Pr CAMUZARD Olivier
Chirurgie de la Main & du Poignet
Urgences Mains SOS Mains
Chirurgie Nerfs Périphériques et Plexus Brachial
Chirurgie des Cancers Cutanés
Chirurgie des Sarcomes Osseux et des Tissus Mous
Chirurgie Reconstructrice Complexe des Membres et du Tronc
Secrétariat : Karima Achile
Tel.: 04.92.03.36.62
Mail: achile.k@chu-nice.fr
Titres
- Professeur des Universités – Praticien Hospitalier
- Chef de Service de Chirurgie Plastique, Réparatrice et de Chirurgie de la Main, Institut Universitaire Locomoteur et du Sport du Centre Hospitalier Universitaire de Nice
Formation hospitalo-universitaire
- Habilitation à Diriger des Recherches soutenu le 25 mai 2022 à Nice
- 2020-2021 : Clinical Fellowship in Peripheral Nerve Microsurgery, Prof. David CC Chuang, Department of Plastic & Reconstructive Surgery. Chang Gung Memorial Hospital. Taipei, Taiwan
- Depuis Septembre 2019: Maître de Conférences des Universités – Praticien Hospitalier, Service de Chirurgie Plastique, Réparatrice et de Chirurgie de la Main, Institut Universitaire Locomoteur et du Sport du CHU de Nice
- 2015 – 2016 :
- Inter – CHU, Institut Gustave Roussy, Dr Kolb, Paris
- Inter – CHU, Service de Chirurgie de la Main et du Poignet, Pr Dautel, CHU de Nancy
- 2014 – 2015 : Année Recherche Master 2 Laboratoire de Recherche MATOs UMR E4320 CEA/Université de Nice
- 2010 – 2016 : Interne des Hôpitaux de Nice, spécialité Chirurgie de le Main et du Poignet, CHU de Nice
- 2004 – 2010 : 1er et 2ème cycles d’Etudes Médicales, Faculté de Médecine de Nice
- 2010 : Examen Classant National Classement ECN : 138/6700
- 2010 : Major de la promotion chirurgie générale 2010
- 2004-2010 : Lauréat de la Faculté de Médecine de Nice, promotion 2004 – 2010
- 2005 : Master 1 : Science de la Vie et de la Santé (Faculté de Médecine de Nice, 2005) : UE d’anatomie humaine (Pr Baqué – Faculté de Médecine de Nice) & UE de physiologie humaine (Pr Crenesse – Faculté de Médecine de Nice)
- 2004 : Baccalauréat Scientifique (Mention Assez Bien)
Concours et Diplômes
- Habilitation à Diriger des Recherches soutenu le 25 mai 2022 à Nice (cf Annexe)
- Clinical Fellowship in Peripheral Nerve Microsurgery, Prof. David CC Chuang, Department of Plastic & Reconstructive Surgery. Chang Gung Memorial Hospital. Taipei, Taiwan (2020 – 2021)
- Thèse de Science, étude du microenvironement de l’ostéosarcome, Laboratoire TIRO – MATOS UMR E4320 CEA/Université de Nice Sophia Antipolis, Dr Valérie Pierrfite-Carle, (2015-2019)
- Thèse de Médecine (Faculté de Médecine de Nice), « Vascularisation cutanée artérielle des régions anté-brachiales et céphalique, de l’anatomie à la chirurgie réparatrice» Mention très honorable avec Félicitations du jury – Prix de Thèse de la Faculté de Médecine de Nice (spécialité chirurgicale), 2017
- DES de Chirurgie Générale, 2016
- DESC Chirurgie Plastique Réparatrice et Esthétique depuis 2017
- Diplômes Universitaire
• DIU d’Anatomie Appliquée à la Chirurgie des Lambeaux, Pr Revol, Paris, 2016
• DIU de Carcinologie Cervico-Faciale, Dr Le Ridant, Institut Gustave Roussy, Villejuif, 2015
• Diplôme Universitaire (DU) d’Anatomie pour le Chirurgien (Pr de Peretti, Dr Bronsard, Nice), 2015
• DIU de Pathologies Chirurgicales de la Main et du Poignet (Secteur Grand Sud, Pr Chammas, Pr Legré, Dr Balaguer), 2014
• DIU de Chirurgie Plastique et Réparatrice de la Face et du Cou (Pr Santini, Pr Bardot), 2014
• DU de Microchirurgie (Pr Casanova – Faculté de médecine de Marseille), 2012
-
- Masters
Master 1 Science de la Vie et de la Santé (Nice) :
– UE d’anatomie humaine (Pr Baqué – faculté de médecine de Nice)
– UE de physiologie humaine (Pr Crenesse – faculté de médecine de Nice),
Master 2 (Université Paris – Descartes – Paris V) : Recherche en sciences de la vie et de la santé, spécialité : Biominéralisation, Morphogénèse et Pathologies Inflammatoires, sur le thème: Étude de l’activité autophagique dans les ostéoblastes au cours du vieillissement et dans les cellules souches tumorales d’ostéosarcome. Laboratoire MATOs UMR E4320 CEA/Université de Nice
- Masters
Prix, Bourse et Contrats de Recherche
- 2019 : Prix d’excellence de l’Université Côte d’Azur
2018 : Prix de la meilleur communication orale, 20ème Société Française de Biologie des Tissus Minéralisés, Monaco - 2017 :
- Prix de Thèse Spécialité Chirurgicale, Faculté de Médecine de Nice
- Prix de la meilleure communication orale, Société Anatomique de Paris
- Prix de la meilleure communication affichée Société Française de l’Autophagie, Paris
- 2015 : Bourse Année Recherche de l’Agence Régionale de santé PACA 2010 : Lauréat de la Faculté de Médecine de Nice Promotion
- 2006-2010 Major de la Promotion 2010 de chirurgie générale
Nominations Administratives et Universitaires
- Membre Titulaire du Conseil d’Administration de la Faculté de Médecine de Nice, élu sur liste des rangs B depuis Novembre 2018
- Membre Titulaire de la Commission Médicale d’Établissement (CME) représentant des Chefs de Cliniques-Assistants depuis 2018
- Co-Responsable Stage Sémiologie L2 Faculté de Médecine de Nice depuis 2021
- Responsable Sportif de Haut Niveau Faculté de médecine de Nice depuis 2020
- Co-Responsable de la centralisation des dossiers SIDES « chirurgie » de la Faculté de Médecine de Nice depuis 2018
- Responsable ECOS chirurgie Plastique depuis 2021
- Membre du Comité Pédagogique National de la FST Chirurgie de la Main
- Responsable Médicale UF 1953, « SOS Main » CHU de Nice depuis 2017.
Organisation d’Evenements et Congrès
- Workshop Arthrex « Pathologie du poignet, ligamentoplastie et arthroscopie » Directeur de l’événement, Nice, Institut d’anatomie Normale, 07 février 2018
- Responsable de la session lambeaux locaux du membre supérieur aux Cours Chirurgicaux du membre supérieur depuis 2016. Pr Dautel, Nancy.
Direction de Travaux de Recherche
- Directeur de 48 mémoires du Master 1 d’Anatomie Générale depuis 2011, Faculté de Médecine de Nice
- Directeur de thèse en chirurgie générale: « Vascularisation neuro-cutané des nerfs superficiels de l’avant-bras ». Marianne Cegarra, Faculté de Médecine de Nice, 2017
- Directeur de thèse en chirurgie générale: « Etude anatomique de l’artère infra orbitaire ». Katarina Hufchmidt Faculté de Médecine de Nice, 2018
- Directeur de thèse en chirurgie générale: « Intérêt des greffes vascularisées de l’os pisiforme en chirurgie de la main : Etude anatomique ». Sébastien Piereschi Faculté de Médecine de Nice, 2018
- Directeur de thèse en chirurgie générale: « Intérêt des greffes artérielles en chirurgie de la main : Revue de la littérature et étude anatomique». Henri Rémy, Faculté de Médecine de Nice, 2019
- Directeur de mémoire du DIU de la main et du poignet : « Prise en charge des fractures du crochets de l’hamatum », Romain Ceccarelli, Faculté de Médecine de Nice, 2017
- Co-Responsable du Projet « Plastination des pièces anatomiques » au Laboratoire d’Anatomie de Nice depuis 2017.
Recherche
Recherche Fondamentale
- Titulaire d’un Master 1 (Science de la Vie et de la Santé)
- Titulaire d’un Master 2 (Biominéralisation, Morphogénèse et Pathologies Inflammatoires)
- Thèse de Science (Faculté de Science, Nice, 2015-2019) au sein du Laboratoire MATOs UMR E4320 CEA/Université de Nice, Dr Georges Carle sous la direction du Dr Valérie Pierrefite-Carles.
Recherche Anatomique et Chirurgicales
- Responsable des mémoires de l’unité d’enseignement (UE) d’Anatomie depuis 2016
- Activité de recherche sur la vascularisation cutanée et nerveuse et en chirurgie de la main et du poignet
- Responsable de la préparation du réseau vasculaire sur pièce anatomique
- Co –responsable du projet plastination au laboratoire d’Anatomie de Nice
Relecteur d’Articles Scientifiques
- Relecteur pour les revues :
- Aesthetic Plastic Surgery
- PRS global open
- Hand Surgery and Rehabilitation
- Plos One
Enseignement
Certification SIDES (Système Informatique Distribué d’Evaluation en Santé) obtenue en Mars 2016.
Étudiants en Médecine :
Premier cycle des études médicales
- Cours d’anatomie : le système nerveux végétatif, les organes des sens, l’appareil tégumentaire et uro-génital de l’homme et de la femme (8H).
Deuxième cycle des études médicales
- Conférences d’internat et préparation universitaire à l’Examen National Classant et au iECN en chirurgie réparatrice, Faculté de médecine de Nice Sophia Antipolis, depuis 2011.
- Responsable des dissections et de la présentation des dissections de l’appareil locomoteur, Laboratoire d’Anatomie, Nice, depuis 2006.
- Cours d’anatomie général depuis 2017.
- Cours relatifs à la chirurgie réparatrice et à la chirurgie de la main, sémiologie locomoteur aux étudiants en médecine en stage hospitalier dans le service : tous les lundi matin, depuis 2017.
- Responsable de l’enseignement des techniques de préparation du réseau vasculaire sur cadavre, depuis 2017.
- Responsable de l’Unité d’Enseignement d’Anatomie (30H et 8 mémoires) depuis 2018.
Troisième cycle des études médicales
- Cours relatifs à la chirurgie réparatrice et à la chirurgie de la main, techniques chirurgicales aux internes du service en stage hospitalier dans le service depuis 2016.
- Responsable des dissections, Laboratoire d’Anatomie, Nice, depuis 2016
Faculté d’Odontologie
- Responsable des cours d’anatomie tête et cou, des dissections de la région cervico-faciale, depuis 2017, 40 H)
Sage-Femme
- Responsable des cours d’anatomie générale et des dissection, depuis 2017, 16 H)
Diplômes inter-universitaires
-
- Participation à l’enseignement du DIU de plaie et cicatrisation, Nice, depuis 2016
- Responsable du DIU de pathologie chirurgicale de la Main et du poignet, Nice, depuis 2020
- Participation à l’enseignement du DIU des pathologies du sport, Nice, depuis 2016
- Participation à l’enseignement du DIU d’ Anesthésie Loco-Régionale, Nice, depuis 2016
Professions paramédicales :
Écoles de soins infirmiers
- Cours à l’école d’infirmières de Nice. Anatomie générale, 2006 – 2008
- Cours à l’école d’infirmières de Nice (Croix Rouge). Anatomie générale, 2006 – 2008
- Formation à la surveillance des lambeaux et des suites opératoire après microchirurgie, CHU de Nice, depuis 2017
École de Kinésithérapie
- Cours à l’école de kinésithérapie de Nice (1ère et 2ème année) depuis 2018
- Membre de l’Association des Jeunes Chirurgiens Oncologues (AJCO) et responsable de la rubrique reconstruction des membres et de la région cervico-faciale.
- Membre du Comité Français d’étude de l’AuTophaGie (CFATG)
- Membre de réseau SUNRiSE « Solid tumor cancer stem cell network »
- Membre de la Sociéte Française de la Biologie des Tissus Minéralisés (SFBTM)
- Membre Junior de la Société Française de Chirurgie de la Main
- Membre du Groupe Sarcome Français – Groupe d’Etude des Tumeurs Osseuses (GSF-GETO)
SIGAPS : 635 points | 54 publications
Publications 2022 du Dr CAMUZARD Olivier
Modern and synchronized clinical anatomy teaching based on the BDIE method (board-digital dissection-imaging-evaluation)
Modern and synchronized clinical anatomy teaching based on the BDIE method (board-digital dissection-imaging-evaluation)
Damien Massalou, Nicolas Bronsard, Laurent Hekayem, Patrick Baqué, Olivier Camuzard
https://pubmed.ncbi.nlm.nih.gov/35482103/
Abstract
Purpose: Anatomy has historically been taught via traditional medical school lectures and dissection. In many countries, practical or legal issues limit access to cadaveric dissection. New technologies are favored by students and could improve learning, complementing traditional teaching.
Methods: All students in second-year medicine at a single medical school were submitted to a novel anatomical course with digital tool exposure. We explored a new combined teaching method: a physical blackboard lesson synchronized with digital dissection, imaging and direct evaluation (BDIE). Synchronized dissection is broadcast live in the classroom and in partner medical schools. Following the course, students completed a short survey about their perception of this new anatomic clinical course.
Results: The survey included 183 students whom 178 completed the questionnaire, i.e., a 97% response rate. Ninety-nine percent of students thought this synchronized method useful to improve their understanding of anatomy and 90% stated it helped them retain this learning.
Conclusion: This BDIE method, in conjunction with teaching guidelines and dissection, is highly appreciated by students who consider it helps them to acquire lasting knowledge.
Keywords: Anatomy teaching; Digital dissection; Dissection; Gross anatomy; Prosection; Radiology.
© 2022. The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature.
A role for metformin in the treatment of Dupuytren disease?
A role for metformin in the treatment of Dupuytren disease?
Alberto Baeri, Michaël Levraut, Serena Diazzi, Olivier Camuzard, Marianne Cegarra-Escolano, Marie-Anne Ploumellec, Thierry Balaguer, Julien Fassy, Roger Rezzonico, Saverio Bellusci, Bernard Mari, Georges Vassaux
https://pubmed.ncbi.nlm.nih.gov/35427821/
Abstract
Dupuytren disease (DD) is a hand-localized fibrotic disorder characterized by a scar-like, collagen-rich cord. Treatment usually comprises surgical removal of the cord, but is associated with a high relapse rate, in some cases requiring finger amputation. There is currently no consensual medical approach for treating DD. Numerous preclinical studies have highlighted antifibrotic properties of metformin, and the aim of this study was to assess a potential antifibrotic role of metformin in DD. Fibroblasts from DD cords (DF) and phenotypically normal palmar fascia (PF) were extracted from surgical specimens and cultured. The fibrotic status of DF and PF was compared at baseline, and under profibrotic (TGF-β stimulation) and antifibrotic (metformin stimulation) conditions, using quantitative RT-PCR, western blot, immunocytochemistry, and a functional fibroblast contraction assay. At baseline, DF showed higher levels of fibrotic markers and contraction capacity compared with PF. Both types of fibroblasts responded to TGF-β stimulation. Treatment of DF and PF with metformin did not affect basal levels of fibrotic markers and contraction but largely prevented their induction by TGF-β. In conclusion, our data show that metformin inhibits TGF-β-induced expression of fibrotic markers and contraction in hand-derived fibroblasts. This supports the case for a clinical trial to assess the repurposing of metformin as an adjuvant to surgery, to prevent, reduce, or delay recurrence in at-risk DD patients.
Keywords: Drug repurposing; Dupuytren contracture; Fibroblasts; Fibrosis; Metformin.
Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
Comparison of Two Rapid Assays for the Detection of BRAF V600 Mutations in Metastatic Melanoma including Positive Sentinel Lymph Nodes
Comparison of Two Rapid Assays for the Detection of BRAF V600 Mutations in Metastatic Melanoma including Positive Sentinel Lymph Nodes
Elodie Long-Mira, Alexandra Picard-Gauci, Sandra Lassalle, Véronique Hofman , Salomé Lalvée, Virginie Tanga , Katia Zahaf, Christelle Bonnetaud, Virginie Lespinet, Olivier Camuzard, Henri Montaudié, Gilles Poissonnet, Thierry Passeron, Marius Ilié, Paul Hofman
https://pubmed.ncbi.nlm.nih.gov/35328303/
Abstract
Testing for the BRAF mutation is mandatory for the management of patients with locally advanced or metastatic melanoma. Molecular analysis based on DNA sequencing remains the gold-standard method for the screening of the different BRAF mutations. These methods must be rapid, sensitive, and specific enough to allow optimal therapeutic management in daily practice and also to include patients in clinical trials. Here, we compared the Idylla BRAF Mutation Test and the anti-BRAF V600E (clone VE1) immunohistochemistry (IHC) in 90 melanoma samples, with a focus on a challenging cohort of 32 positive sentinel lymph nodes. The BRAF status was assessed with both methods independently of the percentage of tumor cells. The concordance rate was calculated excluding both non-contributory analyses and BRAFV600K/R/M mutants due to the specific V600E-IHC test design. The incidence of the BRAFV600E mutation was 33% with both BRAF Idylla and BRAF IHC. The agreement rate was 91% (72/79). Although the agreement rate was high, we suggest that the use of IHC is more suitable for rapid BRAF testing on sentinel lymph node biopsies when associated with a low percentage and scattered tumor cells, which gave a high risk of non-contributory analysis and/or false negative results with the IdyllaTMBRAF Mutation Test.
Keywords: BRAF; RT-PCR; immunohistochemistry; metastatic melanoma; sentinel lymph node.
Flow-Through Arterialized Posterior Interosseous Nerve Grafts for Digital Neurovascular Bundle Defects: Anatomical Study
Flow-Through Arterialized Posterior Interosseous Nerve Grafts for Digital Neurovascular Bundle Defects: Anatomical Study
Gilles Claro, Nicole A Zelenski, Thierry Balaguer, Benoit Chaput, Nicolas Isola, Patrick Baqué, Nicolas Bronsard, Olivier Camuzard
https://pubmed.ncbi.nlm.nih.gov/34936617/
Abstract
Background: Digital neurovascular bundle defects are often encountered during crush or avulsion injuries and require complex reconstruction. Use of an arterialized nerve graft (neurovascular graft) serving both as an interpositional arterial conduit and as a nerve graft could be a reconstructive option in these cases. In this anatomical study, the authors aimed to describe a neurovascular graft of the posterior interosseous nerve and a branch of the anterior interosseous artery for neurovascular bundle reconstruction of the fingers.
Methods: Eighteen forearms were injected with red latex in order to collect the anatomical characteristics of the posterior interosseous nerve and the artery running near it.
Results: In all cases, the posterior interosseous nerve was followed by a branch of the anterior interosseous artery: the distal dorsal branch of the anterior interosseous nerve. The origin of this artery was proximal to the radiocarpal joint, at an average of 56.5 ± 11.1 mm. The proximal and distal diameters of the branch of the anterior interosseous artery were 1.6 ± 0.2 and 1.1 ± 0.2 mm, respectively. The proximal and distal diameters of the posterior interosseous nerve were 1.2 ± 0.3 mm and 1.1 ± 0.3 mm, respectively.
Conclusions: These results show that a potential free neurovascular graft using the posterior interosseous nerve as nerve graft and the anterior interosseous artery as an arterial bypass to reconstruct both the nerve and arterial tree of the finger could be a useful approach. The authors speculate that this graft could be used to reconstruct the neurovascular bundle of amputated or devascularized digits.
Copyright © 2021 by the American Society of Plastic Surgeons.
Publications 2021 du Dr CAMUZARD Olivier
A 3-Dimensional Suture Technique for Flexor Tendon Repair: A Biomechanical Study
A 3-Dimensional Suture Technique for Flexor Tendon Repair: A Biomechanical Study
Marie Castoldi, Federico Solla, Olivier Camuzard, Martine Pithioux , Virginie Rampal, Olivier Rosello
https://pubmed.ncbi.nlm.nih.gov/34848101/
Abstract
Purpose: Flexor tendon injury continues to pose a number of challenges for hand surgeons. Improving mechanical properties of repairs should allow for earlier and unprotected rehabilitation. A 3-dimensional (3D) 4-strand suture technique has been proposed to combine high tensile strength and low gliding resistance without causing suture pullout due to tendon delamination. Our hypothesis is that the 3D technique can result in better mechanical properties than the Adelaide technique.
Methods: Four groups of 10 porcine flexor tendons were sutured using the 3D or Adelaide technique with a 3-0 polypropylene or ultrahigh molecular weight polyethylene (UHMWPE) suture. The axial traction test to failure was performed on each tendon to measure 2-mm gap force and ultimate tensile strength.
Results: The mean 2-mm gap force was 49 N for group A (3D + polypropylene), 145 N for group B (3D + UHMWPE), 47 N for group C (Adelaide + polypropylene), and 80 N for group D (Adelaide + UHMWPE). Failure mode was caused by suture breakage for group A (10/10) and mainly by suture pullout for the other groups (8/10 up to 10/10). With the UHMWPE suture, the mean ultimate tensile strength was 145 N for the 3D technique and 80 N for the Adelaide technique.
Conclusions: Porcine flexor tendons repaired using the 3D technique and UHMWPE suture exceeded a 2-mm gap force and tensile strength of 140 N. The ultimate tensile strength was superior to that of the Adelaide technique, regardless of the suture material.
Clinical relevance: This in vitro study on porcine flexor tendon suture highlights that the mechanical properties of 3D repair are better than those of 3D repair using the Adelaide technique when a UHMWPE suture is used.
Keywords: 2-mm gap force; UHMWPE; flexor tendon; hand injuries; suture techniques; tensile strength.
Copyright © 2023 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.
Anatomical study of the clitoris and its implications on female genital mutilation and surgical repair
Anatomical study of the clitoris and its implications on female genital mutilation and surgical repair
Fanny Blayney, Olivier Camuzard, Arthur Klein, Anne-Sophie Perchenet, Baptiste Bertrand, Cécile Philandrianos, Valentin Massin, Maxime Abellan-Lopez, Dominique Casanova
https://pubmed.ncbi.nlm.nih.gov/34253487/
Abstract
Background: Worldwide, 200 million girls and women have been subjected to female genital mutilation. To restore the clitoral function and vulvar anatomy, clitoral repair has been performed since the 2000s. Nevertheless, there is a lack of precise and comprehensive data on the clitoral anatomy during surgical repair. This study aimed to precisely describe the terminal anatomies of the dorsal nerve and artery of the clitoris, and the clitoral neurovascular flap advancement for reconstruction in patients with female genital mutilation.
Methods: This study was performed on seven fresh female cadavers. The site of origin, diameter, length, and trajectory of each nerve and artery were recorded. The clitoral neurovascular flap advancement was measured after a midline transection of the suspensory ligament was performed and after extensive liberation of the dorsal bundles at their emergence from the pubic rami.
Results: At the distal point of the clitoral body, the width of the dorsal nerve and artery was 1.9 ± 0.3 mm and 0.9 ± 0.2 mm, respectively. The total length of the dorsal bundles was 6.6 cm (± 0.4). The midpart of the suspensory ligament was sectioned, which allowed a mean anteroposterior mobility of 2.7 cm (± 0.2). Extensive dissection of the neurovascular bundles up to their point of emergence from the suspensory ligament allowed a mean mobility of 3.4 ± 0.2 cm.
Conclusion: We described the anatomical characteristics of the dorsal nerve and artery of the clitoris and the mobility of the clitoral neurovascular flap for reconstruction post clitoridectomy. This was done to restore the anatomic position of the glans clitoris while preserving and potentially restoring clitoral function in patients with female genital mutilation.
