approximately 87.5% of cases. Notably, only one instance of long-term growth disturbance was reported. Isolated LT injuries were managed with arthroscopic debridement and pinning, allowing athletes to safely return to sports.
Conclusion: Current evidence regarding carpal ligamentous injuries in the pediatric population is limited and primarily derived from small, heterogeneous case series. Early intervention appears to correlate with improved functional outcomes in SL injuries, with arthroscopy being crucial for accurate diagnosis. In select cases of perilunate injury, closed reduction followed by immobilization may offer satisfactory results. Given the limitations, these findings warrant cautious interpretation, emphasizing the need for higher-quality prospective studies in this area.
Level of evidence: Systematic Review, Level IV.
Keywords: Carpal ligaments; Immature skeletal; Pediatric; Wrist.
Copyright © 2026 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.
Conflict of interest statement
Declaration of competing interest No conflict.
CloseRegulatory T-cells technology and vascularized composite allotransplantation: A scoping reviewRegulatory T-cells technology and vascularized composite allotransplantation: A scoping review
Regulatory T-cells technology and vascularized composite allotransplantation: A scoping review
Amina Oyuntogos, Pharel Njessi, Olivier Camuzard, Marion Cremoni, Antoine Sicard, Elise Lupon
https://doi.org/10.1016/j.trim.2026.102417
Abstract
Background: Vascularized composite allotransplantation (VCA) offers life changing reconstructive options for patients with traumatic injuries or congenital defects, restoring function and appearance. Its success is limited by strong immune responses, and long-term immunosuppression carries significant risks. Emerging cellular therapies, particularly regulatory T cells (Tregs) offer promising strategies to mitigate rejection and reduce immunosuppression dependence. Preclinical studies in animal models suggest that Treg-based approaches may improve graft survival and potentially reduce the need for conventional immunosuppression in VCA.
Methods: An all-time literature search of Regulatory T cell therapy in Vascularized Composite Allotransplantation in animal models was performed on the following electronic databases: PubMed, EMBASE, Cochrane Library, Scopus, Web of Science, and TRIP Database until August 2025. Data was analyzed for graft survival, regulatory T cell activity, chimerism, and tolerance mechanisms.
Results: A total of 2182 studies were screened across six databases, of which 13 met eligibility criteria and 5 were selected focusing on Treg therapy in VCA animal models. Treg therapy consistently prolonged graft survival (>200 days), promoted chimerism, reduced inflammation, and induced donor specific tolerance. CAR-Tregs demonstrated antigen-specific tolerance, while mesenchymal stem cells (MSCs) enhanced immunomodulation, particularly under hypoxic preconditioning. Other cellular therapies, including hematopoietic stem cells (HSC), also improved graft acceptance, demonstrating their potential as adjuncts or alternatives to long term immunosuppression.
Conclusion: Cellular therapies, especially Treg based approaches such as adoptive transfer and local enrichment or induction of Tregs, consistently promote immune tolerance, suppress graft rejection, and extend allograft survival in VCA animal models. These approaches reduce the need for long term immunosuppression and create a pro-tolerogenic environment, supporting their translational potential. However, further clinical validation is required to optimize dosing, persistence and safety for application in human VCA recipients.
Keywords: Cellular therapy; Chimerism; Immune tolerance; Regulatory T cells (Tregs); Vascularized composite allotransplantation.
Copyright © 2026. Published by Elsevier B.V.
Conflict of interest statement
Declaration of competing interest The authors declare no conflicts of interest.
CloseScapholunate Injuries in the Context of Acute Scaphoid Fractures: A Systematic Literature ReviewScapholunate Injuries in the Context of Acute Scaphoid Fractures: A Systematic Literature Review
Scapholunate Injuries in the Context of Acute Scaphoid Fractures: A Systematic Literature Review
Laure Glévarec, Pharel Njessi, Marie-Anne Poumellec, Thierry Balaguer, Olivier Camuzard, Elise Lupon
https://doi.org/10.1177/15589447261430936
Abstract
The association between acute scaphoid fractures and concomitant scapholunate ligament (SLL) injuries has historically been underestimated, yet failure to recognize these lesions may lead to carpal instability, scaphoid nonunion, and long-term degenerative changes. This systematic review synthesizes current evidence on the incidence, diagnostic methods, and management of SLL injuries occurring with acute scaphoid fractures. A comprehensive search of PubMed/MEDLINE, Embase, Scopus, and Web of Science from inception to April 2025 was conducted in accordance with Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, including original articles in English or French reporting on SLL injuries associated with acute scaphoid fractures. Eleven studies met inclusion criteria, comprising prospective and retrospective cohorts, case-control studies, series, and case reports. Reported incidence of SLL injuries ranged from 0% to 71%, with arthroscopy detecting higher rates than radiography or magnetic resonance imaging. Most lesions were Geissler grades I to III, while complete tears were rare. Management was predominantly limited to scaphoid fixation, with only a minority of cases undergoing concomitant SLL repair or pinning. Outcomes were inconsistent, with some studies showing persistent pain and lower Mayo Wrist Scores, whereas others reported no significant differences. Overall methodological quality was low to moderate. These findings suggest that SLL injuries may complicate acute scaphoid fractures more frequently than previously recognized. Routine arthroscopy is not universally recommended, but selective use based on clinical suspicion and imaging may improve detection. Treatment should be tailored to the grade of injury, and further prospective studies with standardized diagnostic protocols and long-term follow-up are required to clarify prognostic impact and optimize management strategies.
Keywords: arthroscopy; associated ligament injury; carpal instability; scaphoid fracture; scapholunate advanced collapse wrist; scapholunate ligament.
Conflict of interest statement
The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: The authors (LG, PN, M-AP, TB, OC, EL) declare that they have no conflicts of interest related to this work.
ClosePreservation Strategies for Vascularized Composite Allotransplantation: An Updated Systematic Review of a Rapidly Expanding FieldPreservation Strategies for Vascularized Composite Allotransplantation: An Updated Systematic Review of a Rapidly Expanding Field
Preservation Strategies for Vascularized Composite Allotransplantation: An Updated Systematic Review of a Rapidly Expanding Field
Pharel Njessi, Pierre Barbat, Rabbani S Piul, Didier F Pisani, Olivier Camuzard, Antoine Sicard, Eduardo Rodriguez, Elise Lupon
https://doi.org/10.1097/sap.0000000000004677
Abstract
Background: Composite allotransplantation has become a viable reconstructive option for selected patients, but preservation remains a major barrier to broader clinical application. Static cold storage is the current gold standard, yet ischemia reperfusion injury and limited preservation times restrict its effectiveness. Recent advances in machine perfusion and subzero nonfreezing storage (or supercooling) have prompted renewed interest in optimizing graft viability.
Methods: Following PRISMA guidelines, we systematically searched PubMed, EMBASE, and Cochrane, covering studies published from June 2022 to August 2025 for studies on ex vivo preservation of vascularized composite allotransplantations. Eligible articles included original studies in English evaluating postharvest, pretransplant preservation strategies. Data extracted were study design, preservation methods, perfusates, and primary outcomes. Risk of bias was assessed using SYRCLE for animal studies and Joanna Briggs Institute for human/cadaver studies.
Results: Seventeen studies met the inclusion criteria: 1 on static cold storage, 13 on machine perfusion, and 3 on supercooling. Static cold storage research has declined, with the only recent study investigating subnormothermic machine perfusion as a recovery adjunct. Machine perfusion studies focused on the optimization of perfusion parameters, perfusate composition, and circuit design. Red blood cell-based perfusates remained common, but alternative oxygen carriers such as polymerized hemoglobin-based oxygen carrier-201 and dextran oxygen microcarriers showed promise despite edema-related challenges. Supercooling studies demonstrated the feasibility of multiday preservation in rodent and porcine models. Overall, risk of bias was high or unclear across animal studies, mainly due to selection and performance bias, whereas the single human ex vivo study showed low risk of bias.
Conclusions: The field of vascularized composite allograft preservation is expanding rapidly, with a combination of static and dynamic techniques emerging as a promising option to extend graft viability beyond the current limits. However, translation to clinical setting remains limited by small preclinical studies, methodological heterogeneity, and the paucity of functional endpoints. Standardized protocols, robust large-animal models, and eventual human feasibility trials are needed to establish clinically applicable preservation strategies.
Keywords: VCA preservation; ex vivo preservation; ischemia-reperfusion injury; machine perfusion; supercooling; translational research; vascularized composite allotransplantation.
Copyright © 2026 Wolters Kluwer Health, Inc. All rights reserved.
Conflict of interest statement
Conflicts of interest and sources of funding: The authors declare that they have no conflicts of interest.
CloseA Model for Malpractice Preparedness for Plastic Surgery ResidentsA Model for Malpractice Preparedness for Plastic Surgery Residents
A Model for Malpractice Preparedness for Plastic Surgery Residents
Silvia Gandolfi, Abdulaziz Asiry, Benoît Chaput, Elise Lupon
https://doi.org/10.1097/gox.0000000000007622
No abstract availableConflict of interest statement
The authors have no financial interest to declare in relation to the content of this article.
CloseAsan Medical Center Plastic Surgery Visit: Insights from FranceAsan Medical Center Plastic Surgery Visit: Insights from France
Asan Medical Center Plastic Surgery Visit: Insights from France
Elise Lupon
https://doi.org/10.1055/a-2726-3307
No abstract availableConflict of interest statement
Conflict of Interest The authors declare that they have no conflict of interest.
CloseAutoclosing Excision Design for Dermatofibrosarcoma Protuberans in Slow Mohs SurgeryAutoclosing Excision Design for Dermatofibrosarcoma Protuberans in Slow Mohs Surgery
Autoclosing Excision Design for Dermatofibrosarcoma Protuberans in Slow Mohs Surgery
Elise Lupon, Ioana Ivan, Olivier Camuzard, Silvia Gandolfi, Dimitri Gangloff
https://doi.org/10.1002/ccr3.73472
Abstract
In DFSP treated with slow Mohs surgery, first-stage planning is critical given delayed histologic results. The pinch test allows intraoperative assessment of skin mobility, enabling margin tailoring beyond the standard 1-1.3 cm when laxity permits, while preserving primary closure. This integrates oncologic and reconstructive planning in a single surgical step.
Keywords: dermatology; inguinal lymph node dissection; melanoma; oncology; surgery.
© 2026 The Author(s). Clinical Case Reports published by John Wiley & Sons Ltd.
Conflict of interest statement
The authors declare no conflicts of interest.
CloseSaphenous Vein-Preserving Inguinal Lymph Node Dissection: A Stepwise Technical ApproachSaphenous Vein-Preserving Inguinal Lymph Node Dissection: A Stepwise Technical Approach
Saphenous Vein-Preserving Inguinal Lymph Node Dissection: A Stepwise Technical Approach
Elise Lupon, Ioana Ivan, Olivier Camuzard, Dimitri Gangloff
https://doi.org/10.1002/ccr3.71712
Abstract
Preserving the great saphenous vein during inguinal lymph node dissection maintains venous outflow and skin drainage while allowing complete oncologic clearance.
Keywords: dermatology; inguinal lymph node dissection; melanoma; oncology; surgery.
© 2025 The Author(s). Clinical Case Reports published by John Wiley & Sons Ltd.
Conflict of interest statement
The authors declare no conflicts of interest.
CloseRefining the SCIP flap: Technical nuances and insights from osteocutaneous and chimeric applicationsRefining the SCIP flap: Technical nuances and insights from osteocutaneous and chimeric applications
Refining the SCIP flap: Technical nuances and insights from osteocutaneous and chimeric applications
Paul Girard , Yanis Berkane, Pharel Njessi, Nicolas Bertheuil, Elise Lupon
https://doi.org/10.1016/j.jham.2025.100397
No abstract availableConflict of interest statement
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
CloseCan large language models provide high-quality desk review decisions in an orthopaedic surgery journal? A concordance study comparing three AI models to human editorial decisionsCan large language models provide high-quality desk review decisions in an orthopaedic surgery journal? A concordance study comparing three AI models to human editorial decisions
Can large language models provide high-quality desk review decisions in an orthopaedic surgery journal? A concordance study comparing three AI models to human editorial decisions
Elise Lupon, Quentin Bérard, Henri Migaud, Philippe Clavert, Grégoire Micicoi
https://doi.org/10.1016/j.otsr.2026.104801
Abstract
Background: Artificial intelligence (AI) is increasingly integrated into scientific publishing workflows, yet no study has formally evaluated the ability of large language models (LLMs) to reproduce human editorial desk-review (R0) decisions in a general orthopaedic surgery journal. We investigated whether three commercially available LLMs could accurately replicate the editorial decisions of the Editorial Board of Orthopaedics & Traumatology: Surgery & Research (OTSR). The study addressed four questions: (1) Is the concordance between LLM and human R0 decisions satisfactory for editorial use? (2) Do LLMs exhibit a severity bias? (3) Do LLMs generate decision letters of acceptable quality, and do they reproduce the specific critiques of human reviewers? (4) Does prompt complexity influence LLM decision-making?
Hypothesis: LLMs used without task-specific fine-tuning or prior exposure to the study corpus would demonstrate at least moderate concordance (κ ≥ 0.40) with human editorial decisions.
Material and methods: A corpus of 32 manuscripts randomly selected from submissions to OTSR between 2025 and 2026 (n = 10 outright rejected at R0: 3 out of scope, 3 plagiarism/dual submission, 4 direct desk rejection; n = 11 accepted for peer review; n = 11 rejected after full peer review) was anonymised and independently evaluated, without task-specific fine-tuning or prior exposure to the study corpus, by ChatGPT (GPT-5.5, OpenAI), Gemini (3.1, Google), and Claude (Sonnet 4.6, Anthropic) using a structured prompt incorporating the OTSR guidelines. The primary outcome was assessed using Cohen’s kappa between LLM and human binary decisions. Secondary outcomes included accuracy, inter-LLM agreement, domain-specific scoring, ARCADIA quality scoring of 115 eligible decision letters by two blinded raters with ICC, human-performed content concordance analysis, sensitivity analysis (structured vs. minimal prompt), and test-retest reproducibility at 24 h.
Results: Overall accuracy (i.e. the decision was similar for LLM and editorial decision) was 59.4% for ChatGPT (19/32) and Claude (19/32), and 62.5% for Gemini (20/32). Cohen’s kappa was near-zero for ChatGPT (κ = -0.05) and Gemini (κ = 0.00), and low for Claude (κ = 0.15). All LLMs showed systematic over-rejection of accepted manuscripts. No LLM identified plagiarism or simultaneous dual submission as a rejection motive. Test-retest concordance was 84.4-90.6 % across models. ARCADIA quality scoring (n = 115 scorable letters, inter-rater ICC = 0.86, 95% CI 0.80-0.90) showed Claude achieved the highest scores (4.46 ± 0.32 /5), significantly above the human OTSR letters (4.01 ± 0.44, p < 0.001), ChatGPT (3.81 ± 0.49, p = 0.002), and Gemini (3.28 ± 0.49, p < 0.001). LLMs reproduced 30-41 % of human reviewer-specific critiques, with Claude achieving the highest match (40.5%) without hallucinations. Switching to a minimal prompt markedly increased acceptance rates for Gemini (87.5%) and Claude (75%), while ChatGPT remained largely insensitive to prompt simplification (15.6%).
Conclusion: The principal finding of this study is the dissociation between formal review quality and true editorial reliability. Although modern LLMs generated persuasive and methodologically structured decision letters, they failed to achieve meaningful concordance with real editorial decisions and displayed stable architecture-specific biases that were highly sensitive to prompt design. These results indicate that current LLMs reproduce the surface features of peer review more successfully than its underlying scientific and contextual reasoning. Consequently, LLMs may represent valuable supervised assistants for editorial workflows, but not reliable autonomous substitutes for human editorial expertise in orthopaedic scientific publishing.
Level of evidence: IV; Observational pilot study, concordance analysis.
Keywords: AI editorial workflow limits (plagiarism-dual submission detection/contextual reasoning/human supervision).; Content concordance (human critiques reproduced/additional valid critiques/hallucinations); Editorial concordance (Cohen’s kappa/accuracy/sensitivity-specificity/over-rejection bias); LLM desk-review decisions (ChatGPT/Gemini/Claude/human editorial R0); Prompt sensitivity (structured vs minimal prompt/test-retest reproducibility); Review-letter quality (ARCADIA score/formal quality/synthetic peer review).
Copyright © 2026. Published by Elsevier Masson SAS.
Conflict of interest statement
Declaration of competing interest Henri Migaud declares being Editor-in-Chief of OTSR and has received fees from Zimmer-Biomet and Corin. Grégoire Micicoi declares being Associate Editor of OTSR and has received financial support and non-financial benefits from Johnson & Johnson, United Orthopaedics, and Adler Ortho. Élise Lupon and Quentin Bérard declare no conflict of interest. Philippe Clavert is paid consultant for Stryker-Tornier and Médartis and perceives royalties from Médartis.
CloseTrapeziectomy With Hemi-Abductor Pollicis Longus and SutureTape InternalBrace: A Technical Note and Case SeriesTrapeziectomy With Hemi-Abductor Pollicis Longus and SutureTape InternalBrace: A Technical Note and Case Series
Trapeziectomy With Hemi-Abductor Pollicis Longus and SutureTape InternalBrace: A Technical Note and Case Series
Richard Lachaux, Marie-Anne Poumellec, André-Pierre Uzel, Thierry Balaguer, Olivier Camuzard, Elise Lupon
https://doi.org/10.1097/gox.0000000000007538
Abstract
Background: Trapeziometacarpal osteoarthritis (rhizarthrosis) is a common cause of thumb pain and functional impairment. Although trapeziectomy remains the gold standard for pain relief, postoperative first metacarpal migration and scaphometacarpal impingement have led to the development of stabilization techniques. These procedures, however, are often technically demanding and lack consensus.
Methods: We describe a simplified suspensionplasty technique combining trapeziectomy with a hemi-abductor pollicis longus tendon and SutureTape InternalBrace reinforcement. A single-center retrospective study included 6 patients with Dell stage II-IV rhizarthrosis treated between January 2018 and March 2025 by a single experienced level IV surgeon (Tang and Giddins classification). Outcomes included pain (visual analog scale), function using the Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) questionnaire, key and grip pinch strength, Kapandji opposition score, and radiographic trapezial index. Pre- and postoperative values were compared.
Results: At a mean follow-up of 36 months, pain significantly decreased from 8.0 ± 0.89 to 1.83 ± 1.47. The QuickDASH score improved from 67.0 ± 15.08 to 17.83 ± 8.80. Key pinch strength increased from 4.07 ± 1.86 to 5.02 ± 2.37 kg, and grip strength increased from 18.0 ± 5.93 to 23.67 ± 6.38 kg. The Kapandji score improved from 7.67 ± 0.82 to 9.67 ± 0.52. The trapezial index decreased from 0.407 ± 0.053 to 0.311 ± 0.078. No major subluxations were observed, and no revision procedures were required.
Conclusions: This simplified InternalBrace-reinforced suspensionplasty seems safe, reproducible, and effective for pain relief and functional improvement in trapeziometacarpal osteoarthritis. Larger prospective studies are needed to confirm long-term outcomes.
Copyright © 2026 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.
CloseComparison of Radiographic and Ultrasound Imaging Techniques for Assessing the Scapholunate Interval in Healthy IndividualsComparison of Radiographic and Ultrasound Imaging Techniques for Assessing the Scapholunate Interval in Healthy Individuals
Comparison of Radiographic and Ultrasound Imaging Techniques for Assessing the Scapholunate Interval in Healthy Individuals
Grégoire Micicoi, Jean Baptiste De Villeneuve Bargemon, Pharel Njessi, Thomas Apard, Nicolas Dréant, Elise Lupon
https://doi.org/10.3390/jcm15114250
Abstract
Background/Objectives: Ultrasound (US) is a valuable tool in hand surgery because of its portability, low cost, and ability to provide noninvasive, real-time evaluation of soft tissue structures. However, it has not been widely assessed for measuring the scapholunate (SL) interval using dynamic stress views. This study aimed to determine whether ultrasound provides comparable measurements to radiography when evaluating the SL interval in healthy subjects. Methods: We analyzed 29 wrists from 29 individuals. Each wrist underwent dynamic stress maneuvers while the SL interval was measured with both radiography and US. The following views were obtained: neutral rotation, ulnar deviation, clenched fist, and a modified dynamic clenched fist view. The latter was performed by applying pressure on the head of the third metacarpal from distal to proximal. Results: The SL interval could be visualized in the clenched fist and ulnar deviation radiographic views, as well as in the modified dynamic clenched fist US view. Ultrasound in the neutral position produced measurements similar to those of traditional stress radiographs. The most pronounced changes in the SL interval occurred between neutral and dynamic views, whether assessed by radiography or US. There was no significant difference in the magnitude of interval change between the two imaging modalities. Conclusions: Ultrasound with dynamic stress maneuvers provided similar dynamic SL interval changes to stress radiographs in healthy individuals. A modified stress view using a slightly clenched fist and manual pressure on the third metacarpal head may offer hand surgeons a simple, real-time tool to noninvasively evaluate SL instability.
Keywords: radiographic stress view; scapholunate gap; scapholunate instability; scapholunate noninvasive assessment; ultrasound; wrist examination; wrist ultrasonic examination.
Conflict of interest statement
The authors declare no conflicts of interest.
CloseArtificial Intelligence in Plastic and Reconstructive Surgery: A Bibliometric Study of the 50 Most-cited ArticlesArtificial Intelligence in Plastic and Reconstructive Surgery: A Bibliometric Study of the 50 Most-cited Articles
Artificial Intelligence in Plastic and Reconstructive Surgery: A Bibliometric Study of the 50 Most-cited Articles
Pharel Njessi, Olivier Camuzard, Elise Lupon
https://doi.org/10.1097/gox.0000000000008120
Abstract
Background: Artificial intelligence (AI) has gained increasing attention in the surgical literature, including plastic and reconstructive surgery (PRS). However, the characteristics and trends of the most influential publications on AI in PRS remain poorly defined.
Methods: The online Web of Science Core Collection was searched on November 18, 2025, to identify articles on AI applications in PRS. Title, authorship information, publication year, journal, funding, and citation count were recorded. Studies were further classified based on application domain and PRS subspecialty.
Results: The 50 most-cited articles on AI in PRS were published between 2001 and 2024, with citation counts ranging from 45 to 124. Most articles originated from the United States (n = 18; 1166 citations) and were published by plastic surgeons (n = 17; 1332 citations). Imaging assessment (n = 21; 1564 citations) represented the most common application of AI, whereas the predominant PRS subspecialty was craniofacial surgery (n = 32; 2364 citations).
Conclusions: This bibliometric analysis highlights the most influential publications and emerging applications of AI in plastic surgery, revealing that image-based approaches predominate, particularly in craniofacial surgery, whereas adoption remains uneven across PRS subspecialties. These findings underscore current research priorities and identify areas where AI development remains limited, offering a foundation to guide future work in this rapidly evolving field.
Copyright © 2026 The Authors. Published by Wolters Kluwer Health, LLC. on behalf of The American Society of Plastic Surgeons.
Conflict of interest statement
The authors have no financial interest to declare in relation to the content of this article.
ClosePreserving Function in Sternal Reconstruction: Complementary Roles of Pectoralis Major and Internal Mammary Artery Perforator FlapsPreserving Function in Sternal Reconstruction: Complementary Roles of Pectoralis Major and Internal Mammary Artery Perforator Flaps
Preserving Function in Sternal Reconstruction: Complementary Roles of Pectoralis Major and Internal Mammary Artery Perforator Flaps
Elise Lupon, Pharel Njessi, Olivier Camuzard, Benoît Chaput, Silvia Gandolfi
https://doi.org/10.1097/sap.0000000000004618
No abstract availableConflict of interest statement
Conflicts of interest and sources of funding: none declared.
CloseCorrespondence on: The management of sternal mediastinitis in heart and lung transplant patients: An 8-year experience and application of reconstructive algorithmCorrespondence on: The management of sternal mediastinitis in heart and lung transplant patients: An 8-year experience and application of reconstructive algorithm
Correspondence on: The management of sternal mediastinitis in heart and lung transplant patients: An 8-year experience and application of reconstructive algorithm
Elise Lupon, Christian Herlin, Pharel Njessi, Benoît Chaput, Silvia Gandolfi
https://doi.org/10.1016/j.bjps.2026.07.042
No abstract availableConflict of interest statement
Declaration of Competing Interest The authors have no conflicts of interests to declare.
CloseComment to ``Current evidence on arthroscopic capsuloligamentoplasty plications as treatment for chronic dynamic scapholunate instability`` by Goorens et al., J Hand Microsurg 2026Comment to ``Current evidence on arthroscopic capsuloligamentoplasty plications as treatment for chronic dynamic scapholunate instability`` by Goorens et al., J Hand Microsurg 2026
Comment to « Current evidence on arthroscopic capsuloligamentoplasty plications as treatment for chronic dynamic scapholunate instability » by Goorens et al., J Hand Microsurg 2026
Jean-Baptiste de Villeneuve Bargemon, Élise Lupon , Camille Brenac
https://doi.org/10.1016/j.jham.2025.100388
No abstract available
Keywords: Capsuloplasty; Dorsal intercarpal; Scapholunate.
Conflict of interest statement
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
CloseLarge Language Models as Simulated Candidates in Objective Structured Clinical Examinations: A Rubric-Mapping Proof-of-Concept StudyLarge Language Models as Simulated Candidates in Objective Structured Clinical Examinations: A Rubric-Mapping Proof-of-Concept Study
Large Language Models as Simulated Candidates in Objective Structured Clinical Examinations: A Rubric-Mapping Proof-of-Concept Study
Elise Lupon, Alexandre O Gérard, Alexandre Destere, Romain Lombardi , Axel Maurice-Szamburski, Grégoire Micicoi
https://doi.org/10.1016/j.hansur.2026.102570
Abstract
Background: Large language models (LLMs) perform well on knowledge-based medical examinations, but evidence on their utility for performance-based assessments such as Objective Structured Clinical Examinations (OSCEs) remains limited. Beyond simulating candidate answers, LLMs could support quality assurance of OSCE stations by auditing the completeness and internal consistency of analytic scoring rubrics.
Methods: In this exploratory, single-run study, GPT-4 Turbo (OpenAI, accessed via the ChatGPT Plus consumer interface, May 2025) simulated a final-year medical student (DFASM3) across 10 validated French national OSCE stations covering all 11 nationally defined competency domains, using a fixed system prompt applied identically across stations. Each station was run once in a baseline condition and once in a reference-augmented (RAG) condition, in which official LiSA learning objectives and Starting Clinical Situation (SCS) documents were additionally provided. Outputs were scored against official analytic rubrics by two clinical educators through independent review (Cohen’s κ=0.84), with disagreements resolved by consensus; off-checklist content was similarly adjudicated.
Results: Mean baseline checklist coverage was 81% (SD 10.2), with A-level item omission averaging 10% (SD 7.2). RAG coverage increased to 95% (SD 5.1; Wilcoxon signed-rank test, p=0.002), recovering 1-4 previously missed items per station. Off-checklist additions averaged 22% of checklist items per station, nearly all clinically relevant; one incorrect addition was identified. Coverage was higher in structured, action-oriented stations (91.6% ± 4.1) than dialogue-heavy stations (73.7% ± 7.4). Given the single-run design and absence of a human comparator, results are exploratory and hypothesis-generating rather than robust performance estimates.
Conclusion: This proof-of-concept study shows that an LLM can generate structured, rubric-mappable OSCE responses and may help educators flag missing, ambiguous, or inconsistent checklist elements for expert review. These exploratory findings support further investigation of LLMs as decision-support tools for OSCE station pre-validation, pending replication with multiple runs, larger station banks, and human comparators.
Keywords: OSCE; artificial intelligence; assessment validation; large language models; medical education; proof-of-concept.
Plain language summary
Medical schools use Objective Structured Clinical Examinations (OSCEs) to test students’ clinical skills in standardized scenarios. Building these exams takes time, and teachers must carefully check that the scoring checklists are complete and consistent. In this study, we tested whether an artificial intelligence tool called a large language model (GPT-4 Turbo, the technology behind ChatGPT) could answer OSCE scenarios the way a medical student would. We then compared its answers with the official scoring checklists to see whether this could help teachers spot missing or unclear items. We tested 10 nationally validated French OSCE stations. The AI covered about 81% of the expected checklist items on average. When we gave it the official learning references, its coverage rose to 95%. The AI also gave extra, clinically appropriate answers that were not on the scoring checklist, suggesting some checklists may be incomplete. We found only one incorrect answer across all 10 stations. These findings suggest that AI tools could help teachers review and improve OSCE checklists before exams, as a quality-control support rather than a replacement for human examiners. This was a small, preliminary study with important limitations. We need larger studies that repeat the test multiple times before using this approach in practice.
© 2026 Lupon et al.
CloseCorrigendum to ``Utility of the caprini risk assessment model in guiding venous thromboembolism prophylaxis after abdominoplasty`` `{`JPRAS Open 46 (2025) 305-315`}`Corrigendum to ``Utility of the caprini risk assessment model in guiding venous thromboembolism prophylaxis after abdominoplasty`` `{`JPRAS Open 46 (2025) 305-315`}`
Corrigendum to « Utility of the caprini risk assessment model in guiding venous thromboembolism prophylaxis after abdominoplasty » [JPRAS Open 46 (2025) 305-315]
Abdulaziz Asiry, Anas Sayegh, Dimitri Gangloff, Hatan Mortada, Silvia Gandolfi, Elise Lupon
https://doi.org/10.1016/j.jpra.2026.01.001
CloseHypothenar Hammer Syndrome: Management of Acute Thromboembolic Complications From an Ulnar Artery AneurysmHypothenar Hammer Syndrome: Management of Acute Thromboembolic Complications From an Ulnar Artery Aneurysm
Hypothenar Hammer Syndrome: Management of Acute Thromboembolic Complications From an Ulnar Artery Aneurysm
Hani Al Shehhi, Tanguy Perraudin, Lilian Pimont, Thierry Balaguer, Olivier Camuzard, Elise Lupon
https://doi.org/10.1097/gox.0000000000007428
Abstract
Hypothenar hammer syndrome is a rare vascular disorder resulting from repetitive trauma to the hypothenar region of the hand, leading to ulnar artery injury and potential aneurysm formation. The aneurysm can eventually release distal emboli and lead to acute digital ischemia. Hypothenar hammer syndrome is often underdiagnosed, particularly in the plastic surgery setting. Management strategies are not standardized, and literature offering detailed surgical techniques, particularly involving palmar arch aneurysms, is sparse. We present the case of a 63-year-old manual laborer with a known ulnar artery aneurysm responsible for recurrent episodes of transient digital ischemia. The condition was initially managed conservatively; however, due to a worsening of symptoms, an elective surgical intervention was scheduled. Three months before the planned procedure, the patient presented to the emergency department with persistent acute ischemia of the third, fourth, and fifth fingers of the left hand. The imaging confirmed complete occlusion of the ulnar artery at the level of the aneurysm. Emergency intervention included aneurysm resection, ulnar artery anastomosis, and thromboembolectomy of the digital arteries. Multiple revascularization techniques were used, including intra-arterial heparinization, thrombolysis with urokinase, and Fogarty catheterization via different surgical approaches to the superficial palmar arch and digital arteries. Revascularization was successfully achieved in the ischemic digits. At the 2-year follow-up, the patient showed no recurrence and no sequelae. This case underscores the risks associated with delayed treatment of large digital aneurysms (>2 cm), called for prompt intervention upon diagnosis, and highlighted surgical tips that may improve outcomes in cases of embolic complications.
Copyright © 2026 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.
CloseAssessing ChatGPT and Gemini Responses to Common Patient Questions Regarding Augmentation MammaplastyAssessing ChatGPT and Gemini Responses to Common Patient Questions Regarding Augmentation Mammaplasty
Assessing ChatGPT and Gemini Responses to Common Patient Questions Regarding Augmentation Mammaplasty
Pharel Njessi, Axel Maurice-Szamburski, Chris Amro, Carter J Boyd, Jérôme Laloze, Elise Lupon
https://doi.org/10.1007/s00266-026-05766-7
Abstract
Background: Large language models (LLMs) are becoming a common source of medical information for patients.
Objective: This study aimed to evaluate and compare the quality and readability of ChatGPT and Google’s Gemini in answering frequently asked questions (FAQs) about augmentation mammaplasty (AM).
Methods: Ten AM FAQs were submitted to ChatGPT (GPT-4.1 mini) and Gemini (2.5 Flash). Responses were de-identified and independently rated by two board-certified plastic surgeons and one senior resident using the Global Quality Score (GQS). Readability was assessed using the Flesch Reading Ease (FRE) and Flesch-Kincaid Grade Level (FKGL). Paired comparisons used the Wilcoxon signed-rank test for per-question median GQS, inter-rater agreement used Kendall’s W, and readability used paired tests as appropriate.
Results: Across 60 individual ratings (3 raters × 10 items × 2 models), per-question median GQS was 5 for 9/10 ChatGPT answers and 10/10 Gemini answers; the paired comparison showed no significant difference (Wilcoxon Z = -1.00; p = 0.317; effect size r = 0.32). Inter-rater agreement was W = 0.24 (ChatGPT, p = 0.091) and W = 0.60 (Gemini, p = 0.002). ChatGPT produced more readable outputs (FRE: 46.53 vs 43.70, p = 0.243; FKGL: 9.71 vs 11.43, p = 0.002), indicating approximately two US grade levels of easier reading.
Conclusion: ChatGPT and Gemini both generated high-quality answers to common AM FAQs, with no difference in quality based on GQS. ChatGPT’s responses were significantly easier to read according to FKGL. LLMs may support patient education when implemented with clinician oversight to mitigate limitations and prevent misinformation.
Level of evidence iv: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Keywords: Artificial intelligence; Augmentation mammaplasty; ChatGPT; Gemini; Large language models; Patient education; Plastic surgery.
© 2026. Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery.
CloseAdoption and perception of artificial intelligence by corresponding authors in orthopaedic research: A global cross-sectional studyAdoption and perception of artificial intelligence by corresponding authors in orthopaedic research: A global cross-sectional study
Adoption and perception of artificial intelligence by corresponding authors in orthopaedic research: A global cross-sectional study
Bernard de Geofroy, Alexandre Gérard, Élise Lupon, Chloé Desrayaud, Camille Choufani, Grégoire Micicoi
https://doi.org/10.1016/j.otsr.2026.104653
Abstract
Background: Generative artificial intelligence (AI) is increasingly integrated into scientific research, particularly in tasks related to academic writing and knowledge synthesis. However, empirical data on how orthopaedic researchers perceive, use, and regulate these tools remain limited. The purpose of this study was to: 1) assess attitudes, perceptions, and patterns of generative AI use among corresponding authors in orthopaedic research; 2) evaluate whether academic career stage influences perceptions, training, familiarity, and intended future use of AI; 3) identify individual and professional factors associated with positive perceptions of future AI use; and 4) examine disclosure practices, transparency issues, and perceived benefits and limitations of AI across the research and scientific publishing process.
Hypothesis: We hypothesized that generative IA tools are already widely adopted by orthopaedic researchers, but that this adoption is heterogeneous and associated with variable perceptions, training levels, and disclosure practices.
Material and methods: An international, anonymous web-based survey was conducted among corresponding authors of orthopaedic research articles published between January 2024 and June 2025. The questionnaire evaluated demographics, AI familiarity, patterns of past and intended AI use throughout the research process, perceived benefits and limitations, training needs, and disclosure practices. Associations with a positive perception of future AI use were analyzed according to career stage using univariate and multivariate logistic regression analyses.
Results: Among 216 respondents, 175 (81.0%) had previously used an AI-based chatbot and 96 (44.4%) had used AI in at least one of their last five publications, mainly for manuscript writing or editing (71/216; 32.9%), translation (64/216; 29.6%), and literature searching (56/216; 25.9%). Career stage did not influence intention to use AI in future research (non-senior: 79/95; 83.2% vs senior: 73/91; 80.2%; p = 0.123), and no significant differences were observed in perceived benefits, including manuscript writing support (3.83 ± 1.20 vs 3.63 ± 1.22; p = 0.275), literature search support (3.64 ± 1.20 vs 3.61 ± 1.20; p = 0.852), and overcoming language barriers (4.08 ± 1.13 vs 4.07 ± 0.99; p = 0.952), although senior researchers reported slightly greater concern about AI-related bias (4.30 ± 0.81 vs 4.01 ± 0.94; p = 0.032). In univariate analysis, male respondents were more likely to report a positive perception of future AI use than female respondents (133/157; 84.7% vs 18/28; 64.3%; p = 0.032), and in multivariate analysis, male gender was the only independent predictor (aOR = 2.85; 95% CI, 1.12-7.29; p = 0.029). Regarding transparency, 93 respondents (43.1%) consistently disclosed AI use, 144 (66.7%) feared negative perception when doing so, and 163 (75.4%) considered AI important or very important for future scientific production.
Conclusion: Generative AI is widely used among orthopaedic researchers but remains underreported, likely due to concerns about negative journal perceptions. Despite this, most researchers consider AI important for future scientific production, highlighting the need for clearer and harmonized guidelines on its use and disclosure among corresponding authors in orthopaedics.
Level of evidence: IV; cross-sectional survey study.
Keywords: Artificial intelligence chatbots; Artificial intelligence in medical research; Orthopaedic surgeons; Publishing ethics; Research ethics; Scientific integrity.
Copyright © 2026 Elsevier Masson SAS. All rights reserved.
Close100 most-cited publications in vascularized composite allotransplantation100 most-cited publications in vascularized composite allotransplantation
Pharel Njessi, Carter J Boyd, Palmina Petruzzo, Olivier Camuzard, Antoine Sicard, Rami Kantar, Eduardo Rodriguez, Elise Lupon
https://doi.org/10.3389/frtra.2026.1745991
Abstract
Background: Citation analysis is a useful bibliometric tool to identify impactful publications and trace the evolution of a specialty or a technique. In the past three decades, the research on vascularized composite allotransplantation (VCA) has grown exponentially but very few studies have examined the most influential papers in this field.
Methods: The Web of Science Core Collection database was searched for articles published from inception to August 4th, 2025. Titles, full authors’ names, years of publication, source journals, regions of origin, and numbers of citations were recorded. VCA anatomical location, main topics, and citation density were determined. Articles were ranked based on number of citations and citation density; they were then categorized based on methodology, study design, and main topic.
Results: The 100 most-cited articles on VCA were published between 1996 and 2018 with the number of citations per article ranging from 61 to 604 citations. There were 53 non-clinical studies, the most prevalent topics were outcomes and rehabilitation (n = 48 articles) and immunology (n = 37). Of the 75 studies evaluated using the Oxford Centre for Evidence-Based Medicine levels of evidence, most (n = 51) were classified as level 4.
Discussion: This list of the top 100 most-cited articles highlights seminal and influential papers in VCA. It also demonstrates the relative novelty of this field with ongoing efforts in immunological research to allow its further expansion. The present study provides an understanding of VCA evolution while directing future clinical and preclinical studies.
Keywords: bibliometric; citation analysis; face transplant; hand transplant; upper extremity transplantation; vascularized composite allograft (VCA).
© 2026 Njessi, Boyd, Petruzzo, Camuzard, Sicard, Kantar, Rodriguez and Lupon.
ClosePublications 2025 du Dr LUPON Élise
Comment to ``Current evidence on arthroscopic capsuloligamentoplasty plications as treatment for chronic dynamic scapholunate instability`` by Goorens et al., J Hand Microsurg 2026Comment to ``Current evidence on arthroscopic capsuloligamentoplasty plications as treatment for chronic dynamic scapholunate instability`` by Goorens et al., J Hand Microsurg 2026
Comment to « Current evidence on arthroscopic capsuloligamentoplasty plications as treatment for chronic dynamic scapholunate instability » by Goorens et al., J Hand Microsurg 2026
Jean-Baptiste de Villeneuve Bargemon, Élise Lupon, Camille Brenac
https://doi.org/10.1016/j.jham.2025.100388
ClosePreserving Function in Sternal Reconstruction: Complementary Roles of Pectoralis Major and Internal Mammary Artery Perforator FlapsPreserving Function in Sternal Reconstruction: Complementary Roles of Pectoralis Major and Internal Mammary Artery Perforator Flaps
Preserving Function in Sternal Reconstruction: Complementary Roles of Pectoralis Major and Internal Mammary Artery Perforator Flaps
Elise Lupon, Pharel Njessi, Olivier Camuzard, Benoît Chaput, Silvia Gandolfi
https://doi.org/10.1097/sap.0000000000004618
CloseReconstruction of a thumb metacarpophalangeal bone defect using the Masquelet technique: A case reportReconstruction of a thumb metacarpophalangeal bone defect using the Masquelet technique: A case report
Reconstruction of a thumb metacarpophalangeal bone defect using the Masquelet technique: A case report
Gauthier Lagarde, Omar Alawadhi, Olivier Camuzard, Thierry Balaguer, Brieuc Monin, Elise Lupon
https://doi.org/10.1016/j.ijscr.2025.111425
Abstract
Introduction: Bone defects of the thumb secondary to trauma or infection pose a significant challenge for surgeons. The limited therapeutic options in such cases may, in the most severe scenarios, necessitate amputation, which has devastating functional consequences. The induced membrane technique, described by Masquelet, has proven effective in reconstructing bone loss in the lower limbs, particularly in septic contexts. However, its application in hand surgery remains underreported.
Case presentation: In this case, we describe a bone and joint defect of the thumb’s metacarpophalangeal joint, complicated by osteoarthritis following a dog bite injury. After failure of initial osteosynthesis, resulting in bone and joint destruction, we performed a two-stage metacarpophalangeal arthrodesis using an iliac bone graft and Masquelet’s technique.
Discussion: The permanent use of a cement spacer is often employed in clinical practice, but it frequently leads to complications, including spacer fractures, pain, and dislocations. Our proposed method is simple, reproductible, and applicable in both emergency and non-emergency settings.
Conclusion: Our findings suggest that the Masquelet technique represents a promising reconstructive option for managing bone loss in osteitis with a high risk of amputation. This approach enables the preservation of sufficient thumb length to maintain pollici-digital function, allowing for satisfactory gripping ability. Further long-term studies are necessary to confirm these preliminary results.
Keywords: Bone defect; Bone graft; Case report; Induced membrane; Osteoarthritis; Thumb reconstruction.
Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.
CloseReconstruction of a Complex Foot Defect with a Chimeric Triple-Component Osteocutaneous SCIP-SIEA Free Flap: A Case Report and Literature ReviewReconstruction of a Complex Foot Defect with a Chimeric Triple-Component Osteocutaneous SCIP-SIEA Free Flap: A Case Report and Literature Review
Reconstruction of a Complex Foot Defect with a Chimeric Triple-Component Osteocutaneous SCIP-SIEA Free Flap: A Case Report and Literature Review
Yanis Berkane, Elise Lupon, Pierre Muret, Jérôme Laloze, Nicolas Bertheuil, Christian Herlin, Paul Girard, Hadrien Paol
https://doi.org/10.1055/a-2635-26802
Abstract
Complex defects resulting from infected bone or joints with or without osteosynthesis or prosthetic material lead to significant challenges that need to be addressed through orthoplastic approaches. Foot and ankle reconstruction is particularly difficult due to the lack of local or regional flap solutions in this highly mobile joint, which often necessitates microsurgical flaps in extended defects. In addition, rigorous bone reconstruction is critical to acute bone infection to minimize the risks of functional impairments. We present a novel approach using a chimeric osteocutaneous flap to address a complex calcaneus fracture with extended postoperative skin necrosis and septic pseudoarthrosis. A dual skin paddle (16 × 6.5 cm and 14 × 4.5 cm) was created using a superficial inferior epigastric artery (SIEA)-to-superficial circumflex iliac artery (SCIA) anastomosis, while the 7-cm pedicle was increased using a deep inferior epigastric artery graft, which was anastomosed to the tibial anterior vessels. The vascularized iliac crest component enabled optimal reconstruction of the bone defect with rapid healing, while the combined SCIP (superficial circumflex iliac artery perforator)-SIEA skin flap was used to cover the bone reconstruction and skin defect. This microsurgical reconstruction allowed optimal functional recovery at 12 months with successful bone integration and soft tissue coverage. The step-by-step intraoperative technique is described through Video 1 and Supplementary Video 2 .
Keywords: SCIP flap; SIEA flap; ankle reconstruction; chimeric flap; foot reconstruction.
CloseAn Experimental Human DIEP Flap Model to Investigate Preservation Strategies for Vascularized Composite Allografts and Free FlapsAn Experimental Human DIEP Flap Model to Investigate Preservation Strategies for Vascularized Composite Allografts and Free Flaps
An Experimental Human DIEP Flap Model to Investigate Preservation Strategies for Vascularized Composite Allografts and Free Flaps
Elise Lupon, Tanguy Perraudin, Pierre Barbat, Styliani Stergiadou, Pharel Njessi, Cassilia Dei, Amina Oyuntogos, Olivier Camuzard, Didier F Pisani, Antoine Sicard
Abstract
Recently, preservation approaches such as cytoprotective agents injection, ex vivo machine perfusion, and supercooling have emerged as strategies to enhance long-term preservation of both standard and marginal organs by mitigating ischemic and hypoxic injury. Although encouraging, its application in the field of vascularized composite allotransplantation (VCA) remains largely confined to preclinical research. To date, most studies investigating VCA perfusion strategies have relied on animal models, particularly swine or rodent composites. While these models provide valuable mechanistic insights, their anatomical, immunological, and physiological differences limit reproducibility and translational relevance to human applications. In this protocol, each surgical step required for the procurement of a human deep inferior epigastric perforator (DIEP) flap for preservation studies is described in detail. The perforator is transected above the fascia without any subfascial dissection, yielding a short yet sufficient pedicle for catheterization. This model takes advantage of discarded tissue from standard abdominoplasty procedures, posing no additional risk to the patient. Critical steps are outlined to ensure a functional flap is harvested without prolonging operative time or compromising patient safety. Functional imaging is subsequently performed to confirm flap viability prior to experimental use, and sequential biopsies may be performed to follow tissue integrity. This model is particularly suited for research involving muscle-sparing VCA procedures — such as partial facial transplantation — and may also have relevance for the study of autologous free flap preservation.
CloseExtemporaneous histological analysis according to slow-Mohs combined with Full-Field Optical Coherence Tomography evaluation (FFOCT) in cutaneous tumor pathology: Toward a digital extemporaneous analysis?Extemporaneous histological analysis according to slow-Mohs combined with Full-Field Optical Coherence Tomography evaluation (FFOCT) in cutaneous tumor pathology: Toward a digital extemporaneous analysis?
Extemporaneous histological analysis according to slow-Mohs combined with Full-Field Optical Coherence Tomography evaluation (FFOCT) in cutaneous tumor pathology: Toward a digital extemporaneous analysis?
Sarah Hendriks, Eugénie Dalimier, Bernard Gasser, Olivier Camuzard, Thérèse Adawa, Elise Lupon
https://doi.org/10.1016/j.bjps.2025.03.025
Abstract
Background: Slow-Mohs micrographic surgery use is limited by the logistic constraints it imposes. Full-field optical coherence tomography (FFOCT) is an emerging non-invasive imaging technique that provides skin tissue imaging at the cellular level without tissue preparation.
Objective: Evaluating the FFOCT technology’s diagnostic possibilities in examining surgical sections in micrographic surgery for basal cell carcinomas compared to slow-Mohs.
Materials and methods: Two plastic surgeons provided 24 Mohs sections from 20 patients with basal cell carcinomas from a single-center. Each section was scanned using FFOCT, and a diagnosis-blinded pathologist reviewed the digital images for malignancy. The FFOCT images were compared with the standard histologic analysis of the sample sections.
Results: The agreement between FFOCT imaging results and slide histology included 17 true positives (VP) and 4 true negatives (TN) for debulking and 19 TN and 2 VP for Mohs peripheral cuts. The positive predictive value (PPV) was 85% for debulking, and the negative predictive value (NPV) was 100%. For recuts, the PPV was 50% and NPV was 95%.
Conclusion: We developed a protocol for analyzing skin tumors ex vivo using FFOCT, providing digital images that can be transmitted remotely. This study serves as a proof of concept. The visualization of peripheral margins in a single image and the predictive values need to be improved before clinical use can be considered.
Keywords: Cutaneous tumor; Full-Field Optical Coherence Tomography; Histology; Mohs; Slow Mohs.
Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.
CloseReconstruction after wide excision of the nail apparatus for in situ or minimally invasive subungual melanoma: A retrospective case seriesReconstruction after wide excision of the nail apparatus for in situ or minimally invasive subungual melanoma: A retrospective case series
Reconstruction after wide excision of the nail apparatus for in situ or minimally invasive subungual melanoma: A retrospective case series
Luc Chouquet, Feriel Boukari, Thierry Balaguer, Henri Montaudié, Olivier Camuzard, Elise Lupon
https://doi.org/10.1016/j.jpra.2025.10.027
Abstract
Introduction: Historically, subungual melanoma (SUM) was treated by amputation of the affected digit. Wide local excision (WLE) of the nail apparatus has since become a conservative alternative for in situ or minimally invasive lesions. While several reconstructive techniques have been described after WLE, few centers have reported their outcomes objectively. This study presents our series of reconstructions following WLE of the nail apparatus.
Methods: We conducted a retrospective study at a university hospital, including patients referred by dermatologists for WLE and nail apparatus reconstruction between 2021 and 2024. Clinical, surgical, functional, and aesthetic outcomes were evaluated using validated scores (QuickDASH, Modified Mayo Wrist Score, AOFAS).
Results: Ten patients were included. Reconstructions were performed with full-thickness skin grafts (n = 6), with or without dermal matrix (n = 4), and local flaps (n = 4). Five patients underwent immediate definitive reconstruction. Two recurrences occurred: one requiring dermal matrix removal, and the other necessitated amputation forinvasive SUM. Functional and aesthetic outcomes were satisfactory, with a mean follow-up of 19 months and no local recurrence in the remaining patients. The mean QuickDASH score was 25.5 ± 16.4 (range: 2.3-41). For the three foot cases, the mean AOFAS score was 86 ± 4.1 (range: 80-90).