Keywords: Clitoral advancement; Clitoral anatomy; Clitoral reconstruction; Clitoral surgery; Dorsal artery of clitoris; Dorsal nerve of clitoris; Female genital mutilation.
Copyright © 2021 Elsevier Ltd. All rights reserved.
Index Finger Pollicization Incisions for Congenital Thumb Aplasia: Review and Design of an Educational Anatomical Model for Skin Incisions
Index Finger Pollicization Incisions for Congenital Thumb Aplasia: Review and Design of an Educational Anatomical Model for Skin Incisions
Anaïs Delgove, Olivier Camuzard, Manuela Perez, Marc Braun , Pierre Journeau, Gilles Dautel
https://pubmed.ncbi.nlm.nih.gov/34153012/
Abstract
Background: Pollicization of the index finger can be considered the gold standard technique for the treatment of congenital thumb aplasia. The aim of this study was to review the described incisions for pollicization and to create an anatomical framework enabling the study and comparison of these incisions.
Methods: A systematic review was performed to collect descriptions of incision sets. An anatomical model was created from the two upper limbs of the same cadaver. Thumb aplasia was modeled on both hands of this cadaver by severing the thumbs; an index finger pollicization was performed on one of the two hands. Comparative analysis of scar positions, first web size, and neothumb aspect of each incision set was conducted using a surgical glove modeling the skin. The glove was fitted onto the aplastic model to draw the incisions and then onto the pollicized hand to adjust the resulting flaps after cutting.
Results: Twelve articles, two textbooks, and one DVD were included in the review, either containing an original description of incisions, or describing an incision pattern with figures and references to the initial author. A total of five different incision sets, described by Buck-Gramcko, Blauth, Foucher, Ezaki, and Malek, were identified and compared using the anatomical model.
Conclusions: This work summarizes five original incisions described for index pollicization in thumb aplasia and presents a standardized and reliable model to study and compare these different sets. The model can be used for educational purposes, either to teach or to optimize an incision set.
Copyright © 2021 by the American Society of Plastic Surgeons.
Vascularization of the lateral and medial antebrachial cutaneous nerves by cutaneous perforator arteries: An anatomical study
Vascularization of the lateral and medial antebrachial cutaneous nerves by cutaneous perforator arteries: An anatomical study
M Cegarra-Escolano, C Jaloux, M-A Poumellec , T Balaguer, P Baqué, N Bronsard , O Camuzard
https://pubmed.ncbi.nlm.nih.gov/33757862/
Abstract
The forearm is an interesting donor site for non-vascularized nerve grafts, especially hand surgeons. Very few studies have described the use of the lateral and medial antebrachial cutaneous nerves (LABCN and MABCN, respectively) as vascularized nerve grafts (VNGs). The aim of this anatomical study was to analyze the characteristics and vascularization of these nerves to describe new potential donor sites for VNGs. Twelve forearms were dissected from fresh cadavers injected with red latex. The number of terminal branches, lengths, and proximal and distal diameters of both the LABCN and MABCN were studied. An anatomical description of the cutaneous perforator arteries from the radial and ulnar arteries that vascularized the nerve was also recorded: number of perforators, length, type of perforator (septo- or musculocutaneous), and location within the forearm (proximal, middle, and distal third). In over 80% of the specimens, the cutaneous perforator arteries from the radial and ulnar artery vascularized the LABCN and the MABCN, respectively. These arteries, found mostly in the proximal third of the forearm, had diameters >0.5mm. Most of them came from the radial and ulnar arteries (for LABCN and MABCN vascularization, respectively). In over 75% of the specimens, the nutrient arteries of both nerves also vascularized the superficial veins and the skin. We found that these nerves are vascularized by perforators arteries, which also participate in vein and skin vascularization. Altogether, this anatomical study shows that reconstructive surgeons could use new VNGs based on the perforator artery of the forearm.
Keywords: Anatomical study; Artère perforante; Forearm cutaneous nerves; Greffe nerveuse vascularisée; Lambeau perforant; Lateral antebrachial cutaneous nerve; Medial antebrachial cutaneous nerve; Nerf cutané latéral de l’avant-bras; Nerf cutané médial de l’avant-bras; Nerfs cutanés de l’avant-bras; Nerve vascularization; Palmar digital nerve repair; Perforator artery; Perforator flap; Réparation des nerfs digitaux palmaires; Vascularization nerveuse; Vascularized nerve graft; Étude anatomique.
Copyright © 2021 SFCM. Published by Elsevier Masson SAS. All rights reserved.
The Vascularized Lateral Antebrachial Cutaneous Nerve Graft Based on a Radial Artery Perforator for Nerve Defect Reconstruction: An Anatomical Study
The Vascularized Lateral Antebrachial Cutaneous Nerve Graft Based on a Radial Artery Perforator for Nerve Defect Reconstruction: An Anatomical Study
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
https://pubmed.ncbi.nlm.nih.gov/33634751/
Abstract
Keywords: Autophagosome; LC3; cancer; flux; lysosome; macroautophagy; neurodegeneration; phagophore; stress; vacuole.
Complex abdominal wall reconstruction after oncologic resection in a sequalae of giant omphalocele: A case report
Complex abdominal wall reconstruction after oncologic resection in a sequalae of giant omphalocele: A case report
Frederica Jessie Tchoungui Ritz , Marie Anne Poumellec, Alexandra Maertens, Lionel Sebastianelli , Olivier Camuzard, Thierry Balaguer, Antonio Iannelli
https://pubmed.ncbi.nlm.nih.gov/33691272/
Abstract
Introduction: Trauma injuries and oncologic resection are common aetiologies of complex abdominal wall defect. Reconstruction of abdominal wall is an everlasting question for general, paediatric and reconstructive surgeons. The plethora of techniques, bioprosthetic and engineered tissues offer countless possibilities.
Presentation of case: The patient was a 28 years old woman, with past history of untreated giant liver omphalocele, admitted for a suspicious hepatic tumefaction without specific clinical signs. The thoraco abdominopelvic CT scan revealed lung metastasis and a bilobed left hepatic tumour. Pre-operative cytologic findings of mild differentiated hepatocellular carcinoma differed from the post-operative findings of hepatoblastoma. The full-thickness abdominal wall defect after a radical resection was reconstructed with a combined acellular dermal matrix, NPWT and skin graft solution. A total epithelization was obtained after 8 weeks follow-up.
Discussion: Hepatoblastoma in adult is rare, with no consensus. A radical resection in context of giant untreated omphalocele is an unusual challenge for the surgical team. The pre-operative evaluation, the defect classification and the general conditions of the patient are paramount steps for an appropriate reconstruction. Primary or delayed reconstruction with myocutaneous flap as gold standard, depends on the oncologic management and anticipated post-operative complications. Acellular dermal matrix used for a bridged fascial repair directly on viscera and covered by NPWT, favourited a healthy granulation tissue. The full-thickness defect was then reconstructed with an ADM, NPWT and skin graft instead of an association with the myocutaneous flap. The patient follow-up was emphasized in the hepatoblastoma, but the complications of this reconstruction strategy are unknown. A total epithelization was obtained, the abdominal bulge or hernia is the first complication under surveillance.
Conclusion: Delayed reconstruction after an oncologic large abdominal wall resection has the advantage to manage post-operative complications and prepare alternative solutions. Acellular dermal matrix was not first designed for skin tissue regeneration, some authors as us experimented the conclusion that this matrix could be used for permanent abdominal wall reconstruction.
Keywords: Abdominal wall reconstruction; Acellular dermal matrix; Hepatoblastoma; Negative Pressure Wound Therapy; Omphalocele.
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Publications 2020 du Dr CAMUZARD Olivier
Autophagy in Osteosarcoma Cancer Stem Cells Is Critical Process which Can Be Targeted by the Antipsychotic Drug Thioridazine
Autophagy in Osteosarcoma Cancer Stem Cells Is Critical Process which Can Be Targeted by the Antipsychotic Drug Thioridazine
Olivier Camuzard, Marie-Charlotte Trojani, Sabine Santucci-Darmanin, Sophie Pagnotta, Véronique Breuil, Georges F Carle, Valérie Pierrefite-Carle
https://pubmed.ncbi.nlm.nih.gov/33297525/
Abstract
Cancer stem cells (CSCs) represent a minor population of cancer cells with stem cell-like properties which are able to fuel tumor growth and resist conventional treatments. Autophagy has been described to be upregulated in some CSCs and to play a crucial role by maintaining stem features and promoting resistance to both hostile microenvironments and treatments. Osteosarcoma (OS) is an aggressive bone cancer which mainly affects children and adolescents and autophagy in OS CSCs has been poorly studied. However, this is a very interesting case because autophagy is often deregulated in this cancer. In the present work, we used two OS cell lines showing different autophagy capacities to isolate CSC-enriched populations and to analyze the autophagy in basal and nutrient-deprived conditions. Our results indicate that autophagy is more efficient in CSCs populations compared to the parental cell lines, suggesting that autophagy is a critical process in OS CSCs. We also showed that the antipsychotic drug thioridazine is able to stimulate, and then impair autophagy in both CSC-enriched populations, leading to autosis, a cell death mediated by the Na+/K+ ATPase pump and triggered by dysregulated accumulation of autophagosomes. Taken together, our results indicate that autophagy is very active in OS CSCs and that targeting this pathway to switch their fate from survival to death could provide a novel strategy to eradicate these cells in osteosarcoma.
Keywords: Na+/K+ ATPase; autophagy; autosis; cancer stem cells; osteosarcoma.
Arterial grafts for proper palmar digital artery reconstruction: An anatomical study
Arterial grafts for proper palmar digital artery reconstruction: An anatomical study
H Remy, F Locatelli, A Maertens, T Balaguer, P Baqué, N Bronsard, O Camuzar
https://pubmed.ncbi.nlm.nih.gov/33137466/
Abstract
Digital ischemia due to arterial defects need urgent surgical management. The traditional treatment consists of vascular reconstruction using a reversed autologous venous graft as a bypass. Very few studies have described the use of arterial grafts for digital artery reconstruction. This cadaver study characterized the forearm perforator arteries to assess the potential feasibility of using them as donor grafts for digital artery reconstruction. Eleven forearms and twenty hands were dissected from freshly injected cadavers. All clinically significant perforators (>0.5 mm) derived from radial or ulnar arteries and digital arteries were evaluated. The digital palmar arteries were measured at three points: metacarpophalangeal (MCP) joint, proximal interphalangeal (PIP) joint, and distal interphalangeal (PIP) joint. In the 11 forearms analyzed, 5.5 ± 1.3 perforators from radial or ulnar arteries with a diameter of at least 0.5 mm were found per dissection. The mean diameters were 0.9 ± 0.18 mm proximally and 0.8 ± 0.15 mm distally; the mean length was 35.6 ± 11.35 mm. The mean diameters for the dominant and non-dominant arteries were 1.5 and 1.3 mm at the MCP, 1.3 and 1.0 mm at the PIP, 0.8 and 0.7 mm at the DIP, respectively. The forearms are good donor sites as they have large-diameter arteries of suitable length for arterial grafting. These new arterial grafts may be suitable for vascular reconstruction of digital arteries starting from the PIP joint.
Keywords: Arterial bypass; Arterial graft; Artère digitale palmaire propre; Artère perforante; Artère radiale; Artère ulnaire; Digital ischemia; Dévascularisation; Greffon artérielle; Perforator artery; Pontage artériel; Proper palmar digital artery; Radial artery; Ulnar artery.
Copyright © 2020 SFCM. Published by Elsevier Masson SAS. All rights reserved.
Autophagy in the crosstalk between tumor and microenvironment
Autophagy in the crosstalk between tumor and microenvironment
Olivier Camuzard, Sabine Santucci-Darmanin, Georges F Carle, Valérie Pierrefite-Carle
https://pubmed.ncbi.nlm.nih.gov/32634449/
Abstract
Autophagy is the major catabolic process in eukaryotic cells for the degradation and recycling of damaged macromolecules and organelles. It plays a crucial role in cell quality control and nutrient supply under stress conditions. Although autophagy is classically described as a degradative mechanism, it can also be involved in some secretion pathways, leading to the extracellular release of proteins, aggregates, or organelles. The role of autophagy in cancer is complex and depends on tumor development stage. While autophagy limits cancer development in the early stages of tumorigenesis, it can also have a protumoral role in more advanced cancers, promoting primary tumor growth and metastatic spread. In addition to its pro-survival role in established tumors, autophagy recently emerged as an active player in the crosstalk between tumor and stromal cells. The aim of this review is to analyze the impact of tumoral autophagy on the microenvironment and conversely the effect of stromal cell autophagy on tumor cells.
Keywords: Autophagosome; Cancer; Degradation; Secretion; Stromal cells.
Copyright © 2020 Elsevier B.V. All rights reserved.
Comment on: Arterialized Posterior Interosseous Nerve Graft for Digital Neuroma
Comment on: Arterialized Posterior Interosseous Nerve Graft for Digital Neuroma
Olivier Camuzard, Abraham Zavala
Medial femoral condyle free flap for reconstruction of carpometacarpal bone defect after giant cell tumour of tendon synovial sheath resection
H Barret, H Remy, S Piereschi, O Camuzard
https://pubmed.ncbi.nlm.nih.gov/32854971/
Abstract
We report the case of a 23-year-old patient treated for a large giant cell tumour of the synovial sheaths of the ulnar edge of the hand and wrist invading the triquetrum, the hamatum, the ulnar part of the capitate as well as the bases of the 3rd, 4th and 5th metacarpals and the floor of the Guyon’s canal and the carpal tunnel. A monobloc resection was performed in a healthy margin ; the loss of bone substance was 7×3.5cm. We performed a bone reconstruction using a cortico-cancellous medial femoral condyle free flap of 8×4cm. Postoperative follow-up was uneventful and bone consolidation was achieved at 2,5 months postoperatively. The cortico-cancellous medial femoral condyle free flap is an interesting option for treating small and medium size bone loss in the hand and wrist. Its use in its pure bone form or in its chimeric form with muscle, cartilage or skin opens up a wide range of choices for the reconstructive surgeon.
Keywords: Giant cell tumour of the synovial sheaths; Hand reconstruction; Lambeau de condyle fémoral médial; Lambeau osseux vascularisé; Medial condyle femoral flap; Reconstruction main; Tumeur à cellule géante des gaines synoviales; Vascularised bone flap.
Copyright © 2020 Elsevier Masson SAS. All rights reserved.
Posttraumatic pseudoaneurysm of a superficial branch of the ulnar artery: A case report
Posttraumatic pseudoaneurysm of a superficial branch of the ulnar artery: A case report
Alexandra Maertens, Frederica Jessie Tchoungui Ritz, Marie Anne Poumellec, Olivier Camuzard, Thierry Balaguer
https://pubmed.ncbi.nlm.nih.gov/32980701/
Abstract
Introduction: Hand and Upper limb pseudoaneurysms are uncommon and misdiagnosed. The delayed diagnostic and treatment lead to severe vascular and nerve complications. Many mechanisms are involved like acute injury, chronic micro traumatism of the hand, with specific clinic and para clinic signs.
Presentation of case: The patient was a 30-years old woman, right-handed, admitted at the emergencies for a penetrating hand injury at the junction of the middle third – distal third of the left forearm, palmar surface, with a good radial and ulnar pulse, without sensory or motor deficit. No vessels injuries observed per operatively. A post-operative worsened pain opposite to the scar with a purplish pulsatile swelling appeared after 20 days of complete wound healing. A needle puncture with a red blood contain, motivated an US Doppler revealing a pseudoaneurysm of a superficial artery of the ulnar artery, surgically resected, without complication.
Discussion: Two main mechanisms are involved in upper limb especially hand pseudoaneurysm: penetrating trauma and repeated micro traumatism. Superficial vessels are rarely damaged compare to deep subfascial vessels according to Laplace law. The diagnostic is clinical confirmed with the medical imaging. A pseudoaneurysm is suspected in front of a pulsatile painful tumefaction following a vessel path, with medical imaging in favor. A delayed misdiagnosis lead to a delayed care with severe complications as thrombosis, embolism and vessel. The therapeutic care is mainly surgical.
Conclusion: This case reports a delayed diagnostic of posttraumatic pseudoaneurysm of a superficial branch of the ulnar artery, managed with a surgical resection.
Keywords: Case report; Hand injury; Pseudoaneurysm; Ulnar artery.
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
Volar fracture dislocation of the 2nd metacarpal base associated with acute carpal tunnel syndrome: A case report
S Piereschi, H Remy, O Camuzard
https://pubmed.ncbi.nlm.nih.gov/32763069/
Abstract
Posttraumatic acute carpal tunnel syndrome is a not a usual complication in traumatic hand injuries but requires more urgent and aggressive management. Compression of the median nerve should be systematically sought when there is a major and painful swelling of the hand, associated with one or several hand and wrist fractures. In rare case, a single metacarpal fracture or dislocation can be the only cause of median nerve compression and requires urgent diagnosis. If missed or neglected irreversible damage could occur to the median nerve. If surgery is perform in a timely manner outcomes are excellent, with complete recovery in most of the cases. We present the case of a 24-year-old man with an acute compression of the median nerve due to an intra-articular fracture of the 2nd metacarpal base. A bony fragment shifting from the base of 2nd metacarpal was found in the carpal tunnel participating, at least in part, in the compression of the median nerve.
Keywords: Acute carpal tunnel symptom; Carpometacarpal dislocation; Compression du nerf médian; Fracture des métacarpien; Hand trauma; Luxation carpo-métacarpienne; Median nerve compression; Metacarpal fracture; Syndrome du canal carpien aigu; Traumatisme main.
Copyright © 2020 Elsevier Masson SAS. All rights reserved.
Publications 2019 du Dr CAMUZARD Olivier
Adaptive Proximal Scaphoid Implant: Indications and Long-Term Results
Adaptive Proximal Scaphoid Implant: Indications and Long-Term Results
Marie-Anne Poumellec, Olivier Camuzard, Jean-Pierre Pequignot, Nicolas Dreant
https://pubmed.ncbi.nlm.nih.gov/31402997/
Abstract
Objective This study aims to define the indications of APSI and to evaluate the long-term results. Patients and Methods This is a monocentric study including patients that underwent an arthroplasty of the scaphoid proximal pole using an APSI between 1994 and 2010. Patients were assessed using autoquestionnaires and measuring ranges of motion, key pinch, and grip strength. X-ray views of the wrist were done to control the mobility of the implant and the evolution of the carpal collapse, if present. Results There were 19 patients included with a mean follow-up of 11 years. The mean range of motion was 106 degrees (65% of contralateral side) in flexion-extension and 33 degrees (78% of contralateral side) in radialulnar deviation. The mean grip strength was 72% of the contralateral side. The mean Mayo wrist score was 69/100, the mean QuickDASH 26/100, and the mean patient-rated wrist evaluation (PRWE) 25/100. After 10 years, evolution to osteoarthritis was noted in 32% of the patients. This was associated with a decrease of the carpal height. More specifically, capito-lunate osteoarthritis was noted after 10 years and two out of three patients were concerned after 20 years of follow-up. No osteoarthritis was diagnosed at the radiolunate articulation. Conclusion APSI is a treatment option that enables patients with scaphoid nonunion advanced collapse (SNAC), scapholunate advanced collapse (SLAC) I or II to preserve the strength and mobility with good functional results. But this arthroplasty does not prevent natural evolution to a carpal collapse after a follow-up of 20 years which is clinically well tolerated.
Keywords: adaptive proximal scaphoid implant; proximal scaphoid replacement; wrist arthritis; wrist arthroplasty.
Minimally Invasive Fixation With a Volar Approach Using a Cannulated Compression Screw for Acute Hook of Hamate Fractures
Romain Ceccarelli, Christian Dumontier, Olivier Camuzard
https://pubmed.ncbi.nlm.nih.gov/30797656/
Abstract
Purpose: Optimal treatment of acute hook of hamate fractures (HHF) remains controversial. Isolated acute HHF can be treated nonsurgically or surgically (with excision of the hook or open reduction internal fixation). The authors present the functional outcomes of a case series of patients who were treated with minimally invasive volar fixation for acute HHF.
Methods: This retrospective study reviewed 6 patients with nondisplaced acute HHF treated with a minimally invasive volar approach and cannulated mini-screw fixation. The development of postoperative complications (tendon and ulnar nerve lesions), pain evaluated using a visual analog scale, and radiological union evaluated on computed tomography scan is reported. Wrist range of motion and grip strength were measured bilaterally. Mayo Wrist Score and Quick-Disabilities of the Arm, Shoulder, and Hand were assessed. All outcomes were measured at 1, 2, 3, and 6 months after surgery.
Results: Fixation of HHF through the volar approach was achieved in all cases with no complications. The clinical and radiological union rate was 100%. All patients were able to return to their work or hobbies after an average of 7 weeks.
Conclusions: This study suggests that acute HHF can be treated successfully by open reduction internal fixation using a volar approach with minimal morbidity and complications, a good union rate, and a fast return to daily activities.
Type of study/level of evidence: Therapeutic V.
Keywords: Acute hamate hook fracture; cannulated mini-screw; minimally invasive surgery; volar approach.
Copyright © 2019 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.
Neoadjuvant isolated limb perfusion in newly diagnosed untreated patients with locally advanced soft tissue sarcomas of the extremities: the Gustave Roussy experience
T Assi, A Cavalcanti, A Le Cesne, M Faron, J F Honart, A Hadiji, O Camuzard, T Ibrahim, C LePéchoux, O Mir, S Dumont, P Terrier, J Adam, C Honoré
https://pubmed.ncbi.nlm.nih.gov/30656606/
Abstract
Background: Limb-sparing surgery in locally advanced soft tissue sarcomas (LA STS) is challenging. The aim of this study is to evaluate upfront isolated limb perfusion (ILP) in untreated patients with LA STS.
Methods: All consecutive patients with LA STS of the limbs deemed borderline or unresectable and treated with upfront ILP as induction treatment between 2003 and 2016 were included. Demographic, clinical and long-term characteristics were obtained and retrospectively analyzed.
Results: 41 patients (pts), with a median age of 51 years [range 21-76], were identified (lower limb 68%, upper limb 32%). Liposarcoma and undifferentiated pleomorphic sarcoma were the most common subtypes (27% and 22%, respectively). Acute toxicities, using Wieberdink classification, were grade II (35 pts, 85%), grade III (2 pts, 5%) and no grade IV-V. Local control rate was 98%. 32 pts had limb-sparing surgery (78%). 1 pt had an early amputation due to progressive disease after ILP. 8 pts were not operated (four had RT alone, one had distant metastases, two had a complete response and one died 3 months after ILP of a pulmonary embolism). 36 pts (84%) received postoperative RT. After a median follow-up of 43 months, 18 pts (47%) relapsed. Median disease-free survival (DFS) was 6.7 years. The median overall survival (OS) was not reached. The 1-year, 5-year and 10-year DFS and OS rates were, respectively, 75%, 50% and 45%, and 90%, 63% and 55%.
Conclusion: Upfront ILP is an efficient and well-tolerated limb-sparing procedure in borderline or unresectable LA STS without hampering OS.
Keywords: Chemotherapy; Isolated limb perfusion; Limb salvage; Neoadjuvant treatment; Soft tissue sarcoma.