Conclusion: Nail apparatus reconstruction is feasible for in situ or minimally invasive SUM, particularly when the Breslow thickness is ≤0.5 mm. In invasive cases, immediate reconstruction risks being performed over residual tumor, supporting a two-stage approach, especially when donor site morbidity is expected. Techniques such as full-thickness skin grafts combined with a dermal matrix provide reliable functional and aesthetic outcomes. A two-stage approach is particularly valuable when oncologic margins are uncertain, as it reduces the risk of reconstructing over residual disease while preserving options with lower donor-site morbidity.
Keywords: Flap; Microsurgery; Nail apparatus; Nail reconstruction; Oncology; Subungual melanoma; Wide local excision.
© 2025 The Author(s).
CloseBalancing secondary intention and reconstruction in nail apparatus melanoma: Plastic surgery insight from a case serieBalancing secondary intention and reconstruction in nail apparatus melanoma: Plastic surgery insight from a case serie
Balancing secondary intention and reconstruction in nail apparatus melanoma: Plastic surgery insight from a case serie
Elise Lupon, Luc Chouquet, Olivier Camuzard
https://doi.org/10.1016/j.ijscr.2025.112030
Abstract
- •Secondary intention healing remains an option for nail apparatus melanoma.
- •Healing time is long and cosmetic results can be unpredictable.
- •Local flaps or dermal substitutes allow faster healing and better outcomes.
- •Perforator flaps can improve comfort and long-term functional results.
Keywords: Dermal substitute; Nail apparatus melanoma; Perforator flap; Reconstructive surgery; Secondary intention healing.
CloseInfluence of the Teaching Hospital Environment on Plastic Surgery Residents' Academic Interest and Career Aspirations: Insights from FranceInfluence of the Teaching Hospital Environment on Plastic Surgery Residents' Academic Interest and Career Aspirations: Insights from France
Influence of the Teaching Hospital Environment on Plastic Surgery Residents’ Academic Interest and Career Aspirations: Insights from France
Yanis Berkane, Haizam Oubari, Jonathan Cornacchini, Olivier Camuzard, Nicolas Bertheuil, Elise Lupon
https://doi.org/10.1097/gox.0000000000006652
Abstract
Background: Plastic surgery residency training in France presents unique challenges and opportunities, with a highly competitive environment and a growing demand for academic plastic surgeons. Understanding the factors influencing residents’ career decisions is essential for optimizing training programs and fostering academic interest.
Methods: A cross-sectional study was conducted using a self-administered questionnaire comprising 14 questions distributed via RedCAP between January and June 2023. The study included all residents and young attendings in all 21 French University Hospital Centers nationwide, from year 1 to postgraduate year 2.
Results: Among 204 contacted participants, 106 responses were obtained. All responses were complete. First-year residents represented 9.4% of respondents, whereas residents in the « deepening » and « consolidation phases » represented 41.5% and 25.6%, respectively. Senior residents such as « junior doctors » and young attendings represented 25.5% of survey respondents. Although most residents expressed interest in private practice, mentorship from academic surgeons emerged as a significant influencer toward academic pursuits. Despite the prevalence of academic mentors (38% of identified mentors), a discrepancy was found between perceived academic orientation and actual research opportunities, indicating a need for improved awareness and exposure to academic possibilities during residency. Financial considerations, including salary differentials and job security, also seemed to play a substantial role in career decision-making.
Conclusions: Cultivating a deeper understanding of academic careers’ multifaceted nature and enhancing the appeal of academic pursuits are essential for nurturing the next generation of academic plastic surgeons. It is hoped that this study will help enhance the appeal of academic vocations in plastic surgery residents.
Copyright © 2025 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.
CloseMorphometric and curvature CT-based study of the distal radius watershed lineMorphometric and curvature CT-based study of the distal radius watershed line
Morphometric and curvature CT-based study of the distal radius watershed line
Thomas Valerio, Elise Lupon, Alexandre Quemener-Tanguy, Eloïse Masse, Camille Brenac, Jean-Baptiste de Villeneuve Bargemon
https://doi.org/10.1016/j.hansur.2025.102168
Abstract
Purpose: Fixation of distal radius fractures involving the volar rim is technically demanding and often complex. In most cases, it requires the use of so-called « specific » plates. Although these plates have been developed using morphometric databases, proper application can still be imperfect-even when the plate appears to be correctly positioned. This mismatch may result in secondary displacement of the fragment, tendon irritation, or even tendon rupture. We hypothesized that anatomical variations in the radius, particularly in the shape of the watershed line, may explain the difficulty in achieving optimal plate adaptation in some patients.
Methods: Nineteen distal radius were analyzed using Computed Tomography-scan segmentation and curvature analysis to assess the shape of the watershed line. K-means clustering was then performed to identify distinct groups based on volar rim curvature patterns.
Results: Clustering analysis revealed two distinct anatomical groups based on volar rim curvature. The first group exhibited a mean curvature of 0.07 ± 0.03 mm–¹, while the second group had a significantly higher curvature of 0.23 ± 0.06 mm–¹ (mean ± SD). A Student’s t-test confirmed a statistically significant difference between the two groups (p < 0.001).
Conclusions: Our findings suggest the existence of at least two anatomical variations in volar rim shape at the watershed line, forming a spectrum between flatter and more sharply curved forms. These anatomical differences may explain inconsistencies in plate adaptation and should be taken into account by surgeons when selecting and positioning fixation hardware.
Level of evidence: Diagnostic study (IIIb).
Keywords: Anatomical variability; Distal radius fracture; Plate fixation; Volar rim; Watershed line.
Copyright © 2025 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.
CloseCoverage of elbow and forearm soft tissue defects with the posterior ulnar recurrent artery perforator flap (PURAP): an anatomical studyCoverage of elbow and forearm soft tissue defects with the posterior ulnar recurrent artery perforator flap (PURAP): an anatomical study
Coverage of elbow and forearm soft tissue defects with the posterior ulnar recurrent artery perforator flap (PURAP): an anatomical study
Elise Lupon, Hadrien Paoli, Yanis Berkane, Nicolas Bertheuil, Jean Baptiste De Villeneuve Bargemon, Olivier Camuzard, Isabelle Pluvy, Benoît Chaput
https://doi.org/10.1007/s00276-025-03616-w
Abstract
Introduction: Covering soft tissue defects from the elbow and forearm is challenging for the plastic surgeon. The posterior ulnar recurrent artery perforator flap is a fasciocutaneous perforator flap vascularized by the perforators emerging from the posterior ulnar recurrent artery. It has multiple functional and aesthetic advantages but has not yet been well studied. This work aimed to examine the number, caliber, and topography of the posterior ulnar recurrent artery’s perforators.
Methods: Perforator mapping was performed by blue latex injection on 20 fresh cadavers’ upper extremities. Thermal mapping by TIRD was used to identify the « hot spots » of these perforators, and the 4D vascular network of the ulnar recurrent artery was scanned. The preoperative design and dissection of the flap were adapted based on the results of this anatomical study. A case study was performed to illustrate the clinical application.
Results: On average, we located 7.7 ± 1.7 perforators per upper extremity with an average caliber of 0.77 ± 0.19 mm (3.5 ± 1.2 in the forearm and 4.2 ± 1.5 in the arm). On average, the arm perforators were located 3.2 ± 1.6 cm proximally from the medial epicondyle. Thermal mapping showed three perforator « hot spots, » two in the forearm (directly at the artery origin level and one more posteriorly) and one in the arm. The 4D CT reconstructions allowed us to estimate the vascular territory at the level of the medial epicondyle and the distal half of the medial aspect of the arm, as well as the ascending course of the artery.
Conclusion: The posterior ulnar recurrent artery perforator flap can be harvested efficiently and reliably, as the posterior ulnar recurrent artery has constant perforators, especially around 3 cm proximal to the medial epicondyle. This reinforces this flap’s status as a potential elbow and forearm tissue defect coverage alternative.
Keywords: Anatomical study; Elbow defect coverage; Forearm defect coverage; Perforator flap; Posterior ulnar recurrent artery; Propeller flap.
© 2025. The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature.
CloseComment on: ``Objectifying aesthetic outcomes following face transplantation - the AI research metrics model``Comment on: ``Objectifying aesthetic outcomes following face transplantation - the AI research metrics model``
Comment on: « Objectifying aesthetic outcomes following face transplantation – the AI research metrics model »
Elise Lupon
CloseA New Method for Preparation of Decellularized Human Scaffolds for Facial ReconstructionA New Method for Preparation of Decellularized Human Scaffolds for Facial Reconstruction
A New Method for Preparation of Decellularized Human Scaffolds for Facial Reconstruction
Elise Lupon, Aylin Acun, Alec R Andrews, Ruben Oganesyan, Hyshem H Lancia, Laurent Lantieri, Mark A Randolph, Curtis L Cetrulo Jr, Alexandre G Lellouch, Basak E Uygun
https://doi.org/10.3390/cimb47040275
Abstract
Vascularized composite allotransplantation (VCA) has emerged as a robust alternative for addressing anatomically complex defects but requires a toxic lifelong immunosuppressive regimen. Tissue engineering offers the promise of creating recipient-specific alternative grafts using a decellularization and recellularization approach. In this article, we establish a reliable protocol for human face decellularization by immersion as a new tool in the development of engineered graft alternatives for reconstructive surgery. Three cadaveric face grafts were immersed in 1% sodium dodecyl sulfate for 216 h followed by 1% Triton X-100 for 48 h, without perfusion through the pedicle. We determined that decellularization was successfully accomplished for three facial specimens as confirmed by histological evaluation and quantification of DNA content. The extracellular components including collagen, glycosaminoglycans, elastin, and matrix-bound growth factors were preserved. Vascular architecture did not show significant differences between native and decellularized grafts as imaged by X-ray angiography. The mechanical strength of the grafts was not altered after decellularization. We also showed that the decellularized grafts were biocompatible in vitro and in vivo allowing cell engraftment. As a result, we have successfully developed a protocol to yield a clinical size decellularized graft suitable for generating a recellularized, potentially non-immunogenic graft for facial reconstruction.
Keywords: decellularization; facial reconstruction; recellularization; regenerative medicine; scaffold; tissue engineering; vascularized composite allotransplantation.
CloseManagement of a large abdominal dermatofibrosarcoma protuberans requiring a life-threatening excision: A case reportManagement of a large abdominal dermatofibrosarcoma protuberans requiring a life-threatening excision: A case report
Management of a large abdominal dermatofibrosarcoma protuberans requiring a life-threatening excision: A case report
Rawan Albadia, Perrine Rousset, Damien Massalou, Olivier Camuzard, Henri Montaudié, Elise Lupon
https://doi.org/10.1016/j.ijscr.2025.111579
Introduction and importance: Dermatofibrosarcoma protuberans (DFSP) is a rare malignant tumor of the dermis and subcutaneous tissue, characterized by local aggressiveness and a high recurrence rate. The gold standard treatment is wide excision with negative margins, sometimes using Mohs surgery, with careful planning for reconstruction. In challenging cases, neoadjuvant imatinib therapy and adjuvant radiotherapy may help optimize outcomes. We report a case of extensive abdominal DFSP requiring a multidisciplinary approach after resection exposed the liver and the last three right ribs.
Case presentation: Neoadjuvant imatinib was administered to reduce tumor size, followed by radical resection and immediate reconstruction using prosthetic mesh and three pedicled flaps: a deep inferior epigastric perforator flap, an anterior intercostal artery perforator flap, and a pedicled latissimus dorsi flap. The reconstruction was performed as a single-stage procedure. Postoperative ischemia due to hematoma required conversion of the latissimus dorsi flap into a free flap and remobilization of the remaining flap. A split-thickness skin graft was applied on postoperative day ten. Histology confirmed negative margins. At six months, the patient showed complete healing, no recurrence, and a satisfactory reconstructive outcome.
Clinical discussion: In such extensive DFSP cases, immediate flap reconstruction helps prevent complications related to exposed bone or viscera and preserves functional and aesthetic outcomes. It does not hinder oncologic follow-up and may reduce morbidity.
Conclusion: This case highlights the surgical and reconstructive challenges of large DFSPs and the vital role of a plastic surgery team in planning tailored, multidisciplinary management within an oncodermatology center.
Keywords: DFSP; Dermatofibrosarcoma protuberans; Imatinib; Perforators flaps.
Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.
CloseSaphenous Vein-Preserving Inguinal Lymph Node Dissection: A Stepwise Technical ApproachSaphenous Vein-Preserving Inguinal Lymph Node Dissection: A Stepwise Technical Approach
Saphenous Vein-Preserving Inguinal Lymph Node Dissection: A Stepwise Technical Approach
Elise Lupon, Ioana Ivan, Olivier Camuzard, Dimitri Gangloff
https://doi.org/10.1002/ccr3.71712
Abstract
Preserving the great saphenous vein during inguinal lymph node dissection maintains venous outflow and skin drainage while allowing complete oncologic clearance.
Keywords: dermatology; inguinal lymph node dissection; melanoma; oncology; surgery.
ClosePerforator identification for propeller flap harvest: Technical insights from a case seriePerforator identification for propeller flap harvest: Technical insights from a case serie
Perforator identification for propeller flap harvest: Technical insights from a case serie
Elise Lupon
CloseInternalBrace™ for intercarpal ligament reconstruction: An ``All-dorsal`` variant technique with capsular preservationInternalBrace™ for intercarpal ligament reconstruction: An ``All-dorsal`` variant technique with capsular preservation
InternalBrace™ for intercarpal ligament reconstruction: An « All-dorsal » variant technique with capsular preservation
Jean Baptiste de Villeneuve Bargemon, Antoine Martins, Brieuc Monin, Elise Lupon
CloseThe First Dorsal Metatarsal Artery Perforator Flap: A Description and Anatomical StudyThe First Dorsal Metatarsal Artery Perforator Flap: A Description and Anatomical Study
The First Dorsal Metatarsal Artery Perforator Flap: A Description and Anatomical Study
Mathilde Saboye, Alexis Majchrzak, Grégoire d’Andréa, Nicolas Bronsard, Olivier Camuzard, Elise Lupo
https://doi.org/10.3390/jcm14124136
Abstract
Background/Objectives: Soft-tissue defects surrounding the big toe can be a challenging problem for reconstructive surgeons. The first dorsal metatarsal artery (FDMtA) arises from the dorsalis pedis artery, which itself arises in front of the ankle joint from the anterior tibial artery. This study aimed to characterize the FDMtA cutaneous perforators (FDMtAPs) and evaluate the potential of a local pedicled perforator flap to cover a hallux soft-tissue defect. Methods: Nine feet from fresh cadavers were dissected to describe the FDMtAP anatomy. For each artery, we recorded the origin’s position from the FDMtA, the proximal and distal diameters, and the artery’s course, length, number, and type. We described the FDMtA perforator flap harvest and its application through a clinical case. Results: A mean of 3.67 ± 1.23 FDMtAPs were found from the nine dissected feet, with at least 2 perforators per foot. Around 88% were located between 0 and 4 cm along the axis at their origin from the FDMtA, with an area of around 8 cm2 and a mean of 2.35 ± 0.36 cm long. The proximal diameter had a mean of 0.178 ± 0.037 mm and 0.110 ± 0.008 mm at the distal diameter. A pedicled flap was readily feasible for all dissections. The case described had satisfactory healing, correct functional, and aesthetic recovery at two months. Conclusions: The first dorsal metatarsal artery perforator flap seems to be a reliable and valuable solution for the hallux soft-tissue reconstruction, notably after the excision of acral melanoma.
Keywords: acral melanoma reconstruction; anatomical study; first dorsal metatarsal artery perforator flap; greater toe coverage; hallux soft-tissue reconstruction; perforator flap.
CloseLetter to the Editor regarding ``Brachial plexus compression following a laterjet procedure``Letter to the Editor regarding ``Brachial plexus compression following a laterjet procedure``
Letter to the Editor regarding « Brachial plexus compression following a laterjet procedure »
Olivier Camuzard, Tanguy Perraudin, Lucas Lo Cunsolo, Elise Lupon
CloseRE: How Artificial Intelligence Differs From Humans in Peer ReviewRE: How Artificial Intelligence Differs From Humans in Peer Review
RE: How Artificial Intelligence Differs From Humans in Peer Review
Gauthier Largarde, Grégoire Micicoi, Elise Lupon
CloseVascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise ApproachVascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach
Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach
Tanguy Perraudin, Yanis Berkane, Antoine Sicard, Nicolas Bronsard, Olivier Camuzard, Elise Lupon
Abstract
Upper limb amputations represent a real medical and surgical challenge. The ideal treatment should restore function, sensation, and body image. At present, neither traditional reconstructions nor prostheses meet all these criteria. However, vascularized composite allografts offer a unique option for restoring form and function satisfactorily despite harmful immunosuppression. Ideally, donor tissue is procured in excess to repair without tension. The donor upper limb is procured through a fish-mouth incision at the mid-arm level. Then, the brachial artery and vein, median, ulnar, and radial nerve are located and dissected. The biceps, brachioradialis, and triceps muscles are sectioned, and then an osteotomy of the humerus is performed above the elbow. For distal forearm transplantation, the donor upper limb can also be procured below the elbow by disarticulating through the joint. The brachial artery is cannulated, and the graft is irrigated with a preservative solution. Preparation of the graft then begins with two incisions, anterior and posterior, to raise two lateral skin flaps. A medial skin flap exposes the basilic vein, medial antebrachial cutaneous nerve, medial epicondylar muscles, ulnar nerve, median nerve, brachial artery, and vein. A lateral skin flap, including the cephalic vein, the lateral antebrachial cutaneous nerve, the radial nerve up to its division, the brachioradialis, and the lateral epicondylar muscles, completes graft preparation. In the case of transplantation, cutting guides are attached to the posterior surface of the two forearm bones to perform the osteotomies. This protocol presents a systematized procedure for procuring and preparing a vascularized forearm composite allograft to ensure optimal results and minimize tissue damage during procurement.
CloseEvolution of cell therapies derived from adipose tissue: historical perspectives, current development trends and future directionsEvolution of cell therapies derived from adipose tissue: historical perspectives, current development trends and future directions
Evolution of cell therapies derived from adipose tissue: historical perspectives, current development trends and future directions
Silvia Gandolfi, Elise Lupon, Audrey Varin, Agnes Coste, Brigitte Sallerin, Carla Boyer, Yanis Berkane, Benoit Chaput
https://doi.org/10.1186/s13062-025-00682-3
Abstract
Over the last few decades, adipose tissue has attracted increasing attention in the field of regenerative medicine, thanks to discoveries related to its regenerative, anti-inflammatory, and pro-angiogenic properties. Over the years, with the advancement of sophisticated research around adipose tissue, there has been a shift from tissue transfer to cell transfer, and then to the application of cell-free derivatives and bioengineering. Understanding the evolution of this scientific revolution around adipose tissue not only helps clarify potential therapeutic products and indications but also allows us to discuss its limitations and future directions.
Keywords: Adipose tissue; Cell therapy; Regenerative medicine.
© 2025. The Author(s).
CloseUtility of the Caprini risk assessment model in guiding venous thromboembolism prophylaxis after abdominoplastyUtility of the Caprini risk assessment model in guiding venous thromboembolism prophylaxis after abdominoplasty
Utility of the Caprini risk assessment model in guiding venous thromboembolism prophylaxis after abdominoplasty
Abdulaziz Asiry, Anas Sayegh, Dimitri Gangloff, Hatan Mortada, Silvia Gandolfi, Elise Lupon
https://doi.org/10.1016/j.jpra.2025.09.01722
Abstract
Introduction: Abdominoplasty carries a significant risk of venous thromboembolism (VTE). Two main strategies have been described for prophylaxis: systematic administration of low molecular weight heparin (LMWH) and risk-stratified management using the Caprini score. This study aimed to assess thromboembolic risk in abdominoplasty patients and compare the cost-effectiveness of a Caprini-based strategy with routine prophylaxis.
Methods: A retrospective review was performed on 219 patients who underwent abdominoplasty at a university plastic surgery unit where systematic LMWH prophylaxis was standard. Demographic data, Caprini score components, complications, and costs were analyzed, and a cost-effectiveness comparison between systematic LMWH and a Caprini-based approach was performed.
Results: The mean Caprini score was 3.3 ± 1.1 (range 1-10). All patients received LMWH for a mean of 14.9 ± 1.5 days. One patient (0.45 %) developed pulmonary embolism, and 13 (5.9 %) developed hematomas. Cost analysis indicated that a risk-stratified approach could reduce LMWH expenditure by 44.5 %.
Conclusions: Applying the Caprini score for VTE prophylaxis in abdominoplasty may reduce unnecessary anticoagulation and associated complications, while generating substantial cost savings for centers that do not currently use this model.
Keywords: Abdominoplasty; Body contouring; Caprini risk assessment model; Low molecular weight heparin; Venous thromboembolism.
© 2025 The Author(s).
CloseTrapeziectomy with an innovative suspensionplasty technique for trapeziometacarpal osteoarthritisTrapeziectomy with an innovative suspensionplasty technique for trapeziometacarpal osteoarthritis
Trapeziectomy with an innovative suspensionplasty technique for trapeziometacarpal osteoarthritis
Richard Lachaux, André-Pierre Uzel, Marie-Anne Poumellec, Thierry Balaguer, Olivier Camuzard, Elise Lupon
CloseSurgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite AllotransplantationSurgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation
Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation
Elise Lupon, Sergio A Segrera, Tanguy Perraudin, Anandhini D Narayanan, Alexis K Gursky, Hailey P Wyatt, Eduardo D Rodriguez
Abstract
Full facial vascularized composite allotransplantation (VCA) offers a reconstructive option for patients with severe facial disfigurement who cannot be treated with conventional methods. This article details a surgical protocol for donor procurement of a full facial allograft, focusing on soft tissue with limited bony harvest restricted to the nasal framework, and emphasizes key anatomical landmarks and technical considerations for safe and efficient harvest. The procedure involves dissection of the entire facial soft tissues while preserving the external carotid artery, internal jugular veins and subsequent thyro-linguofacial, and branches of the facial and maxillary nerves to maximize pedicle length for later neurorrhaphy. The protocol describes systematic exposure of the vascular pedicles at their origin in the neck, subperiosteal elevation of the scalp, identification and division of the supraorbital and infraorbital nerves, and preparation of the facial nerve at its root to achieve optimal length. Strategies to minimize ischemia time and ensure allograft integrity are highlighted. This article provides a comprehensive visual guide to the procurement phase of a full soft tissue face allograft and aims to standardize the technique for research application and surgical training in advanced vascularized composite allotransplantation.
CloseVascularized Composite Upper Limb Allograft Harvesting for Proximal Arm AllotransplantationVascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation
Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation
Tanguy Perraudin, Selma Lahlali, Nicolas Bronsard, Antoine Sicard, Olivier Camuzard, Elise Lupon
Abstract
In vascularized composite allograft (VCA) for upper limb reconstruction, upper arm-level or transhumeral transplantations are performed less frequently than forearm and hand transplantations. Transplantation is technically more feasible at this proximal level, largely owing to the use of macrovascular anastomoses. Despite these challenges, the outlook for arm allotransplantation remains encouraging, and this protocol provides a standardized technique for harvesting a vascularized upper arm composite allograft, ensuring both optimal outcomes and minimal tissue trauma. In the case of upper arm transplant, the technique varies according to the level of transplantation: supracondylar, transhumeral at a proximal arm level, or through the shoulder with the donor humeral head. A circumferential skin incision at mid-arm, or depending on the level at the origin of the upper limb, is made. A skin flap, such as a deltoid flap, can be harvested from the donor for skin closure at proximal levels. Dissection of the cephalic vein and deeper the brachial or axillary artery and veins is required. Then, the surgeon must identify the nerves depending on the level (terminal branches of brachial plexus or anteromedial and anterolateral cords for proximal transplantation) and transect the biceps, brachialis, and triceps muscles. The coracobrachialis and the deltoid muscles may also be dissected depending on the amputation level. Finally, the surgeon must make a transhumeral osteotomy or, if needed, harvest the donor humeral head for shoulder reconstruction. In this case, a peroneus longus graft for the suspension ligamentoplasty can also be harvested. The goal of this protocol is to standardize the procedure of harvesting and preparing an upper arm allotransplant.
CloseReconstruction After Wide Excision of the Nail Apparatus in the Treatment of Melanoma: A Systematic Literature ReviewReconstruction After Wide Excision of the Nail Apparatus in the Treatment of Melanoma: A Systematic Literature Review
Reconstruction After Wide Excision of the Nail Apparatus in the Treatment of Melanoma: A Systematic Literature Review
Luc Chouquet, Feriel Boukari, Thierry Balaguer, Henri Montaudié, Olivier Camuzard, Elise Lupon
https://doi.org/10.3390/jcm14175932
Abstract
Background/Objectives: Historically, the treatment of subungual melanoma was based on amputation of the affected digit. However, extended wide local excision of the nail apparatus is now considered the conservative gold standard for in situ or minimally invasive forms. There are many after wide local excision reconstruction techniques, but few studies have objectively compared their results. The objectives were to carry out a systematic review of reconstruction after wide local excision reconstructions in the treatment of subungual melanoma. Methods: This systematic review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. An exhaustive search was conducted in the PubMed (Medline), Embase, and Cochrane Library databases, up to July 2025. Articles reporting reconstructions after wide local excision for subungual melanoma of the fingers or toes were included. Clinical, technical, and outcome data were analyzed. Results: The literature review comprised 24 articles on 373 patients, primarily those with in situ subungual melanoma. Reconstruction was most often performed using total skin grafts, sometimes combined with dermal matrices. Some authors used local or free flaps. Few studies used validated functional scores. Local recurrences were significant, affecting 18% of patients and requiring secondary amputation. Conclusions: Nail apparatus reconstructions are primarily indicated for in situ or minimally invasive subungual melanomas. Immediate reconstruction carries a risk of performing the reconstruction over residual tumor tissue, particularly in the case of invasive melanomas. Reconstructive techniques, such as full-thickness skin grafts and the use of dermal matrices, can provide satisfactory functional and aesthetic outcomes. However, objective evaluations of these results remain limited, and better standardization of clinical practice, along with prospective studies, is needed to refine long-term outcome assessment.
Keywords: nail apparatus; nail melanoma; nail reconstruction; subungual melanoma; wide local excision.
CloseOutcomes of All-Dorsal Augmented Intercarpal Ligament ReconstructionOutcomes of All-Dorsal Augmented Intercarpal Ligament Reconstruction
Outcomes of All-Dorsal Augmented Intercarpal Ligament Reconstruction
Jean-Baptiste de Villeneuve Bargemon, Silvia Gandolfi, Elise Lupon
CloseProcurement for a Vascularized and Reinnervated Abdominal Wall AllotransplantationProcurement for a Vascularized and Reinnervated Abdominal Wall Allotransplantation
Procurement for a Vascularized and Reinnervated Abdominal Wall Allotransplantation
Pierre Barbat, Antoine Sicard, Yanis Berkane, Nicolas Bronsard, Olivier Camuzard, Elise Lupon
Abstract
Abstract
Extensive and complex abdominal wall defects, particularly those associated with intestinal or visceral organ damage, pose significant medical and surgical challenges. An ideal reconstruction must restore anatomy, function, sensation, and body image. Currently, no conventional reconstruction method fulfills all these criteria in such complex scenarios. However, vascularized composite allotransplantation (VCA) offers a unique solution, providing satisfactory anatomical and functional outcomes — albeit at the cost of lifelong immunosuppression. Since the first reported human case in 2003, approximately 40 abdominal wall transplants have been performed worldwide, all in conjunction with intestinal or multivisceral transplantation. While various technical adaptations have been described, the procedure has proven to be both safe and effective for patients with complex abdominal wall defects. To date, no reinnervated abdominal wall allograft has been attempted in humans. However, reinnervation appears to be the next frontier, with the potential to enhance functional outcomes and reduce complications. This protocol outlines a standardized procedure for harvesting and preparing a vascularized abdominal wall composite allograft, designed to ensure optimal results and minimize tissue damage. The graft, vascularized via the deep inferior epigastric vessels, is harvested with generous margins to enable tension-free reconstruction. We also detail the specific steps required to collect an innervated specimen. At the end of the procedure, the two deep inferior epigastric arteries are cannulated, and the graft is perfused with preservation solution for transport. Ultimately, this protocol aims to standardize abdominal wall graft procurement. It is intended as a valuable resource for both translational research and clinical applications, particularly as interest in abdominal wall transplantation continues to grow.
CloseApplication of Microgravity Experiments in Plastic Surgery: A Literature ReviewApplication of Microgravity Experiments in Plastic Surgery: A Literature Review
Application of Microgravity Experiments in Plastic Surgery: A Literature Review
Jonathan Cornacchini, Yanis Berkane, Vlad Tereshenko, Olivier Camuzard, Alexandre G Lellouch, Elise Lupon
https://doi.org/10.1097/gox.0000000000006802
Abstract
Background: Interest in microgravity is growing in the medical and surgical fields. This literature review aims to synthesize existing evidence on microgravity applications in plastic surgery, focusing on experimental methods, outcomes, and prospects.
Methods: All reported articles up to October 2023, including publications and news reports, were screened for inclusion using Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The PubMed keywords and Boolean operators were « plastic surgery AND microgravity, » « plastic surgery AND spaceflight, » « wound healing AND microgravity, » « skin aging AND microgravity, » « skin cancer AND microgravity, » and « melanoma AND microgravity. »
Results: A total of 201 articles were identified, and 14 studies were included. Plastic surgery procedures can be performed under microgravity, resulting in a delayed wound healing process. Four studies demonstrated that microgravity could reduce skin thickness and modify cell metabolism. In 2 studies, neoplastic melanoma cells have shown behavioral modifications under microgravity with induced apoptosis but increased potential for metastasis.
Conclusions: Microgravity represents a unique environment with potential implications in plastic surgery, although further rigorous studies need to be conducted in humans. The anticipated rise and development of spaceflights render the study of biological changes in space an impactful and significant topic.
Copyright © 2025 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.
ClosePublications 2024 du Dr LUPON Élise
Superior Pedicle Breast Reduction: Multivariate Analysis of Complication Risk Factors and Building a Predictive Score in 1306 PatientsSuperior Pedicle Breast Reduction: Multivariate Analysis of Complication Risk Factors and Building a Predictive Score in 1306 Patients
Superior Pedicle Breast Reduction: Multivariate Analysis of Complication Risk Factors and Building a Predictive Score in 1306 Patients
Paul Girard, Yanis Berkane, Jérôme Laloze, Chloé Rousseau, Elise Lupon, Sacha Schutz, Eric Watier, Nicolas Bertheuil
https://doi.org/10.1097/prs.0000000000010828
Abstract
Background: Breast reduction surgery for hypertrophy is one of the most commonly performed procedures in plastic surgery. This surgery exposes patients to complications that are well-documented in the literature. The objective of this study is to identify risk factors to establish an estimate of the risk of developing complications. The authors propose the first predictive score of postoperative complications, including continuous preoperative variables such as body mass index (BMI) and suprasternal notch-to-nipple distance (SSN:N).
Methods: An analytic observational retrospective cohort study was conducted including 1306 patients who underwent superior pedicle reduction mammaplasty at the Rennes University Hospital (France) between January 1, 2011, and December 31, 2016. The primary endpoint was to study the association between known preoperative risk factors and occurrence of any complications using multivariable logistic regression to identify independent risk factors. A secondary endpoint was to establish a score to estimate a probability of occurrence of complications.
Results: A total of 1306 patients were analyzed. Multivariable logistic regression showed three independent risk factors: active smoking [OR, 6.10 (95% CI: 4.23, 8.78); P < 0.0001], BMI [OR, 1.16 (95% CI: 1.11, 1.22); P < 0.0001], and SSN:N [OR, 1.14 (95% CI: 1.08, 1.21); P < 0.0001]. The Rennes Plastic Surgery Score estimating the occurrence of postoperative complications was determined, integrating regression coefficients of each risk factor.
Conclusions: Active smoking, BMI, and SSN:N distance are independent preoperative risk factors for the occurrence of breast reduction complications. The Rennes Plastic Surgery Score including the continuous values of BMI and SSN:N allows us to provide our patients with a reliable estimation of the risk of occurrence of these complications.
Clinical question/level of evidence: Risk, III.
Copyright © 2023 by the American Society of Plastic Surgeons.
CloseRegarding ``Adjuvant Arthroscopy Does Not Improve the Functional Outcome of Volar Locking Plate for Distal Radius Fractures: A Randomized Clinical Trial``Regarding ``Adjuvant Arthroscopy Does Not Improve the Functional Outcome of Volar Locking Plate for Distal Radius Fractures: A Randomized Clinical Trial``
Regarding « Adjuvant Arthroscopy Does Not Improve the Functional Outcome of Volar Locking Plate for Distal Radius Fractures: A Randomized Clinical Trial »
Jean-Baptiste de Villeneuve Bargemon, Elise Lupon, Marie Witters, Camille Brenac
CloseAbdominoplasty and Lower Body Lift Surgery Improves the Quality of Life after Massive Weight Loss: A Prospective Multicenter StudyAbdominoplasty and Lower Body Lift Surgery Improves the Quality of Life after Massive Weight Loss: A Prospective Multicenter Study
Abdominoplasty and Lower Body Lift Surgery Improves the Quality of Life after Massive Weight Loss: A Prospective Multicenter Study
Yanis Berkane, François Saget, Elise Lupon, Camille Mocquard, Isabelle Pluvy, Eric Watier, Alexandre G Lellouch, Jérôme Duisit, Benoit Chaput, Nicolas Bertheuil
https://doi.org/10.1097/prs.0000000000010683
Abstract
Background: This study was conducted to assess the impact of abdominoplasty and lower body lift surgery following massive weight loss on both the general quality of life and the sexual life of patients.
Methods: The authors performed a multicenter prospective study on the quality of life after massive weight loss using three scoring questionnaires: The Short-Form 36 questionnaire, the Female Sexual Function Index questionnaire, and the Moorehead-Ardelt Quality of Life Questionnaire. Seventy-two patients who underwent lower body lift and 57 patients who underwent abdominoplasty in three centers with preoperative and postoperative evaluation were included.
Results: The mean age of the patients was 43.2 ± 13.2 years. All categories of the Medical Outcomes Study Short-Form 36 Health Status Survey questionnaire were statistically significant at 6 months, and all categories except health change were significantly improved at 12 months postoperatively. Overall, the Moorehead-Ardelt questionnaire showed a higher quality of life in general (1.78 ± 0.92 and 1.64 ± 1.03 at 6 and 12 months, respectively) and in all domains (ie, self-esteem, physical activity, social relationships, work performance, and sexual activity). Interestingly, global sexual activity improved at 6 months but not at 12 months. Some domains of sexual life improved at 6 months (ie, desire, arousal, lubrication, satisfaction), but only desire remained improved at 12 months.
Conclusions: Abdominoplasty and lower body lift improve the quality of life of patients after massive weight loss and the sexual quality of life. This should be an additional valid reason for promoting reconstructive surgery for massive weight loss patients.
Clinical question/level of evidence: Therapeutic, IV.
Copyright © 2023 by the American Society of Plastic Surgeons.
CloseIntrafocal Pinning in Distal Extraarticular Radius Fracture: A Retrospective Study Based on Patient AgeIntrafocal Pinning in Distal Extraarticular Radius Fracture: A Retrospective Study Based on Patient Age
Intrafocal Pinning in Distal Extraarticular Radius Fracture: A Retrospective Study Based on Patient Age
Abdulaziz Asiry, Jean Baptiste De Villeneuve Bargemon, Stéphanie Delclaux, Pierre Mansat, Silvia Gandolfi, Elise Lupon
https://doi.org/10.1097/gox.0000000000006229
Abstract
Background: Percutaneous intrafocal pinning is one of the many surgical options for extraarticular distal radius fracture with minimal comminution. This study aims to describe the role and indications of intrafocal pinning.
Methods: This monocentric, retrospective study included 49 patients who underwent intrafocal pinning for distal radius fractures in 2013 in our French hand surgery department. All the patients underwent posteroanterior and lateral x-ray on days 2 and 45 to measure radial inclination, distal radioulnar index, and volar tilt.
Results: The mean age of the patients was 45.4 years, with women representing approximately 61.2% of the sample (n = 30). The patients were divided into three groups: group A (17-50 y), 26 patients; group B (50-70 y), 15 patients; and group C (>70 y), eight patients. We documented on x-ray images, 21 secondary displacements, including seven in group C. There were three displacements (all in group C) and one surgical revision within 15 days for a previous displacement. The distal radioulnar index increased in all three groups.
Conclusions: The percutaneous intrafocal pinning fixation technique exposes a high risk of complications, especially for those older than 50 years, for whom this technique should be avoided. Overall, due to the frequency of secondary displacements encountered, our first-line treatment favors plate osteosynthesis for all patients. Pinning fixation should only be considered with caution in younger patients if plate osteosynthesis is not possible, but it requires a strict 6-week immobilization. The fracture morphology must also be considered.
Copyright © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.
CloseVascularized posterior interosseous nerve graft for digital neurovascular bundle reconstructionVascularized posterior interosseous nerve graft for digital neurovascular bundle reconstruction
Vascularized posterior interosseous nerve graft for digital neurovascular bundle reconstruction
George Paleu, Tanguy Perraudin, Alexis Majchrzak, Mihai Grigore, Elise Lupon, Olivier Camuzard
https://doi.org/10.1016/j.hansur.2024.101761
Abstract
Introduction: Despite the progress in microsurgery in recent decades, neurovascular bundle defects during ring finger injuries still pose challenges for the surgeon. Usually, a reversed venous graft and a non-vascularized nerve graft are utilized to reconstruct this defect. One of the most common challenges encountered when using a venous graft is the caliber mismatch between the graft and the digital arterial ends. The use of an arterialized nerve graft (neurovascular graft) is poorly described and could represent an attractive reconstructive option.
Case presentation: We present the case of a 36-year-old manual worker, a non-smoker, with no significant medical or surgical comorbidities, who presented a ring avulsion type trauma, leading to the amputation of the third left finger at the distal interphalangeal joint and avulsion of the circumferential skin at the level of the middle and proximal phalanges (Urbaniak III). The patient presented a neurovascular bundle defect of 3 cm, reconstructed by the vascularized posterior interosseous nerve graft along the distal perforator of the dorsal branch of the anterior interosseous artery serving both as an interpositional arterial conduit and as a nerve graft. The results of postoperative nerve regeneration at three years are satisfactory, with the patient demonstrating a two-point discrimination measured at 6 mm.
Conclusion: Simultaneous digital artery and nerve reconstruction using a neurovascular flap is very appealing to the hand surgeon as it offers several advantages over traditional methods, particularly the ideal diameter match between the digital arteries and the distal perforator of the dorsal branch of the anterior interosseous artery.
Keywords: Branch of the anterior interosseous artery; Digit amputation; Digital neurovascular bundle reconstruction; Posterior interosseous nerve; Ring finger; Vascularized nerve graft.
Copyright © 2024 SFCM. Published by Elsevier Masson SAS. All rights reserved.
CloseExploring Iodide and Hydrogen Sulfide as ROS Scavengers to Delay Acute Rejection in MHC-Defined Vascularized Composite AllograftsExploring Iodide and Hydrogen Sulfide as ROS Scavengers to Delay Acute Rejection in MHC-Defined Vascularized Composite Allografts
Exploring Iodide and Hydrogen Sulfide as ROS Scavengers to Delay Acute Rejection in MHC-Defined Vascularized Composite Allografts
Philipp Tratnig-Frankl, Alec R Andrews, Yanis Berkane, Claire Guinier, Marion Goutard, Elise Lupon, Hyshem H Lancia, Michael L Morrison, Mark B Roth, Mark A Randolph, Curtis L Cetrulo Jr, Alexandre G Lellouch
https://doi.org/10.3390/antiox13050531
Abstract
Vascularized composite allografts (VCA) face ischemic challenges due to their limited availability. Reperfusion following ischemia triggers oxidative stress and immune reactions, and scavenger molecules could mitigate ischemia-reperfusion injuries and, therefore, immune rejection. We compared two scavengers in a myocutaneous flap VCA model. In total, 18 myocutaneous flap transplants were performed in Major histocompatibility complex (MHC)-defined miniature swine. In the MATCH group (n = 9), donors and recipients had minor antigen mismatch, while the animals were fully mismatched in the MISMATCH group (n = 9). Grafts were pretreated with saline, sodium iodide (NaI), or hydrogen sulfide (H2S), stored at 4 °C for 3 h, and then transplanted. Flaps were monitored until clinical rejection without immunosuppression. In the MATCH group, flap survival did not significantly differ between the saline and hydrogen sulfide treatments (p = 0.483) but was reduced with the sodium iodide treatment (p = 0.007). In the MISMATCH group, survival was similar between the saline and hydrogen sulfide treatments (p = 0.483) but decreased with the sodium iodide treatment (p = 0.007). Rhabdomyolysis markers showed lower but non-significant levels in the experimental subgroups for both the MATCH and MISMATCH animals. This study provides insightful data for the field of antioxidant-based approaches in VCA and transplantation.
Keywords: VCA; acute rejection; free radical scavengers; ischemia–reperfusion injury; transplantation; vascularized composite allotransplantation.
CloseImmunosuppressant drug monitor: A non-invasive device to measure tacrolimus level in the saliva of transplanted patientsImmunosuppressant drug monitor: A non-invasive device to measure tacrolimus level in the saliva of transplanted patients
Immunosuppressant drug monitor: A non-invasive device to measure tacrolimus level in the saliva of transplanted patients
Laura Charlès, Elise Lupon, Tia Sheth, Olivier Camuzard, Alexandre G Lellouch, Chetan Shende, Stuart Farquharson, Kassem Safa, Curtis L Cetrulo Jr
https://doi.org/10.1016/j.ijpharm.2024.123858
Abstract
Solid organ and vascularized composite allograft transplantation are pivotal in enhancing both life expectancy and quality of life. However, the significant risk of donor tissue rejection requires lifelong immunosuppressive therapy. Tacrolimus, a common component of immunosuppressive regimens, offers effectiveness in preventing organ rejection but poses challenges due to its narrow therapeutic window and toxicity, making it essential to carefully monitor its concentration. Tacrolimus trough levels are currently measured in blood, requiring frequent blood draws from patients, and results are available after 3 to 6 h. To address the need for a fast, minimally-invasive, and simple method to monitor tacrolimus concentrations, we have assessed a new device for at-home analysis, the Immunosuppressant Drug Monitor (IDM) that can extract, identify and quantify tacrolimus in saliva within 15 min. We included males and females hospitalized at Massachusetts General Hospital Transplant Unit, between the ages of 21 and 65 years, and treated with Tacrolimus. Informed consent, demographic and treatment data were collected. Each subject was asked to provide a 5 mL saliva sample that was de-identified and processed by the IDM, while a 5 mL blood sample was drawn and supplied to the MGH clinical lab for analysis by the current standard, immunoassays. The predicted tacrolimus concentration found in saliva was compared to the blood trough level results. 62 samples from 31 different patients were obtained. The male to female ratio and ethnicity distribution were well balanced. The majority of patients were within 30 days of initiating tacrolimus treatment. After IDM calibration and exclusion, 21 samples were measured by the IDM. Using an exponential function fit, the IDM showed a correlation of R2 = 0.39 between the saliva Test Line absorption and the measured tacrolimus concentration in blood, with an average absolute error of 1.8 ng/mL. Our results demonstrate a clear correlation between blood and saliva measurements. The IDM provided promising results to monitor immunosuppressant drug concentrations in patients after transplantation. Future larger studies will further develop the correlation, and the IDM’s potential impact on patient outcomes.
Keywords: Absorption spectroscopy; At-home; Saliva analysis; Tacrolimus; Toxicity; Transplant.
Copyright © 2024 Elsevier B.V. All rights reserved.
CloseOptimized Decellularization of a Porcine Fasciocutaneaous FlapOptimized Decellularization of a Porcine Fasciocutaneaous Flap
Optimized Decellularization of a Porcine Fasciocutaneaous Flap
Elise Lupon, Aylin Acun, Corentin B Taveau, Ruben Oganesyan, Hyshem H Lancia, Alec R Andrews, Mark A Randolph, Curtis L Cetrulo Jr, Alexandre G Lellouch, Basak E Uygun
https://doi.org/10.3390/bioengineering11040321
Abstract
Reconstructive techniques to repair severe tissue defects include the use of autologous fasciocutaneous flaps, which may be limited due to donor site availability or lead to complications such as donor site morbidity. A number of synthetic or natural dermal substitutes are in use clinically, but none have the architectural complexity needed to reconstruct deep tissue defects. The perfusion decellularization of fasciocutaneous flaps is an emerging technique that yields a scaffold with the necessary composition and vascular microarchitecture and serves as an alternative to autologous flaps. In this study, we show the perfusion decellularization of porcine fasciocutaneous flaps using sodium dodecyl sulfate (SDS) at three different concentrations, and identify that 0.2% SDS results in a decellularized flap that is efficiently cleared of its cellular material at 86%, has maintained its collagen and glycosaminoglycan content, and preserved its microvasculature architecture. We further demonstrate that the decellularized graft has the porous structure and growth factors that would facilitate repopulation with cells. Finally, we show the biocompatibility of the decellularized flap using human dermal fibroblasts, with cells migrating as deep as 150 µm into the tissue over a 7-day culture period. Overall, our results demonstrate the promise of decellularized porcine flaps as an interesting alternative for reconstructing complex soft tissue defects, circumventing the limitations of autologous skin flaps.
Keywords: decellularization; recellularization; soft tissue reconstruction; tissue engineering; vascularized composite allotransplantation.
CloseTissue engineering strategies for breast reconstruction: a literature review of current advances and future directionsTissue engineering strategies for breast reconstruction: a literature review of current advances and future directions
Tissue engineering strategies for breast reconstruction: a literature review of current advances and future directions
Yanis Berkane, Haizam Oubari, Loïc van Dieren, Laura Charlès, Elise Lupon, Michelle McCarthy, Curtis L Cetrulo Jr, Nicolas Bertheuil, Basak E Uygun, David M Smadja, Alexandre G Lellouch
https://doi.org/10.21037/atm-23-1724
Abstract
Background and objective: Mastectomy is a primary treatment for breast cancer patients, and both autologous and implant-based reconstructive techniques have shown excellent results. In recent years, advancements in bioengineering have led to a proliferation of innovative approaches to breast reconstruction. This article comprehensively explores the promising perspectives offered by bioengineering and tissue engineering in the field of breast reconstruction.
Methods: A literature review was conducted between April and June 2023 on PubMed and Google Scholar Databases. All English and French articles related to bioengineering applied to the field of breast reconstruction were included. We used the Evidence-Based Veterinary Medicine Association (EBVM) Toolkit 14 checklist for narrative reviews as a quality assurance measure and the Scale for the Assessment of Narrative Review Articles (SANRA) tool to self-assess our methodology.
Key content and findings: Over 130 references related to breast bioengineering were included. The analysis revealed four key applications: enhancing the quality of the skin envelope, improving the viability of fat grafting, creating breast shape and volume via bio-printing, and optimizing nipple reconstruction through engineering techniques. The primary identified approaches revolved around establishing structural support and enhancing cellular viability. Structural techniques predominantly involved the implementation of 3D printed, decellularized, or biocompatible material scaffolds. Meanwhile, promoting cellular content trophicity primarily focused on harnessing the regenerative potential of adipose-derived stem cells (ADSCs) and increasing the tissue’s survivability and cell trophicity.
Conclusions: Tissue and bioengineering hold immense promise in the field of breast reconstruction, offering a diverse array of approaches. By combining existing techniques with novel advancements, they have the potential to significantly enhance the therapeutic options available to plastic and reconstructive surgeons.
Keywords: Breast surgery; acellular matrix; breast reconstruction; scaffold; tissue engineering.
2024 Annals of Translational Medicine. All rights reserved.
CloseUpdate/Refinement of Targeted Muscle Reinnervation Indication: A Scoping Review of Applications for Non-AmputeesUpdate/Refinement of Targeted Muscle Reinnervation Indication: A Scoping Review of Applications for Non-Amputees
Update/Refinement of Targeted Muscle Reinnervation Indication: A Scoping Review of Applications for Non-Amputees
Jonathan Cornacchini, Haïzam Oubari, Vlad Tereshenko, Maria Bejar-Chapa, Yanis Berkane, Anna Scarabosio, Alexandre G Lellouch, Olivier Camuzard, Kyle R Eberlin, Elise Lupon
https://doi.org/10.3390/jcm13206107
Abstract
Background: Targeted muscle reinnervation (TMR) was originally developed to enhance prosthetic control in amputees. However, it has also serendipitously demonstrated benefits in reducing phantom pain and neuromas. As a result, it has emerged as a secondary treatment for chronic neuromas in amputees and holds promise for managing neuropathic pain in non-amputee patients, particularly those with neuromas. This review synthesizes the current literature on TMR indications for non-amputee patients, highlighting its potential to address chronic peripheral nerve pain and neuromas beyond its original application in amputation. Methods: A thorough search of the PubMed and Cochrane databases up to January 2024 was conducted following the PRISMA guidelines. Inclusion criteria comprised case series, cohort studies, and randomized controlled trials reporting TMR outcomes in non-amputees. Results: Of 263 articles initially identified, 8 met the inclusion criteria after screening and full-text assessment. The articles were all case series with varied sample sizes and mainly focused on neuroma treatment (n = 6) and neuropathic pain management (n = 2) for both upper and lower extremities. Clinical studies included TMR efficacy for sural nerve neuromas in the lower extremities and hand neuromas, showing pain relief and improved function. Key findings were encouraging, showing successful pain relief, patient satisfaction, and psychosocial improvement, with only rare occurrences of complications such as motor deficits. Conclusions: In non-amputee patients, TMR appears to be a promising option for the surgical management of neuropathic pain, demonstrating favorable patient satisfaction and psychosocial outcomes along with low morbidity rates. Although functional improvements in gait recovery and range of motion are encouraging, further research will be important to confirm and expand upon these findings.