Role of autophagy in osteosarcoma
Role of autophagy in osteosarcoma
Olivier Camuzard, Sabine Santucci-Darmanin, Georges F Carle, Valérie Pierrefite-Carle
https://pubmed.ncbi.nlm.nih.gov/31011524/
Abstract
Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents. It is a highly aggressive tumor with a tendency to spread to the lungs, which are the most common site of metastasis. Advanced osteosarcoma patients with metastasis share a poor prognosis. Despite the use of chemotherapy to treat OS, the 5-year overall survival rate for patients has remained unchanged at 65-70% for the past 20 years. In addition, the 5-year survival of patients with a metastatic disease is around 20%, highlighting the need for novel therapeutic targets. Autophagy is an intracellular degradation process which eliminates and recycles damaged proteins and organelles to improve cell lifespan. In the context of cancer, numerous studies have demonstrated that autophagy is used by tumor cells to repress initial steps of carcinogenesis and/or support the survival and growth of established tumors. In osteosarcoma, autophagy appears to be deregulated and could also act both as a pro or anti-tumoral process. In this manuscript, we aim to review these major findings regarding the role of autophagy in osteosarcoma.
Keywords: Autophagy; Cell death; Osteosarcoma; Survival.
Autophagy Involvement in Aseptic Loosening of Arthroplasty Components
Autophagy Involvement in Aseptic Loosening of Arthroplasty Components.
Camuzard, Olivier MD; Breuil, Véronique MD, PhD; Carle, Georges F. PhD; Pierrefite-Carle, Valérie PhD
https://pubmed.ncbi.nlm.nih.gov/30845042/
The infraorbital artery: From descriptive anatomy to mucosal perforator flap design
The infraorbital artery: From descriptive anatomy to mucosal perforator flap design
Katharina Hufschmidt, Olivier Camuzard, Thierry Balaguer, Patrick Baqué, Fernand de Peretti, Joseph Santini, Nicolas Bronsard, Quentin Qassemyar
https://pubmed.ncbi.nlm.nih.gov/30684276/
Abstract
Background: The terminal and perforating branches of the infraorbital artery (IOA) are poorly described. Its anatomical situation and mucosal component could provide an interesting donor site for mucosal reconstruction. The aims of the following study were to establish an anatomical description and to assess the feasibility of mucosal perforator flaps for eyelid and nasal reconstruction.
Methods: Twenty-three fresh cadaver hemifaces were studied in order to perform an IOA anatomical classification by recording the artery’s characteristics, its course, number, type, and diameter of terminal branches. We also examined the feasibility of local flaps for facial reconstruction.
Results: We highlighted five different types of courses. All cadavers had at least one superior vestibular branch with a caliber of ≥0.4 mm. A pedicled flap arising from the vestibular branch was raised in all dissections.
Conclusion: The vestibular perforator flap based on the IOA seems to be a reliable flap in reconstruction of mucosal defects.
Keywords: eyelid repair; infraorbital artery; mucosal reconstruction; nostril repair; perforator flap.
© 2019 Wiley Periodicals, Inc.
Ultrasound-guided percutaneous release of the carpal tunnel: comparison of the learning curves of a senior versus a junior operator. A cadaveric study
Chloé Dekimpe, Olivier Andreani, Olivier Camuzard, Charles Raffaelli, David Petrover, Pauline Foti, Nicolas Amoretti
https://pubmed.ncbi.nlm.nih.gov/31114970/
Abstract
Objective: The purpose was to evaluate, in a cadaveric cohort, the feasibility and the learning curve of ultrasound-guided percutaneous carpal tunnel release.
Materials and methods: Fourteen carpal tunnel releases were carried out on unembalmed cadavers by a senior and a junior radiologist. Procedures were realized with an 18-MHz linear probe. An anatomical evaluation was first performed using ultrasound to detect any anatomical variant. After hydrodissection of the carpal tunnel with lidocaine, a 3-mm hook knife was introduced into the security zone to perform a retrograde section of the transverse carpal ligament (TCL) under ultrasound guidance. Anatomical dissection was performed for each wrist. The main evaluation criterion was the complete TCL section. The procedure duration (minutes), skin incision size (millimeters), the integrity of the median nerve, thenar motor branch, and palmar vascular arch were also evaluated.
Results: The senior operator was able to perform a complete release after training on three specimens and the junior operator after four specimens (p > 0.05). In most of the cases when complete release was not achieved, it was due to an incomplete section of the distal TCL (10 mm missing section on average). Mean duration time of procedure was 14 min (11 min for the senior versus 17 min for the junior, p > 0.05). Damage of neither the median nerve nor the vascular structure was observed. Mean size of the skin incision was 3 mm.
Conclusion: The ultrasound-guided percutaneous release of the carpal tunnel is demonstrated to be a procedure with a rapid learning curve.
Keywords: Cadaver; Carpal tunnel syndrome; Learning curve; Median nerve; Ultrasound.
Publications 2018 du Dr CAMUZARD Olivier
Is it possible to give a single definition of the rectosigmoid junction?
Is it possible to give a single definition of the rectosigmoid junction?
Damien Massalou, David Moszkowicz, Daniela Mariage, Patrick Baqué, Olivier Camuzard, Nicolas Bronsard
https://pubmed.ncbi.nlm.nih.gov/29218384/
Abstract
Aim: The rectosigmoid junction is the limit separating the sigmoid colon and rectum. This transition zone has different definitions. We want to highlight different landmarks of the rectosigmoid junction (RSJ), to help the clinicians to adopt a consensual definition.
Method: We reviewed anatomical, endoscopic, physiological and surgical points of view concerning the rectosigmoid junction (RSJ).
Results: The rectosigmoid junction has a different definition depending on who is studying it. Nevertheless, it is a high pressure location, a place connecting different muscles organizations, neurological systems or vascular anastomosis. The clear pathophysiology of the RSJ is not yet determined with certainty, but its resection is essential for the therapeutic care of patients and also for the improvement of surgical skills. From a surgical point of view, anatomical landmarks has to be chosen: easily reproducible and identifiable. The disappearance of taenia coli (belonging to the colon) and the peritoneal reflection (recto-genital pouch), located below the upper rectum, seem the most reliable. The level of rectal section must, in any case, be below the promontory.
Conclusion: There is not a single definition, but rather several definitions of the RSJ. Each one of them reflects one appearance of this region: embryological and anatomical evolution or clinical entity. From a surgical point of view, the criterion which seems to be the most reliable is the disappearance of taenia coli and the peritoneal reflection (recto-genital pouch).
Keywords: Anatomy; Lymph node; Rectosigmoid junction; Rectum.
Reliability of Color Doppler Ultrasound Imaging for the Assessment of Anterolateral Thigh Flap Perforators: A Prospective Study of 30 Perforators
Alexandre Debelmas, Olivier Camuzard, Paola Aguilar, Quentin Qassemyar
https://pubmed.ncbi.nlm.nih.gov/29481406/
Abstract
Despite numerous advantages, the anterolateral thigh perforator flap suffers from the variable position and nature of its perforators. The aim of the authors’ study was to assess the reliability of preoperative color Doppler ultrasound imaging for the exploration of perforator location and course of anterolateral thigh perforator flaps. A prospective cohort study involving patients for whom head and neck reconstruction was planned with thin anterolateral thigh perforator flaps was conducted. Each patient underwent a color Doppler ultrasound exploration of the thighs, in the operating room, immediately before surgery. The sonographer was the surgeon who raised the flaps. Perforators were sought according to surgical needs, and the same location protocol was followed for all of the cases, using an orthonormal coordinate system to report the passages of the perforators through the vastus lateralis aponeurosis. Between January of 2016 and January of 2017, 22 thin anterolateral thigh perforator flaps were successfully harvested. Thirty perforators were located and used. The median distance between the preoperative color Doppler ultrasound planning and the final location of the perforators was 5 mm, statistically smaller than a 10-mm threshold (p = 0.002). Color Doppler ultrasound effectively predicted the nature of the perforators in 90 percent of the cases. The median duration for perforator color Doppler ultrasound location was 3 minutes, statistically shorter than 10 minutes (p = 0.0001). Preoperative color Doppler ultrasound seems to be reliable, accurate, and compatible with a quick routine assessment during patient setup for the elevation of thin anterolateral thigh perforator flaps.
Clinical question/level of evidence: Diagnostic, II.
Rice-body formation without rheumatic disease or tuberculosis in a ``sausage`` ring finger
Rice-body formation without rheumatic disease or tuberculosis in a « sausage » ring finger
M Cegarra-Escolano, C Jaloux, O Camuzard
https://pubmed.ncbi.nlm.nih.gov/29786532/
Abstract
Rice bodies are very unusual lesions, generally encountered in chronic synovitis due to rheumatoid diseases or tuberculosis. A 31-year-old right-handed man presented with a 15-year history of progressively growing « sausage-like » swelling of the 4th finger and palm of his right hand. There was an immovable, painless mass with restriction of the finger’s ROM without local or general associated signs. Imaging showed a large non-aggressive mass within the tendon sheath. Complete excision of the mass was performed. Histopathological examination showed synovial villi with rice bodies and central necrosis suggestive of tuberculous synovitis or rheumatoid arthritis (RA). Tests for mycobacterial infections were all negative and there was no argument in favor of a rheumatoid pathology. There is no established standard treatment in a case like ours, which has no origin in tuberculosis or RA. Prolonged follow-up will be needed to confirm absence of recurrence after complete excision.
Keywords: Chronic synovitis; Flexor tendon sheath; Gaine des tendons fléchisseurs; Grains de riz; Polyarthrite rhumatoïde; Rheumatoid arthritis; Rice bodies; Synovite chronique; Tuberculose; Tuberculosis.
Copyright © 2018. Published by Elsevier Masson SAS.
The infraorbital artery: Clinical relevance in esthetic medicine and identification of danger zones of the midface
K Hufschmidt, N Bronsard, R Foissac, P Baqué, T Balaguer, B Chignon-Sicard, J Santini, O Camuzard
https://pubmed.ncbi.nlm.nih.gov/30327185/
Abstract
Background: Over the past decade, cosmetic injections of dermal fillers or fat have become a popular procedure in facial rejuvenation in an overconsuming society. However, complications such as arterial embolism and occlusion can occur even with experienced injectors, especially in high-risks zones namely the glabella, the nasal dorsum or the nasolabial fold. The aim of this study was to define the vascular danger zones of the infraorbital area in order to provide guidelines helping avoid them.
Materials and methods: The infraorbital artery, its main branches and their anastomoses with neighbouring vessels were studied in 18 fresh cadavers. Mimetic injections of inked hyaluronic acid were performed in the infraorbital area in the interest of analyzing its distribution and to determine potential vascular risks towards the infraorbital artery and its branches.
Results: The infraorbital artery and its branches were located in common injection regions and anastomosed to the supratrochlear artery, the dorsal nasal artery and the angular artery through the nasal branch of the infraorbital artery. Two danger zones could be depicted: injections can be risky when performed too superficially in the midcheek area, and likewise risky when performed in a periosteal layer in infraorbital hollow or tear-trough correction, because of an obvious possibility of retrograde embolism.
Conclusion: The infraorbital artery can be involved in anatomic mechanism of arterial occlusion, further blindness and stroke, among the related neighbouring arteries. Based on the findings of this study, injections to the periosteum layer in tear-trough correction and above the periosteum on the zygomatic arch is not advised.
Keywords: Anatomical study; Cheek enhancement; Infraorbital artery; Tear-trough correction; Vascular filler complications.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Versatility of cervicofacial flaps: Cervical-medial cheek flap for reconstruction in cutaneous substance loss of the inner cheek
Katharina Hufschmidt, Alexandre Bozec, Olivier Camuzard, Cyril Clerico, Riadh Berguiga, Olivier Dassonville, Joseph Santini, Gilles Poissonnet
https://pubmed.ncbi.nlm.nih.gov/30447111/
Abstract
Background: Preservation of facial harmony is a major challenge in reconstruction after resection of head and neck skin tumors. For large medial cheek-skin defects, we used a derived posterior-based cervicofacial flap, or cervical-medial cheek flap (CMCF).
Methods: We present a retrospective review of cases treated at a university-based cancer center. Patient characteristics, surgical technique, and complication rates are described.
Results: Eighteen patients were treated between 2014 and 2017 with reconstruction for integumentary cheek defect after skin tumor surgery using CMCF. Mean defect size was 5.7 cm in length and 3.9 cm in width. The main histological subtype was lentigo maligna (33.3%). We report no flap necrosis but 4 minor complications occurred over a mean follow-up of 14.4 months. At last follow-up, satisfaction rate was very high (88.9%) with no evidence of recurrence.
Conclusion: The CMCF is a promising yet infrequently used option in medial cheek reconstruction, with excellent cosmetic and functional outcomes.
Keywords: cervicofacial flap; cheek reconstruction; head and neck oncology; midfacial third defect; skin tumor.
© 2018 Wiley Periodicals, Inc.
Publications 2017 du Dr CAMUZARD Olivier
A Modified Patient Positioning for Transaxillary Breast Augmentation
A Modified Patient Positioning for Transaxillary Breast Augmentation
Rémi Foissac, Olivier Camuzard, Jonathan Fernandez, Joel Levy
Autophagy, a key process in bone homeostasis
Autophagy, a key process in bone homeostasis
Olivier Camuzard, Sabine Santucci-Darmanin, Georges F Carle, Valérie Pierrefite-Carle
Coverage of Tendon Exposure after Radial Forearm Free Flap by the Dorsoulnar Artery Perforator Flap
Coverage of Tendon Exposure after Radial Forearm Free Flap by the Dorsoulnar Artery Perforator Flap
Rémi Foissac, Marc Benatar, Olivier Dassonville, Alexandre Bozec, Gilles Poissonnet, Olivier Camuzard
https://pubmed.ncbi.nlm.nih.gov/28195002/
Abstract
Objective This study was designed to assess the effectiveness of an alternative technique using a perforator flap to manage secondary tendon exposure after a radial forearm free flap in head and neck oncologic surgery. Study Design Prospective cohort study. Setting Plastic Reconstructive Surgery Unit, Nice University Hospital, Pasteur 2 Hospital, France. Subjects and Methods Despite its numerous advantages, the radial forearm free flap is associated with significant donor site morbidity and the risk of secondary tendon exposure. Conventional skin grafts for secondary tendon exposure can lead to diminished wrist range of motion and grip strength, with residual pain and cold intolerance. Between 2012 and 2015, we prospectively studied 20 patients with secondary tendon exposure after a forearm radial free flap for head and neck reconstruction. Two techniques of secondary coverage were compared: a reference technique with a secondary full skin graft (10 patients) and a dorsoulnar artery perforator (DUAP) flap (10 patients). Results Maximum wrist extension (100%) was observed for the DUAP group compared with only 87% for the skin graft (SG) group ( P = .001). An improvement in grip strength (+14 kg) ( P = .028) and a decrease in pain or cold intolerance ( P = .002) were also observed in the DUAP group, in addition to a better aesthetic appearance. Conclusion The perforator flap procedure is an interesting tool in reconstructive surgery. The DUAP flap is a reliable, useful flap for secondary tendon exposure coverage after a radial forearm free flap. Level of Evidence III (case-control analytic studies of 1 center).
Keywords: dorsoulnar artery perforator flap; head and neck reconstruction; radial forearm free flap; secondary tendon exposure; skin graft.
Glomus tumors of the upper limb: Single-center retrospective study of clinical and functional outcomes
K Hufschmidt, R Foissac, O Camuzard, N Cardot-Leccia, B Chignon-Sicard, T Balaguer
https://pubmed.ncbi.nlm.nih.gov/28549884/
Abstract
Glomus tumors are rare and benign hamartomas, arising from neuro-myo-arterial proliferation and deriving from mesenchymal origin. As they have a long-term impact on the individual’s quality of life, the primary complaint is unbearable pain. The aim of this study was to assess the clinical and functional outcomes of their surgical treatment, and to review their clinical, radiological and therapeutic features. We performed a retrospective study over a 16-year period including 31 patients with an upper limb glomus tumor. Epidemiologic, diagnostic, therapeutic and follow-up data were collected and a functional outcome questionnaire was filled out postoperatively. Thirty-one patients underwent surgery with safe macroscopic resection margins. The glomus tumor was located on the fingers in 77.4% of cases, with predominance in the ring finger (41.9% of the cases). Patient age at surgery ranged from 22 to 80 years old (mean: 54.6) with a sex ratio of 0.48. Upon clinical suspicion, magnetic resonance imaging and ultrasound were done in most cases. Immediate pain relief was obtained in 18 cases. Only one patient underwent a second surgery for incomplete removal and persistent pain. The QuickDASH questionnaire was completed by 24 patients, resulting in a mean score of 1.61, with a mean follow-up time of 88.8 months (range: 3-171 months). Seven patients were lost to follow-up. These subcutaneous, mostly subungual, nodules, with predominance on the ring finger, have a disproportionate negative impact despite their small size. The long-term outcomes after microscope-assisted surgery indicate obvious improvement in the quality of life and the patient’s satisfaction, with a very low rate of recurrence.
Keywords: Chirurgie de la main; Glomus tumors; Hand surgery; Membre supérieur; Periungual; Périunguéal; QuickDASH; Tumeurs glomiques; Upper limb.
Copyright © 2017 SFCM. Published by Elsevier Masson SAS. All rights reserved.
High-Resolution Magnetic Resonance Imaging of Aging Upper Face Fat Compartments
High-Resolution Magnetic Resonance Imaging of Aging Upper Face Fat Compartments
Rémi Foissac , Olivier Camuzard, Sébastien Piereschi, Pascal Staccini, Olivier Andreani, Charalambos Georgiou, Marc Benatar
https://pubmed.ncbi.nlm.nih.gov/28350655/
Abstract
Background: Age-related changes in fat compartments have yet to be fully characterized. Uncertainty remains in terms of volume gains/losses or shape fluctuations over time. The authors’ aim was to determine the evolution of subcutaneous fat in the aging upper face, focusing on shifts in volume and dimension.
Methods: Over the course of 4.5 years, 100 faces of living female Caucasian patients were prospectively studied using high-resolution magnetic resonance imaging. Subjects were stratified by age as follows: group 1, 18 to 30 years; group 2, 30 to 60 years; and group 3, older than 60 years. Superficial temporal and central forehead compartments were delimited, analyzing respective volumes and dimensions by group.
Results: In 85 patients studied, superficial temporal fat (mean volume, 5.14 cm) increased 35.48 percent in total volume between youth and old age (p = 0.046). Overall height and magnitude of the lower one-third also increased with aging. Central forehead fat (mean volume, 2.56 cm), studied in 83 patients, showed a 209.75 percent volume gain in group 2 (versus group 1) and a 17.59 percent volume loss in group 3 (versus group 2) (p = 0.001).
Conclusion: Subcutaneous facial fat fluctuates with aging, increasing in the upper face and promoting ptosis through basal compartmental expansion.
Homeotic and Embryonic Gene Expression in Breast Adipose Tissue and in Adipose Tissues Used as Donor Sites in Plastic Surgery
Rémi Foissac, Phi Villageois, Bérengère Chignon-Sicard, Charalambos Georgiou, Olivier Camuzard, Christian Dani
https://pubmed.ncbi.nlm.nih.gov/28234838/
Abstract
Background: Autologous fat grafting has become an essential procedure in breast reconstructive surgery. However, molecular knowledge of different adipose donor sites remains inadequate. Tissue regeneration studies have shown that it is essential to match the Hox code of transplanted cells and host tissues to achieve correct repair. This study aims to provide a better molecular understanding of adipose tissue.
Methods: Over the course of 1 year, the authors prospectively included 15 patients and studied seven adipose areas: chin, breast, arm, abdomen, thigh, hip, and knee. The first step consisted of the surgical harvesting of adipose tissue. RNA was then extracted and converted into cDNA to study gene expression levels of 10 targeted genes by real-time polymerase chain reaction.
Results: Forty samples from Caucasian women with a mean age of 48 years were studied. The expression of PAX3, a marker of neuroectodermal origin, was significantly higher in the breast, with a decreasing gradient from the upper to lower areas of the body. An inverse gradient was found for the expression of HOXC10. This expression profile was statistically significant for the areas of the thigh and knee compared with the breast (p < 0.0083).
Conclusions: Breast fat may have a specific embryologic origin compared with the knee and thigh. The reinjection of adipocytes from the infraumbilical area leads to the transfer of cells highly expressing HOXC10. This study raises questions about the safety of this procedure, and future studies will be required to examine molecular modifications of adipose cells transferred to a heterotopic location.
Clinical question/level of evidence: Therapeutic, V.
Primary radical ablative surgery and fibula free-flap reconstruction for T4 oral cavity squamous cell carcinoma with mandibular invasion: oncologic and functional results and their predictive factors
Olivier Camuzard, Olivier Dassonville, Marc Ettaiche, Emmanuel Chamorey, Gilles Poissonnet, Riadh Berguiga, Axel Leysalle, Karen Benezery, Frédéric Peyrade, Esma Saada, Raphael Hechema, Anne Sudaka, Juliette Haudebourg, François Demard, José Santini, Alexandre Bozec
https://pubmed.ncbi.nlm.nih.gov/27438536/
Abstract
The aims of this study were to evaluate clinical outcomes and to determine their predictive factors in patients with oral cavity squamous cell carcinoma (OCSCC) invading the mandibular bone (T4) who underwent primary radical surgery and fibula free-flap reconstruction. Between 2001 and 2013, all patients who underwent primary surgery and mandibular fibula free-flap reconstruction for OCSCC were enrolled in this retrospective study. Predictive factors of oncologic and functional outcomes were assessed in univariate and multivariate analysis. 77 patients (55 men and 22 women, mean age 62 ± 10.6 years) were enrolled in this study. Free-flap failure and local and general complication rates were 9, 31, and 22 %, respectively. In multivariate analysis, ASA score (p = 0.002), pathologic N-stage (p = 0.01), and close surgical margins (p = 0.03) were independent predictors of overall survival. Six months after therapy, oral diet, speech intelligibility, and mouth opening functions were normal or slightly impaired in, respectively, 79, 88, and 83 % of patients. 6.5 % of patients remaining dependent on enteral nutrition 6 months after therapy. With acceptable postoperative outcomes and satisfactory oncologic and functional results, segmental mandibulectomy with fibula free-flap reconstruction should be considered the gold standard primary treatment for patients with OCSCC invading mandible bone. Oncologic outcomes are dependent on three main factors: ASA score, pathologic N-stage, and surgical margin status.
Keywords: Fibula; Free-flap; Head neck cancer; Mandible; Oral cavity; Reconstruction.
Publications 2016 du Dr CAMUZARD Olivier
Inferior Cubital Artery Perforator Flap for Soft-Tissue Coverage of the Elbow: Anatomical Study and Clinical Application
Olivier Camuzard, Rémi Foissac, Cyril Clerico, Jonathan Fernandez, Thierry Balaguer, Tarik Ihrai, Fernand de Peretti, Patrick Baqué, Pascal Boileau, Charalambos Georgiou, Nicolas Bronsard
https://pubmed.ncbi.nlm.nih.gov/26984913/
Abstract
Background: Soft-tissue defects surrounding the elbow can be a challenging problem for the orthopaedic surgeon. Reliable reconstruction with use of muscular flaps or even perforator flaps derived from the surrounding vessels has been described. The inferior cubital artery (ICA) is an indirect septocutaneous perforator branch that most frequently arises from the lateral side of the radial artery. The purposes of the present study were to characterize the capillary cutaneous perforators of the ICA and to evaluate the potential of a local perforator flap procedure for soft-tissue coverage of the elbow.
Methods: Twenty fresh cadaveric forearms were dissected in order to describe the ICA anatomy, and in ten additional forearms the ICA was selectively injected with a red ink solution to detail the ICA vascular territory. For each artery, we recorded the site of origin, the diameter of the artery at its source, the course of the artery, and the number, type, and diameter of capillary cutaneous perforators.