Keywords: TMR; complex regional pain syndrome; neuroma; neuropathic pain; non-amputee; post-mastectomy pain syndrome.
CloseMicrosurgery in low- and middle-income countries: Results of 20 years of experience in CambodiaMicrosurgery in low- and middle-income countries: Results of 20 years of experience in Cambodia
Microsurgery in low- and middle-income countries: Results of 20 years of experience in Cambodia
Elise Lupon, Benoît Chaput, Yong-June Kim, Sopheap Pogn, Aymeric Andre, Frédéric Lauwers
https://doi.org/10.1016/j.bjps.2024.08.073
Abstract
Background: Microsurgical free tissue transfer is the gold standard for reconstructing major bone or soft tissue defects but requires complex training, and specific resources. Therefore, some authors have stated that microsurgery is impossible in low- and middle-income countries.
Methods: Patients from Khmer underwent free flap surgery at the Children’s Surgical Centre in Phnom Penh between 2004 and 2023. Two non-governmental organizations facilitated the program: Rose Charities Cambodia provided the facilities, patients and local staff, and Doctors of the World provided the surgeons, and anesthetists. At least one Khmer surgeon was trained during these operations. Digital data were collected retrospectively, and analyzed in June 2023.
Results: Fifty-six free flaps in 54 patients have been performed since 2004. The most frequent sites requiring reconstruction were the head and neck (35.7%), lower limbs (30.4%), and upper limbs (21.4%). The most frequent free flaps were free fibula (44.6%), gracilis (19.6%), and anterolateral thigh (16.1%). Among the 56 flaps, 41 (= 73.2%) were viable long-term and 15 (26.7%) were microsurgical failures. Sixteen flaps underwent revision in the operating room. Twenty-three flap-related complications were reported in 21 patients with mostly vascular thrombosis (n = 12), hematoma (n = 3) and infections (3). However, 83.3% had improved or were cured of their initial pathology after final surgical management.
Conclusions: Free flaps performed in our series as part of international surgical collaborations in a low-income country are feasible, but we experienced higher failure rates, and later revisions compared to the results in high-income countries. We identified several solutions to improve the microsurgery outcomes in low-income settings.
Keywords: Free flap; Free tissue transfer; International surgical collaborations; Low- and middle-income countries; Microsurgery; Surgical missions.
Copyright © 2024 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
CloseNonsurgical Treatment of Postburn Hypopigmentation: A Literature ReviewNonsurgical Treatment of Postburn Hypopigmentation: A Literature Review
Nonsurgical Treatment of Postburn Hypopigmentation: A Literature Review
Elise Lupon, Yanis Berkane, Nicolas Bertheuil, Curtis L Cetrulo, Camille Vaillant, Benoît Chaput, Olivier Camuzard, Alexandre G Lellouch
https://doi.org/10.1093/jbcr/irae030
Abstract
The treatment of postburn hypopigmentation was primarily surgical before the advent of new technologies. Medical devices and therapies are emerging to manage scar sequelae that can be disfiguring and associated with severe psychosocial impact. These innovations have been poorly investigated for hypopigmentation, but they represent a real hope. We reviewed all articles published on Pubmed up to June 2022. Included studies had to specifically focus on treating postburn hypopigmented scars. All articles evaluating transient solutions such as make-up, and articles describing inflammation-linked hypopigmentation with no etiological details or no burn injury history were excluded. Through this review, we have highlighted 6 different types of nonsurgical treatments reported in postburn leukoderma potentially allowing definitive results. Electrophoto-biomodulation or E light (combining intensive pulsed light, radiofrequency, and cooling), topical daylight psoralen UVA therapy, and lasers (fractional lasers using pulse energies or CO2FL devices, lasers-assisted drug delivery as local bimatoprost and tretinoin or pimecrolimus) have been explored with encouraging results in hypopigmented burns. Finally, other promising medical strategies include using FK506, a nonsteroidal anti-inflammatory drug, to induce melanogenesis or using melanocyte-stimulating hormones with fractional laser-assisted drug deliveries, which are expected to emerge soon.
Keywords: dyschromia; hypopigmentation; leukoderma; postburn sequelae; skin burn.
Close`{`Advances and perspectives in vascularized composite allotransplantation preservation`}``{`Advances and perspectives in vascularized composite allotransplantation preservation`}`
A[Advances and perspectives in vascularized composite allotransplantation preservation]
Yanis Berkane, Haizam Oubari, Elise Lupon, Marion Goutard, Pierre Tawa, Mark A Randolph, Curtis L Cetrulo Jr, Nicolas Bertheuil, Alexandre G Lellouch, Korkut Uygun
https://doi.org/10.1016/j.banm.2024.09.001
Abstract
Les allotransplantations de tissus composites (ATC) concernent les transplantations de face, de membre supérieur, de trachée, de pénis, de paroi abdominale et, plus récemment, d’utérus. Ces greffons ont la particularité de comporter de nombreux tissus spécialisés dérivant de plusieurs feuillets embryonnaires, chacun présentant des contraintes spécifiques. Là où la composante cutanée, en tant que barrière immunologique, est un véritable challenge sur le plan de la tolérance immunitaire, le muscle est très sensible à l’ischémie, et les lésions d’ischémiereperfusion peuvent mener à un relargage antigénique favorisant les épisodes de rejet. Si le gold standard de la préservation de ces greffons demeure la préservation froide statique (4 °C), l’émergence des techniques dynamiques de perfusion en transplantation d’organes solides permet d’envisager leur adaptation aux ATC. Par cette revue, nous exposons les défis posés par l’allotransplantation de tissus composites, et discutons les dernières avancées en matière de préservation d’ATC basées sur machine de perfusion mais également sur les techniques statiques à températures négatives. Une attention particulière est portée à la préservation par perfusion subnormothermique et aux techniques de supercooling (surfusion), développées par notre équipe, tentant d’importer ces techniques optimisées en préservation d’organes solides. © 2024 l’Academie nationale de médecine. Publié par Elsevier Masson SAS. Tous droits réservés, y compris ceux relatifs à la fouille de textes et de données, à l’entraînement de l’intelligence artificielle et aux technologies similaires.
Keywords: Composite tissue allografts; Cryopreservation/methods; Organ preservation; Organ preservation/methods; Perfusion/methods; Vascularized composite allotransplantation.
ClosePublications 2023 du Dr LUPON Élise
Superior Pedicle Breast Reduction: Multivariate Analysis of Complication Risk Factors and Building a Predictive Score in 1306 PatientsSuperior Pedicle Breast Reduction: Multivariate Analysis of Complication Risk Factors and Building a Predictive Score in 1306 Patients
Abdominoplasty and Lower Body Lift Surgery Improves the Quality of Life after Massive Weight Loss: A Prospective Multicenter Study/strong>
Paul Girard, Yanis Berkane, Jérôme Laloze, Chloé Rousseau, Elise Lupon, Sacha Schutz, Eric Watier, Nicolas Bertheuil
https://doi.org/10.1097/prs.0000000000010828
CloseRegarding ``Clinical Outcomes of Arthroscopic One-Tunnel Triangular Fibrocartilage Complex Transosseous Suture Repair Are Not Diminished in Cases of Ulnar Styloid Process Fracture Nonunion``Regarding ``Clinical Outcomes of Arthroscopic One-Tunnel Triangular Fibrocartilage Complex Transosseous Suture Repair Are Not Diminished in Cases of Ulnar Styloid Process Fracture Nonunion``
Abdominoplasty and Lower Body Lift Surgery Improves the Quality of Life after Massive Weight Loss: A Prospective Multicenter Study/strong>
Jean-Baptiste de Villeneuve Bargemon, Elise Lupon, Brieuc Monin, Christophe Mathoulin
https://doi.org/10.1016/j.arthro.2023.01.095
CloseComment to: Dorsal bridge plating versus bridging external fixation for management of complex distal radius fractureComment to: Dorsal bridge plating versus bridging external fixation for management of complex distal radius fracture
Abdominoplasty and Lower Body Lift Surgery Improves the Quality of Life after Massive Weight Loss: A Prospective Multicenter Study/strong>
Jean-Baptiste de Villeneuve Bargemon, Romain Mari, Christophe Mathoulin, Elise Lupon
https://doi.org/10.1016/j.injury.2023.01.0113
CloseAbdominoplasty and Lower Body Lift Surgery Improves the Quality of Life after Massive Weight Loss: A Prospective Multicenter StudyAbdominoplasty and Lower Body Lift Surgery Improves the Quality of Life after Massive Weight Loss: A Prospective Multicenter Study
Abdominoplasty and Lower Body Lift Surgery Improves the Quality of Life after Massive Weight Loss: A Prospective Multicenter Study/strong>
Yanis Berkane, François Saget, Elise Lupon, Camille Mocquard, Isabelle Pluvy, Eric Watier, Alexandre G Lellouch, Jérôme Duisit, Benoit Chaput, Nicolas Bertheuil
CloseTargeted partial arthroscopic trapeziectomy with temporary distraction: a retrospective study with 5-year follow-upTargeted partial arthroscopic trapeziectomy with temporary distraction: a retrospective study with 5-year follow-up
Targeted partial arthroscopic trapeziectomy with temporary distraction: a retrospective study with 5-year follow-up
Jean-Baptiste de Villeneuve Bargemon, Elise Lupon, Guillaume Soudé, Charlotte Jaloux, Paul Levet, Michel Levadoux
CloseFencing wrist: a 10-year retrospective study of wrist injuries in fencersFencing wrist: a 10-year retrospective study of wrist injuries in fencers
Fencing wrist: a 10-year retrospective study of wrist injuries in fencers
Jean-Baptiste de Villeneuve Bargemon, Christophe Mathoulin, Elise Lupon
CloseOutcomes of Autologous Fat Graft Injection(s) in Treating Sequelae of Digital Trauma: A Case SeriesOutcomes of Autologous Fat Graft Injection(s) in Treating Sequelae of Digital Trauma: A Case Series
Outcomes of Autologous Fat Graft Injection(s) in Treating Sequelae of Digital Trauma: A Case Series
Elise Lupon, Hadrien Paoli, Jean Baptiste De Villeneuve Bargemon, François Loisel, Olivier Camuzard, Isabelle Pluvy
CloseResponse to: Parasacral Perforator Flaps for Buttock EnhancementResponse to: Parasacral Perforator Flaps for Buttock Enhancement
Response to: Parasacral Perforator Flaps for Buttock Enhancement
Elise Lupon, Gilles Claro, Olivier Camuzard, Benoit Chaput
ClosePractical Strategies in Reconstruction of Soft-Tissue SarcomaPractical Strategies in Reconstruction of Soft-Tissue Sarcoma
Practical Strategies in Reconstruction of Soft-Tissue Sarcoma
Elise Lupon, Alessander D’Ascoli, Olivier Camuzar
CloseTissue engineering strategies for breast reconstruction: a literature review of current advances and future directionsTissue engineering strategies for breast reconstruction: a literature review of current advances and future directions
Tissue engineering strategies for breast reconstruction: a literature review of current advances and future directions
Yanis Berkane, Haizam Oubari, Loïc van Dieren, Laura Charlès, Elise Lupon, Michelle McCarthy, Curtis L. Cetrulo Jr, Nicolas Bertheuil, Basak E. Uygun, David M. Smadja, Alexandre G. Lelloucht
CloseResponse to: Parasacral Perforator Flaps for Buttock EnhancementResponse to: Parasacral Perforator Flaps for Buttock Enhancement
Response to: Parasacral Perforator Flaps for Buttock Enhancement
Elise Lupon, Gilles Claro, Olivier Camuzard, Benoit Chaput
ClosePublications 2022 du Dr LUPON Élise
Acellular Nipple Scaffold Development, Characterization, and Preliminary Biocompatibility Assessment in a Swine ModelAcellular Nipple Scaffold Development, Characterization, and Preliminary Biocompatibility Assessment in a Swine Model
Ruben V Oganesyan, Alexandre G Lellouch, Aylin Acun, Elise Lupon, Corentin B Taveau, Laura C Burlage, Laurent A Lantieri, Mark A Randolph, Curtis L Cetrulo Jr, Basak E Uygun
https://pubmed.ncbi.nlm.nih.gov/36472499/
Abstract
Background: The standard in nipple reconstruction remains the autologous skin flap. Unfortunately, the results are not satisfying, with up to 75% loss of nipple projection over time. Existing studies investigated the use of primates as a source of implants. The authors hypothesized that the porcine nipple can serve as a perfect shape-supporting implant because of functional similarities to the human nipple. A decellularization protocol was developed to obtain an acellular nipple scaffold (ANS) for nipple reconstruction.
Methods: Tissue samples were collected from eight disease-free female Yorkshire pigs (60 to 70 kg) and then decellularized. The decellularization efficiency and extracellular matrix characterization was performed histologically and quantitatively (DNA, total collagen, elastin, and glycosaminoglycan content). In vitro and in vivo biocompatibility was determined by human dermal fibroblast culture and subcutaneous implantation of six ANSs in a single Yorkshire pig (60 to 70 kg), respectively. Inflammation and adverse events were monitored daily based on local clinical signs.
Results: The authors showed that all cellular structures and 96% of DNA [321.7 ± 57.6 ng DNA/mg wet tissue versus 11.7 ± 10.9 ng DNA/mg wet tissue, in native and ANS, respectively ( P < 0.001)] can be successfully removed. However, this was associated with a decrease in collagen [89.0 ± 11.4 and 58.8 ± 9.6 μg collagen/mg ( P < 0.001)] and elastin [14.2 ± 1.6 and 7.9 ± 2.4 μg elastin/mg ( P < 0.05)] and an increase in glycosaminoglycan content [5.0 ± 0.7 and 6.0 ± 0.8 ng/mg ( P < 0.05)]. ANS can support continuous cell growth in vitro and during preliminary biocompatibility tests in vivo.
Conclusion: This is a preliminary report of a novel promising ANS for nipple reconstruction, but more research is needed to validate results.
Clinical relevance statement: Breast cancer is very common among women. Treatment involves mastectomy, but its consequences affect patient mental well-being, and can lead to depression. Nipple-areola complex reconstruction is critical, and existing methods lead to unsatisfactory outcomes.
Copyright © 2022 by the American Society of Plastic Surgeons.
CloseA Dynamic Anatomic Study of Parasacral Perforators: Mapping, Perforasome, and Applications for Buttock EnhancementA Dynamic Anatomic Study of Parasacral Perforators: Mapping, Perforasome, and Applications for Buttock Enhancement
Gilles Claro, Elise Lupon, Farouk Dargai, Farid Bekara, Fatima Zohra Mokrane, Benoit Chaput
https://pubmed.ncbi.nlm.nih.gov/35665801/
Abstract
Background: Due to the lack of knowledge about parasacral artery perforators, flaps from this region cannot be used with complete confidence in their security and effectiveness. Knowledge of the clusters and perforasome of these perforators could help in the design of more reliable flaps and extend the range of applications.
Objectives: This study aimed to identify the location, number, and density of perforators, and to subsequently analyze the perfusion flow and linking vessel distribution.
Methods: Five fresh cadavers were harvested and dissected. For the mapping, after injecting lateral sacral arteries with colored latex, perforators with a diameter of >0.5 cm were examined in 5 sacral regions. All data were collected on the suprafascial plane, with an orthonormal coordinate system placed on iliac crests and median lines. For perforasome analysis, 5 perforators and 3 three sacral flaps were injected with radiopaque dye. A dynamic (4-dimensional) computed tomographic angiography completed the analysis.
Results: A mean [standard deviation] of 8.4 [1.36] perforators per corpse, with a mean diameter of 0.72 [0.14] mm, were identified. There was a higher density of parasacral perforators close to the median line and 7.6 cm above the iliac crests. This pattern was not a random distribution (P < 0.05). The perfusion area was preferentially in the superior gluteal region. Perfusion flow was permitted by the dominant direct-linking vessels towards adjacent lumbar perforators, oriented diagonally upward and outward to the midline.
Conclusions: Parasacral perforator flaps appear to be a useful procedure in reconstruction and in aesthetic surgery, especially in gluteal augmentation. Their reliability depends on sound anatomic knowledge, with accurate preoperative perforator mapping.
© The Author(s) 2022. Published by Oxford University Press on behalf of The Aesthetic Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
CloseA Reliable Porcine Fascio-Cutaneous Flap Model for Vascularized Composite Allografts Bioengineering StudiesA Reliable Porcine Fascio-Cutaneous Flap Model for Vascularized Composite Allografts Bioengineering Studies
Victor Pozzo, Golda Romano, Marion Goutard, Elise Lupon, Pierre Tawa, Aylin Acun, Alec R Andrews, Corentin B Taveau, Basak E Uygun, Mark A Randolph, Curtis L Cetrul, Alexandre G Lellouch
https://pubmed.ncbi.nlm.nih.gov/35435906/
Abstract
Vascularized Composite Allografts (VCA) such as hand, face, or penile transplant represents the cutting-edge treatment for devastating skin defects, failed by the first steps of the reconstructive ladder. Despite promising aesthetic and functional outcomes, the main limiting factor remains the need for a drastically applied lifelong immunosuppression and its well-known medical risks, preventing broader indications. Therefore, lifting the immune barrier in VCA is essential to tip the ethical scale and improve patients’ quality of life using the most advanced surgical techniques. De novo creation of a patient-specific graft is the upcoming breakthrough in reconstructive transplantation. Using tissue engineering techniques, VCAs can be freed of donor cells and customized for the recipient through perfusion-decellularization-recellularization. To develop these new technologies, a large-scale animal VCA model is necessary. Hence, swine fascio-cutaneous flaps, composed of skin, fat, fascia, and vessels, represent an ideal model for preliminary studies in VCA. Nevertheless, most VCA models described in the literature include muscle and bone. This work reports a reliable and reproducible technique for saphenous fascio-cutaneous flap harvest in swine, a practical tool for various research fields, especially vascularized composite tissue engineering.
CloseBreasts and congenital chest-wall deformities: Surgical strategy with 3D implantsBreasts and congenital chest-wall deformities: Surgical strategy with 3D implants
Breasts and congenital chest-wall deformities: Surgical strategy with 3D implants
J-P Chavoin, S Gandolfi, P Leyx, F Facchini, C Schirmer, J-L Grolleau, E Lupon, B Chaput
https://pubmed.ncbi.nlm.nih.gov/35931576/
Abstract
Computer-aided design and manufacturing of custom-made elastomer implants leads from a CT scan to fill in with precision, a congenital chest wall congenital deformity, both bone (pectus excavatum) and muscle (Poland Syndrome), resulting in a natural repositioning of the breasts. We report our 25 years’ experience in 301 women (234 Pectus+64 Poland). Parietal correction must always be done in first intention. It is common to have to carry out a second stage in women with an additional mammaplasty especially in the presence of insufficient glandular volume or a fairly frequently associated tuberous breast.
Keywords: Asymétrie mammaire; Breast asymmetry; Computer-aided design; Computer-aided manufacturing; Conception assistée par ordinateur; Custom-made implants; Fabrication assistée par ordinateur; Implants de silicone; Implants sur mesure; Pectus excavatum; Poland syndrome; Seins tubéreux; Silicone Implants; Tuberous breasts.
Copyright © 2022 Elsevier Masson SAS. All rights reserved.
CloseCombinatorial Use of Therapeutic ELP-Based Micelle Particles in Tissue EngineeringCombinatorial Use of Therapeutic ELP-Based Micelle Particles in Tissue Engineering
Combinatorial Use of Therapeutic ELP-Based Micelle Particles in Tissue Engineering
Beyza Bulutoglu, Aylin Acun, Sarah L Deng, Safak Mert, Elise Lupon, Alexandre G Lellouch, Curtis L Cetrulo Jr, Basak E Uygun, Martin L Yarmush
https://pubmed.ncbi.nlm.nih.gov/35373501/
Abstract
Elastin-like peptides (ELPs) are a versatile platform for tissue engineering and drug delivery. Here, micelle forming ELP chains are genetically fused to three therapeutic molecules, keratinocyte growth factor (KGF), stromal cell-derived growth factor 1 (SDF1), and cathelicidin (LL37), to be used in wound healing. Chronic wounds represent a growing problem worldwide. A combinatorial therapy approach targeting different aspects of wound healing would be beneficial, providing a controlled and sustained release of active molecules, while simultaneously protecting these therapeutics from the surrounding harsh wound environment. The results of this study demonstrate that the conjugation of the growth factors KGF and SDF1 and the antimicrobial peptide LL37 to ELPs does not affect the micelle structure and that all three therapeutic moieties retain their bioactivity in vitro. Importantly, when the combination of these micelle ELP nanoparticles are applied to wounds in diabetic mice, over 90 % wound closure is observed, which is significantly higher than when the therapeutics are applied in their naked forms. The application of the nanoparticles designed here is the first report of targeting different aspect of wound healing synergistically.
Keywords: cathelicidin; elastin-like peptides; keratinocyte growth factor; micelle particles; protein engineering; stromal cell-derived growth factor 1; wound healing.
© 2022 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.
CloseComplications and quality of life after bodylift: About 143 patientsComplications and quality of life after bodylift: About 143 patients
Complications and quality of life after bodylift: About 143 patients
J Heranney, E Lupon, D Guillier, D Feuvrier, I Pluvy
https://pubmed.ncbi.nlm.nih.gov/36028411/
Abstract
Introduction: The rise of bariatric surgery has led to a considerable increase in the demand for weight loss surgery. The lower body lift consists of removing the residual abdominal fat and skin excess and re-tensioning the surfaces. The objective of our study was to evaluate the associated complications, as well as the consequences of this surgery on the quality of life of the patients.
Materials and methods: A retrospective monocentric study was conducted in patients operated on for lower body lift between 2010 and 2019 at the University Hospital of Besançon. We collected postoperative complications and studied the satisfaction and quality of life of the operated patients using the Body-QoL and SF-36 questionnaires.
Results: One hundred forty-three patients were included with a mean age of 41.2 years. The mean body mass index was 26.6kg/m2 with a mean weight of 73.8kg and a mean weight loss of 54.4kg. Forty-one patients (29.7%) had at least one complication. Most complications were minor, with 16.8% of scar disunions, and 7% of complications were major, requiring revision surgery. Ninety-three patients (65%) responded to the satisfaction questionnaires with improvement mostly in physical symptoms and social life.
Conclusion: The lower body lift is an effective, safe procedure with mostly minor complications that do not influence quality of life. Patient satisfaction is high, and it is therefore justified to continue offering this procedure to correct the sequelae of massive weight loss.
Keywords: Amaigrissement massif; Bodylift; Complications; Massive weight loss; Quality of life; Qualité de vie.
Copyright © 2022 Elsevier Masson SAS. All rights reserved.
CloseEngineering Vascularized Composite Allografts Using Natural Scaffolds: A Systematic ReviewEngineering Vascularized Composite Allografts Using Natural Scaffolds: A Systematic Review
Engineering Vascularized Composite Allografts Using Natural Scaffolds: A Systematic Review
Elise Lupon, Alexandre G Lellouch, Aylin Acun, Alec R Andrews, Ruben Oganesyan, Marion Goutard, Corentin B Taveau, Laurent A Lantieri, Curtis L Cetrulo, Basak E Uygun
https://pubmed.ncbi.nlm.nih.gov/34238047/
Abstract
Vascularized composite allotransplantation (VCA) refers to the transplantation of multiple tissues as a functional unit from a deceased donor to a recipient with a severe injury. These grafts serve as potential replacements for traumatic tissue losses. The main problems are the consequences of the long immunosuppressive drugs and the lack of compatible donor. To avoid these limitations, decellularization/recellularization constitutes an attractive approach. The aim of decellularization/recellularization technology is to develop immunogenic free biological substitutes that will restore, maintain, or improve tissue and organ’s function. A PubMed search was performed for articles on decellularization and recellularization of composite tissue allografts between February and March 2021, with no restrictions in publication year. The selected reports were evaluated in terms of decellularization protocols, assessment of decellularized grafts, and evaluation of their biocompatibility and repopulation with cells both in vitro and in vivo. The search resulted in a total of 88 articles. Each article was reviewed, 77 were excluded, and the remaining 11 articles reported decellularization of 12 different vascular composite allografts in humans (4), large animals (3), and small animals (rodents; 5). The decellularization protocol for VCA varies slightly between studies, but majority of the reports employ 1% sodium dodecyl sulfate as the main reagent for decellularization. The immunological response of the decellularized scaffolds remain poorly evaluated. Few authors have been able to attempt the recellularization and transplantation of these scaffolds. Successful transplantation seems to require prior recellularization. Decellularization/recellularization is a promising, growing, and emerging developing research field in vascular composite allotransplantation. Impact statement Tissue engineering for vascular composite allotransplantation using decellularization and recellularization approach is a fast-growing area of interest in the reconstructive surgery field. This review will be a very useful tool to get a clear overview for researchers interested in this field.