Results: A total of seventy-eight ICA capillary perforators were analyzed from the twenty dissected forearms: forty-six were in-transit capillary perforators, nineteen were terminal capillary perforators, and thirteen were musculocutaneous capillary perforators. Of these seventy-eight perforators, sixteen (21%) had a caliber of <0.5 mm and sixty-two capillary perforators (79%) had a caliber of ≥0.5 mm. Ten ICAs were selectively injected, and the mean size of all stained skin areas was 30.9 ± 11.9 cm(2). A perforator pedicled flap was readily feasible for all dissections. We also describe the case of a patient with a medial soft-tissue defect of the elbow that was covered with a pedicled perforator flap based on an ICA. The patient had satisfactory healing at two months.
Conclusions: The ICA flap is a reliable and useful flap for elbow soft-tissue reconstruction.
Clinical relevance: The perforator flap procedure is a major advancement in reconstructive surgery. One potential application of the perforator flaps is the use of tissue adjacent to a defect as a perforator-based island flap. The use of this tissue allows for thinner flaps to be tailored for more accurate reconstruction. A flap that depends on a perforator branch of the radial artery called the inferior cubital artery seems to be an excellent solution for soft-tissue coverage of the elbow.
Copyright © 2016 by The Journal of Bone and Joint Surgery, Incorporated.
Intravenous Hyaluronidase with Urokinase as Treatment for Arterial Hyaluronic Acid Embolism
Intravenous Hyaluronidase with Urokinase as Treatment for Arterial Hyaluronic Acid Embolism
Rémi Foissac, Philippe Kestemont, Olivier Camuzard
Sex-specific autophagy modulation in osteoblastic lineage: a critical function to counteract bone loss in female
Olivier Camuzard, Sabine Santucci-Darmanin, Véronique Breuil, Chantal Cros, Tatiana Gritsaenko, Sophie Pagnotta, Laurence Cailleteau 5, Séverine Battaglia, Patricia Panaïa-Ferrari, Dominique Heymann, Georges F Carle, Valérie Pierrefite-Carle
https://pubmed.ncbi.nlm.nih.gov/27634908/
Abstract
Age-related bone loss is associated with an increased oxidative stress which is worsened by estrogen fall during menauposis. This observation has drawn attention to autophagy, a major cellular catabolic process, able to alleviate oxidative stress in osteoblasts (OB) and osteocytes (OST), two key bone cell types. Moreover, an autophagy decline can be associated with aging, suggesting that an age-related autophagy deficiency in OB and/or OST could contribute to skeletal aging and osteoporosis onset.In the present work, autophagy activity was analyzed in OST and OB in male and female mice according to their age and hormonal status. In OST, autophagy decreases with aging in both sexes. In OB, although a 95% decrease in autophagy is observed in OB derived from old females, this activity remains unchanged in males. In addition, while ovariectomy has no effect on OB autophagy levels, orchidectomy appears to stimulate this process. An inverse correlation between autophagy and the oxidative stress level was observed in OB derived from males or females. Finally, using OB-specific autophagy-deficient mice, we showed that autophagy deficiency aggravates the bone loss associated with aging and estrogen deprivation.Taken together, our data indicate that autophagic modulation in bone cells differs according to sex and cell type. The lowering of autophagy in female OB, which is associated with an increased oxidative stress, could play a role in osteoporosis pathophysiology and suggests that autophagy could be a new therapeutic target for osteoporosis in women.
Keywords: Gerotarget; aging; autophagy; osteoblast; osteocyte; osteoporosis.
The Vascularized Lateral Antebrachial Cutaneous Nerve Graft Based on a Radial Artery Perforator for Nerve Defect Reconstruction: An Anatomical Study
Olivier Camuzard, Rémi Foissac, Patrick Baqué, Nicolas Bronsard, Charalambos Georgiou
Publications 2015 du Dr CAMUZARD Olivier
AJCO: Association of Young Surgical Oncologists
AJCO: Association of Young Surgical Oncologists
Thomas Sorin, Olivier Camuzard, Adnan El-Bakri, Thomas Sagardoy, Antoine Legras
The Vascularized Lateral Antebrachial Cutaneous Nerve Graft Based on a Radial Artery Perforator for Nerve Defect Reconstruction: An Anatomical Study
A rare cause of ulnar nerve entrapment at the elbow area illustrated by six cases: The anconeus epitrochlearis muscle
J Fernandez, O Camuzard, M-O Gauci, M Winter
https://pubmed.ncbi.nlm.nih.gov/26545312/
Abstract
Ulnar nerve entrapment is the second most common compressive neuropathy after carpal tunnel syndrome. The accessory anconeus epitrochlearis muscle – present in 4% to 34% of the general population – is a known, but rare cause of ulnar nerve entrapment at the elbow. The aim of this article was to expand our knowledge about this condition based on six cases that we encountered at our hospital between 2011 and 2015. Every patient had a typical clinical presentation: hypoesthesia or sensory deficit in the fourth and fifth fingers; potential intrinsics atrophy of the fourth intermetacarpal space; loss of strength and difficulty with fifth finger abduction. Although it can be useful to have the patient undergo ultrasonography or MRI to aid in the diagnosis, only electromyography (EMG) was performed in our patients. EMG revealed clear compression in the ulnar groove, with conduction block and a large drop in nerve conduction velocity. Treatment typically consists of conservative treatment first (splint, analgesics). Surgical treatment should be considered when conservative treatment has failed or the patient presents severe neurological deficits. In all of our patients, the ulnar nerve was surgically released but not transposed. Five of the six patients had completely recovered after 0.5 to 4years follow-up. Ulnar nerve entrapment at the elbow by the anconeus epitrochlearis muscle is not common, but it must not be ignored. Only ultrasonography, MRI or, preferably, surgical exploration can establish the diagnosis. EMG findings such as reduced motor nerve conduction velocity in a short segment of the ulnar nerve provides evidence of anconeus epitrochlearis-induced neuropathy.
Keywords: Anconeus epitrochlearis muscle; Compression du nerf ulnaire; Compressive neuropathy; Muscle anconeus epitrochlearis; Neurolyse; Neurolysis; Neuropathie compressive; Ulnar nerve compression.
Copyright © 2015 SFCM. Published by Elsevier Masson SAS. All rights reserved.
A strange form of dysphonia... . Laryngeal paraganglioma
A strange form of dysphonia… . Laryngeal paraganglioma
Etienne Berta, Olivier Camuzard, Gilles Poissonnet
Autophagy in bone: Self-eating to stay in balance
Autophagy in bone: Self-eating to stay in balance
Valérie Pierrefite-Carle, Sabine Santucci-Darmanin, Véronique Breuil, Olivier Camuzard, Georges F Carle
https://pubmed.ncbi.nlm.nih.gov/26318060/
Abstract
Autophagy, a major catabolic pathway responsible of the elimination of damaged proteins and organelles, is now recognized as an anti-aging process. In addition to its basal role in cell homeostasis, autophagy is also a stress-responsive mechanism for survival purposes. Here, we review recent literature to highlight the autophagy role in the different bone cell types, i.e., osteoblasts, osteoclasts and osteocytes. We also discuss the effects of autophagy modulators in bone physiology and of bone anabolic compounds in autophagy. Finally, we analyzed studies regarding bone cell autophagy-deficient mouse models to obtain a more general view on how autophagy modulates bone physiology and pathophysiology, particularly during aging.
Keywords: Autophagy; Bone; Osteoporosis.
Copyright © 2015 Elsevier B.V. All rights reserved.
Contribution of breast skin elastometry measurement in breast augmentation surgery: A pilot study evaluating the correlation between skin elasticity and nipple-to-inframammary fold distance
Rémi Foissac, Olivier Camuzard, Charalambos Georgiou, Pauline Foty, Thierry Balaguer, Bérengère Chignon-Sicard, Dominique Casanova
Facial artery perforator flap for reconstruction of perinasal defects: An anatomical study and clinical application
Olivier Camuzard, Rémi Foissac, Charalambos Georgiou, Lucas Andot, Florent Alcaraz, Patrick Baqué, Nicolas Bronsard, Gilles Poissonnet
https://pubmed.ncbi.nlm.nih.gov/26590853/
Abstract
Background: The concept of the facial artery perforator flap was developed for improved freedom during the reconstruction of perioral and perinasal defects. This flap enables tailor-made reconstruction and a shift from the traditional two-stage procedure to a one-stage technique. In this cadaveric study, the authors quantify the number, length, and diameter of facial artery perforators (FAPs) and present their clinical experience with the FAP flap.
Methods: The authors performed 20 dissections of facial arteries (FAs). All FAPs greater than 0.5 mm were dissected to study the number, length, and diameter of FAPs. In addition, the authors report a case series of 15 perinasal defect reconstruction procedures performed using facial artery-based perforator flap.
Results: A total of 125 FAPs were dissected. We identified a mean of six FAPs per hemiface (range five to eight). The average length of all FAPs was 17.6 ± 1.9 mm, and the mean diameter of the FAPs was 0.91 ± 0.2. Fifteen patients underwent a perinasal defect reconstruction using a FAP flap with good aesthetic and functional results.
Conclusions: The following study thus improves our understanding of FAP anatomy and clinical application and will enable the nasolabial fold to become the area where perinasal defect reconstruction using perforator flaps is performed.
Keywords: Cadaveric study; Facial artery; Facial artery perforator; Facial artery perforator flap; Facial reconstruction; Latex injection.
Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
New cutaneous strategy in sural flap surgery and possibility to adapt this technique to other pedicled flaps
J Fernandez, C Clérico, O Camuzard, B Chignon-Sicard
https://pubmed.ncbi.nlm.nih.gov/25963526/
Abstract
Introduction: Therapeutic managements in losses of substance of the lower limb using sural flap give an important scar and, sometimes, an impossibility to close the flap donor site. That led us to think about an operative procedure that can reduce those scars without increasing the risk of necrosis of the cutaneous paddle.
Patients and method: We present this operative procedure which underwent in the plastic and reconstructive surgery service in our hospital. Classical flap procedure with two cutaneous parts was used. The cutaneous laxity was evaluated so as to close with one cutaneous part; the other cutaneous part was taken and used like a skin graft after the suture of the calf and the formation of a bursa on the donor site. The leg was closed with only one cutaneous flap.
Results: This technique is illustrated by a case report. Results at the 4th month are very interesting with an acceptable scar and a good result of the skin graft. However, with this technique, we don’t decrease the venous risk of this flap. We used this technique for an antebrachial flap.
Conclusion: This technique is an easy and reliable technique based on cutaneous laxity and that decreases scarring of this very useful flap: the neurocutaneous sural flap. We can have a diminution of the number of surgery, a diminution of the scar and good aesthetics results.
Keywords: Cutaneous laxity; Cutaneous strategy; Lambeau sural; Laxité cutanée; Neurocutaneous sural flap; Pedicled; Pédiculé; Rançon cicatricielle; Scar; Stratégie cutanée.
Copyright © 2015 Elsevier Masson SAS. All rights reserved.
Publications 2014 du Dr CAMUZARD Olivier
Axillary hyperhidrosis, botulinium A toxin treatment: Review
Axillary hyperhidrosis, botulinium A toxin treatment: Review
C Clerico 1, J Fernandez 2, O Camuzard 2, B Chignon-Sicard 2, T Ihrai 2
https://pubmed.ncbi.nlm.nih.gov/25555435/
Abstract
Injection of type A botulinum toxin in the armpits is a temporary treatment for axillary hyperhidrosis. This technique described in 1996 by Bushara et al., is known to be efficient and safe. The purpose of this article was to review the data concerning the treatment of axillary hyperhidrosis with botulinum toxin type A, and discuss the other treatment modalities for this socially disabling entity.
Keywords: Axillary hyperhidrosis; Botulinium toxin; Hyperhidrose; Hyperhidrosis; Injections; Région axillaire; Toxine botulique.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.
Breast lesions of a metastatic melanoma on a radiotherapy territory: Treatment by vemurafenib and carcinologic surgery
J Fernandez 1, H Montaudié 2, A Courdi 3, C Georgiou 4, O Camuzard 4, B Chignon-Sicard 4
https://pubmed.ncbi.nlm.nih.gov/25446470/
Abstract
Introduction: This article describes the unique case of a female patient who presented distant melanoma metastasis on the breast while having irradiation therapy for breast cancer. This happened eight months after the initial treatment for a melanoma of the back (under the right scapula). Furthermore, this case report demonstrates the efficiency of Vemurafenib® as a treatment for late stage melanomas.
Case report: The patient was a 47-year-old female that had a superficial spreading melanoma under the right scapula (Breslow 1.02mm) that was treated with 2cm skin excision and sentinel lymph node sampling that was negative. The melanoma was positive for the BRAF600E mutation. One month after this incident, the patient developed breast cancer that was treated with conservative surgery and radiotherapy. Three months after the end of the irradiation treatment, she developed multiple melanoma metastasis on the skin of the breast. Our multidisciplinary team decided to initiate a treatment with vemurafenib. The patient showed an excellent response, so the surgical team completed the treatment with a radical mastectomy and immediate reconstruction with a pedicled latissimus dorsi flap. The histologic report of the mastectomy specimen showed no sign of melanocytic proliferation, that demonstrates the efficacy of vemurafenib. The patient showed no relapse after two years of follow-up.
Discussion: The speed of development and location of cutaneous metastases in this case brought us to think about the effects of radiation therapy on the skin. Radiation therapy causes acute complications (radiodermatitis) by cellular and molecular mechanisms. Moreover, depressed immunity is found after irradiation. Association of these mecanisms could explain the appearance of these metastases in irradiation field. The efficiency of vemurafenib found in our case is consistent with what is described in literature, especially with the improvement in median overall survival.
Conclusion: This case demonstrates a unique case of distant melanoma metastasis on the irradiation field of a breast cancer. It also demonstrates the efficacy of vemurafenib as well as the efficacy of a radical complementary surgical treatment in these patients.
Keywords: BRAFV600E; Breast cancer; Cancer du sein; Champ d’irradiation; Cutaneous metastasis; Immunomodulation; Irradiation territory; Melanoma; Mélanome; Métastases cutanées; Radiotherapie; Radiothérapie; Survie; Survival; Vemurafenib; Vémurafénib.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.
Characteristics of the male facelift
Characteristics of the male facelift
R Foissac, T R Colson, O Camuzard, P Kestemont
https://pubmed.ncbi.nlm.nih.gov/26521365/
Abstract
Male face lifting is the cosmetic surgery which has witnessed the greatest rise in demand in recent years. A result of social evolution and development of non-surgical techniques for facial rejuvenation, this intervention represents a real challenge for the surgeon who operates mainly on women. Man has specific characteristics which include differences in the aging process, and a multitude of anatomical and psychosocial factors that will require adjustments in the patient’s overall care. Indeed, the adaptation of the conventional technique of the female facelift would lead to an unnatural result, not satisfactory for the patient. To best meet the demands of the male patient, the surgeon must take into account the male facial characteristics in order to optimize the results.
Severe granulomatous reaction associated with hypercalcemia occurring after silicone soft tissue augmentation of the buttocks: a case report
O Camuzard, P Dumas, R Foissac, J Fernandez, S David, T Balaguer, B Chignon-Sicard, C Dumontier
https://pubmed.ncbi.nlm.nih.gov/24281899/
Abstract
Liquid silicone is a permanent filler. Its use to augment soft tissues for aesthetic purposes was widespread worldwide in the 1960s. Although initially considered to be biologically inert, this substance may cause, after its injection, an inflammatory granulomatous effect of variable severity and, in very rare cases, a severe hypercalcemia, which can be life threatening. The reported case highlights the well-known physiopathology of hypercalcemia, and the various therapeutic options are discussed.
Level of evidence v: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Publications 2013 du Dr CAMUZARD Olivier
Treatment of Dupuytren's contracture by collagenase injection
Treatment of Dupuytren’s contracture by collagenase injection
R Foissac, O Camuzard, P Dumas, C Dumontier, B Chignon-Sicard
https://pubmed.ncbi.nlm.nih.gov/23856551/
Abstract
Dupuytren’s disease is a disorder of the palmar aponeurosis responsible for apparition of pathological collagen cords that will gradually lead to a digital retraction. These cords cause functional disability to the hand with a real handicap for the patient. No curative treatment exists currently in this disease. Injections of collagenase from Clostridium histolyticum cause lysis of the collagen present in the cords and cause an interruption of the palmar cord. It is a new treatment in the management of Dupuytren’s disease. The use of collagenase injection in the treatment of palmar form of Dupuytren’s disease gives good results in the short and medium terms. It is a simple, minimally invasive treatment, several studies have proven its effectiveness and it approximates percutaneous needle fasciotomy in its easy use and its indications. Patients should be well informed about local reactions and transient pain with the injection of C. histolyticum collagenase. Diffusion of this technique is still limited by: the assessment of its cost compared to that of other methods of treatment and particularly the needle fasciotomy, and the evaluation of results over the long-term.
Keywords: Brides de collagène; Clostridium histolyticum collagenase; Collagen cords; Collagénase de Clostridium histolyticum; Digital retraction; Dupuytren’s disease; Maladie de Dupuytren; Rétraction digitale.
Copyright © 2013 Elsevier Masson SAS. All rights reserved.
Publications 2011 du Dr CAMUZARD Olivier
Melanotic neuroectodermal tumor of infancy: case report and review of the literature
Melanotic neuroectodermal tumor of infancy: case report and review of the literature
O Camuzard , O Rosello, C Maschi, L Castillo, A Deville, C Boyer, A Chevallier, S Bailleux
https://pubmed.ncbi.nlm.nih.gov/22533073/
Abstract
Melanotic Neuroectodermal Tumor of Infancy (MNTI) is a rare but distinct neoplastic entity in infancy. Diagnosis is usually made before the age of 12 months. The common clinical presentation is a rapidly growing mass of the pre-maxillary area. Its surface is unevenly pigmented. To affirm the diagnosis a biopsy is necessary. Few cases of malignancy have been described (5% of cases). Adequate surgical excision is the treatment of choice. Recurrence rate is about 10 to 15% within 5 years. We report in this article the case of a newborn with MNTI illustrating that an R0 surgical excision can be correlated to a favourable prognosis. In this case the 5 years follow up didn’t show any local or distant recurrence.
Congrès Nationaux
Communications 2019 du Pr CAMUZARD Olivier
- Transfert sélectif de la racine C7 controlatérale pour la prise en charge des avulsions complètes post- traumatiques du plexus brachial
Société Française de Chirurgie de la Main,GEM, Decembre 2018
Communications 2020 du Pr CAMUZARD Olivier
- Transfert Nerveux Vascularisé du Nerf Interosseux Postérieur
Société Française de Chirurgie de la Main,GEM, Decembre 2021 - Analyse des muscles paravertébraux comme critère de diagnistque des avulsions du plexus brachial
Société Française de Chirurgie de la Main,GEM, Decembre 2021
Communications 2018 du Pr CAMUZARD Olivier
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- Rôle de l’autophagie dans le dialogue entre son microenvironnement et l’ostéosarcome Société Française de Biomatériaux et des Tissus Minéralisés, Monaco, Avril 2018, Prix de la meilleur communication orale.
- Vascularisation des nerfs sensitifs superficiels de l’avant-bras, applications cliniques en reconstruction de la main et des doigts Société Française de Chirurgie de la Main,GEM, Decembre 2018
- Utilisation de greffon artériel pour les reconstructions des artères collatérales digitales par pontage : étude anatomique de faisabilité Société Française de Chirurgie de la Main,GEM, Decembre 2018
- Transfert sélectif de la racine C7 controlatérale pour la prise en charge des avulsions complètes post- traumatiques du plexus brachial Société Française de Chirurgie de la Main,GEM, Decembre 2018
- Pseudo anévrisme d’une branche cutanée de l’artère ulnaire, diagnostic rare d’une masse post traumatisme pénétrant : case report et revue de la littérature Société Française de Chirurgie de la Main,GEM, Decembre 2018
- Osteosynthèse mini-invasive par voie palmaire avec vis de compression canulée pour fractures du crochet de l’hamatum non déplacées en aigü Société Française de Chirurgie de la Main,GEM, Decembre 2018
- Utilisation de greffon artériel pour les reconstructions des artères collatérales digitales par pontage : étude anatomique de faisabilité Congrès de la Société Française de Chirurgie Plastique Reconstructrice et Esthétique, Novembre 2018
- Osteosynthèse mini-invasive par voie palmaire avec vis de compression canulée pour fractures du crochet de l’hamatum non déplacées en aigü Congrès de la Société Française de Chirurgie Plastique Reconstructrice et Esthétique, Novembre 2018
Communications 2017 du Pr CAMUZARD Olivier
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- Greffe nerveuse vascularisée du nerf inter-osseux postérieur.
Société Française de Chirurgie de la Main,GEM, Décembre 2017 - Le lambeau perforant de l’Artère Cubitale Inférieure pour les pertes de substance du coude: Étude Anatomique et Applications Cliniques.
Société Française de Chirurgie Orthopédique et Traumatologique (SOFCOT), Paris, Décembre 2017
- Greffe nerveuse vascularisée du nerf inter-osseux postérieur.
Communications 2016 du Pr CAMUZARD Olivier
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- Le lambeau muqueux de la branche vestibulaire supérieure de l’artère infra-orbitaire : Etude anatomique et application clinique.
Journée des Jeunes Plasticiens Paris, Mars 2016 - Le lambeau chimérique antéro-latéral de cuisse fin double palette cutanée avec aponévrose vascularisé pour la reconstruction d’une perte de substance transfixiante de la joue et de la commissure orale.
Journée des Jeunes Plasticiens Paris, Mars 2016 - Sauvetage d’une oesophagectomie totale après échec de coloplastie et de lambeau libre de jéjunum comliqué d’une mediastinite.
Journée des Jeunes Plasticiens Paris, Mars 2016 - Le lambeau perforant de l’Artère Cubitale Inférieure pour les pertes de substance du coude: Etude Anatomique et Applications Cliniques.
Société Française de Microchirurgie, Paris, Juin 2016 - Le lambeau chimérique antéro-latéral de cuisse fin double palette cutanée avec aponévrose vascularisé pour la reconstruction d’une perte de substance transfixiante de la joue et de la commissure orale.
Société Française de Microchirurgie, Paris, Juin 2016 - Technique de reconstruction des pharyngo-laryngectomies partielles par un lambeau antéro-latéral de cuisse fin armé de cartilage.
Société Française de Microchirurgie, Paris, Juin 2016 - Analyse de l’activité autophagique dans les cellules souches tumorales d’ostéosarcome.
Société Française de Biomatériaux et des Tissus Minéralisés, Nancy, Juin 2016 - L’autophagie, une nouvelle cible thérapeutique dans le traitement de l’ostéoporose ?
Société Française de Biomatériaux et des Tissus Minéralisés, Nancy, Juin 2016 - Le lambeau perforant scapulo-dorsal avec extension adipeuse pour les reconstructions des hémi-maxillectomies.
Société Française d’Oto-Rhino-Laryngologie, Paris, Octobre 2016 - Le lambeau chimérique antéro-latéral de cuisse fin double palette cutanée avec aponévrose vascularisé pour la reconstruction d’une perte de substance transfixiante de la joue et de la commissure orale.
Société Française d’Oto-Rhino-Laryngologie, Paris, Octobre 2016 - Les Lambeaux Locaux en Ilot Vrai sur les Perforantes de l’Artère Faciale : de l’Anatomie aux Applications Cliniques.
Société Française d’Oto-Rhino-Laryngologie, Paris, Octobre 2016 - Association perfusion de membres isolés sous circulation extracorporelle et reconstruction par lambeau pour le sauvetage des membres atteints de sarcome localement avancé des tissus mous : résultats à long terme
Congrés de la Société Française de Chirurgie Plastique Reconstructrice et Esthétique, Paris Novembre 2016 - Le lambeau perforant scapulo-dorsal avec extension adipeuse pour les reconstructions des hémi-maxillectomies.