Keywords: decellularization; recellularization; vascularized composite allotransplantation.
CloseJuvenile and tuberous breast hypertrophyJuvenile and tuberous breast hypertrophy
Juvenile and tuberous breast hypertrophy
J L Grolleau, E Lupon, S Gandolfi
https://pubmed.ncbi.nlm.nih.gov/35902286/
Abstract
Adolescence is defined as the period extending from puberty to adulthood, the limit of which is difficult to determine. It is a delicate period, in which the distancing from one’s own body image can have deleterious consequences on psychological development and social-emotional life. Breast hypertrophy and the correction of hypertrophic tuberous breasts in adolescents raise some questions that we will attempt to answer in this article. There are specificities to manage, in relation to surgical indications, resection volume, postoperative follow-up and cutaneous healing.
Keywords: Adolescence; Breast Hypertrophy; Hypertrophie mammaire; Juvenile breast; Sein; Sein tubéreux; Tuberous breast.
Copyright © 2022 Elsevier Masson SAS. All rights reserved.
CloseModified nanofat grafting: Stromal vascular fraction simple and efficient mechanical isolation technique and perspectives in clinical recellularization applicationsModified nanofat grafting: Stromal vascular fraction simple and efficient mechanical isolation technique and perspectives in clinical recellularization applications
Paul Girard, Joelle Dulong, Jerome Duisit, Camille Mocquard, Simon Le Gallou, Benoit Chaput, Elise Lupon, Eric Watier, Audrey Varin, Karin Tarte, Nicolas Bertheuil
https://pubmed.ncbi.nlm.nih.gov/36177178/
Abstract
Background: Nanofat grafting (NG) is a simple and cost-effective method of lipoaspirates with inter-syringe passages, to produce stromal vascular fraction (SVF) and isolate adipose-derived stem cells (ASCs). This represents a tremendous interest in the future clinical needs of tissue engineering. In this study, we optimized the NG technique to increase the yield of ASC extractions.
Methods: We analyzed three groups of SVF obtained by 20, 30, and 40 inter-syringe passages. The control group was an SVF obtained by enzymatic digestion with Celase. We studied their cell composition by flow cytometry, observed their architecture by confocal microscopy, and observed immunomodulatory properties of the ASCs from each of the SVFs by measuring inflammatory markers of macrophages obtained by an ASC monocyte co-culture. Results: We have established the first cell mapping of the stromal vascular fraction of adipose tissue. The results showed that SVF obtained by 20 inter-syringe passages contains more statistically significant total cells, more cells expressing the ASC phenotype, more endothelial cells, and produces more CFU-F than the SVF obtained by 30 and 40 passages and by enzymatic digestion. Confocal microscopy showed the presence of residual adipocytes in SVF obtained by inter-syringe passages but not by enzymatic digestion. The functional study indicates an orientation toward a more anti-inflammatory profile and homogenization of their immunomodulatory properties.
Conclusion: This study places mechanically dissociated SVF in the center of approaches to easily extract ASCs and a wide variety and number of other progenitor cells, immediately available in a clinical setting to provide both the amount and quality of cells required for decellularized tissues.
Keywords: SVF; adipose derived stem cells; adipose tissue; clinical applicability; immunomodulatory properties; mechanical isolation; nanofat; recellularization.
Copyright © 2022 Girard, Dulong, Duisit, Mocquard, Le Gallou, Chaput, Lupon, Watier, Varin, Tarte and Bertheuil.
CloseOutcomes and Reliability of Perforator Flaps in the Reconstruction of Hidradenitis Suppurativa Defects: A Systemic Review and Meta-AnalysisOutcomes and Reliability of Perforator Flaps in the Reconstruction of Hidradenitis Suppurativa Defects: A Systemic Review and Meta-Analysis
Camille Vaillant, Yanis Berkane, Elise Lupon, Michael Atlan, Pascal Rousseau, Alexandre G Lellouch, Jérôme Duisit, Nicolas Bertheuil
https://pubmed.ncbi.nlm.nih.gov/36233681/
Abstract
Introduction: Hidradenitis suppurativa (HS) is a common and debilitating disease, in which the only effective treatment involves a wide excision of the affected skin. Secondary wound healing and skin grafting are two well-known options for managing these defects, but perforator flaps provide a new therapeutic alternative by ensuring reconstructions of large defects, reducing donor site morbidity, and enhancing functional recovery. The aim of this study was to achieve a systematic review of perforator flaps use in HS.
Patients and methods: PubMed and Cochrane databases were searched from 1989 to 2021. The PRISMA statement was used in the study selection process and the review was registered on PROSPERO. Furthermore, patient characteristics, operative technique, complications, and recurrences were searched.
Results: Thirty-six articles were selected including 286 patients and 387 flaps. Axillary localization was mostly represented (83.2%). Direct donor site closure was achieved in 99.1% of cases. In total, 15.1% of the flaps presented at least one of the following complications: wound dehiscence (5.5%), partial necrosis (2.9%), hematoma or seroma (2.1%), infection (2.1%), venous congestion (1.8%), and nerve injury (0.3%). Two cases of total necrosis were recorded. Recurrence of the disease was observed in 2.7% of the defects.
Conclusions: Pedicled perforator flaps are a reliable and reproducible technique in the reconstruction of HS defects. They are associated with a low recurrence rate while ensuring an effective reconstruction with reduced morbidity and faster recovery compared to the techniques classically used in this indication.
Keywords: complications; hidradenitis suppurativa; island flap; perforator flap; propeller flap; recovery; recurrence; verneuil disease.
CloseSpotlight in Plastic Surgery: January 2022Spotlight in Plastic Surgery: January 2022
Spotlight in Plastic Surgery: January 2022
Brett T Phillips, Daniel Boczar, Carter J Boyd, Joseph M Escandón, Sameer H Halani, Efstathios Karamanos, Karen B Lu, Elise Lupon, Maciej J Mazurek, Amanda R Sergesketter, Harsh R Shah, Amiteshwar Singh, Arun K Gosain
CloseStent migration in the distal ulnar artery: A case reportStent migration in the distal ulnar artery: A case report
Stent migration in the distal ulnar artery: A case report
H Paoli, E Lupon, S Gandolfi, I Pluvy, D Feuvrier
https://pubmed.ncbi.nlm.nih.gov/35077909/
Abstract
Angioplasty has taken an important place in treating cardiovascular ischemic lesions, and stenting has become a widespread routine practice. Stent loss is a complication that, although rare, can result in stent migration into a vessel with dramatic complications due to occlusion. We report the case of a 77-year-old woman who underwent surgery to remove a loose stent that had migrated into the right distal ulnar artery just before the superficial palmar arch following coronary angioplasty. The stent could be removed with the help of fluoroscopy and microscope while preserving vascular integrity. Different therapeutic strategies can be discussed in front of a stent lost in the general circulation, and those must be approached on a case by case basis.
Keywords: Angioplasty complication; Arcade palmaire; Complication de l’angioplastie; Hand; Main; Microchirurgie; Microsurgery; Migration de stent; Palmar arch; Perte de stent; Stent lost; Stent migration.
Copyright © 2022. Published by Elsevier Masson SAS.
CloseSurgical management of slightly or non-displaced corporal scaphoid fractures by retrograde percutaneous screw fixation through the anterior trapezium horn: A single-center retrospective French study of 33 patients between January 2015 and January 2019Surgical management of slightly or non-displaced corporal scaphoid fractures by retrograde percutaneous screw fixation through the anterior trapezium horn: A single-center retrospective French study of 33 patients between January 2015 and January 2019
E Lupon, J B De Villeneuve Bargemon, Y Dalmas, S Gandolfi, B Chaput, O Camuzard, P Mansat, S Delclaux
https://pubmed.ncbi.nlm.nih.gov/36216645/
Abstract
Introduction: Percutaneous screw fixation has recently gained popularity as an alternative to conservative treatment to avoid prolonged immobilization. The placement of a screw in the central axis of the scaphoid has been shown to be biomechanically superior to its eccentricity. Still, it poses difficulties in performing percutaneous screw fixation via both palmar and dorsal approaches.
Objective: We describe a palmar percutaneous screwing of corporal fractures of the scaphoid by a simple palmar transtrapezial approach allowing an optimal centering of the screw.
Method: We selected patients operated on by the same surgeon using the palmar transtrapezial approach between January 2015 and January 2019 based on the coding used for these fractures and the operative reports. In addition, pre- and postoperative data were collected from the patient’s computer and paper records and by telephone contact with the patients.
Results: Thirty-three patients were included. Percutaneous screw fixation of the scaphoid was performed under locoregional anesthesia in the operating room with one arm in the supine position on the arm table. No hyper-extension of the wrist was performed. The Kirchner guidewire passed through the anterior horn of the trapezium and then into the trapezium-scaphoid joint. A screw replaced it after satisfactory centering in the axis of the scaphoid. Management took place on average within 12 days after the trauma. 75.8% were A2 fractures, according to Herbert’s classification. The average operating time was 16.63minutes, and in 91% of the cases, the patient was hospitalized for one day. The variation of the scapholunate angle on the preoperative profile radiographs with the angle defined by the axis of the scaphoid screw and the lunate postoperatively was on average 2.94°. One patient presented nonunion, and four showed an undersized screw with a screw overhang requiring revision surgery.
Conclusion: The transtrapezial approach to fixation of acute scaphoid fractures facilitates precise percutaneous screw placement in the central axis of the scaphoid. A study of long-term complications, including the degenerative impact on the scaphotrapezial joint, is needed to assess the safety of passage through the anterior horn of the trapezium.
Keywords: Corporal fracture; Fracture corporéale; Fracture scaphoïde; Percutaneous screw fixation; Retrograde screw fixation; Scaphoid; Scaphoid fracture; Scaphoïde; Transtrapezium; Transtrapézien; Vissage percutané; Vissage rétrograde.
Copyright © 2022 Elsevier Masson SAS. All rights reserved.
CloseTotal Denervation of the Elbow: Cadaveric Feasibility StudyTotal Denervation of the Elbow: Cadaveric Feasibility Study
Total Denervation of the Elbow: Cadaveric Feasibility Study
Pierre Laumonerie, Suzanne Robert, Meagan E Tibbo, Elise Lupon, Patrick Chaynes, Nicolas Bonnevialle, Pierre Mansat
https://pubmed.ncbi.nlm.nih.gov/34074568/
Abstract
Purpose: Total elbow arthroplasty for the treatment of patients with severe elbow osteoarthritis is associated with postoperative activity limitations and risk of midterm complications. Elbow denervation could be an attractive therapeutic option for young, active patients. The aim of our study was to assess the feasibility of selective total elbow denervation via 2 anteriorly based approaches.
Methods: Selective total elbow denervation was performed in 14 cadaver elbows by 2 fellowship-trained elbow surgeons. Lateral and medial approaches to the elbow were used. The length of skin incisions and the minimum distance between them were noted. The number of articular branches identified and their respective distances from the lateral or medial epicondyle of the humerus were recorded.
Results: The anterolateral and anteromedial approaches allowed for the identification of all mixed and sensory nerves in all 14 cases. The mean number of resultant articular branches per cadaver was 1 for the musculocutaneous nerve, 2 (range, 1-3) for the radial nerve, 1 (range, 1-3) for the posterior cutaneous nerve of the forearm, 2 (range, 1-3) for the ulnar nerve, and 2 (range, 1-3) for the medial antebrachial cutaneous nerve; the collateral ulnar nerve was connected directly to the capsule. The length of the medial and lateral incisions was 15 cm (range, 12-18 cm) and 12 cm (range, 10-16 cm), respectively. The mean minimum distance between the incisions was 7.5 cm (range, 6.7-8.5 cm).
Conclusions: The findings suggest that selective elbow denervation via 2 approaches is feasible.
Clinical relevance: Selective elbow denervation via 2 approaches is feasible. Surgeons should target the articular branches of the musculocutaneous, radial, ulnar, and collateral ulnar nerves, posterior cutaneous nerve of the forearm, as well as medial antebrachial cutaneous nerves when carrying out this procedure.
Keywords: Anatomy; denervation; elbow; microsurgery; nerve; osteoarthritis.
Copyright © 2022 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.
CloseTreatment of hyperpigmentation after burn: A literature reviewTreatment of hyperpigmentation after burn: A literature review
Treatment of hyperpigmentation after burn: A literature review
Elise Lupon, Jérôme Laloze, Benoit Chaput, Paul Girard, Curtis L Cetrulo, Laurent A Lantieri, Jean Louis Grolleau, Olivier Camuzard, Alexandre G Lellouch
https://pubmed.ncbi.nlm.nih.gov/35537921/
Abstract
Objectify: Skin pigmentation disorders are one of the most frequent sequelae after burn injury. While these conditions often improve over time, some are permanent and cause severe psychological disorders (especially on the face). Given the frequency of these disorders and their benign nature, the scientific community has great difficulty postponing these patient follow-ups. Publications on their management are rare, and there is no consensus on the gold standard treatment for skin dyschromia. Herein, we performed a literature review including the various treatments currently proposed to manage these hyperpigmentations.
Methods: All reported articles up to February 2021 were reviewed on Pubmed. Studies on the treatment of hyperpigmented scars were included if they were secondary to burn injuries. Excluded articles evaluated transient treatments, such as makeup, and articles on inflammatory hyperpigmentation without etiological details or not secondary to burns.
Results: 201 articles were identified, and 13 studies were included. Topical creams used in inflammatory hyperpigmented lesions such as hydroquinone and first-line retinoids are controversial due to their inconstant efficacy. Various types of laser and pulsed light treatments have shown their effectiveness but can also aggravate pigmentation.
Conclusion: Dyschromia after burn remains a therapeutic challenge. Hyperpigmentations after burn should be treated on a case-by-case basis, using data from the literature, clinical experience and measuring the risk/benefit ratio.
Keywords: Dyschromia; Hydroquinone; Hyperpigmentation; Post-burn sequelae; Skin burn.
Copyright © 2022. Published by Elsevier Ltd.
ClosePublications 2021 du Dr LUPON Élise
Augmentation mammaplasty by superolateral thoracic flap: a case reportAugmentation mammaplasty by superolateral thoracic flap: a case report
Augmentation mammaplasty by superolateral thoracic flap: a case report
Elise Lupon, Benoit Chaput, Thomas Meresse
https://pubmed.ncbi.nlm.nih.gov/34784968/
Abstract
Background: The lateral chest wall is intimately associated with the esthetics of the breast. Patients with massive weight loss often have excess skin and fat in the lateral thoracic region causing functional, esthetic, and psychological discomfort. In addition, the breasts exhibit extreme ptosis after weight loss due to a reduction in volume and projection that is exacerbated by qualitative changes in the skin, with loss of its natural elasticity. This article describes a reliable new technique for simultaneous autologous breast augmentation and lateral thoracic dermolipectomy to provide autologous tissue for breast augmentation and simultaneous rejuvenation of the chest wall.
Case presentation: A 30-year-old Caucasian woman who had lost 58 kg after bariatric surgery had major skin excess sequelae combined with major breast ptosis. She wanted to correct her brachial and lateral thoracic skin and fat excess, as well as rejuvenate her breasts. The lateral thoracic panicle present was harvested and transposed in the retroglandular plane to perform autologous breast augmentation with lateral thoracic dermolipectomy.
Results: The patient was totally healed and complication-free at day 15. Both esthetic results and patient satisfaction were good at 6 months post-surgery.
Conclusions: Superolateral thoracic flap augmentation mammaplasty during thoracic dermolipectomy is a simple and safe procedure for selected patients. Durable and natural autologous breast augmentation may be achieved in a single step without the need for a breast implant, while rejuvenating the thoracic region.
Keywords: Autologous breast augmentation; Bariatric surgery; Fat compartment; Lateral chest wall; Superolateral thoracic flap.
© 2021. The Author(s).
CloseComment on “The Impact of Microsurgery on the Treatment of Ring Avulsion Injuries ”Comment on “The Impact of Microsurgery on the Treatment of Ring Avulsion Injuries ”
Comment on “The Impact of Microsurgery on the Treatment of Ring Avulsion Injuries ”
Elise Lupon, Marion Goutard, Benoit Chaput, Jean Louis Grolleau, Curtis L Cetrulo Jr, Pierre Laumonerie, Alexandre Gaston Lellouch
CloseComplications after Ravitch versus Nuss repair of pectus excavatum: What if none of these techniques are the right one?Complications after Ravitch versus Nuss repair of pectus excavatum: What if none of these techniques are the right one?
Elise Lupon, Jérôme Laloze, Benoit Chaput, Jean-Louis Grolleau, Jean-Pierre Chavoin
CloseCorrection of Calf Atrophy With a Custom-Made Silicone Implant for Reconstruction: An UpdateCorrection of Calf Atrophy With a Custom-Made Silicone Implant for Reconstruction: An Update
Correction of Calf Atrophy With a Custom-Made Silicone Implant for Reconstruction: An Update
Elise Lupon, Benoit Chaput, Benjamin Moreno, Jean-Louis Grolleau, Jean-Pierre Chavoin
CloseLocal FK506 implants in non-human primates to prevent early acute rejection in vascularized composite allograftsLocal FK506 implants in non-human primates to prevent early acute rejection in vascularized composite allografts
Alexandre G Lellouch, Corentin B Taveau, Alec R Andrews, Joseph Molde, Zhi Yang Ng, Philipp Tratnig-Frankl, Ivy A Rosales, Marion Goutard, Elise Lupon, Laurent A Lantieri, Robert B Colvin, Mark A Randolph, Joachim Kohn, Curtis L Cetrulo Jr
https://pubmed.ncbi.nlm.nih.gov/34422982/
Abstract
Background: Previous vascularized composite allograft (VCA) studies from our laboratory have shown that topical FK506 delivery in non-human primates (NHPs) was limited by inadequate dermal penetration and rejection persisted. Herein, we report the first utilization of FK506 via subcutaneously implanted discs to mitigate VCA rejection in NHPs.
Methods: Full major histocompatibility complex (MHC)-mismatched NHP pairs underwent partial-face VCA and FK506 disc implantation along the suture line. All allotransplants were maintained post-operatively for two months on the FK506 discs, methylprednisolone, mycophenolate mofetil, and supplemented with intramuscular FK506 if necessary. Group 1 (n=4) was used for optimization of the implant, while Group 2 (n=3) underwent delayed bone marrow transplantation (DBMT) after two months. VCA skin biopsies and peripheral blood samples were obtained for serial assessment of rejection and mixed chimerism by histopathology and flow cytometry respectively.
Results: In Group 1, two technical failures occurred. Of the remaining two NHPs, one developed supratherapeutic levels of FK506 (50-120 ng/mL) and had to be euthanized on postoperative day (POD) 12. Reformulation of the implant resulted in stable FK506 levels (20-30 ng/mL) up to POD12 when further intramuscular (IM) FK506 injections were necessitated. In Group 2, two NHPs survived to undergo conditioning and one successfully developed chimerism at 2-3 weeks post-DBMT (96-97% granulocytes and 7-11% lymphocytes of recipient-origin). However, all three NHPs had to be terminated from study at POD64, 77 and 86 due to underlying post-transplant lymphoproliferative disorder. All VCAs remained rejection-free up to study endpoint otherwise.
Conclusions: This study shows preliminary results of local FK506 implants in potentially mitigating VCA acute rejection for tolerance protocols based on mixed chimerism approach.
Keywords: Immunosuppression; tacrolimus; vascularized composite allograft (VCA).
2021 Annals of Translational Medicine. All rights reserved.
CloseMeasured Level of Human Adipose Tissue-Derived Stem Cells in Adipose Tissue is Strongly Dependent on Harvesting Method and Stem Cell Isolation TechniqueMeasured Level of Human Adipose Tissue-Derived Stem Cells in Adipose Tissue is Strongly Dependent on Harvesting Method and Stem Cell Isolation Technique
Jérôme Laloze, Elise Lupon, Julie Usseglio, Paul Girard, Alexis Desmoulière, Loïc Fiévet
ClosePartial Heterotopic Hindlimb Transplantation Model in RatsPartial Heterotopic Hindlimb Transplantation Model in Rats
Partial Heterotopic Hindlimb Transplantation Model in Rats
Marion Goutard, Mark A Randolph, Corentin B Taveau, Elise Lupon, Laurent Lantieri, Korkut Uygun, Curtis L Cetrulo Jr, Alexandre G Lellouch
https://pubmed.ncbi.nlm.nih.gov/34180905/
Abstract
Vascularized composite allotransplantations (VCA) represent the most advanced reconstruction option for patients without autologous surgical possibilities after a complex tissue defect. Face and hand transplantations have changed disfigured patients’ lives, giving them a new aesthetic and functional social organ. Despite promising outcomes, VCA is still underperformed due to life-long immunosuppression comorbidities and infectious complications. The rat is an ideal animal model for in vivo studies investigating immunological pathways and graft rejection mechanisms. Rats are also widely used in novel composite tissue graft preservation techniques, including perfusion and cryopreservation studies. Models used for VCA in rats must be reproducible, reliable, and efficient with low postoperative morbidity and mortality. Heterotopic limb transplantation procedures fulfill these criteria and are easier to perform than orthotopic limb transplants. Mastering rodent microsurgical models requires solid experience in microsurgery and animal care. Herein is reported a reliable and reproducible model of partial heterotopic osteomyocutaneous flap transplantation in rats, the postoperative outcomes, and the means of prevention of potential complications.
CloseSupplementation with Extracellular Vesicles Derived from Adipose-Derived Stem Cells Increases Fat Graft Survival and Browning in Mice: A Cell-Free Approach to Construct Beige Fat from White Fat GraftingSupplementation with Extracellular Vesicles Derived from Adipose-Derived Stem Cells Increases Fat Graft Survival and Browning in Mice: A Cell-Free Approach to Construct Beige Fat from White Fat Grafting
Jérôme Laloze, Elise Lupon, Paul Girard, Silvia Gandolfi, Loïc Fiévet, Alexis Desmoulière
CloseSurgery, the neglected child of the world's health systemsSurgery, the neglected child of the world's health systems
CloseThe Perception of Plastic Surgery by Community-Based, Private Practice Nurses: A French National Descriptive StudyThe Perception of Plastic Surgery by Community-Based, Private Practice Nurses: A French National Descriptive Study
Elise Lupon, Paul Girard, Amélie Lupon, Loriane Jacques, Ludivine Jung, Zhi Yang Ng, Laurent Alexandre Lantieri, Jérôme Laloze, Alexandre Gaston Lellouch
https://pubmed.ncbi.nlm.nih.gov/33626557/
Abstract
Plastic surgery is a dynamic field but remains poorly understood by general practitioners, medical students, health professionals, and the public. The main health care professionals in the community who are involved in the follow-up of plastic surgery patients are nurses; they help to facilitate wound healing and rehabilitation in the postoperative period. In this study, the authors assessed the medical knowledge and perceptions of plastic surgery by nurses working in the community setting and explored their understanding of classical scenarios commonly encountered in reconstructive surgery. An online survey was designed to assess the demographics of nurses working in the community in France and their knowledge of plastic surgery. This was disseminated to all practicing nurses working outside of hospitals by means of an online social network from the period of April 2019 to June 2019. The survey was completed by 318 nurses. Specific training in plastic surgical nursing will be required to optimize the management of these patients following discharge from hospital. This gap in knowledge may affect patient recovery negatively.
Copyright © 2021 International Society of Plastic and Aesthetic Nurses. All rights reserved.
CloseVascularized Composite Allotransplantation in a Post-COVID-19 Pandemic WorldVascularized Composite Allotransplantation in a Post-COVID-19 Pandemic World
Vascularized Composite Allotransplantation in a Post-COVID-19 Pandemic World
Elise Lupon, Curtis L Cetrulo Jr, Laurent A Lantieri, Alexandre G Lellouch
ClosePublications 2020 du Dr LUPON Élise
BCGitis of the wrist after intravesical BCG therapy: A case reportBCGitis of the wrist after intravesical BCG therapy: A case report
BCGitis of the wrist after intravesical BCG therapy: A case report
E Lupon, G Martin-Blondel, T Pollon, C Berthier, A G Lellouch, P Mansat
https://pubmed.ncbi.nlm.nih.gov/32659383/
Abstract
Septic arthritis of the wrist can result in joint destruction, making timely diagnosis crucial for initiating empiric antibiotics and surgical intervention. Mycobacterium is a rare cause of this disorder. A 47-year-old man with bladder cancer was treated surgically and received BCG intravesical therapy. Eleven months later, this patient developed severe carpal BCGitis requiring total carpal resection. The first step was addition of a cement spacer and radiometacarpal stabilisation (Masquelet technique). Secondary infections occurred aggravating the prognosis. This case emphasises the importance of taking into account the patient’s medical history. Tuberculosis of the wrist is a rare etiology for septic arthritis; delayed treatment leads to severe complications and functional sequelae.
Keywords: BCGite; BCGitis; Carpectomie; Carpectomy; Infection du poignet; Osteoarthritis of the wrist; Ostéite du poignet; Ostéoarthrite du poignet; Ostéomyélite du poignet; Tuberculose; Tuberculosis; Wrist infection; Wrist osteitis; Wrist osteomyelitis.