Congrés de la Société Française de Chirurgie Plastique Reconstructrice et Esthétique, Paris Novembre 2016
- Le lambeau muqueux de la branche vestibulaire supérieure de l’artère infra-orbitaire : Etude anatomique et application clinique.
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Communications 2015 du Pr CAMUZARD Olivier
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- Les artères perforantes à destinée cutanée de l’artère faciale : Etude anatomique et Application clinique
Journée des Jeunes Plasticiens Paris, Mars 2015 - Analyse de l’activité autophagique dans les cellules souches tumorales d’ostéosarcome
BIOSARC, Groupe Français d’étude des Sarcomes Paris, Septembre 2015 - Le lambeau perforant de l’artère cubital inférieure : Etude anatomique et Application clinique
Congrés de la Société Française de Chirurgie Plastique Reconstructrice et Esthétique, Paris Novembre 2015 - Les artères perforantes à destinée cutanée de l’artère faciale : Etude anatomique et Application clinique
Congrés de la Société Française de Chirurgie Plastique Reconstructrice et Esthétique, Paris Novembre 2015 - Le lambeau perforant de l’artère cubital inférieure : Etude anatomique et Application clinique
Société Française de Chirurgie de la Main, Paris, Decembre 2015
- Les artères perforantes à destinée cutanée de l’artère faciale : Etude anatomique et Application clinique
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Communications 2014 du Pr CAMUZARD Olivier
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- Pointe Carrée dans la prise en charge des fractures du col des métacarpiens.
3ème Journée de la recherche Médicale des hopitaux pédiatriques de Nice CHU-LENVAL Février 2014 - Lambeau perforant de l’artère cubital inférieure : à propos d’un cas
Journée des Jeunes Plasticiens Paris, Mars 2014
- Pointe Carrée dans la prise en charge des fractures du col des métacarpiens.
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Communications 2013 du Pr CAMUZARD Olivier
- Hypercalcémie maligne secondaire à une granulomatose inflammatoire réactionnelle à une injection de silicone liquide : à propos d’un cas.
Journée des Jeunes Plasticiens Paris, Mars 2013
Congrès Internationaux
- Facial artery perforator flap for nasal reconstruction
IFOS, ENT word congress, Paris 2017 - Anatomy and Microsurgery
IMC, Webinar May,2021
Congrès Nationaux
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- Autophagy: a new therapeutic target in osteoporosis ?
Club Francophone d’étude de l’Autophagy, Lille, Octobre 2015 - Autophagic activity in osteosarcoma cancer stem cells
Groupe Francophone d’étude des Cellules Souches Cancéreuses, Marseille, Decembre 2015 - Autophagy: a new therapeutic target in osteoporosis ?
Société Francaise de Rhumatologie, Paris, Decembre 2015 - Rôle de l’autophagie dans les cellules souches tumorales d’ostéosarcome ?
Club Francophone d’étude de l’Autophagy, Paris, Octobre 2018 - Rôle de l’autophagie dans le micro environnement de l’ostéosarcome ?
Groupe Francophone d’étude des Cellules Souches Cancéreuses, Montpellier, Decembre 2017
- Autophagy: a new therapeutic target in osteoporosis ?
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Congrès Internationaux
- Implication of autophagy in a preclinical mouse model of bone ageing and of osteoporosis
European Calcified Tissue Society Congress, Rome, Mai 2016 - Feasability and results of surgery with free flap coverage after isolated limb perfusion for soft tissue sarcoma
Connective Tissue Oncology Society, Lisbon, Novembre 2016
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Sociétés savantes
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- Membre de l’Association des Jeunes Chirurgiens Oncologues (AJCO) et responsable de la rubrique reconstruction des membres et de la région cervico-faciale.
- Membre du Comité Français d’étude de l’AuTophaGie (CFATG)
- Membre de réseau SUNRiSE « Solid tumor cancer stem cell network »
- Membre de la Sociéte Française de la Biologie des Tissus Minéralisés (SFBTM)
- Membre Junior de la Société Française de Chirurgie de la Main
- Membre du Groupe Sarcome Français – Groupe d’Etude des Tumeurs Osseuses (GSF-GETO)
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Publications
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SIGAPS : 635 points | 54 publications
Publications 2022 du Dr CAMUZARD Olivier
Modern and synchronized clinical anatomy teaching based on the BDIE method (board-digital dissection-imaging-evaluation)Modern and synchronized clinical anatomy teaching based on the BDIE method (board-digital dissection-imaging-evaluation)
Modern and synchronized clinical anatomy teaching based on the BDIE method (board-digital dissection-imaging-evaluation)
Damien Massalou, Nicolas Bronsard, Laurent Hekayem, Patrick Baqué, Olivier Camuzard
https://pubmed.ncbi.nlm.nih.gov/35482103/
Abstract
Purpose: Anatomy has historically been taught via traditional medical school lectures and dissection. In many countries, practical or legal issues limit access to cadaveric dissection. New technologies are favored by students and could improve learning, complementing traditional teaching.
Methods: All students in second-year medicine at a single medical school were submitted to a novel anatomical course with digital tool exposure. We explored a new combined teaching method: a physical blackboard lesson synchronized with digital dissection, imaging and direct evaluation (BDIE). Synchronized dissection is broadcast live in the classroom and in partner medical schools. Following the course, students completed a short survey about their perception of this new anatomic clinical course.
Results: The survey included 183 students whom 178 completed the questionnaire, i.e., a 97% response rate. Ninety-nine percent of students thought this synchronized method useful to improve their understanding of anatomy and 90% stated it helped them retain this learning.
Conclusion: This BDIE method, in conjunction with teaching guidelines and dissection, is highly appreciated by students who consider it helps them to acquire lasting knowledge.
Keywords: Anatomy teaching; Digital dissection; Dissection; Gross anatomy; Prosection; Radiology.
© 2022. The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature.
CloseA role for metformin in the treatment of Dupuytren disease?A role for metformin in the treatment of Dupuytren disease?
A role for metformin in the treatment of Dupuytren disease?
Alberto Baeri, Michaël Levraut, Serena Diazzi, Olivier Camuzard, Marianne Cegarra-Escolano, Marie-Anne Ploumellec, Thierry Balaguer, Julien Fassy, Roger Rezzonico, Saverio Bellusci, Bernard Mari, Georges Vassaux
https://pubmed.ncbi.nlm.nih.gov/35427821/
Abstract
Dupuytren disease (DD) is a hand-localized fibrotic disorder characterized by a scar-like, collagen-rich cord. Treatment usually comprises surgical removal of the cord, but is associated with a high relapse rate, in some cases requiring finger amputation. There is currently no consensual medical approach for treating DD. Numerous preclinical studies have highlighted antifibrotic properties of metformin, and the aim of this study was to assess a potential antifibrotic role of metformin in DD. Fibroblasts from DD cords (DF) and phenotypically normal palmar fascia (PF) were extracted from surgical specimens and cultured. The fibrotic status of DF and PF was compared at baseline, and under profibrotic (TGF-β stimulation) and antifibrotic (metformin stimulation) conditions, using quantitative RT-PCR, western blot, immunocytochemistry, and a functional fibroblast contraction assay. At baseline, DF showed higher levels of fibrotic markers and contraction capacity compared with PF. Both types of fibroblasts responded to TGF-β stimulation. Treatment of DF and PF with metformin did not affect basal levels of fibrotic markers and contraction but largely prevented their induction by TGF-β. In conclusion, our data show that metformin inhibits TGF-β-induced expression of fibrotic markers and contraction in hand-derived fibroblasts. This supports the case for a clinical trial to assess the repurposing of metformin as an adjuvant to surgery, to prevent, reduce, or delay recurrence in at-risk DD patients.
Keywords: Drug repurposing; Dupuytren contracture; Fibroblasts; Fibrosis; Metformin.
Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
CloseComparison of Two Rapid Assays for the Detection of BRAF V600 Mutations in Metastatic Melanoma including Positive Sentinel Lymph NodesComparison of Two Rapid Assays for the Detection of BRAF V600 Mutations in Metastatic Melanoma including Positive Sentinel Lymph Nodes
Comparison of Two Rapid Assays for the Detection of BRAF V600 Mutations in Metastatic Melanoma including Positive Sentinel Lymph Nodes
Elodie Long-Mira, Alexandra Picard-Gauci, Sandra Lassalle, Véronique Hofman , Salomé Lalvée, Virginie Tanga , Katia Zahaf, Christelle Bonnetaud, Virginie Lespinet, Olivier Camuzard, Henri Montaudié, Gilles Poissonnet, Thierry Passeron, Marius Ilié, Paul Hofman
https://pubmed.ncbi.nlm.nih.gov/35328303/
Abstract
Testing for the BRAF mutation is mandatory for the management of patients with locally advanced or metastatic melanoma. Molecular analysis based on DNA sequencing remains the gold-standard method for the screening of the different BRAF mutations. These methods must be rapid, sensitive, and specific enough to allow optimal therapeutic management in daily practice and also to include patients in clinical trials. Here, we compared the Idylla BRAF Mutation Test and the anti-BRAF V600E (clone VE1) immunohistochemistry (IHC) in 90 melanoma samples, with a focus on a challenging cohort of 32 positive sentinel lymph nodes. The BRAF status was assessed with both methods independently of the percentage of tumor cells. The concordance rate was calculated excluding both non-contributory analyses and BRAFV600K/R/M mutants due to the specific V600E-IHC test design. The incidence of the BRAFV600E mutation was 33% with both BRAF Idylla and BRAF IHC. The agreement rate was 91% (72/79). Although the agreement rate was high, we suggest that the use of IHC is more suitable for rapid BRAF testing on sentinel lymph node biopsies when associated with a low percentage and scattered tumor cells, which gave a high risk of non-contributory analysis and/or false negative results with the IdyllaTMBRAF Mutation Test.
Keywords: BRAF; RT-PCR; immunohistochemistry; metastatic melanoma; sentinel lymph node.
CloseFlow-Through Arterialized Posterior Interosseous Nerve Grafts for Digital Neurovascular Bundle Defects: Anatomical StudyFlow-Through Arterialized Posterior Interosseous Nerve Grafts for Digital Neurovascular Bundle Defects: Anatomical Study
Flow-Through Arterialized Posterior Interosseous Nerve Grafts for Digital Neurovascular Bundle Defects: Anatomical Study
Gilles Claro, Nicole A Zelenski, Thierry Balaguer, Benoit Chaput, Nicolas Isola, Patrick Baqué, Nicolas Bronsard, Olivier Camuzard
https://pubmed.ncbi.nlm.nih.gov/34936617/
Abstract
Background: Digital neurovascular bundle defects are often encountered during crush or avulsion injuries and require complex reconstruction. Use of an arterialized nerve graft (neurovascular graft) serving both as an interpositional arterial conduit and as a nerve graft could be a reconstructive option in these cases. In this anatomical study, the authors aimed to describe a neurovascular graft of the posterior interosseous nerve and a branch of the anterior interosseous artery for neurovascular bundle reconstruction of the fingers.
Methods: Eighteen forearms were injected with red latex in order to collect the anatomical characteristics of the posterior interosseous nerve and the artery running near it.
Results: In all cases, the posterior interosseous nerve was followed by a branch of the anterior interosseous artery: the distal dorsal branch of the anterior interosseous nerve. The origin of this artery was proximal to the radiocarpal joint, at an average of 56.5 ± 11.1 mm. The proximal and distal diameters of the branch of the anterior interosseous artery were 1.6 ± 0.2 and 1.1 ± 0.2 mm, respectively. The proximal and distal diameters of the posterior interosseous nerve were 1.2 ± 0.3 mm and 1.1 ± 0.3 mm, respectively.
Conclusions: These results show that a potential free neurovascular graft using the posterior interosseous nerve as nerve graft and the anterior interosseous artery as an arterial bypass to reconstruct both the nerve and arterial tree of the finger could be a useful approach. The authors speculate that this graft could be used to reconstruct the neurovascular bundle of amputated or devascularized digits.
Copyright © 2021 by the American Society of Plastic Surgeons.
ClosePublications 2021 du Dr CAMUZARD Olivier
A 3-Dimensional Suture Technique for Flexor Tendon Repair: A Biomechanical StudyA 3-Dimensional Suture Technique for Flexor Tendon Repair: A Biomechanical Study
A 3-Dimensional Suture Technique for Flexor Tendon Repair: A Biomechanical Study
Marie Castoldi, Federico Solla, Olivier Camuzard, Martine Pithioux , Virginie Rampal, Olivier Rosello
https://pubmed.ncbi.nlm.nih.gov/34848101/
Abstract
Purpose: Flexor tendon injury continues to pose a number of challenges for hand surgeons. Improving mechanical properties of repairs should allow for earlier and unprotected rehabilitation. A 3-dimensional (3D) 4-strand suture technique has been proposed to combine high tensile strength and low gliding resistance without causing suture pullout due to tendon delamination. Our hypothesis is that the 3D technique can result in better mechanical properties than the Adelaide technique.
Methods: Four groups of 10 porcine flexor tendons were sutured using the 3D or Adelaide technique with a 3-0 polypropylene or ultrahigh molecular weight polyethylene (UHMWPE) suture. The axial traction test to failure was performed on each tendon to measure 2-mm gap force and ultimate tensile strength.
Results: The mean 2-mm gap force was 49 N for group A (3D + polypropylene), 145 N for group B (3D + UHMWPE), 47 N for group C (Adelaide + polypropylene), and 80 N for group D (Adelaide + UHMWPE). Failure mode was caused by suture breakage for group A (10/10) and mainly by suture pullout for the other groups (8/10 up to 10/10). With the UHMWPE suture, the mean ultimate tensile strength was 145 N for the 3D technique and 80 N for the Adelaide technique.
Conclusions: Porcine flexor tendons repaired using the 3D technique and UHMWPE suture exceeded a 2-mm gap force and tensile strength of 140 N. The ultimate tensile strength was superior to that of the Adelaide technique, regardless of the suture material.
Clinical relevance: This in vitro study on porcine flexor tendon suture highlights that the mechanical properties of 3D repair are better than those of 3D repair using the Adelaide technique when a UHMWPE suture is used.
Keywords: 2-mm gap force; UHMWPE; flexor tendon; hand injuries; suture techniques; tensile strength.
Copyright © 2023 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.
CloseAnatomical study of the clitoris and its implications on female genital mutilation and surgical repairAnatomical study of the clitoris and its implications on female genital mutilation and surgical repair
Anatomical study of the clitoris and its implications on female genital mutilation and surgical repair
Fanny Blayney, Olivier Camuzard, Arthur Klein, Anne-Sophie Perchenet, Baptiste Bertrand, Cécile Philandrianos, Valentin Massin, Maxime Abellan-Lopez, Dominique Casanova
https://pubmed.ncbi.nlm.nih.gov/34253487/
Abstract
Background: Worldwide, 200 million girls and women have been subjected to female genital mutilation. To restore the clitoral function and vulvar anatomy, clitoral repair has been performed since the 2000s. Nevertheless, there is a lack of precise and comprehensive data on the clitoral anatomy during surgical repair. This study aimed to precisely describe the terminal anatomies of the dorsal nerve and artery of the clitoris, and the clitoral neurovascular flap advancement for reconstruction in patients with female genital mutilation.
Methods: This study was performed on seven fresh female cadavers. The site of origin, diameter, length, and trajectory of each nerve and artery were recorded. The clitoral neurovascular flap advancement was measured after a midline transection of the suspensory ligament was performed and after extensive liberation of the dorsal bundles at their emergence from the pubic rami.
Results: At the distal point of the clitoral body, the width of the dorsal nerve and artery was 1.9 ± 0.3 mm and 0.9 ± 0.2 mm, respectively. The total length of the dorsal bundles was 6.6 cm (± 0.4). The midpart of the suspensory ligament was sectioned, which allowed a mean anteroposterior mobility of 2.7 cm (± 0.2). Extensive dissection of the neurovascular bundles up to their point of emergence from the suspensory ligament allowed a mean mobility of 3.4 ± 0.2 cm.
Conclusion: We described the anatomical characteristics of the dorsal nerve and artery of the clitoris and the mobility of the clitoral neurovascular flap for reconstruction post clitoridectomy. This was done to restore the anatomic position of the glans clitoris while preserving and potentially restoring clitoral function in patients with female genital mutilation.
Keywords: Clitoral advancement; Clitoral anatomy; Clitoral reconstruction; Clitoral surgery; Dorsal artery of clitoris; Dorsal nerve of clitoris; Female genital mutilation.
Copyright © 2021 Elsevier Ltd. All rights reserved.
CloseIndex Finger Pollicization Incisions for Congenital Thumb Aplasia: Review and Design of an Educational Anatomical Model for Skin IncisionsIndex Finger Pollicization Incisions for Congenital Thumb Aplasia: Review and Design of an Educational Anatomical Model for Skin Incisions
Index Finger Pollicization Incisions for Congenital Thumb Aplasia: Review and Design of an Educational Anatomical Model for Skin Incisions
Anaïs Delgove, Olivier Camuzard, Manuela Perez, Marc Braun , Pierre Journeau, Gilles Dautel
https://pubmed.ncbi.nlm.nih.gov/34153012/
Abstract
Background: Pollicization of the index finger can be considered the gold standard technique for the treatment of congenital thumb aplasia. The aim of this study was to review the described incisions for pollicization and to create an anatomical framework enabling the study and comparison of these incisions.
Methods: A systematic review was performed to collect descriptions of incision sets. An anatomical model was created from the two upper limbs of the same cadaver. Thumb aplasia was modeled on both hands of this cadaver by severing the thumbs; an index finger pollicization was performed on one of the two hands. Comparative analysis of scar positions, first web size, and neothumb aspect of each incision set was conducted using a surgical glove modeling the skin. The glove was fitted onto the aplastic model to draw the incisions and then onto the pollicized hand to adjust the resulting flaps after cutting.
Results: Twelve articles, two textbooks, and one DVD were included in the review, either containing an original description of incisions, or describing an incision pattern with figures and references to the initial author. A total of five different incision sets, described by Buck-Gramcko, Blauth, Foucher, Ezaki, and Malek, were identified and compared using the anatomical model.
Conclusions: This work summarizes five original incisions described for index pollicization in thumb aplasia and presents a standardized and reliable model to study and compare these different sets. The model can be used for educational purposes, either to teach or to optimize an incision set.
Copyright © 2021 by the American Society of Plastic Surgeons.
CloseVascularization of the lateral and medial antebrachial cutaneous nerves by cutaneous perforator arteries: An anatomical studyVascularization of the lateral and medial antebrachial cutaneous nerves by cutaneous perforator arteries: An anatomical study
Vascularization of the lateral and medial antebrachial cutaneous nerves by cutaneous perforator arteries: An anatomical study
M Cegarra-Escolano, C Jaloux, M-A Poumellec , T Balaguer, P Baqué, N Bronsard , O Camuzard
https://pubmed.ncbi.nlm.nih.gov/33757862/
Abstract
The forearm is an interesting donor site for non-vascularized nerve grafts, especially hand surgeons. Very few studies have described the use of the lateral and medial antebrachial cutaneous nerves (LABCN and MABCN, respectively) as vascularized nerve grafts (VNGs). The aim of this anatomical study was to analyze the characteristics and vascularization of these nerves to describe new potential donor sites for VNGs. Twelve forearms were dissected from fresh cadavers injected with red latex. The number of terminal branches, lengths, and proximal and distal diameters of both the LABCN and MABCN were studied. An anatomical description of the cutaneous perforator arteries from the radial and ulnar arteries that vascularized the nerve was also recorded: number of perforators, length, type of perforator (septo- or musculocutaneous), and location within the forearm (proximal, middle, and distal third). In over 80% of the specimens, the cutaneous perforator arteries from the radial and ulnar artery vascularized the LABCN and the MABCN, respectively. These arteries, found mostly in the proximal third of the forearm, had diameters >0.5mm. Most of them came from the radial and ulnar arteries (for LABCN and MABCN vascularization, respectively). In over 75% of the specimens, the nutrient arteries of both nerves also vascularized the superficial veins and the skin. We found that these nerves are vascularized by perforators arteries, which also participate in vein and skin vascularization. Altogether, this anatomical study shows that reconstructive surgeons could use new VNGs based on the perforator artery of the forearm.
Keywords: Anatomical study; Artère perforante; Forearm cutaneous nerves; Greffe nerveuse vascularisée; Lambeau perforant; Lateral antebrachial cutaneous nerve; Medial antebrachial cutaneous nerve; Nerf cutané latéral de l’avant-bras; Nerf cutané médial de l’avant-bras; Nerfs cutanés de l’avant-bras; Nerve vascularization; Palmar digital nerve repair; Perforator artery; Perforator flap; Réparation des nerfs digitaux palmaires; Vascularization nerveuse; Vascularized nerve graft; Étude anatomique.
Copyright © 2021 SFCM. Published by Elsevier Masson SAS. All rights reserved.
CloseThe Vascularized Lateral Antebrachial Cutaneous Nerve Graft Based on a Radial Artery Perforator for Nerve Defect Reconstruction: An Anatomical StudyThe Vascularized Lateral Antebrachial Cutaneous Nerve Graft Based on a Radial Artery Perforator for Nerve Defect Reconstruction: An Anatomical Study
The Vascularized Lateral Antebrachial Cutaneous Nerve Graft Based on a Radial Artery Perforator for Nerve Defect Reconstruction: An Anatomical Study
Olivier Camuzard, Rémi Foissac, Patrick Baqué, Nicolas Bronsard, Charalambos GeorgiouCloseGuidelines for the use and interpretation of assays for monitoring autophagy (4th edition)Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
https://pubmed.ncbi.nlm.nih.gov/33634751/
Abstract
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.Keywords: Autophagosome; LC3; cancer; flux; lysosome; macroautophagy; neurodegeneration; phagophore; stress; vacuole.
CloseComplex abdominal wall reconstruction after oncologic resection in a sequalae of giant omphalocele: A case reportComplex abdominal wall reconstruction after oncologic resection in a sequalae of giant omphalocele: A case report
Complex abdominal wall reconstruction after oncologic resection in a sequalae of giant omphalocele: A case report
Frederica Jessie Tchoungui Ritz , Marie Anne Poumellec, Alexandra Maertens, Lionel Sebastianelli , Olivier Camuzard, Thierry Balaguer, Antonio Iannelli
https://pubmed.ncbi.nlm.nih.gov/33691272/
Abstract
Introduction: Trauma injuries and oncologic resection are common aetiologies of complex abdominal wall defect. Reconstruction of abdominal wall is an everlasting question for general, paediatric and reconstructive surgeons. The plethora of techniques, bioprosthetic and engineered tissues offer countless possibilities.
Presentation of case: The patient was a 28 years old woman, with past history of untreated giant liver omphalocele, admitted for a suspicious hepatic tumefaction without specific clinical signs. The thoraco abdominopelvic CT scan revealed lung metastasis and a bilobed left hepatic tumour. Pre-operative cytologic findings of mild differentiated hepatocellular carcinoma differed from the post-operative findings of hepatoblastoma. The full-thickness abdominal wall defect after a radical resection was reconstructed with a combined acellular dermal matrix, NPWT and skin graft solution. A total epithelization was obtained after 8 weeks follow-up.
Discussion: Hepatoblastoma in adult is rare, with no consensus. A radical resection in context of giant untreated omphalocele is an unusual challenge for the surgical team. The pre-operative evaluation, the defect classification and the general conditions of the patient are paramount steps for an appropriate reconstruction. Primary or delayed reconstruction with myocutaneous flap as gold standard, depends on the oncologic management and anticipated post-operative complications. Acellular dermal matrix used for a bridged fascial repair directly on viscera and covered by NPWT, favourited a healthy granulation tissue. The full-thickness defect was then reconstructed with an ADM, NPWT and skin graft instead of an association with the myocutaneous flap. The patient follow-up was emphasized in the hepatoblastoma, but the complications of this reconstruction strategy are unknown. A total epithelization was obtained, the abdominal bulge or hernia is the first complication under surveillance.