Copyright © 2020 SFCM. Published by Elsevier Masson SAS. All rights reserved.
CloseCombating hypoxemia in COVID-19 patients with a natural oxygen carrier, HEMO2Life® (M101)Combating hypoxemia in COVID-19 patients with a natural oxygen carrier, HEMO2Life® (M101)
Combating hypoxemia in COVID-19 patients with a natural oxygen carrier, HEMO2Life® (M101)
Elise Lupon, Alexandre G Lellouch, Franck Zal, Curtis L Cetrulo Jr, Laurent A Lantieri
https://pubmed.ncbi.nlm.nih.gov/33308935/
Abstract
Background: Infection with SARS-CoV-2 is responsible for the COVID-19 crisis affecting the whole world. This virus can provoke acute respiratory distress syndrome (ARDS) leading to overcrowed the intensive care unit (ICU). Over the last months, worldwide experience demonstrated that the ARDS in COVID-19 patients are in many ways « atypical ». The mortality rate in ventilated patients is high despite the application of the gold standard treatment (protective ventilation, curare, prone position, inhaled NO). Several studies suggested that the SARS-CoV-2 could interact negatively on red blood cell homeostasis. Furthermore, SarsCov2 creates Reactive Oxygen Species (ROS), which are toxic and generate endothelial dysfunction. Hypothesis/objective(s) We hypothesis that HEMO2Life® administrated intravenously is safe and could help symptomatically the patient condition. It would increase arterial oxygen content despite lung failure and allow better tissue oxygenation control. The use of HEMO2Life® is also interesting due to its anti-oxidative effect preventing cytokine storm induced by the SARS-CoV-2. Evaluation of the hypothesis: Hemarina is based on the properties of the hemoglobin of the Arenicola marina sea-worm (HEMO2Life®). This extracellular hemoglobin has an oxygen capacity 40 times greater than the hemoglobin of vertebrates. Furthermore, the size of this molecule is 250 times smaller than a human red blood cell, allowing it to diffuse in all areas of the microcirculation, without diffusing outside the vascular sector. It possesses an antioxidative property du a Superoxide Dismutase Activity. This technology has been the subject of numerous publications and HEMO2Life® was found to be well-tolerated and did not induce toxicity. It was administered intravenously to hamsters and rats, and showed no acute effect on heart rate and blood pressure and did not cause microvascular vasoconstriction. In preclinical in vivo models (mice, rats, and dogs), HEMO2Life® has enabled better tissue oxygenation, especially in the brain. This molecule has already been used in humans in organ preservation solutions and the patients showed no abnormal clinical signs.
Consequences of the hypothesis: The expected benefits of HEMO2Life® for COVID-19 patients are improved survival, avoidance of tracheal intubation, shorter oxygen supplementation, and the possibility of treating a larger number of patients as molecular respirator without to use an invasive machine.
Keywords: COVID-19; HEMO2Life; Hypoxemia; M101; Oxygen Carrier; SARS-CoV-2.
Copyright © 2020 Elsevier Ltd. All rights reserved.
CloseComments on ``Combined Non-Ablative Laser and Microfat Grafting for Burn Scar Treatment``Comments on ``Combined Non-Ablative Laser and Microfat Grafting for Burn Scar Treatment``
Comments on « Combined Non-Ablative Laser and Microfat Grafting for Burn Scar Treatment »
Elise Lupon, Jérôme Laloze, Jean Louis Grolleau, Laurent Alexandre Lantieri, Alexandre Gaston Lellouch
CloseComment on ``First Russian Experience of Composite Facial Tissue Allotransplantation``Comment on ``First Russian Experience of Composite Facial Tissue Allotransplantation``
Comment on « First Russian Experience of Composite Facial Tissue Allotransplantation »
Elise Lupon, Curtis L Cetrulo Jr, Marion Goutard, Corentin B Taveau, Jean-Louis Grolleau, Laurent A Lantieri, Alexandre G Lellouch
CloseCorrecting of Calf Atrophy With a Custom-Made Silicone Implant: Contribution of Three-Dimensional Computer-Aided Design Reconstruction: A Pilot StudyCorrecting of Calf Atrophy With a Custom-Made Silicone Implant: Contribution of Three-Dimensional Computer-Aided Design Reconstruction: A Pilot Study
Jean-Pierre Chavoin, Elise Lupon, Benjamin Moreno, Pierre Leyx, Jean-Louis Grolleau, Benoit Chaput
https://pubmed.ncbi.nlm.nih.gov/32593168/
Abstract
Background: Calf shape is an essential aesthetic parameter of the leg, and calf atrophy can lead to complex problems. The functional consequences of calf atrophy are generally moderate. Prefilled silicone gel implants represent the vast majority of currently placed prostheses, but this technique does not ensure optimal adaptation of the implant shape due to loss of volume.
Objectives: The aim of this study was to describe an innovative procedure for correcting acquired calf atrophy based on 3-dimensional (3D) modeling.
Methods: The study involved 22 patients treated for calf atrophy caused by illness. Implants were made with solid rubber silicone, and 3D reconstructions were created by computer-aided design based on computed tomography scans. The implants were introduced through a horizontal popliteal incision.
Results: Forty-one implants were placed. No cases of infection, hematoma, or compartment syndrome were encountered. We experienced 1 case of skin necrosis and 1 case of periprosthetic seroma. In addition, lipofilling was performed in 5 cases. Two patients sought to benefit from a surgical reduction in implant size.
Conclusions: Our innovative procedure to correct calf atrophy with custom solid rubber silicone implants produces a calf shape that better adapts to volume loss than prefilled silicone gel implants. The material maintains its shape and facilitates retrofitting of the prosthesis. There is no risk of hull formation or breakage, and the life span of the implants is limitless. This 3D computer-aided design approach has optimized our reconstructions.
© 2020 The Aesthetic Society. Reprints and permission: journals.permissions@oup.com.
CloseElbow flexion reconstruction after arm-sparing excision for high-grade triton sarcoma: a case reportElbow flexion reconstruction after arm-sparing excision for high-grade triton sarcoma: a case report
Elbow flexion reconstruction after arm-sparing excision for high-grade triton sarcoma: a case report
Elise Lupon, Christine Chevreau, Alexandre Gaston Lellouch, Dimitry Gangloff, Thomas Meresse
https://pubmed.ncbi.nlm.nih.gov/32620140/
Abstract
Background: Soft tissue sarcomas affecting the root of an upper extremity raise the question of limb amputation depending on their location, size, and malignancy. Malignant triton tumors are a rare subtype of neurofibrosarcomas that have been poorly reported in the literature. We report the case of a challenging reconstruction of the upper extremity using a pedicled latissimus dorsal flap.
Case presentation: A 25-year-old Occidental man was referred to our sarcoma unit for the management of a large, high-grade malignant peripheral nerve sheath tumor with no regional or distant extension and very fast progression. He was treated first by concomitant neoadjuvant radiotherapy and chemotherapy. Carcinologic excision was performed « en bloc » including the skin, the tumor, and the flexor muscles of our patient’s elbow. Coverage of the skin defect and elbow flexion restoration were achieved by using a homolateral pedicled musculocutaneous latissimus dorsi flap. Histological analysis showed an R0 resection. The reconstruction process recovered a complete bending of his elbow. He is still in remission at 26 months follow-up.
Conclusions: A malignant triton tumor is a rare, aggressive, and high-grade sarcoma. It was successfully treated and this case report describes an effective treatment modality. Reconstructive surgery, allowing large, complete tumor removal, is indispensable after neoadjuvant chemotherapy and radiotherapy.
Keywords: Malignant peripheral nerve sheath tumor; Malignant triton tumor; Neurofibrosarcoma; Rhabdomyoblastic differentiation.
CloseMuscle-Derived Stem Cell-Enriched Scaffolds Are Capable of Enhanced Healing of a Murine Volumetric Muscle Loss DefectMuscle-Derived Stem Cell-Enriched Scaffolds Are Capable of Enhanced Healing of a Murine Volumetric Muscle Loss Defect
Jérôme Laloze, Benoit Chaput, Elise Lupon, Audrey Varin, Charlotte Vaysse, Charline Berthier
https://pubmed.ncbi.nlm.nih.gov/31834231/
CloseProspective study of 80 volar wounds of the hand and wrist: Correlations between clinical examination and intraoperative findingsProspective study of 80 volar wounds of the hand and wrist: Correlations between clinical examination and intraoperative findings
T Baron-Trocellier, M Rongières, O Mericq, E Lupon, P Mansat
https://pubmed.ncbi.nlm.nih.gov/32376508/
Abstract
Hand and wrist volar wounds are a common cause of emergency room (ER) visits. These wounds are explored surgically in the operating room at most hospitals. The main objective of our study was to prospectively assess the correlation between clinical examination in the ER performed by a surgical resident and the tendon, vascular and/or nerve damage found during surgery in hand and wrist volar wounds. The second objective was to describe the lesions based on their mechanism, as well as their topography. Eighty patients from two hand surgery referral centers were included. Patients’ past medical history was obtained, as well as records of their physical examination in the ER and description of lesions found during surgery. In 28% of wounds with a normal clinical examination, tendon, vascular or nerve damage was found on surgical exploration. Out of the cases that tested negative for tendon injury in the ER, 16% had partial tendon injury or digital tunnel wound discovered during surgery. Nerve damage was found during surgery in 12% of cases that had not been detected clinically preoperatively. Based on our findings, we recommend performing surgical exploration for all volar hand and wrist wounds in the operating room, as physical examination does not detect all tendons, vascular or nerve injuries.
Keywords: Clinical examination; Examen clinique; Hand lacerations; Pedicles; Plaies de main; Pédicules; Tendon.
Copyright © 2020 SFCM. Published by Elsevier Masson SAS. All rights reserved.
CloseSurgical treatment of a digital metastasis of a large cell lung neuroendocrine carcinoma: A rare secondary anatomical localizationSurgical treatment of a digital metastasis of a large cell lung neuroendocrine carcinoma: A rare secondary anatomical localization
CloseThe perception of plastic surgery by physiotherapists: a French national descriptive studyThe perception of plastic surgery by physiotherapists: a French national descriptive study
The perception of plastic surgery by physiotherapists: a French national descriptive study
Elise Lupon, Arthur Bedet, Paul Girard, Jerome Laloze, Jean L Grolleau, Laurent Lantieri, Alexandre G Lellouch
https://pubmed.ncbi.nlm.nih.gov/32309331/
Abstract
Background: Plastic surgery is a transversal discipline that many people misunderstand, including general practitioners, medical students, paramedics and the public. Plastic surgeons often collaborate with physiotherapists for post-acute care and rehabilitation. They ensure optimal post-operative recovery of the patient. Herein, the authors assessed the medical knowledge and perceptions of plastic surgery by physiotherapists working outside health centers and explored their attitudes towards classic reconstructive surgery scenarios.
Methods: To assess physiotherapists’ medical knowledge and perceptions of plastic surgery, the authors conducted an online questionnaire survey. A total of 1,262 physiotherapists responded.
Results: The physiotherapists confirmed the suspected lack of knowledge regarding the plastic surgery field. Although they were generally aware that plastic surgeons perform cosmetic procedures and treat burns, they were largely unaware that plastic surgeons perform hand surgeries and microsurgical operations. More than 70% of them stated that they did not have the necessary knowledge to properly manage patients in this specialty. This lack of knowledge can sometimes have a negative impact on patients’ recovery, particularly for fear of making a mistake.
Conclusions: Physiotherapists, outside the hospital, have an incomplete conception of plastic surgery. They would need a specific plastic surgery training in order to manage these patients in an optimal way.
Keywords: Physiotherapists; perception; plastic surgery; rehabilitation; surgical physiotherapy.
2020 Annals of Translational Medicine. All rights reserved.
CloseWant to Regain Motivation? Five Essential Publications You Should ReadWant to Regain Motivation? Five Essential Publications You Should Read
ClosePublications 2019 du Dr LUPON Élise
Comments on: An Open, Prospective Study to Evaluate the Effectiveness and Safety of Hyaluronic Acid for Pectus Excavatum TreatmentComments on: An Open, Prospective Study to Evaluate the Effectiveness and Safety of Hyaluronic Acid for Pectus Excavatum Treatment
Jean Pierre Chavoin, Elise Lupon, Benoit Chaput, Jean Louis Grolleau
CloseHirschsprung disease in an adult with intestinal malrotation and volvulus: an exceptional associationHirschsprung disease in an adult with intestinal malrotation and volvulus: an exceptional association
Elise Lupon, François Labbe, Emile Nini, Sixte Sondji
https://pubmed.ncbi.nlm.nih.gov/31030669/
Abstract
Background: Hirschsprung disease is a neonatal discovery in almost all cases, and the association of Hirschsprung disease in adults with symptomatic intestinal malrotation is unusual. This combination delays diagnosis and can lead to mistake in surgical strategy.
Case presentation: A 43-year-old patient with a history of colectomy for colonic inertia and megadolichocolon was admitted to the Carcassonne Hospital emergency room for a volvulus of small bowel obstruction in a chronic intestinal obstruction context with episodes of acute, variable-looking occlusive syndromes. Intestinal malrotation was discovered during surgical small bowel detorsion. The acute occlusion syndrome recurred after the procedure. In view of the unfavorable evolution, an emptying of the dilated small bowel and a discharge ileostomy upstream of the rectum were performed. In the face of postoperative improvement, rectal manometry and deep full parietal rectal biopsies made it possible to highlight the diagnosis of Hirschsprung disease. The patient thus had functional acute occlusive syndromes and chronic occlusion due to Hirschsprung disease of attenuated form and acute organic occlusive syndromes related to her incomplete common mesentery.
Conclusions: This rare association, which may be responsible for delayed diagnostic and therapeutic wandering, highlights the importance of performing manometry and deep full parietal biopsies before a colectomy for colonic inertia, as well as the possibility of suggesting a common Hirschsprung disease and/or mesentery in an adult with multiple occlusive syndromes of variable appearance.
Keywords: Adult Hirschsprung disease; Chronic occlusion; Constipation; Malrotation intestinal; Multiple occlusive syndrome; Small bowel volvulus.
CloseInternes en médecine et cicatrisation des plaies : une étude descriptive multicentrique entre Février et Avril 2018Internes en médecine et cicatrisation des plaies : une étude descriptive multicentrique entre Février et Avril 2018
E Lupon, U Turrian, J Malloizel-Delaunay, A Bura-Rivière, J L Grolleau
https://pubmed.ncbi.nlm.nih.gov/31474342/
Abstract
Objectives: Around 2.5 million wounds are recorded in France, representing, in terms of cost and quality of life, a real problem of public health issue. In France, residents are among the first line personnel having to manage wounds and their complications: this study is carried out to identify the view and feelings of residents concerning their preparation and training in this field.
Materials and methods: A questionnaire was distributed to residents throughout France. Residents’ characteristics, interests and training in wound healing, training courses and opinions concerning their training were recorded.
Results: Seven hundred and eleven French residents answered the questionnaire, the majority of whom (79 %) had not experienced training in wound healing. The majority of residents (69 %) believe that all physicians are concerned. Training in wound management and wound healing is considered insufficient (94 %) and most (79 %) had never received any training in wound management and wound healing. Ninety-eight percent stated they needed additional training courses in wound management.
Conclusions: Wound management and healing is a topic of interest to residents. Residents need more training in wound management in their curriculum to improve their practice.
Keywords: Cicatrisation; Dressing; Etudes médicales; Healing; Internes; Medical studies; Pansement; Plaie; Residents; Wound.
Copyright © 2019 Elsevier Masson SAS. All rights reserved.
CloseReconstruction of a dorsal thoracic wall defect by the intercostal artery perforator flap after removal of a bulky cutaneaous squamous cell carcinomaReconstruction of a dorsal thoracic wall defect by the intercostal artery perforator flap after removal of a bulky cutaneaous squamous cell carcinoma
E Lupon, A G Lellouch, F Deilhes, B Chaput, C Berthier
https://pubmed.ncbi.nlm.nih.gov/31526388/
Abstract
Introduction: Surgical reconstruction of large soft tissue defects of the upper back is challenging. Although the usefulness of free perforator flaps has been demonstrated, local options remain limited. The dorsal intercostal artery perforator flap was recently described but its use is still uncommon.
Case report: An 88-year-old Causasian woman presented with a large, ulcerated, left prescapular cutaneous squamous cell carcinoma (T3N0M0). Complete excision was performed, and the resulting defect was reconstructed with a dorsal intercostal artery perforator flap based on two perforators. Postoperative recovery was uncomplicated and adjuvant radiotherapy commenced 10 weeks later.
Conclusion: Compared to conventional muscle flaps, the dorsal intercostal artery perforator flap offers greater protection of muscle function, is less invasive, and lowers donor site morbidity. Based on these advantages, this flap should be considered a useful local option for reconstructing large cutaneous defects of the upper back.
Keywords: Carcinoma; Perforator flap; Squamous cell; Surgical flaps.
CloseThe palatal mucosal graft: The adequate posterior lamellar reconstruction in extensive full-thickness eyelid defectsThe palatal mucosal graft: The adequate posterior lamellar reconstruction in extensive full-thickness eyelid defects
S Hendriks, C Bruant-Rodier, E Lupon, S Zink, F Bodin, C Dissaux
https://pubmed.ncbi.nlm.nih.gov/30795932/
Abstract
Introduction: Full-thickness eyelid defects exceeding 25% of the eyelid width should benefit from a skillful, immediate and simultaneous reconstruction of two layers; anterior and posterior lamella. In this article, we recall, through an original series of cases, the possibility of using a palatal fibromucosal graft during the reconstruction of the posterior lamella as well as the modalities of its optimal use.
Patients and methods: Retrospective study, including 8 patients with an extensive full-thickness eyelid defect affecting more than half of the upper and/or lower eyelid, after tumor excisions. 4 cases were involved in lower eyelid reconstruction, 2 in upper one and 2 in both. Posterior lamella was reconstructed using a palatal mucosal graft. Anterior lamella was reconstructed using different flaps: Esser-Mustardé flap, medially and laterally based orbicularis oculi myocutaneous flap, Tripier and orbitonasolabial flaps. Mean follow-up was 12.75 months.
Results: The survival rate of grafts and flaps was excellent with only one flap border necrosis. The donor site healed in an average time of 3 weeks. Functional recovery, complete eye closure and opening, was obtained in all cases. Lining, texture and color was considered satisfactory in all cases.
Conclusion: The palatal mucosal graft provides a good and lasting structural support to the eyelid, which is essential for the inferior eyelid, especially when combined with a flap. Slight overcorrection is recommended.
Keywords: Eyelid reconstruction; Full-thickness eyelid reconstruction; Greffe fibromuqueuse; Greffe palatine; Lambeau musculocutané palpébral supérieur; Mucosal graft; Orbicularis myocutaneous flap; Palatal graft; Reconstruction de paupières; Reconstruction des paupières pleine épaisseur.
Copyright © 2019 Elsevier Masson SAS. All rights reserved.
ClosePublications 2018 du Dr LUPON Élise
Surgical antegrade transcatheter valve implantation and heavily calcified heartSurgical antegrade transcatheter valve implantation and heavily calcified heart
Surgical antegrade transcatheter valve implantation and heavily calcified heart
Elise Lupon, Anais Lemaire, Christophe Cron, Bertrand Marcheix
https://doi.org/10.1177/0218492318783306
Abstract
It is well known that a heavily calcified mitral valve significantly increases the perioperative and postoperative risks of mitral valve surgery. A 71-year-old woman was referred to our department with severe mitral valve disease. Cardiac imaging revealed extremely severe calcification of the entire left heart. Surgery was performed through a median sternotomy with standard cardiopulmonary bypass. After dilating the mitral orifice with a balloon, we replaced the valve with a transcatheter Edwards Sapiens 3 aortic valve under direct vision. Seven months after the procedure, the patient was doing well and no longer suffered from dyspnea.
Keywords: Calcinosis; Coronary artery bypass; Heart valve prosthesis implantation; Mitral valve insufficiency; Mitral valve stenosis.
Close- E. Lupon, AG. Lellouch, M. Goutard, C.L.Cetrulo. Chapitre de livre intitulé « Decellularization and Recellularization of Composite Tissue Allografts” Book: « Two Decades of Experience in Clinical Reconstructive Transplantation – Lessons Learned” Taylor and Francis Special Edition: Reconstructive Transplantation and Regenerative Medicine – The Emerging Interface. 2020.
- E. Lupon, J. Saboye, JL. Grolleau, B. Chaput. “Chirurgie esthétique des paupières”. EMC (Encyclopédie Médico-Chirurgicale Elsevier Masson).(EMC Chirurgie Plastique et EMC Chirurgie Maxillo-faciale). http://dx.doi.org/10.1016/S1286-9325(20)85633-7
- E. Lupon, AG. Lellouch, P.Girard, P. Mansat, JL. Grolleau, J. Laloze, S. Riot. Total thumb reconstruction by an original groin Pocket Flap-Graft design. Journal of Clinical Images & Medical Case reports http://jcimcr.org/articles.php. ISSN 2766-7820. Mars 2021.
- Alexandre Bourcier, Anudari Zorigtbaatar, Elise Lupon, Daniel S. Nteranya, Arsène D. Nyalundja, Jean W. Lartigue, David Masheka, Ulrick S. Kanmounye. Qu’est-ce la chirurgie globale en 2020 ? Pan African Medical Journal Clinical Medicine. DOI: 10.11604/pamj-cm.2020.3.172.24474
Publications sans comité de lecture
- Alexandre G. Lellouch, Corentin Taveau, Alec R. Andrews, Marion Goutard, Philipp Tratnig-Frankl, Elise Lupon, Joseph Molde, Zhi Yang Ng, Mark A. Randolph, Joachim Kohn, Curtis L. Cetrulo. Local delivery of FK506 to prevent VCA early acute rejection in a delayed mixed chimerism protocol. Transplantation. DOI: 10.1097/01.tp.0000702016.20235.b7.
- Philipp Tratnig-Frankl, Alec R. Andrews, Corentin Taveau, Alexandre G. Lellouch, Michael M. Jonczyk, Marion Goutard, Elise Lupon, Joseph Molde, Zhi Yang Ng, Mark A. Randolph, Michael L. Morrison, Mark B. Roth, Curtis L. Cetrulo. The impact of oxygen free radical scavenger on acute rejection in a histocompatible miniature swine model. Transplantation. DOI: 10.1097/01.tp.0000699276.73135.b0.
- E. Lupon, A. Acun, Corentin Taveau, Alexandre G. Lellouch, Marion Goutard, Elise Lupon, L. Lantieri, Curtis L. Cetrulo, B.Uygun. VCA. Decellularization Protocol for porcine Fasciocutaneaous flap: An update. The American Society for Reconstructive Transplantation. DOI:10.17.7/20503121103534
- E. Lupon, A. Acun, R. Oganesyan, AG. Lellouch, C. Taveau, Marion Goutard, B. Uygun, Curtis L. Cetrulo. Decellularization of vascularized engineered scaffolds for face and ear reconstruction. VCA – The American Society for Reconstructive Transplantation. DOI:10.17.7/20503121103534
Chapitre / Livre
- Chronique dans le journal PRS et Plastic Surgery Resident Magazine :
* E.Lupon. Covid-19: A great Opportunity to Improve Our Surgical Residency Training. PRS.
* E.Lupon. COVID-19 and plastic surgery residency training: A French experience. Plastic Surgery Resident Magazine. Winter 2020.
https://imirus.com/tmp/13491/19121/-1/pm13491.pdf
* E.Lupon. Time Management. Plastic Surgery Resident Magazine. Spring 2021. https://view.imirus.com/1006/document/13537/page/12
Abstracts publiés
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- E. Lupon, D. Gangloff, T.Meresse. Couverture et reconstruction de la flexion du coude par un lambeau de grand dorsal après exérèse d’un volumineux sarcome du bras dominant. SFCO Montpellier. (vidéo disponible sur « Oncostream »). 16 Mai 2019.
- E.Lupon. « Mon master 2 en 180 secondes ». SFCO Montpellier. 16 Mai 2019.
- E. Lupon, B. Chaput, JL.Grolleau, LA. Lantieri, AG Lellouch. Traitement permanent des dyschromies cutanées post brûlures. Société Française de Brûlologie- Cap d’agde. 6 Juin 2019.
- P. Girard, E. Lupon, J. Laloze, E. Watier, J. Duisit, B. Chaput, N. Bertheuil. Technique de couverture de perte de substance péri vulvaire par lambeau perforant de type IGAP (Inferior Gluteal Artery Perforator), Videocorner SOFCPRE 2019, Paris, 21 Novembre 2019.
- Berthier C, Lupon E, Gangloff D, Meresse T. Lambeau musculocutané de grand dorsal pédiculé dans la chirurgie du sarcome, Vidéocorner SOFCPRE 2019, Paris, 22 Novembre 2019
- E. Lupon. Vascularized Composite Allotransplantation. Decellularization/Revascularization project. Science Slam. Massachusetts General Hospital Research Institute. Boston, 14 Janvier 2020.