Conclusion: Delayed reconstruction after an oncologic large abdominal wall resection has the advantage to manage post-operative complications and prepare alternative solutions. Acellular dermal matrix was not first designed for skin tissue regeneration, some authors as us experimented the conclusion that this matrix could be used for permanent abdominal wall reconstruction.
Keywords: Abdominal wall reconstruction; Acellular dermal matrix; Hepatoblastoma; Negative Pressure Wound Therapy; Omphalocele.
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
ClosePublications 2020 du Dr CAMUZARD Olivier
Arterial grafts for proper palmar digital artery reconstruction: An anatomical studyAutophagy in Osteosarcoma Cancer Stem Cells Is Critical Process which Can Be Targeted by the Antipsychotic Drug Thioridazine
Autophagy in Osteosarcoma Cancer Stem Cells Is Critical Process which Can Be Targeted by the Antipsychotic Drug Thioridazine
Olivier Camuzard, Marie-Charlotte Trojani, Sabine Santucci-Darmanin, Sophie Pagnotta, Véronique Breuil, Georges F Carle, Valérie Pierrefite-Carle
https://pubmed.ncbi.nlm.nih.gov/33297525/
Abstract
Cancer stem cells (CSCs) represent a minor population of cancer cells with stem cell-like properties which are able to fuel tumor growth and resist conventional treatments. Autophagy has been described to be upregulated in some CSCs and to play a crucial role by maintaining stem features and promoting resistance to both hostile microenvironments and treatments. Osteosarcoma (OS) is an aggressive bone cancer which mainly affects children and adolescents and autophagy in OS CSCs has been poorly studied. However, this is a very interesting case because autophagy is often deregulated in this cancer. In the present work, we used two OS cell lines showing different autophagy capacities to isolate CSC-enriched populations and to analyze the autophagy in basal and nutrient-deprived conditions. Our results indicate that autophagy is more efficient in CSCs populations compared to the parental cell lines, suggesting that autophagy is a critical process in OS CSCs. We also showed that the antipsychotic drug thioridazine is able to stimulate, and then impair autophagy in both CSC-enriched populations, leading to autosis, a cell death mediated by the Na+/K+ ATPase pump and triggered by dysregulated accumulation of autophagosomes. Taken together, our results indicate that autophagy is very active in OS CSCs and that targeting this pathway to switch their fate from survival to death could provide a novel strategy to eradicate these cells in osteosarcoma.
Keywords: Na+/K+ ATPase; autophagy; autosis; cancer stem cells; osteosarcoma.
CloseArterial grafts for proper palmar digital artery reconstruction: An anatomical studyArterial grafts for proper palmar digital artery reconstruction: An anatomical study
Arterial grafts for proper palmar digital artery reconstruction: An anatomical study
H Remy, F Locatelli, A Maertens, T Balaguer, P Baqué, N Bronsard, O Camuzar
https://pubmed.ncbi.nlm.nih.gov/33137466/
Abstract
Digital ischemia due to arterial defects need urgent surgical management. The traditional treatment consists of vascular reconstruction using a reversed autologous venous graft as a bypass. Very few studies have described the use of arterial grafts for digital artery reconstruction. This cadaver study characterized the forearm perforator arteries to assess the potential feasibility of using them as donor grafts for digital artery reconstruction. Eleven forearms and twenty hands were dissected from freshly injected cadavers. All clinically significant perforators (>0.5 mm) derived from radial or ulnar arteries and digital arteries were evaluated. The digital palmar arteries were measured at three points: metacarpophalangeal (MCP) joint, proximal interphalangeal (PIP) joint, and distal interphalangeal (PIP) joint. In the 11 forearms analyzed, 5.5 ± 1.3 perforators from radial or ulnar arteries with a diameter of at least 0.5 mm were found per dissection. The mean diameters were 0.9 ± 0.18 mm proximally and 0.8 ± 0.15 mm distally; the mean length was 35.6 ± 11.35 mm. The mean diameters for the dominant and non-dominant arteries were 1.5 and 1.3 mm at the MCP, 1.3 and 1.0 mm at the PIP, 0.8 and 0.7 mm at the DIP, respectively. The forearms are good donor sites as they have large-diameter arteries of suitable length for arterial grafting. These new arterial grafts may be suitable for vascular reconstruction of digital arteries starting from the PIP joint.
Keywords: Arterial bypass; Arterial graft; Artère digitale palmaire propre; Artère perforante; Artère radiale; Artère ulnaire; Digital ischemia; Dévascularisation; Greffon artérielle; Perforator artery; Pontage artériel; Proper palmar digital artery; Radial artery; Ulnar artery.
Copyright © 2020 SFCM. Published by Elsevier Masson SAS. All rights reserved.
CloseAutophagy in the crosstalk between tumor and microenvironmentAutophagy in the crosstalk between tumor and microenvironment
Autophagy in the crosstalk between tumor and microenvironment
Olivier Camuzard, Sabine Santucci-Darmanin, Georges F Carle, Valérie Pierrefite-Carle
https://pubmed.ncbi.nlm.nih.gov/32634449/
Abstract
Autophagy is the major catabolic process in eukaryotic cells for the degradation and recycling of damaged macromolecules and organelles. It plays a crucial role in cell quality control and nutrient supply under stress conditions. Although autophagy is classically described as a degradative mechanism, it can also be involved in some secretion pathways, leading to the extracellular release of proteins, aggregates, or organelles. The role of autophagy in cancer is complex and depends on tumor development stage. While autophagy limits cancer development in the early stages of tumorigenesis, it can also have a protumoral role in more advanced cancers, promoting primary tumor growth and metastatic spread. In addition to its pro-survival role in established tumors, autophagy recently emerged as an active player in the crosstalk between tumor and stromal cells. The aim of this review is to analyze the impact of tumoral autophagy on the microenvironment and conversely the effect of stromal cell autophagy on tumor cells.
Keywords: Autophagosome; Cancer; Degradation; Secretion; Stromal cells.
Copyright © 2020 Elsevier B.V. All rights reserved.
CloseComment on: Arterialized Posterior Interosseous Nerve Graft for Digital NeuromaComment on: Arterialized Posterior Interosseous Nerve Graft for Digital Neuroma
Comment on: Arterialized Posterior Interosseous Nerve Graft for Digital Neuroma
Olivier Camuzard, Abraham Zavala
CloseMedial femoral condyle free flap for reconstruction of carpometacarpal bone defect after giant cell tumour of tendon synovial sheath resectionMedial femoral condyle free flap for reconstruction of carpometacarpal bone defect after giant cell tumour of tendon synovial sheath resection
H Barret, H Remy, S Piereschi, O Camuzard
https://pubmed.ncbi.nlm.nih.gov/32854971/
Abstract
We report the case of a 23-year-old patient treated for a large giant cell tumour of the synovial sheaths of the ulnar edge of the hand and wrist invading the triquetrum, the hamatum, the ulnar part of the capitate as well as the bases of the 3rd, 4th and 5th metacarpals and the floor of the Guyon’s canal and the carpal tunnel. A monobloc resection was performed in a healthy margin ; the loss of bone substance was 7×3.5cm. We performed a bone reconstruction using a cortico-cancellous medial femoral condyle free flap of 8×4cm. Postoperative follow-up was uneventful and bone consolidation was achieved at 2,5 months postoperatively. The cortico-cancellous medial femoral condyle free flap is an interesting option for treating small and medium size bone loss in the hand and wrist. Its use in its pure bone form or in its chimeric form with muscle, cartilage or skin opens up a wide range of choices for the reconstructive surgeon.
Keywords: Giant cell tumour of the synovial sheaths; Hand reconstruction; Lambeau de condyle fémoral médial; Lambeau osseux vascularisé; Medial condyle femoral flap; Reconstruction main; Tumeur à cellule géante des gaines synoviales; Vascularised bone flap.
Copyright © 2020 Elsevier Masson SAS. All rights reserved.
ClosePosttraumatic pseudoaneurysm of a superficial branch of the ulnar artery: A case reportPosttraumatic pseudoaneurysm of a superficial branch of the ulnar artery: A case report
Posttraumatic pseudoaneurysm of a superficial branch of the ulnar artery: A case report
Alexandra Maertens, Frederica Jessie Tchoungui Ritz, Marie Anne Poumellec, Olivier Camuzard, Thierry Balaguer
https://pubmed.ncbi.nlm.nih.gov/32980701/
Abstract
Introduction: Hand and Upper limb pseudoaneurysms are uncommon and misdiagnosed. The delayed diagnostic and treatment lead to severe vascular and nerve complications. Many mechanisms are involved like acute injury, chronic micro traumatism of the hand, with specific clinic and para clinic signs.
Presentation of case: The patient was a 30-years old woman, right-handed, admitted at the emergencies for a penetrating hand injury at the junction of the middle third – distal third of the left forearm, palmar surface, with a good radial and ulnar pulse, without sensory or motor deficit. No vessels injuries observed per operatively. A post-operative worsened pain opposite to the scar with a purplish pulsatile swelling appeared after 20 days of complete wound healing. A needle puncture with a red blood contain, motivated an US Doppler revealing a pseudoaneurysm of a superficial artery of the ulnar artery, surgically resected, without complication.
Discussion: Two main mechanisms are involved in upper limb especially hand pseudoaneurysm: penetrating trauma and repeated micro traumatism. Superficial vessels are rarely damaged compare to deep subfascial vessels according to Laplace law. The diagnostic is clinical confirmed with the medical imaging. A pseudoaneurysm is suspected in front of a pulsatile painful tumefaction following a vessel path, with medical imaging in favor. A delayed misdiagnosis lead to a delayed care with severe complications as thrombosis, embolism and vessel. The therapeutic care is mainly surgical.
Conclusion: This case reports a delayed diagnostic of posttraumatic pseudoaneurysm of a superficial branch of the ulnar artery, managed with a surgical resection.
Keywords: Case report; Hand injury; Pseudoaneurysm; Ulnar artery.
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
CloseVolar fracture dislocation of the 2nd metacarpal base associated with acute carpal tunnel syndrome: A case reportVolar fracture dislocation of the 2nd metacarpal base associated with acute carpal tunnel syndrome: A case report
S Piereschi, H Remy, O Camuzard
https://pubmed.ncbi.nlm.nih.gov/32763069/
Abstract
Posttraumatic acute carpal tunnel syndrome is a not a usual complication in traumatic hand injuries but requires more urgent and aggressive management. Compression of the median nerve should be systematically sought when there is a major and painful swelling of the hand, associated with one or several hand and wrist fractures. In rare case, a single metacarpal fracture or dislocation can be the only cause of median nerve compression and requires urgent diagnosis. If missed or neglected irreversible damage could occur to the median nerve. If surgery is perform in a timely manner outcomes are excellent, with complete recovery in most of the cases. We present the case of a 24-year-old man with an acute compression of the median nerve due to an intra-articular fracture of the 2nd metacarpal base. A bony fragment shifting from the base of 2nd metacarpal was found in the carpal tunnel participating, at least in part, in the compression of the median nerve.
Keywords: Acute carpal tunnel symptom; Carpometacarpal dislocation; Compression du nerf médian; Fracture des métacarpien; Hand trauma; Luxation carpo-métacarpienne; Median nerve compression; Metacarpal fracture; Syndrome du canal carpien aigu; Traumatisme main.
Copyright © 2020 Elsevier Masson SAS. All rights reserved.
ClosePublications 2019 du Dr CAMUZARD Olivier
Adaptive Proximal Scaphoid Implant: Indications and Long-Term ResultsAdaptive Proximal Scaphoid Implant: Indications and Long-Term Results
Adaptive Proximal Scaphoid Implant: Indications and Long-Term Results
Marie-Anne Poumellec, Olivier Camuzard, Jean-Pierre Pequignot, Nicolas Dreant
https://pubmed.ncbi.nlm.nih.gov/31402997/
Abstract
Objective This study aims to define the indications of APSI and to evaluate the long-term results. Patients and Methods This is a monocentric study including patients that underwent an arthroplasty of the scaphoid proximal pole using an APSI between 1994 and 2010. Patients were assessed using autoquestionnaires and measuring ranges of motion, key pinch, and grip strength. X-ray views of the wrist were done to control the mobility of the implant and the evolution of the carpal collapse, if present. Results There were 19 patients included with a mean follow-up of 11 years. The mean range of motion was 106 degrees (65% of contralateral side) in flexion-extension and 33 degrees (78% of contralateral side) in radialulnar deviation. The mean grip strength was 72% of the contralateral side. The mean Mayo wrist score was 69/100, the mean QuickDASH 26/100, and the mean patient-rated wrist evaluation (PRWE) 25/100. After 10 years, evolution to osteoarthritis was noted in 32% of the patients. This was associated with a decrease of the carpal height. More specifically, capito-lunate osteoarthritis was noted after 10 years and two out of three patients were concerned after 20 years of follow-up. No osteoarthritis was diagnosed at the radiolunate articulation. Conclusion APSI is a treatment option that enables patients with scaphoid nonunion advanced collapse (SNAC), scapholunate advanced collapse (SLAC) I or II to preserve the strength and mobility with good functional results. But this arthroplasty does not prevent natural evolution to a carpal collapse after a follow-up of 20 years which is clinically well tolerated.
Keywords: adaptive proximal scaphoid implant; proximal scaphoid replacement; wrist arthritis; wrist arthroplasty.
CloseMinimally Invasive Fixation With a Volar Approach Using a Cannulated Compression Screw for Acute Hook of Hamate FracturesMinimally Invasive Fixation With a Volar Approach Using a Cannulated Compression Screw for Acute Hook of Hamate Fractures
Romain Ceccarelli, Christian Dumontier, Olivier Camuzard
https://pubmed.ncbi.nlm.nih.gov/30797656/
Abstract
Purpose: Optimal treatment of acute hook of hamate fractures (HHF) remains controversial. Isolated acute HHF can be treated nonsurgically or surgically (with excision of the hook or open reduction internal fixation). The authors present the functional outcomes of a case series of patients who were treated with minimally invasive volar fixation for acute HHF.
Methods: This retrospective study reviewed 6 patients with nondisplaced acute HHF treated with a minimally invasive volar approach and cannulated mini-screw fixation. The development of postoperative complications (tendon and ulnar nerve lesions), pain evaluated using a visual analog scale, and radiological union evaluated on computed tomography scan is reported. Wrist range of motion and grip strength were measured bilaterally. Mayo Wrist Score and Quick-Disabilities of the Arm, Shoulder, and Hand were assessed. All outcomes were measured at 1, 2, 3, and 6 months after surgery.
Results: Fixation of HHF through the volar approach was achieved in all cases with no complications. The clinical and radiological union rate was 100%. All patients were able to return to their work or hobbies after an average of 7 weeks.
Conclusions: This study suggests that acute HHF can be treated successfully by open reduction internal fixation using a volar approach with minimal morbidity and complications, a good union rate, and a fast return to daily activities.
Type of study/level of evidence: Therapeutic V.
Keywords: Acute hamate hook fracture; cannulated mini-screw; minimally invasive surgery; volar approach.
Copyright © 2019 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.
CloseNeoadjuvant isolated limb perfusion in newly diagnosed untreated patients with locally advanced soft tissue sarcomas of the extremities: the Gustave Roussy experienceNeoadjuvant isolated limb perfusion in newly diagnosed untreated patients with locally advanced soft tissue sarcomas of the extremities: the Gustave Roussy experience
T Assi, A Cavalcanti, A Le Cesne, M Faron, J F Honart, A Hadiji, O Camuzard, T Ibrahim, C LePéchoux, O Mir, S Dumont, P Terrier, J Adam, C Honoré
https://pubmed.ncbi.nlm.nih.gov/30656606/
Abstract
Background: Limb-sparing surgery in locally advanced soft tissue sarcomas (LA STS) is challenging. The aim of this study is to evaluate upfront isolated limb perfusion (ILP) in untreated patients with LA STS.
Methods: All consecutive patients with LA STS of the limbs deemed borderline or unresectable and treated with upfront ILP as induction treatment between 2003 and 2016 were included. Demographic, clinical and long-term characteristics were obtained and retrospectively analyzed.
Results: 41 patients (pts), with a median age of 51 years [range 21-76], were identified (lower limb 68%, upper limb 32%). Liposarcoma and undifferentiated pleomorphic sarcoma were the most common subtypes (27% and 22%, respectively). Acute toxicities, using Wieberdink classification, were grade II (35 pts, 85%), grade III (2 pts, 5%) and no grade IV-V. Local control rate was 98%. 32 pts had limb-sparing surgery (78%). 1 pt had an early amputation due to progressive disease after ILP. 8 pts were not operated (four had RT alone, one had distant metastases, two had a complete response and one died 3 months after ILP of a pulmonary embolism). 36 pts (84%) received postoperative RT. After a median follow-up of 43 months, 18 pts (47%) relapsed. Median disease-free survival (DFS) was 6.7 years. The median overall survival (OS) was not reached. The 1-year, 5-year and 10-year DFS and OS rates were, respectively, 75%, 50% and 45%, and 90%, 63% and 55%.
Conclusion: Upfront ILP is an efficient and well-tolerated limb-sparing procedure in borderline or unresectable LA STS without hampering OS.
Keywords: Chemotherapy; Isolated limb perfusion; Limb salvage; Neoadjuvant treatment; Soft tissue sarcoma.
CloseRole of autophagy in osteosarcomaRole of autophagy in osteosarcoma
Role of autophagy in osteosarcoma
Olivier Camuzard, Sabine Santucci-Darmanin, Georges F Carle, Valérie Pierrefite-Carle
https://pubmed.ncbi.nlm.nih.gov/31011524/
Abstract
Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents. It is a highly aggressive tumor with a tendency to spread to the lungs, which are the most common site of metastasis. Advanced osteosarcoma patients with metastasis share a poor prognosis. Despite the use of chemotherapy to treat OS, the 5-year overall survival rate for patients has remained unchanged at 65-70% for the past 20 years. In addition, the 5-year survival of patients with a metastatic disease is around 20%, highlighting the need for novel therapeutic targets. Autophagy is an intracellular degradation process which eliminates and recycles damaged proteins and organelles to improve cell lifespan. In the context of cancer, numerous studies have demonstrated that autophagy is used by tumor cells to repress initial steps of carcinogenesis and/or support the survival and growth of established tumors. In osteosarcoma, autophagy appears to be deregulated and could also act both as a pro or anti-tumoral process. In this manuscript, we aim to review these major findings regarding the role of autophagy in osteosarcoma.
Keywords: Autophagy; Cell death; Osteosarcoma; Survival.
CloseRole of autophagy in osteosarcomaAutophagy Involvement in Aseptic Loosening of Arthroplasty Components
Autophagy Involvement in Aseptic Loosening of Arthroplasty Components.
Camuzard, Olivier MD; Breuil, Véronique MD, PhD; Carle, Georges F. PhD; Pierrefite-Carle, Valérie PhD
https://pubmed.ncbi.nlm.nih.gov/30845042/
CloseThe infraorbital artery: From descriptive anatomy to mucosal perforator flap designThe infraorbital artery: From descriptive anatomy to mucosal perforator flap design
The infraorbital artery: From descriptive anatomy to mucosal perforator flap design
Katharina Hufschmidt, Olivier Camuzard, Thierry Balaguer, Patrick Baqué, Fernand de Peretti, Joseph Santini, Nicolas Bronsard, Quentin Qassemyar
https://pubmed.ncbi.nlm.nih.gov/30684276/
Abstract
Background: The terminal and perforating branches of the infraorbital artery (IOA) are poorly described. Its anatomical situation and mucosal component could provide an interesting donor site for mucosal reconstruction. The aims of the following study were to establish an anatomical description and to assess the feasibility of mucosal perforator flaps for eyelid and nasal reconstruction.
Methods: Twenty-three fresh cadaver hemifaces were studied in order to perform an IOA anatomical classification by recording the artery’s characteristics, its course, number, type, and diameter of terminal branches. We also examined the feasibility of local flaps for facial reconstruction.
Results: We highlighted five different types of courses. All cadavers had at least one superior vestibular branch with a caliber of ≥0.4 mm. A pedicled flap arising from the vestibular branch was raised in all dissections.
Conclusion: The vestibular perforator flap based on the IOA seems to be a reliable flap in reconstruction of mucosal defects.
Keywords: eyelid repair; infraorbital artery; mucosal reconstruction; nostril repair; perforator flap.
© 2019 Wiley Periodicals, Inc.
CloseUltrasound-guided percutaneous release of the carpal tunnel: comparison of the learning curves of a senior versus a junior operator. A cadaveric studyUltrasound-guided percutaneous release of the carpal tunnel: comparison of the learning curves of a senior versus a junior operator. A cadaveric study
Chloé Dekimpe, Olivier Andreani, Olivier Camuzard, Charles Raffaelli, David Petrover, Pauline Foti, Nicolas Amoretti
https://pubmed.ncbi.nlm.nih.gov/31114970/
Abstract
Objective: The purpose was to evaluate, in a cadaveric cohort, the feasibility and the learning curve of ultrasound-guided percutaneous carpal tunnel release.
Materials and methods: Fourteen carpal tunnel releases were carried out on unembalmed cadavers by a senior and a junior radiologist. Procedures were realized with an 18-MHz linear probe. An anatomical evaluation was first performed using ultrasound to detect any anatomical variant. After hydrodissection of the carpal tunnel with lidocaine, a 3-mm hook knife was introduced into the security zone to perform a retrograde section of the transverse carpal ligament (TCL) under ultrasound guidance. Anatomical dissection was performed for each wrist. The main evaluation criterion was the complete TCL section. The procedure duration (minutes), skin incision size (millimeters), the integrity of the median nerve, thenar motor branch, and palmar vascular arch were also evaluated.
Results: The senior operator was able to perform a complete release after training on three specimens and the junior operator after four specimens (p > 0.05). In most of the cases when complete release was not achieved, it was due to an incomplete section of the distal TCL (10 mm missing section on average). Mean duration time of procedure was 14 min (11 min for the senior versus 17 min for the junior, p > 0.05). Damage of neither the median nerve nor the vascular structure was observed. Mean size of the skin incision was 3 mm.
Conclusion: The ultrasound-guided percutaneous release of the carpal tunnel is demonstrated to be a procedure with a rapid learning curve.
Keywords: Cadaver; Carpal tunnel syndrome; Learning curve; Median nerve; Ultrasound.
ClosePublications 2018 du Dr CAMUZARD Olivier
Is it possible to give a single definition of the rectosigmoid junction?Is it possible to give a single definition of the rectosigmoid junction?
Is it possible to give a single definition of the rectosigmoid junction?
Damien Massalou, David Moszkowicz, Daniela Mariage, Patrick Baqué, Olivier Camuzard, Nicolas Bronsard
https://pubmed.ncbi.nlm.nih.gov/29218384/
Abstract
Aim: The rectosigmoid junction is the limit separating the sigmoid colon and rectum. This transition zone has different definitions. We want to highlight different landmarks of the rectosigmoid junction (RSJ), to help the clinicians to adopt a consensual definition.
Method: We reviewed anatomical, endoscopic, physiological and surgical points of view concerning the rectosigmoid junction (RSJ).
Results: The rectosigmoid junction has a different definition depending on who is studying it. Nevertheless, it is a high pressure location, a place connecting different muscles organizations, neurological systems or vascular anastomosis. The clear pathophysiology of the RSJ is not yet determined with certainty, but its resection is essential for the therapeutic care of patients and also for the improvement of surgical skills. From a surgical point of view, anatomical landmarks has to be chosen: easily reproducible and identifiable. The disappearance of taenia coli (belonging to the colon) and the peritoneal reflection (recto-genital pouch), located below the upper rectum, seem the most reliable. The level of rectal section must, in any case, be below the promontory.