- Elise Lupon, Aylin Acun, Marion Goutard, Ruben Oganesyan, Alexandre Lellouch, Laurent Lantieri, Jean louis Grolleau, Basak Uygun, Curtis Cetrulo Decellularization of vascularized engineered scaffolds for facial reconstruction. Virtual Plastic Surgery (the meeting). 89th Annual meeting. Présenté le 16 Octobre 2020 (5 minutes).
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Activité éditoriale
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- Associate Editor on the Editorial Board of Plastic and Reconstructive Surgery – Janvier 2025 (journal international #1 en chirurgie plastique et réparatrice)
- Membre du PRS & PRS Global open Resident Advisory Board 2020 – 2024
- Peer review PRS & PRSGlobal Open (voir Web of Science ID ABA-5705-2020) >130 peer-review
- Guest Editor Jove “Protocols for Graft Procurement: Preservation, Organ Engineering, and Educational Training” (8 articles de pédagogie chirurgicale publiés en collaboration avec le laboratoire d’anatomie de Nice dans cette collection)
- Relecture nationale de l’Outil pour la pratique des médecins généralistes sur les mélanomes cutanés / Institut Nationale du Cancer (2024)
- Reviewer occasionnel pour Frontiers, Hand Surgery & Rehabilitation Journal, Annales de chirurgie plastique depuis 2021
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Sociétés savantes
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- Membre élu au VCA board de l’European Society for Organ transplantation (ESOT) 2026/2027.
- Membre de la société internationale de microchirurgie « The World Society of reconstructive Microsurgery » depuis 2024
- Secrétaire (élue) du chapitre « Main et microchirurgie » de la Société Française de chirurgie plastique, reconstructrice et Esthétique (SOFCPRE) depuis 2025
- Membre élu du chapitre « Recherche, Idées & Innovations » de la SOFCPRE depuis 2025
- Membre élu du chapitre « Oncologie » de la SOFCPRE depuis 2025
- Membre du comité d’administration de la Société Francophone de chirurgie Oncologique (SFCO) depuis 2020
- Membre du comité scientifique du congrès de la SFCO depuis 2022
- Membre de l’ASPS (American Society of Plastic Surgeon), ID 166840 depuis 2020, élue International membership en 2026
- Présidente de l’Association Jeune Chirurgiens Oncologues (AJCO) de Octobre 2020 à Mai 2024
- Référente chirurgie plastique de l’AJCO – (Association Jeunes Chirurgiens Oncologues), depuis Mai 2019.
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Enseignement
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Diplôme universitaire (DU) et inter-universitaire (DIU)
- Enseignement au DIU des lambeaux perforants depuis 2023 (3*3 jours de cours annuellement)
- Membre enseignant / Modératrice auDIU Européen de pratiques chirurgicales en Cancérologie depuis 2024 (5 heures annuellement)
- Membre enseignant et évaluateur du DU plaie et cicatrisation de Nice depuis 2024
- Membre enseignant au DU de Pédagogie (thématique IA, prévu 24/03/ 2027)
- Membre enseignant du DU du SUD de Nice (Sport, Urgence, Dégénératif) (prévu en Janvier 2027)
- Membre enseignant du DIU de la verge et des reconstructions uro-génitales (session Nice, Juin 2024 )
- Membre enseignant du DIU de la main nationale tous les 2 ans (session couverture cutané, Nice, Avril 2024 et Mai 2026)
- Membre enseignant et évaluateur du DU plaie et cicatrisation de Nice, UCA, depuis 2024
- Enseignement au DU « plaies et cicatrisation » à Toulouse , Université Rangueil, (2018 – 2019)
Troisième cycle
- Enseignement Parage et cicatrisation aux néo-internes de chirurgie de Nice « BootCamp » annuellement depuis 2024
- Cours de DESC du collège de Chirurgie Plastique, Réparatrice et Esthétique (CPRE) « Les nouveautés dans la chirurgie des lambeaux » 23.03.2024 et « reconstructions thoraciques » le 27 Juin 2026. 30 minutes.
Premier et Deuxième cycle
- Cours en présentiel aux 6-ème année. « Sémiologie en chirurgie de la main et infections ». Le 28 Octobre 2026. Faculté de Médecine de Nice. « UE Professionnalisante – M3 ».
- Responsable de l’atelier « suture et stérilité » aux étudiants en médecine de Nice « UE Professionnalisante – M3 ». Séances de préparation aux stations procédurales ECOS nationaux. Formation de tuteurs pour former des TP de petits groupes (environ 250 étudiants répartis sur 3 jours annuellement depuis 2024)
- Responsable de parcours – ECOS nationaux Juin 2026.
- Groupe de suivi scénarios ECOS /Banque ECOS (2026) : Relecture des ECOS et constitution d’une banque locale de scénarios ECOS (coordination Dr J. Bernardor)
- Vidéo de calibrage ECOS (2025 – 2026) (coordination Dr J. Bernardor)
- Séance de révisions EDN 2024/2025 « Anatomie et chirurgie de la main » : 4 août 2025 pour la promotion de M2 (2 heures), 2026
- Participation au concours blanc M1 2025 (rédaction 30 QCM et correction)
- Examinateur des ECOS formatives, validantes, nationale, Université Côte d’Azur de Nice depuis 2022
- Surveillance des examens LAS 1, L2, L3, M1, M2 ; Université Côte d’Azur de Nice (2022 – présent)
- Tutorat de la faculté de médecine de Rennes 1 : Tutrice des étudiants de Première Année Commune aux études de santé (année scolaire 2014-2015)
Paramédicaux
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- Membre enseignant aux kinésithérapeutes de Nice (prévu 28/01/2027)
- Enseignement à l’IFSI de Nice annuellement depuis 2022 (4 heures)
- Enseignements aux kinésithérapeutes de Toulouse (2022)
- Enseignement aux éducateurs de la CAMI Sport & Cancer (2022 – 2023).
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Encadrement
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Directrice de thèse de Médecine (8):
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- Mathilde Saboye (UVic/soutenance Espagne, 31 Mai 2024)
- Luc Chouquet (soutenance Nice, 16 Mai 2025). Prix de thèse UCA.
- Richard Lachaux (soutenance Nice, 19 Juin 2025).
- Steven Roussihles (co-encadrement Toulouse, 15 Octobre 2025)
- Tanguy Perraudin (soutenance Nice, 7 Novembre 2025).
- En cours :
- Thibault Guillermin (soutenance Nice, prévu 2028).
- Thibault Caudemont (soutenance Nice, prévu 2029).
- Paul Le Trepuec (soutenance Nice, prévu 2029)
Directrice de Master 2 (9):
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- Jonathan Cornacchini (UPEC/Paris, VCA Lab Boston, 2023 – 2024)
- Pierre Barbat (Marseille, LP2M Nice, 2024 – 2025)
- Benjamin Hertzog (CRT Nice, LP2M Nice, 2025 – 2026)
- Ioana Ivan (CRT Nice, LP2M Nice, 2025 – 2026)
- Pharel Ulrich Njessi (CRT Nice, LP2M Nice, 2025 – 2026)
- Abdullah Al Quarshi (Sorbonne, LP2M Nice, 2025 – 2026)
- Joseph Sfeir (Sorbonne, LP2M Nice, 2026 – 2027)
- Alexandru Mihalache (Sorbonne, LP2M Nice, 2026 – 2027)
- Tanguy Perraudin (Sorbonne, LP2M Nice, 2026 – 2027)
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(Co)-Directrice de Doctorant en Science (1) :
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- Amina Oyuntogos (ED Nice/ LP2M) -> Encadrement pour l’obtention de la Bourse Campus France 2026/2029. Inscrite le 24 Septembre 2026.
- Pharel Njessi (ED Nice / LP2M) prévu en début année 2027
- Abdullah AL Qurashi (ED Sorbonne / LP2M) prévu en début année 2027
Membre de jury de thèse de médecine extérieur à l’UCA (3):
- Benjamin Hertozg (7 Octobre 2025)
- Yanis Berkane (24 Octobre 2025)
- Nicolas Cavadore (5 Juin 2026)
Membre de jury de thèse de science extérieur à l’UCA (1) :
- Lolita Micicoi (Marseilles, 26 Novembre 2026)
Mémoire DIU de la main > 15 étudiants, tous publiés<
Communications orales des étudiants en congrès (études supervisées en dernier auteur et présenté par l’encadré) :
- Luc Chouquet (SFCM, 2024 et ASPLD, 2025, sofcpre 2025).
- Jonathan Cornacchini (TMR, sofcpre 2024)
- Tanguy Perraudin (Lambeaux perforants IMAP, Sofcpre 2024 et poster WSRM 2025, vidéoforum 2026)
- Yanis Berkane (Activité universitaire en France, Sofcpre 2024 et VCA en France, ASPLD 2025)
- Pharel Njessi (Sofcep 2026)
- Thibaut Caudemont (*2 vidéoforum 2026)
- Abdullah AL Qrashi (*2 vidéoforum 2026)
- Salman Shaaban (vidéoforum 2026)
- Omer Al Balushi (*2 vidéoforum 2026)
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Communications
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Communications écrites (poster)
- Lupon, U.Turrian, J. Malloizel-Delaunay, A. Bura-Rivière. « Internes en médecine et cicatrisation des plaies : que pensent les internes de leur formation ? » Société française de Médecine vasculaire. Congrès du 25-28/09/2019.
- Philipp Tratnig-Frank, Alec R. Andrews, Corentin B. Taveau, Alexandre G. Lellouch, Michael M. Jonczyk, Marion Goutard, Elise Lupon, Mark A. Randolph, Michael L. Morrison, Mark B. Roth, Curtis L. Cetrulo, Jr. The Impact of oxygen free radical scavenger on acute rejection in a histocompatible miniature swine model. 28th congress of The Transplantation Society, 2020 virtual (e-poster)
- Alexandre Lellouch, Corentin Taveau, Alec Andrews, Marion Goutard, Philipp Tratnig-Frankl,
- Lupon E, Acun, M. Goutard, R. Oganesyan, A.G. Lellouch, L.A. Lantieri, Alec R. Andrews, M. Randolph, C.L. Cetrulo Jr, B. Uygun. Decellularization of Vascularized Engineered Scaffolds for Facial Reconstruction. MGH SAC Poster 2021. virtual (e-poster)
- Elise LUPON, Hadrien PAOLI, Yanis BERKANE, Nicolas BERTHEUIL, Jean Baptiste DE VILLENEUVE DE BARGEMON, Isabelle PLUVY, Olivier CAMUZARD, Benoît CHAPUT. Coverage of elbow and forearm soft tissue defects with the posterior ulnar artery perforator flap (PURAP): anatomical study and surgical description. World Society for Reconstructive Microsurgery (WSRM 2023), Singapour. Poster diffusé du 16 au 19 Août 2023.
- Elise LUPON. Vascularized Composite Allotransplantation in the past decade: What’s hot and What’s not?. World Society for Reconstructive Microsurgery (WSRM 2025), Barcelone. Poster diffusé du 24 au 26 Avril 2025.
- Vascularized Composite allotransplantation in France: overview and update. Helsinski. Juin 2025. Abstract publié dans Transplantation.
- A New Method for Preparation of Decellularized Human Scaffolds for Facial Reconstruction. Helsinski. Juin 2025. Abstract publié dans Transplantation.
Communications orales
- E. Lupon, D. Gangloff, T.Meresse. Couverture et reconstruction de la flexion du coude par un lambeau de grand dorsal après exérèse d’un volumineux sarcome du bras dominant. SFCO Montpellier. (vidéo disponible sur « Oncostream »). 16 Mai 2019.
- E.Lupon. « Mon master 2 en 180 secondes ». SFCO Montpellier. 16 Mai 2019.
- E. Lupon, B. Chaput, JL.Grolleau, LA. Lantieri, AG Lellouch. Traitement permanent des dyschromies cutanées post brûlures. Société Française de Brûlologie- Cap d’agde. 6 Juin 2019.
- P. Girard, E. Lupon, J. Laloze, E. Watier, J. Duisit, B. Chaput, N. Bertheuil. Technique de couverture de perte de substance péri vulvaire par lambeau perforant de type IGAP (Inferior Gluteal Artery Perforator), Videocorner SOFCPRE 2019, Paris, 21 Novembre 2019.
- Berthier C, Lupon E, Gangloff D, Meresse T. Lambeau musculocutané de grand dorsal pédiculé dans la chirurgie du sarcome, Vidéocorner SOFCPRE 2019, Paris, 22 Novembre 2019
- E. Lupon. Vascularized Composite Allotransplantation. Decellularization/Revascularization project. Science Slam. Massachusetts General Hospital Research Institute. Boston, 14 Janvier 2020.
- Elise Lupon, Aylin Acun, Marion Goutard, Ruben Oganesyan, Alexandre Lellouch, Laurent Lantieri, Jean louis Grolleau, Basak Uygun, Curtis Cetrulo Decellularization of vascularized engineered scaffolds for facial reconstruction. Virtual Plastic Surgery (the meeting). 89th Annual meeting. Présenté le 16 Octobre 2020 (5 minutes).
- Elise Lupon, Aylin Acun, Marion Goutard, Ruben Oganesyan, Alexandre Lellouch, Laurent Lantieri, Jean louis Grolleau, Basak Uygun, Curtis Cetrulo Decellularization protocol for porcine Fasciocutaneaousflap : an update. The Virtual Virginia Society of Plastic Surgeron « VASPS » (virtuel). Présenté le 24 Octobre 2020 (8 minutes).
- Elise Lupon, Aylin Acun, Alexandre Lellouch, Corentin Taveau, Ruben Oganesyan, Marion Goutard, Laurent Lantieri, Curtis Cetrulo Basak Uygun. Decellularisation/Recellularisation des Allogreffes de tissus Composites. Académie de chirurgie (virtuel). Présentation orale 10 minutes, 4 Décembre 2020.
- Marion Goutard, R.J. de Vries, A.G. Lellouch, E. Lupon, C. Pendexter, S. N. Tessier, M.A. Randolph, L. Lantieri, C.L. Cetrulo, K. Uygun. Recovery After extended Static Cold Storage Preservation Using Subnoormothermic Machine Perfusion In VCA. ATC 5 Juin 2021.
- E.Lupon. « Mon master 2 en 180 secondes ». e-congrès. SFCO. 6 Mai 2021. (Oratrice et modératrice).
- Elise Lupon, Aylin Acun, Marion Goutard, Alexandre G. Lellouch, Ruben Oganesyan, Alec R. Andrews, Laurent Lantieri, Mark A. Randolph, Curtis L. Cetrulo, Jr., Basak Uygun. Decellularization Of Vascularized Composite Allografts In The Rat. PSRC virtual. Pentathon. June 9 2021.https://ps-rc.org/meeting/abstracts/2021/QS29.cgi
- Marion Goutard, Alexandre Lellouch, Elise Lupon, Casie Pendexter, Mark A. Randolph, Laurent Lantieri, Curtis L. Cetrulo, Jr., Korkut Uygun. Effect Of Static Cold Storage On Vascularized Composite Allotransplantation On Rodent. PSRC virtual. Pentathon. June 9 2021. https://ps-rc.org/meeting/abstracts/2021/QS37.cgi
- Victor pozzo, Aylin Acun, Elise Lupon, Alexandre G. Lellouch, Ruben Oganesyan, Alec R. Andrews, Laurent Lantieri, Mark A. Randolph, Curtis L. Cetrulo, Jr., Basak Uygun. Reendothelialization of decellularized swine fasciocutaneous flap: a proof-of-concept study. IXA-CTRMS 2021 (Septembre 2021)
- Lupon E, Acun A, Ruben Oganesyan, Lantieri L, Uygun B, Cetrulo L. C, Lellouch A.G. Protocole d’immersion/décellularisation d’Allotransplantation de Face, 8 min, SOFCPRE, 18 Novembre 2021.
- E.Lupon. « Présentation des travaux de Master 2 / Lauréate parcours 3R ». UPEC. 8 Avril 2022.
- E.Lupon. « Mon master 2 en 180 secondes ». e-congrès. SFCO. 12 Mai 2022. (Organisatrice et modératrice).
- E. Lupon, A. Bizos, P. Marek, A. Ciron, D. T.Meresse, J.Segal, D.Gangloff. SFCO Toulouse. 12 Mai 2022. Couverture et reconstruction vasculaire et tissulaire du scarpa gauche après exérèse d’un myxosarcome récidivant.
- E. Lupon, T.Meresse, Benoit Chaput. SFCO Toulouse. 12 Mai 2022. Reconstruction mammaire par gracilis prélevé́ selon un schéma de cruroplastie interne.
- E. Lupon, D. Gangloff. SFCO Toulouse. 13 Mai 2022. Comment je fais : curage inguinal dans le cadre du mélanome avec envahissement ganglionnaire. (Également présenté au vidéoforum le 02/07/2022)
- Elise Lupon, Yoann Dalmas, Benoit Chaput, Pierre Mansat, Stéphanie Delclaux. « Prise en charge chirurgicale des fractures corporéales peu ou non déplacées du scaphoïde par vissage percutané rétrograde en passant par la corne antérieure du trapèze : Une étude Française rétrospective uni-centrique auprès de 33 patients”. # 27694 DOI: 10.1016/j.hansur.2021.10.099. GEM 57eme Congrès de la Société Française de Chirurgie de la Main. 2021, 6 minutes, 16 Décembre 2021.
- Elise Lupon « Évaluation fonctionnelle de la prise en charge chirurgicale de l’arthrose scapho-trapézo-trapézoïdienne isolée : série rétrospective monocentrique de 24 patients”. Lafaye Gregory, Rongieres Michel, Lupon Elise, Grolleau Jean-Louis, Riot Samuel, Mansat Pierre. TABLE RONDE. GEM 57eme Congrès de la Société Française de Chirurgie de la Main. 2021, 8 minutes, 18 Décembre 2021. (Également présentée au vidéoforum le 1/07/2022)
- E. Lupon, T. Meresse, D. Gangloff. VidéoForum Toulouse. 02 Juillet 2022. Comment je fais : Actualisation dans la prise en charge du Dermatofibrosarcome de Darrier-Ferrand. (également modératrice de la session)
- E. Lupon, I. Ongenda, A. Bourcier, A. Zorigtbaatar, U. Kanmounye, F. Lauwers. Journée des jeunes plasticiens, Toulouse. 30 Juin 2022. Introduction à la chirurgie Mondiale « Global Surgery ».
- E. Lupon. Medial sural artery perforator flap for leg and knee coverage: Extended skin paddle with a two perforator harvesting. Octobre 2022. Plastic Surgery The Meeting. Boston. Abstract #: 2845
- E. Lupon. Formation du jeune chirurgien oncologue au sarcome. SFCO Paris. 11 Mai 2023.
- Organisation et modération de la session « Prise en charge du lymphœdème » avec intervenants internationaux (JP Hong, Jaume Masia). SFCO Paris. 11 Mai 2023
- Session work shop. Orateur du “Speed mentoring” – Conseillère aux chirurgiens oncologues en formation. SFCO Paris. 12 Mai 2023 (également organisatrice et modératrice de session).
- Elise Lupon, Sarah Hendriks, Eugénie Dalamier, Bernard Gasser, Thérèse Adawa. Analyse histologique extemporanée selon Mohs en pathologie tumorale cutanée : possibilités et limites de l’évaluation tomographique par cohérence optique plein champ FFOCT (Full-Field Optical Coherence Tomography). SFCO Paris. 12 Mai 2023 et présenté le 28 Octobre au PSTM Texas 2023 (5 minutes).
- Elise Lupon, Inès Ongenda, Olivier Camuzard, Jacques Saboye, Frédéric Lauwers. La chirurgie oncologique mondiale. SFCO Paris. 12 Mai 2023 (également modératrice de session).
- Elise LUPON, Aylin Acun, Alexandre G. Lellouch, Ruben Oganesyan, Hyshem Lancia, Olivier Camuzard, Alec R. Andrews, Mark Randolph, Curtis L. Cetrulo Jr, Basak E. Uygun. Decellularization and recellularization of Vascularized Composite tissue Allografts: current status and new concepts. World Society for Reconstructive Microsurgery (WSRM 2023), Singapour. 17 Août 2023 (5 minutes).
- Elise LUPON, Gilles CLARO, Farid BEKARA, Fatima Zohra MOKRANE, Olivier CAMUZARD, Benoit CHAPUT. A dynamic anatomical study of parasacral perforators: mapping, perforasome and applications for buttock enhancement. WSRM 2023, Singapour. 17 Août 2023 (5 minutes).
- Elise LUPON, Hadrien PAOLI, Yanis BERKANE, Nicolas BERTHEUIL, Jean Baptiste DE VILLENEUVE DE BARGEMON, Isabelle PLUVY, Olivier CAMUZARD, Benoît CHAPUT. Coverage of elbow and forearm soft tissue defects with the posterior ulnar artery perforator flap (PURAP): anatomical study and surgical description. Plastic Surgery The meeting (PSTM 2023), Austin, Texas. 28 Octobre 2023 (5 minutes).
- Elise Lupon, Benoît Chaput, yong-June kim, Aymeric André, Frédéric « Microsurgery without border: Result of 20 years’ experience in Cambodia, 6 min, SOFCPRE, 16 Novembre 2023.
- Elise Lupon. Association des jeunes chirurgiens oncologues : pourquoi vous y intéresser ? 20 min, SOFCPRE/Table ronde, 18 Novembre 2023.
- Présentation des travaux de thèse de Science. JEDNs 85. Valrose, Université Côte d’Azur 21 Mai 2024 (8 minutes).
- Elise Lupon, Benoît Chaput, yong-June kim, Aymeric André, Frédéric Lauwers. Reconstructions tumorales microchirurgicales « sans frontières » : Résultat de 9 ans d’expérience au Cambodge, 8 min, SFCO Nantes, 24 Mai 2024. (également modératrice de session).
- Elise Lupon, Roxane Elaldi, Olivier Malard. Modération de la table ronde ORL. SFCO Nantes, 24 Mai 2024
- Elise Lupon « Quoi de neuf en chirurgie oncologique ? ». (25 minutes). SOFCPRE. Novembre 2024.
- Elise Lupon, Laura Charlès, Tia Sheth, Kassem Saffa, Alexandre G. Lellouch, Curtis Cetrulo. “Monitorage de médicaments immunosuppresseurs : Un dispositif non invasif pour une mesure salivaire du tacrolimus ».(8 minutes).
SOFCPRE. Novembre 2024. - Elise Lupon « Place des lambeaux perforant en chirurgie de la main ».(10 minutes). Table ronde. SOFCPRE. Novembre 2024. (également modératrice et organisatrice de session).
- Elise Lupon, Inès Ongenda, Alexandre Bourcier, Anudari Zorigtbaatar, Jacques Saboye, Ulrick Sidney Kanmounye, Fréderic Lauwers. La chirurgie mondiale : clarification et état des lieux dans la population francophone (8 minutes). SOFCPRE. Novembre 2024.
- Modératrice de session au congrès M.I.S.S (Mini Invasive Spine and Skeletal meeting) Galet, Nice (Session Squelette périphérique)
- Présidente, Modératrice et présentatrice (20 minutes). 5ème réunion d’échange sur la réparation tissulaire. Galet. Nice*
- Avancées dans le traitements chirurgical du lymphoedeme. Journée de medecine vasculaire nicoise 20 minutes. E-webinar.
- Webinar CNCEM. “Enseigner en Santé à l’Heure de l’IA Générative”. IA et santé. Évaluation du rôle des grands modèles de langage dans la simulation et la génération d’ECOS. 3 Juin 2025. CNEM.
- Organisation et modération table ronde Microchirurgie et main – Sofcpre 20 Novembre 2025. Oratrice présnetation “IA et microchirurgie”.
- Oratrice table ronde Oncologie – Sofcpre 21 Novembre 2025. “IA et Oncologie en chirurgie plastique”.
- Oratrice table ronde Innovation – Sofcpre 20 Novembre 2025. “IA en chirurgie plastique”.
- MedIntechs 10 mars 2026. Innovation chirurgicale. Simlife pour la chirurgie avancée des lambeaux. Parc Floral, Paris.
- Académie nationale de chirurgie. Impact des traitements systémiques sur la chirurgie en oncodermatologie. 15 minutes. 20 Mai 2026.
- « Expanding the role of perforator flaps in oncologic dermatologic reconstruction “ – Cours aux chirurgiens du Pakistan 7 Mai 2026 – ASPF / International visiting professor ( 1 heure)
- Prélèvement d’une allogreffe faciale complète de tissus mous pour la transplantation composite vascularisée. Vidéoforum le 26 Juin 2026.
- Un modèle expérimental humain de lambeau DIEP pour l’étude des stratégies de préservation des allogreffes composites vascularisées et des lambeaux libres. Vidéoforum. Le 27 Juin 2026.
- Le modèle cadavérique humain reperfusé SIMLife® comme plateforme translationnelle pour la chirurgie avancée des lambeaux. Vidéoforum. Le 27 Juin 2026.
- Transplantation hétérotopique de membre postérieur au cou chez la souris : un modèle de supermicrochirurgie appliqué à la transplantation composite vascularisée. Vidéoforum. Le 27 Juin 2026.
- Session 2. Modération Journée jeunes plasticiens. Vidéoforum. Toulouse. Le 25 Juin 2026.