Conclusion: There is not a single definition, but rather several definitions of the RSJ. Each one of them reflects one appearance of this region: embryological and anatomical evolution or clinical entity. From a surgical point of view, the criterion which seems to be the most reliable is the disappearance of taenia coli and the peritoneal reflection (recto-genital pouch).
Keywords: Anatomy; Lymph node; Rectosigmoid junction; Rectum.
CloseReliability of Color Doppler Ultrasound Imaging for the Assessment of Anterolateral Thigh Flap Perforators: A Prospective Study of 30 PerforatorsReliability of Color Doppler Ultrasound Imaging for the Assessment of Anterolateral Thigh Flap Perforators: A Prospective Study of 30 Perforators
Alexandre Debelmas, Olivier Camuzard, Paola Aguilar, Quentin Qassemyar
https://pubmed.ncbi.nlm.nih.gov/29481406/
Abstract
Despite numerous advantages, the anterolateral thigh perforator flap suffers from the variable position and nature of its perforators. The aim of the authors’ study was to assess the reliability of preoperative color Doppler ultrasound imaging for the exploration of perforator location and course of anterolateral thigh perforator flaps. A prospective cohort study involving patients for whom head and neck reconstruction was planned with thin anterolateral thigh perforator flaps was conducted. Each patient underwent a color Doppler ultrasound exploration of the thighs, in the operating room, immediately before surgery. The sonographer was the surgeon who raised the flaps. Perforators were sought according to surgical needs, and the same location protocol was followed for all of the cases, using an orthonormal coordinate system to report the passages of the perforators through the vastus lateralis aponeurosis. Between January of 2016 and January of 2017, 22 thin anterolateral thigh perforator flaps were successfully harvested. Thirty perforators were located and used. The median distance between the preoperative color Doppler ultrasound planning and the final location of the perforators was 5 mm, statistically smaller than a 10-mm threshold (p = 0.002). Color Doppler ultrasound effectively predicted the nature of the perforators in 90 percent of the cases. The median duration for perforator color Doppler ultrasound location was 3 minutes, statistically shorter than 10 minutes (p = 0.0001). Preoperative color Doppler ultrasound seems to be reliable, accurate, and compatible with a quick routine assessment during patient setup for the elevation of thin anterolateral thigh perforator flaps.
Clinical question/level of evidence: Diagnostic, II.
CloseRice-body formation without rheumatic disease or tuberculosis in a ``sausage`` ring fingerRice-body formation without rheumatic disease or tuberculosis in a ``sausage`` ring finger
Rice-body formation without rheumatic disease or tuberculosis in a « sausage » ring finger
M Cegarra-Escolano, C Jaloux, O Camuzard
https://pubmed.ncbi.nlm.nih.gov/29786532/
Abstract
Rice bodies are very unusual lesions, generally encountered in chronic synovitis due to rheumatoid diseases or tuberculosis. A 31-year-old right-handed man presented with a 15-year history of progressively growing « sausage-like » swelling of the 4th finger and palm of his right hand. There was an immovable, painless mass with restriction of the finger’s ROM without local or general associated signs. Imaging showed a large non-aggressive mass within the tendon sheath. Complete excision of the mass was performed. Histopathological examination showed synovial villi with rice bodies and central necrosis suggestive of tuberculous synovitis or rheumatoid arthritis (RA). Tests for mycobacterial infections were all negative and there was no argument in favor of a rheumatoid pathology. There is no established standard treatment in a case like ours, which has no origin in tuberculosis or RA. Prolonged follow-up will be needed to confirm absence of recurrence after complete excision.
Keywords: Chronic synovitis; Flexor tendon sheath; Gaine des tendons fléchisseurs; Grains de riz; Polyarthrite rhumatoïde; Rheumatoid arthritis; Rice bodies; Synovite chronique; Tuberculose; Tuberculosis.
Copyright © 2018. Published by Elsevier Masson SAS.
CloseThe infraorbital artery: Clinical relevance in esthetic medicine and identification of danger zones of the midfaceThe infraorbital artery: Clinical relevance in esthetic medicine and identification of danger zones of the midface
K Hufschmidt, N Bronsard, R Foissac, P Baqué, T Balaguer, B Chignon-Sicard, J Santini, O Camuzard
https://pubmed.ncbi.nlm.nih.gov/30327185/
Abstract
Background: Over the past decade, cosmetic injections of dermal fillers or fat have become a popular procedure in facial rejuvenation in an overconsuming society. However, complications such as arterial embolism and occlusion can occur even with experienced injectors, especially in high-risks zones namely the glabella, the nasal dorsum or the nasolabial fold. The aim of this study was to define the vascular danger zones of the infraorbital area in order to provide guidelines helping avoid them.
Materials and methods: The infraorbital artery, its main branches and their anastomoses with neighbouring vessels were studied in 18 fresh cadavers. Mimetic injections of inked hyaluronic acid were performed in the infraorbital area in the interest of analyzing its distribution and to determine potential vascular risks towards the infraorbital artery and its branches.
Results: The infraorbital artery and its branches were located in common injection regions and anastomosed to the supratrochlear artery, the dorsal nasal artery and the angular artery through the nasal branch of the infraorbital artery. Two danger zones could be depicted: injections can be risky when performed too superficially in the midcheek area, and likewise risky when performed in a periosteal layer in infraorbital hollow or tear-trough correction, because of an obvious possibility of retrograde embolism.
Conclusion: The infraorbital artery can be involved in anatomic mechanism of arterial occlusion, further blindness and stroke, among the related neighbouring arteries. Based on the findings of this study, injections to the periosteum layer in tear-trough correction and above the periosteum on the zygomatic arch is not advised.
Keywords: Anatomical study; Cheek enhancement; Infraorbital artery; Tear-trough correction; Vascular filler complications.
Copyright © 2018 Elsevier Ltd. All rights reserved.
CloseVersatility of cervicofacial flaps: Cervical-medial cheek flap for reconstruction in cutaneous substance loss of the inner cheekVersatility of cervicofacial flaps: Cervical-medial cheek flap for reconstruction in cutaneous substance loss of the inner cheek
Katharina Hufschmidt, Alexandre Bozec, Olivier Camuzard, Cyril Clerico, Riadh Berguiga, Olivier Dassonville, Joseph Santini, Gilles Poissonnet
https://pubmed.ncbi.nlm.nih.gov/30447111/
Abstract
Background: Preservation of facial harmony is a major challenge in reconstruction after resection of head and neck skin tumors. For large medial cheek-skin defects, we used a derived posterior-based cervicofacial flap, or cervical-medial cheek flap (CMCF).
Methods: We present a retrospective review of cases treated at a university-based cancer center. Patient characteristics, surgical technique, and complication rates are described.
Results: Eighteen patients were treated between 2014 and 2017 with reconstruction for integumentary cheek defect after skin tumor surgery using CMCF. Mean defect size was 5.7 cm in length and 3.9 cm in width. The main histological subtype was lentigo maligna (33.3%). We report no flap necrosis but 4 minor complications occurred over a mean follow-up of 14.4 months. At last follow-up, satisfaction rate was very high (88.9%) with no evidence of recurrence.
Conclusion: The CMCF is a promising yet infrequently used option in medial cheek reconstruction, with excellent cosmetic and functional outcomes.
Keywords: cervicofacial flap; cheek reconstruction; head and neck oncology; midfacial third defect; skin tumor.
© 2018 Wiley Periodicals, Inc.
ClosePublications 2017 du Dr CAMUZARD Olivier
A Modified Patient Positioning for Transaxillary Breast AugmentationA Modified Patient Positioning for Transaxillary Breast Augmentation
A Modified Patient Positioning for Transaxillary Breast Augmentation
Rémi Foissac, Olivier Camuzard, Jonathan Fernandez, Joel Levy
CloseAutophagy, a key process in bone homeostasisAutophagy, a key process in bone homeostasis
Autophagy, a key process in bone homeostasis
Olivier Camuzard, Sabine Santucci-Darmanin, Georges F Carle, Valérie Pierrefite-Carle
CloseCoverage of Tendon Exposure after Radial Forearm Free Flap by the Dorsoulnar Artery Perforator FlapCoverage of Tendon Exposure after Radial Forearm Free Flap by the Dorsoulnar Artery Perforator Flap
Coverage of Tendon Exposure after Radial Forearm Free Flap by the Dorsoulnar Artery Perforator Flap
Rémi Foissac, Marc Benatar, Olivier Dassonville, Alexandre Bozec, Gilles Poissonnet, Olivier Camuzard
https://pubmed.ncbi.nlm.nih.gov/28195002/
Abstract
Objective This study was designed to assess the effectiveness of an alternative technique using a perforator flap to manage secondary tendon exposure after a radial forearm free flap in head and neck oncologic surgery. Study Design Prospective cohort study. Setting Plastic Reconstructive Surgery Unit, Nice University Hospital, Pasteur 2 Hospital, France. Subjects and Methods Despite its numerous advantages, the radial forearm free flap is associated with significant donor site morbidity and the risk of secondary tendon exposure. Conventional skin grafts for secondary tendon exposure can lead to diminished wrist range of motion and grip strength, with residual pain and cold intolerance. Between 2012 and 2015, we prospectively studied 20 patients with secondary tendon exposure after a forearm radial free flap for head and neck reconstruction. Two techniques of secondary coverage were compared: a reference technique with a secondary full skin graft (10 patients) and a dorsoulnar artery perforator (DUAP) flap (10 patients). Results Maximum wrist extension (100%) was observed for the DUAP group compared with only 87% for the skin graft (SG) group ( P = .001). An improvement in grip strength (+14 kg) ( P = .028) and a decrease in pain or cold intolerance ( P = .002) were also observed in the DUAP group, in addition to a better aesthetic appearance. Conclusion The perforator flap procedure is an interesting tool in reconstructive surgery. The DUAP flap is a reliable, useful flap for secondary tendon exposure coverage after a radial forearm free flap. Level of Evidence III (case-control analytic studies of 1 center).
Keywords: dorsoulnar artery perforator flap; head and neck reconstruction; radial forearm free flap; secondary tendon exposure; skin graft.
CloseGlomus tumors of the upper limb: Single-center retrospective study of clinical and functional outcomesGlomus tumors of the upper limb: Single-center retrospective study of clinical and functional outcomes
K Hufschmidt, R Foissac, O Camuzard, N Cardot-Leccia, B Chignon-Sicard, T Balaguer
https://pubmed.ncbi.nlm.nih.gov/28549884/
Abstract
Glomus tumors are rare and benign hamartomas, arising from neuro-myo-arterial proliferation and deriving from mesenchymal origin. As they have a long-term impact on the individual’s quality of life, the primary complaint is unbearable pain. The aim of this study was to assess the clinical and functional outcomes of their surgical treatment, and to review their clinical, radiological and therapeutic features. We performed a retrospective study over a 16-year period including 31 patients with an upper limb glomus tumor. Epidemiologic, diagnostic, therapeutic and follow-up data were collected and a functional outcome questionnaire was filled out postoperatively. Thirty-one patients underwent surgery with safe macroscopic resection margins. The glomus tumor was located on the fingers in 77.4% of cases, with predominance in the ring finger (41.9% of the cases). Patient age at surgery ranged from 22 to 80 years old (mean: 54.6) with a sex ratio of 0.48. Upon clinical suspicion, magnetic resonance imaging and ultrasound were done in most cases. Immediate pain relief was obtained in 18 cases. Only one patient underwent a second surgery for incomplete removal and persistent pain. The QuickDASH questionnaire was completed by 24 patients, resulting in a mean score of 1.61, with a mean follow-up time of 88.8 months (range: 3-171 months). Seven patients were lost to follow-up. These subcutaneous, mostly subungual, nodules, with predominance on the ring finger, have a disproportionate negative impact despite their small size. The long-term outcomes after microscope-assisted surgery indicate obvious improvement in the quality of life and the patient’s satisfaction, with a very low rate of recurrence.
Keywords: Chirurgie de la main; Glomus tumors; Hand surgery; Membre supérieur; Periungual; Périunguéal; QuickDASH; Tumeurs glomiques; Upper limb.
Copyright © 2017 SFCM. Published by Elsevier Masson SAS. All rights reserved.
CloseHigh-Resolution Magnetic Resonance Imaging of Aging Upper Face Fat CompartmentsHigh-Resolution Magnetic Resonance Imaging of Aging Upper Face Fat Compartments
High-Resolution Magnetic Resonance Imaging of Aging Upper Face Fat Compartments
Rémi Foissac , Olivier Camuzard, Sébastien Piereschi, Pascal Staccini, Olivier Andreani, Charalambos Georgiou, Marc Benatar
https://pubmed.ncbi.nlm.nih.gov/28350655/
Abstract
Background: Age-related changes in fat compartments have yet to be fully characterized. Uncertainty remains in terms of volume gains/losses or shape fluctuations over time. The authors’ aim was to determine the evolution of subcutaneous fat in the aging upper face, focusing on shifts in volume and dimension.
Methods: Over the course of 4.5 years, 100 faces of living female Caucasian patients were prospectively studied using high-resolution magnetic resonance imaging. Subjects were stratified by age as follows: group 1, 18 to 30 years; group 2, 30 to 60 years; and group 3, older than 60 years. Superficial temporal and central forehead compartments were delimited, analyzing respective volumes and dimensions by group.
Results: In 85 patients studied, superficial temporal fat (mean volume, 5.14 cm) increased 35.48 percent in total volume between youth and old age (p = 0.046). Overall height and magnitude of the lower one-third also increased with aging. Central forehead fat (mean volume, 2.56 cm), studied in 83 patients, showed a 209.75 percent volume gain in group 2 (versus group 1) and a 17.59 percent volume loss in group 3 (versus group 2) (p = 0.001).
Conclusion: Subcutaneous facial fat fluctuates with aging, increasing in the upper face and promoting ptosis through basal compartmental expansion.
CloseHomeotic and Embryonic Gene Expression in Breast Adipose Tissue and in Adipose Tissues Used as Donor Sites in Plastic SurgeryHomeotic and Embryonic Gene Expression in Breast Adipose Tissue and in Adipose Tissues Used as Donor Sites in Plastic Surgery
Rémi Foissac, Phi Villageois, Bérengère Chignon-Sicard, Charalambos Georgiou, Olivier Camuzard, Christian Dani
https://pubmed.ncbi.nlm.nih.gov/28234838/
Abstract
Background: Autologous fat grafting has become an essential procedure in breast reconstructive surgery. However, molecular knowledge of different adipose donor sites remains inadequate. Tissue regeneration studies have shown that it is essential to match the Hox code of transplanted cells and host tissues to achieve correct repair. This study aims to provide a better molecular understanding of adipose tissue.
Methods: Over the course of 1 year, the authors prospectively included 15 patients and studied seven adipose areas: chin, breast, arm, abdomen, thigh, hip, and knee. The first step consisted of the surgical harvesting of adipose tissue. RNA was then extracted and converted into cDNA to study gene expression levels of 10 targeted genes by real-time polymerase chain reaction.
Results: Forty samples from Caucasian women with a mean age of 48 years were studied. The expression of PAX3, a marker of neuroectodermal origin, was significantly higher in the breast, with a decreasing gradient from the upper to lower areas of the body. An inverse gradient was found for the expression of HOXC10. This expression profile was statistically significant for the areas of the thigh and knee compared with the breast (p < 0.0083).
Conclusions: Breast fat may have a specific embryologic origin compared with the knee and thigh. The reinjection of adipocytes from the infraumbilical area leads to the transfer of cells highly expressing HOXC10. This study raises questions about the safety of this procedure, and future studies will be required to examine molecular modifications of adipose cells transferred to a heterotopic location.
Clinical question/level of evidence: Therapeutic, V.
ClosePrimary radical ablative surgery and fibula free-flap reconstruction for T4 oral cavity squamous cell carcinoma with mandibular invasion: oncologic and functional results and their predictive factorsPrimary radical ablative surgery and fibula free-flap reconstruction for T4 oral cavity squamous cell carcinoma with mandibular invasion: oncologic and functional results and their predictive factors
Olivier Camuzard, Olivier Dassonville, Marc Ettaiche, Emmanuel Chamorey, Gilles Poissonnet, Riadh Berguiga, Axel Leysalle, Karen Benezery, Frédéric Peyrade, Esma Saada, Raphael Hechema, Anne Sudaka, Juliette Haudebourg, François Demard, José Santini, Alexandre Bozec
https://pubmed.ncbi.nlm.nih.gov/27438536/
Abstract
The aims of this study were to evaluate clinical outcomes and to determine their predictive factors in patients with oral cavity squamous cell carcinoma (OCSCC) invading the mandibular bone (T4) who underwent primary radical surgery and fibula free-flap reconstruction. Between 2001 and 2013, all patients who underwent primary surgery and mandibular fibula free-flap reconstruction for OCSCC were enrolled in this retrospective study. Predictive factors of oncologic and functional outcomes were assessed in univariate and multivariate analysis. 77 patients (55 men and 22 women, mean age 62 ± 10.6 years) were enrolled in this study. Free-flap failure and local and general complication rates were 9, 31, and 22 %, respectively. In multivariate analysis, ASA score (p = 0.002), pathologic N-stage (p = 0.01), and close surgical margins (p = 0.03) were independent predictors of overall survival. Six months after therapy, oral diet, speech intelligibility, and mouth opening functions were normal or slightly impaired in, respectively, 79, 88, and 83 % of patients. 6.5 % of patients remaining dependent on enteral nutrition 6 months after therapy. With acceptable postoperative outcomes and satisfactory oncologic and functional results, segmental mandibulectomy with fibula free-flap reconstruction should be considered the gold standard primary treatment for patients with OCSCC invading mandible bone. Oncologic outcomes are dependent on three main factors: ASA score, pathologic N-stage, and surgical margin status.
Keywords: Fibula; Free-flap; Head neck cancer; Mandible; Oral cavity; Reconstruction.
ClosePublications 2016 du Dr CAMUZARD Olivier
Inferior Cubital Artery Perforator Flap for Soft-Tissue Coverage of the Elbow: Anatomical Study and Clinical ApplicationInferior Cubital Artery Perforator Flap for Soft-Tissue Coverage of the Elbow: Anatomical Study and Clinical Application
Olivier Camuzard, Rémi Foissac, Cyril Clerico, Jonathan Fernandez, Thierry Balaguer, Tarik Ihrai, Fernand de Peretti, Patrick Baqué, Pascal Boileau, Charalambos Georgiou, Nicolas Bronsard
https://pubmed.ncbi.nlm.nih.gov/26984913/
Abstract
Background: Soft-tissue defects surrounding the elbow can be a challenging problem for the orthopaedic surgeon. Reliable reconstruction with use of muscular flaps or even perforator flaps derived from the surrounding vessels has been described. The inferior cubital artery (ICA) is an indirect septocutaneous perforator branch that most frequently arises from the lateral side of the radial artery. The purposes of the present study were to characterize the capillary cutaneous perforators of the ICA and to evaluate the potential of a local perforator flap procedure for soft-tissue coverage of the elbow.
Methods: Twenty fresh cadaveric forearms were dissected in order to describe the ICA anatomy, and in ten additional forearms the ICA was selectively injected with a red ink solution to detail the ICA vascular territory. For each artery, we recorded the site of origin, the diameter of the artery at its source, the course of the artery, and the number, type, and diameter of capillary cutaneous perforators.
Results: A total of seventy-eight ICA capillary perforators were analyzed from the twenty dissected forearms: forty-six were in-transit capillary perforators, nineteen were terminal capillary perforators, and thirteen were musculocutaneous capillary perforators. Of these seventy-eight perforators, sixteen (21%) had a caliber of <0.5 mm and sixty-two capillary perforators (79%) had a caliber of ≥0.5 mm. Ten ICAs were selectively injected, and the mean size of all stained skin areas was 30.9 ± 11.9 cm(2). A perforator pedicled flap was readily feasible for all dissections. We also describe the case of a patient with a medial soft-tissue defect of the elbow that was covered with a pedicled perforator flap based on an ICA. The patient had satisfactory healing at two months.
Conclusions: The ICA flap is a reliable and useful flap for elbow soft-tissue reconstruction.
Clinical relevance: The perforator flap procedure is a major advancement in reconstructive surgery. One potential application of the perforator flaps is the use of tissue adjacent to a defect as a perforator-based island flap. The use of this tissue allows for thinner flaps to be tailored for more accurate reconstruction. A flap that depends on a perforator branch of the radial artery called the inferior cubital artery seems to be an excellent solution for soft-tissue coverage of the elbow.
Copyright © 2016 by The Journal of Bone and Joint Surgery, Incorporated.
CloseIntravenous Hyaluronidase with Urokinase as Treatment for Arterial Hyaluronic Acid EmbolismIntravenous Hyaluronidase with Urokinase as Treatment for Arterial Hyaluronic Acid Embolism
Intravenous Hyaluronidase with Urokinase as Treatment for Arterial Hyaluronic Acid Embolism
Rémi Foissac, Philippe Kestemont, Olivier Camuzard
CloseSex-specific autophagy modulation in osteoblastic lineage: a critical function to counteract bone loss in femaleSex-specific autophagy modulation in osteoblastic lineage: a critical function to counteract bone loss in female
Olivier Camuzard, Sabine Santucci-Darmanin, Véronique Breuil, Chantal Cros, Tatiana Gritsaenko, Sophie Pagnotta, Laurence Cailleteau 5, Séverine Battaglia, Patricia Panaïa-Ferrari, Dominique Heymann, Georges F Carle, Valérie Pierrefite-Carle
https://pubmed.ncbi.nlm.nih.gov/27634908/
Abstract
Age-related bone loss is associated with an increased oxidative stress which is worsened by estrogen fall during menauposis. This observation has drawn attention to autophagy, a major cellular catabolic process, able to alleviate oxidative stress in osteoblasts (OB) and osteocytes (OST), two key bone cell types. Moreover, an autophagy decline can be associated with aging, suggesting that an age-related autophagy deficiency in OB and/or OST could contribute to skeletal aging and osteoporosis onset.In the present work, autophagy activity was analyzed in OST and OB in male and female mice according to their age and hormonal status. In OST, autophagy decreases with aging in both sexes. In OB, although a 95% decrease in autophagy is observed in OB derived from old females, this activity remains unchanged in males. In addition, while ovariectomy has no effect on OB autophagy levels, orchidectomy appears to stimulate this process. An inverse correlation between autophagy and the oxidative stress level was observed in OB derived from males or females. Finally, using OB-specific autophagy-deficient mice, we showed that autophagy deficiency aggravates the bone loss associated with aging and estrogen deprivation.Taken together, our data indicate that autophagic modulation in bone cells differs according to sex and cell type. The lowering of autophagy in female OB, which is associated with an increased oxidative stress, could play a role in osteoporosis pathophysiology and suggests that autophagy could be a new therapeutic target for osteoporosis in women.
Keywords: Gerotarget; aging; autophagy; osteoblast; osteocyte; osteoporosis.
CloseThe Vascularized Lateral Antebrachial Cutaneous Nerve Graft Based on a Radial Artery Perforator for Nerve Defect Reconstruction: An Anatomical StudyThe Vascularized Lateral Antebrachial Cutaneous Nerve Graft Based on a Radial Artery Perforator for Nerve Defect Reconstruction: An Anatomical Study
Olivier Camuzard, Rémi Foissac, Patrick Baqué, Nicolas Bronsard, Charalambos Georgiou
ClosePublications 2015 du Dr CAMUZARD Olivier
AJCO: Association of Young Surgical OncologistsAJCO: Association of Young Surgical Oncologists
AJCO: Association of Young Surgical Oncologists
Thomas Sorin, Olivier Camuzard, Adnan El-Bakri, Thomas Sagardoy, Antoine Legras
CloseAJCO: Association of Young Surgical OncologistsThe Vascularized Lateral Antebrachial Cutaneous Nerve Graft Based on a Radial Artery Perforator for Nerve Defect Reconstruction: An Anatomical Study
Olivier Camuzard, Rémi Foissac, Patrick Baqué, Nicolas Bronsard, Charalambos GeorgiouCloseA rare cause of ulnar nerve entrapment at the elbow area illustrated by six cases: The anconeus epitrochlearis muscleA rare cause of ulnar nerve entrapment at the elbow area illustrated by six cases: The anconeus epitrochlearis muscle
J Fernandez, O Camuzard, M-O Gauci, M Winter
https://pubmed.ncbi.nlm.nih.gov/26545312/
Abstract
Ulnar nerve entrapment is the second most common compressive neuropathy after carpal tunnel syndrome. The accessory anconeus epitrochlearis muscle – present in 4% to 34% of the general population – is a known, but rare cause of ulnar nerve entrapment at the elbow. The aim of this article was to expand our knowledge about this condition based on six cases that we encountered at our hospital between 2011 and 2015. Every patient had a typical clinical presentation: hypoesthesia or sensory deficit in the fourth and fifth fingers; potential intrinsics atrophy of the fourth intermetacarpal space; loss of strength and difficulty with fifth finger abduction. Although it can be useful to have the patient undergo ultrasonography or MRI to aid in the diagnosis, only electromyography (EMG) was performed in our patients. EMG revealed clear compression in the ulnar groove, with conduction block and a large drop in nerve conduction velocity. Treatment typically consists of conservative treatment first (splint, analgesics). Surgical treatment should be considered when conservative treatment has failed or the patient presents severe neurological deficits. In all of our patients, the ulnar nerve was surgically released but not transposed. Five of the six patients had completely recovered after 0.5 to 4years follow-up. Ulnar nerve entrapment at the elbow by the anconeus epitrochlearis muscle is not common, but it must not be ignored. Only ultrasonography, MRI or, preferably, surgical exploration can establish the diagnosis. EMG findings such as reduced motor nerve conduction velocity in a short segment of the ulnar nerve provides evidence of anconeus epitrochlearis-induced neuropathy.
Keywords: Anconeus epitrochlearis muscle; Compression du nerf ulnaire; Compressive neuropathy; Muscle anconeus epitrochlearis; Neurolyse; Neurolysis; Neuropathie compressive; Ulnar nerve compression.
Copyright © 2015 SFCM. Published by Elsevier Masson SAS. All rights reserved.
CloseA strange form of dysphonia... . Laryngeal paragangliomaA strange form of dysphonia... . Laryngeal paraganglioma
A strange form of dysphonia… . Laryngeal paraganglioma
Etienne Berta, Olivier Camuzard, Gilles Poissonnet
CloseAutophagy in bone: Self-eating to stay in balanceAutophagy in bone: Self-eating to stay in balance
Autophagy in bone: Self-eating to stay in balance
Valérie Pierrefite-Carle, Sabine Santucci-Darmanin, Véronique Breuil, Olivier Camuzard, Georges F Carle
https://pubmed.ncbi.nlm.nih.gov/26318060/
Abstract
Autophagy, a major catabolic pathway responsible of the elimination of damaged proteins and organelles, is now recognized as an anti-aging process. In addition to its basal role in cell homeostasis, autophagy is also a stress-responsive mechanism for survival purposes. Here, we review recent literature to highlight the autophagy role in the different bone cell types, i.e., osteoblasts, osteoclasts and osteocytes. We also discuss the effects of autophagy modulators in bone physiology and of bone anabolic compounds in autophagy. Finally, we analyzed studies regarding bone cell autophagy-deficient mouse models to obtain a more general view on how autophagy modulates bone physiology and pathophysiology, particularly during aging.
Keywords: Autophagy; Bone; Osteoporosis.
Copyright © 2015 Elsevier B.V. All rights reserved.
CloseContribution of breast skin elastometry measurement in breast augmentation surgery: A pilot study evaluating the correlation between skin elasticity and nipple-to-inframammary fold distanceContribution of breast skin elastometry measurement in breast augmentation surgery: A pilot study evaluating the correlation between skin elasticity and nipple-to-inframammary fold distance
Rémi Foissac, Olivier Camuzard, Charalambos Georgiou, Pauline Foty, Thierry Balaguer, Bérengère Chignon-Sicard, Dominique Casanova
CloseFacial artery perforator flap for reconstruction of perinasal defects: An anatomical study and clinical applicationFacial artery perforator flap for reconstruction of perinasal defects: An anatomical study and clinical application
Olivier Camuzard, Rémi Foissac, Charalambos Georgiou, Lucas Andot, Florent Alcaraz, Patrick Baqué, Nicolas Bronsard, Gilles Poissonnet
https://pubmed.ncbi.nlm.nih.gov/26590853/
Abstract
Background: The concept of the facial artery perforator flap was developed for improved freedom during the reconstruction of perioral and perinasal defects. This flap enables tailor-made reconstruction and a shift from the traditional two-stage procedure to a one-stage technique. In this cadaveric study, the authors quantify the number, length, and diameter of facial artery perforators (FAPs) and present their clinical experience with the FAP flap.
Methods: The authors performed 20 dissections of facial arteries (FAs). All FAPs greater than 0.5 mm were dissected to study the number, length, and diameter of FAPs. In addition, the authors report a case series of 15 perinasal defect reconstruction procedures performed using facial artery-based perforator flap.
Results: A total of 125 FAPs were dissected. We identified a mean of six FAPs per hemiface (range five to eight). The average length of all FAPs was 17.6 ± 1.9 mm, and the mean diameter of the FAPs was 0.91 ± 0.2. Fifteen patients underwent a perinasal defect reconstruction using a FAP flap with good aesthetic and functional results.
Conclusions: The following study thus improves our understanding of FAP anatomy and clinical application and will enable the nasolabial fold to become the area where perinasal defect reconstruction using perforator flaps is performed.
Keywords: Cadaveric study; Facial artery; Facial artery perforator; Facial artery perforator flap; Facial reconstruction; Latex injection.
Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
CloseNew cutaneous strategy in sural flap surgery and possibility to adapt this technique to other pedicled flapsNew cutaneous strategy in sural flap surgery and possibility to adapt this technique to other pedicled flaps
J Fernandez, C Clérico, O Camuzard, B Chignon-Sicard
https://pubmed.ncbi.nlm.nih.gov/25963526/
Abstract
Introduction: Therapeutic managements in losses of substance of the lower limb using sural flap give an important scar and, sometimes, an impossibility to close the flap donor site. That led us to think about an operative procedure that can reduce those scars without increasing the risk of necrosis of the cutaneous paddle.
Patients and method: We present this operative procedure which underwent in the plastic and reconstructive surgery service in our hospital. Classical flap procedure with two cutaneous parts was used. The cutaneous laxity was evaluated so as to close with one cutaneous part; the other cutaneous part was taken and used like a skin graft after the suture of the calf and the formation of a bursa on the donor site. The leg was closed with only one cutaneous flap.
Results: This technique is illustrated by a case report. Results at the 4th month are very interesting with an acceptable scar and a good result of the skin graft. However, with this technique, we don’t decrease the venous risk of this flap. We used this technique for an antebrachial flap.
Conclusion: This technique is an easy and reliable technique based on cutaneous laxity and that decreases scarring of this very useful flap: the neurocutaneous sural flap. We can have a diminution of the number of surgery, a diminution of the scar and good aesthetics results.
Keywords: Cutaneous laxity; Cutaneous strategy; Lambeau sural; Laxité cutanée; Neurocutaneous sural flap; Pedicled; Pédiculé; Rançon cicatricielle; Scar; Stratégie cutanée.
Copyright © 2015 Elsevier Masson SAS. All rights reserved.
ClosePublications 2014 du Dr CAMUZARD Olivier
Axillary hyperhidrosis, botulinium A toxin treatment: ReviewAxillary hyperhidrosis, botulinium A toxin treatment: Review
Axillary hyperhidrosis, botulinium A toxin treatment: Review
C Clerico 1, J Fernandez 2, O Camuzard 2, B Chignon-Sicard 2, T Ihrai 2
https://pubmed.ncbi.nlm.nih.gov/25555435/
Abstract
Injection of type A botulinum toxin in the armpits is a temporary treatment for axillary hyperhidrosis. This technique described in 1996 by Bushara et al., is known to be efficient and safe. The purpose of this article was to review the data concerning the treatment of axillary hyperhidrosis with botulinum toxin type A, and discuss the other treatment modalities for this socially disabling entity.
Keywords: Axillary hyperhidrosis; Botulinium toxin; Hyperhidrose; Hyperhidrosis; Injections; Région axillaire; Toxine botulique.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.
CloseBreast lesions of a metastatic melanoma on a radiotherapy territory: Treatment by vemurafenib and carcinologic surgeryBreast lesions of a metastatic melanoma on a radiotherapy territory: Treatment by vemurafenib and carcinologic surgery
J Fernandez 1, H Montaudié 2, A Courdi 3, C Georgiou 4, O Camuzard 4, B Chignon-Sicard 4
https://pubmed.ncbi.nlm.nih.gov/25446470/
Abstract
Introduction: This article describes the unique case of a female patient who presented distant melanoma metastasis on the breast while having irradiation therapy for breast cancer. This happened eight months after the initial treatment for a melanoma of the back (under the right scapula). Furthermore, this case report demonstrates the efficiency of Vemurafenib® as a treatment for late stage melanomas.
Case report: The patient was a 47-year-old female that had a superficial spreading melanoma under the right scapula (Breslow 1.02mm) that was treated with 2cm skin excision and sentinel lymph node sampling that was negative. The melanoma was positive for the BRAF600E mutation. One month after this incident, the patient developed breast cancer that was treated with conservative surgery and radiotherapy. Three months after the end of the irradiation treatment, she developed multiple melanoma metastasis on the skin of the breast. Our multidisciplinary team decided to initiate a treatment with vemurafenib. The patient showed an excellent response, so the surgical team completed the treatment with a radical mastectomy and immediate reconstruction with a pedicled latissimus dorsi flap. The histologic report of the mastectomy specimen showed no sign of melanocytic proliferation, that demonstrates the efficacy of vemurafenib. The patient showed no relapse after two years of follow-up.
Discussion: The speed of development and location of cutaneous metastases in this case brought us to think about the effects of radiation therapy on the skin. Radiation therapy causes acute complications (radiodermatitis) by cellular and molecular mechanisms. Moreover, depressed immunity is found after irradiation. Association of these mecanisms could explain the appearance of these metastases in irradiation field. The efficiency of vemurafenib found in our case is consistent with what is described in literature, especially with the improvement in median overall survival.
Conclusion: This case demonstrates a unique case of distant melanoma metastasis on the irradiation field of a breast cancer. It also demonstrates the efficacy of vemurafenib as well as the efficacy of a radical complementary surgical treatment in these patients.
Keywords: BRAFV600E; Breast cancer; Cancer du sein; Champ d’irradiation; Cutaneous metastasis; Immunomodulation; Irradiation territory; Melanoma; Mélanome; Métastases cutanées; Radiotherapie; Radiothérapie; Survie; Survival; Vemurafenib; Vémurafénib.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.
CloseCharacteristics of the male faceliftCharacteristics of the male facelift
Characteristics of the male facelift
R Foissac, T R Colson, O Camuzard, P Kestemont
https://pubmed.ncbi.nlm.nih.gov/26521365/
Abstract
Male face lifting is the cosmetic surgery which has witnessed the greatest rise in demand in recent years. A result of social evolution and development of non-surgical techniques for facial rejuvenation, this intervention represents a real challenge for the surgeon who operates mainly on women. Man has specific characteristics which include differences in the aging process, and a multitude of anatomical and psychosocial factors that will require adjustments in the patient’s overall care. Indeed, the adaptation of the conventional technique of the female facelift would lead to an unnatural result, not satisfactory for the patient. To best meet the demands of the male patient, the surgeon must take into account the male facial characteristics in order to optimize the results.CloseSevere granulomatous reaction associated with hypercalcemia occurring after silicone soft tissue augmentation of the buttocks: a case reportSevere granulomatous reaction associated with hypercalcemia occurring after silicone soft tissue augmentation of the buttocks: a case report
O Camuzard, P Dumas, R Foissac, J Fernandez, S David, T Balaguer, B Chignon-Sicard, C Dumontier
https://pubmed.ncbi.nlm.nih.gov/24281899/
Abstract
Liquid silicone is a permanent filler. Its use to augment soft tissues for aesthetic purposes was widespread worldwide in the 1960s. Although initially considered to be biologically inert, this substance may cause, after its injection, an inflammatory granulomatous effect of variable severity and, in very rare cases, a severe hypercalcemia, which can be life threatening. The reported case highlights the well-known physiopathology of hypercalcemia, and the various therapeutic options are discussed.
Level of evidence v: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
ClosePublications 2013 du Dr CAMUZARD Olivier
Treatment of Dupuytren's contracture by collagenase injectionTreatment of Dupuytren's contracture by collagenase injection
Treatment of Dupuytren’s contracture by collagenase injection
R Foissac, O Camuzard, P Dumas, C Dumontier, B Chignon-Sicard
https://pubmed.ncbi.nlm.nih.gov/23856551/
Abstract
Dupuytren’s disease is a disorder of the palmar aponeurosis responsible for apparition of pathological collagen cords that will gradually lead to a digital retraction. These cords cause functional disability to the hand with a real handicap for the patient. No curative treatment exists currently in this disease. Injections of collagenase from Clostridium histolyticum cause lysis of the collagen present in the cords and cause an interruption of the palmar cord. It is a new treatment in the management of Dupuytren’s disease. The use of collagenase injection in the treatment of palmar form of Dupuytren’s disease gives good results in the short and medium terms. It is a simple, minimally invasive treatment, several studies have proven its effectiveness and it approximates percutaneous needle fasciotomy in its easy use and its indications. Patients should be well informed about local reactions and transient pain with the injection of C. histolyticum collagenase. Diffusion of this technique is still limited by: the assessment of its cost compared to that of other methods of treatment and particularly the needle fasciotomy, and the evaluation of results over the long-term.
Keywords: Brides de collagène; Clostridium histolyticum collagenase; Collagen cords; Collagénase de Clostridium histolyticum; Digital retraction; Dupuytren’s disease; Maladie de Dupuytren; Rétraction digitale.
Copyright © 2013 Elsevier Masson SAS. All rights reserved.
ClosePublications 2011 du Dr CAMUZARD Olivier
Melanotic neuroectodermal tumor of infancy: case report and review of the literatureMelanotic neuroectodermal tumor of infancy: case report and review of the literature
Melanotic neuroectodermal tumor of infancy: case report and review of the literature
O Camuzard , O Rosello, C Maschi, L Castillo, A Deville, C Boyer, A Chevallier, S Bailleux
https://pubmed.ncbi.nlm.nih.gov/22533073/
Abstract
Melanotic Neuroectodermal Tumor of Infancy (MNTI) is a rare but distinct neoplastic entity in infancy. Diagnosis is usually made before the age of 12 months. The common clinical presentation is a rapidly growing mass of the pre-maxillary area. Its surface is unevenly pigmented. To affirm the diagnosis a biopsy is necessary. Few cases of malignancy have been described (5% of cases). Adequate surgical excision is the treatment of choice. Recurrence rate is about 10 to 15% within 5 years. We report in this article the case of a newborn with MNTI illustrating that an R0 surgical excision can be correlated to a favourable prognosis. In this case the 5 years follow up didn’t show any local or distant recurrence.
Close -
Communications orales
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Congrès Nationaux
Communications 2019 du Pr CAMUZARD Olivier
- Transfert sélectif de la racine C7 controlatérale pour la prise en charge des avulsions complètes post- traumatiques du plexus brachial
Société Française de Chirurgie de la Main,GEM, Decembre 2018
Communications 2020 du Pr CAMUZARD Olivier
- Transfert Nerveux Vascularisé du Nerf Interosseux Postérieur
Société Française de Chirurgie de la Main,GEM, Decembre 2021 - Analyse des muscles paravertébraux comme critère de diagnistque des avulsions du plexus brachial
Société Française de Chirurgie de la Main,GEM, Decembre 2021
Communications 2018 du Pr CAMUZARD Olivier
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- Rôle de l’autophagie dans le dialogue entre son microenvironnement et l’ostéosarcome Société Française de Biomatériaux et des Tissus Minéralisés, Monaco, Avril 2018, Prix de la meilleur communication orale.
- Vascularisation des nerfs sensitifs superficiels de l’avant-bras, applications cliniques en reconstruction de la main et des doigts Société Française de Chirurgie de la Main,GEM, Decembre 2018
- Utilisation de greffon artériel pour les reconstructions des artères collatérales digitales par pontage : étude anatomique de faisabilité Société Française de Chirurgie de la Main,GEM, Decembre 2018
- Transfert sélectif de la racine C7 controlatérale pour la prise en charge des avulsions complètes post- traumatiques du plexus brachial Société Française de Chirurgie de la Main,GEM, Decembre 2018
- Pseudo anévrisme d’une branche cutanée de l’artère ulnaire, diagnostic rare d’une masse post traumatisme pénétrant : case report et revue de la littérature Société Française de Chirurgie de la Main,GEM, Decembre 2018
- Osteosynthèse mini-invasive par voie palmaire avec vis de compression canulée pour fractures du crochet de l’hamatum non déplacées en aigü Société Française de Chirurgie de la Main,GEM, Decembre 2018
- Utilisation de greffon artériel pour les reconstructions des artères collatérales digitales par pontage : étude anatomique de faisabilité Congrès de la Société Française de Chirurgie Plastique Reconstructrice et Esthétique, Novembre 2018
- Osteosynthèse mini-invasive par voie palmaire avec vis de compression canulée pour fractures du crochet de l’hamatum non déplacées en aigü Congrès de la Société Française de Chirurgie Plastique Reconstructrice et Esthétique, Novembre 2018
Communications 2017 du Pr CAMUZARD Olivier
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- Greffe nerveuse vascularisée du nerf inter-osseux postérieur.
Société Française de Chirurgie de la Main,GEM, Décembre 2017 - Le lambeau perforant de l’Artère Cubitale Inférieure pour les pertes de substance du coude: Étude Anatomique et Applications Cliniques.
Société Française de Chirurgie Orthopédique et Traumatologique (SOFCOT), Paris, Décembre 2017
- Greffe nerveuse vascularisée du nerf inter-osseux postérieur.
Communications 2016 du Pr CAMUZARD Olivier
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- Le lambeau muqueux de la branche vestibulaire supérieure de l’artère infra-orbitaire : Etude anatomique et application clinique.
Journée des Jeunes Plasticiens Paris, Mars 2016 - Le lambeau chimérique antéro-latéral de cuisse fin double palette cutanée avec aponévrose vascularisé pour la reconstruction d’une perte de substance transfixiante de la joue et de la commissure orale.
Journée des Jeunes Plasticiens Paris, Mars 2016 - Sauvetage d’une oesophagectomie totale après échec de coloplastie et de lambeau libre de jéjunum comliqué d’une mediastinite.
Journée des Jeunes Plasticiens Paris, Mars 2016 - Le lambeau perforant de l’Artère Cubitale Inférieure pour les pertes de substance du coude: Etude Anatomique et Applications Cliniques.
Société Française de Microchirurgie, Paris, Juin 2016 - Le lambeau chimérique antéro-latéral de cuisse fin double palette cutanée avec aponévrose vascularisé pour la reconstruction d’une perte de substance transfixiante de la joue et de la commissure orale.
Société Française de Microchirurgie, Paris, Juin 2016 - Technique de reconstruction des pharyngo-laryngectomies partielles par un lambeau antéro-latéral de cuisse fin armé de cartilage.
Société Française de Microchirurgie, Paris, Juin 2016 - Analyse de l’activité autophagique dans les cellules souches tumorales d’ostéosarcome.
Société Française de Biomatériaux et des Tissus Minéralisés, Nancy, Juin 2016 - L’autophagie, une nouvelle cible thérapeutique dans le traitement de l’ostéoporose ?
Société Française de Biomatériaux et des Tissus Minéralisés, Nancy, Juin 2016 - Le lambeau perforant scapulo-dorsal avec extension adipeuse pour les reconstructions des hémi-maxillectomies.
Société Française d’Oto-Rhino-Laryngologie, Paris, Octobre 2016 - Le lambeau chimérique antéro-latéral de cuisse fin double palette cutanée avec aponévrose vascularisé pour la reconstruction d’une perte de substance transfixiante de la joue et de la commissure orale.
Société Française d’Oto-Rhino-Laryngologie, Paris, Octobre 2016 - Les Lambeaux Locaux en Ilot Vrai sur les Perforantes de l’Artère Faciale : de l’Anatomie aux Applications Cliniques.
Société Française d’Oto-Rhino-Laryngologie, Paris, Octobre 2016 - Association perfusion de membres isolés sous circulation extracorporelle et reconstruction par lambeau pour le sauvetage des membres atteints de sarcome localement avancé des tissus mous : résultats à long terme
Congrés de la Société Française de Chirurgie Plastique Reconstructrice et Esthétique, Paris Novembre 2016 - Le lambeau perforant scapulo-dorsal avec extension adipeuse pour les reconstructions des hémi-maxillectomies.
Congrés de la Société Française de Chirurgie Plastique Reconstructrice et Esthétique, Paris Novembre 2016
- Le lambeau muqueux de la branche vestibulaire supérieure de l’artère infra-orbitaire : Etude anatomique et application clinique.
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Communications 2015 du Pr CAMUZARD Olivier
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- Les artères perforantes à destinée cutanée de l’artère faciale : Etude anatomique et Application clinique
Journée des Jeunes Plasticiens Paris, Mars 2015 - Analyse de l’activité autophagique dans les cellules souches tumorales d’ostéosarcome
BIOSARC, Groupe Français d’étude des Sarcomes Paris, Septembre 2015 - Le lambeau perforant de l’artère cubital inférieure : Etude anatomique et Application clinique
Congrés de la Société Française de Chirurgie Plastique Reconstructrice et Esthétique, Paris Novembre 2015 - Les artères perforantes à destinée cutanée de l’artère faciale : Etude anatomique et Application clinique
Congrés de la Société Française de Chirurgie Plastique Reconstructrice et Esthétique, Paris Novembre 2015 - Le lambeau perforant de l’artère cubital inférieure : Etude anatomique et Application clinique
Société Française de Chirurgie de la Main, Paris, Decembre 2015
- Les artères perforantes à destinée cutanée de l’artère faciale : Etude anatomique et Application clinique
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Communications 2014 du Pr CAMUZARD Olivier
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- Pointe Carrée dans la prise en charge des fractures du col des métacarpiens.
3ème Journée de la recherche Médicale des hopitaux pédiatriques de Nice CHU-LENVAL Février 2014 - Lambeau perforant de l’artère cubital inférieure : à propos d’un cas
Journée des Jeunes Plasticiens Paris, Mars 2014
- Pointe Carrée dans la prise en charge des fractures du col des métacarpiens.
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Communications 2013 du Pr CAMUZARD Olivier
- Hypercalcémie maligne secondaire à une granulomatose inflammatoire réactionnelle à une injection de silicone liquide : à propos d’un cas.
Journée des Jeunes Plasticiens Paris, Mars 2013
Congrès Internationaux
- Facial artery perforator flap for nasal reconstruction
IFOS, ENT word congress, Paris 2017 - Anatomy and Microsurgery
IMC, Webinar May,2021
- Transfert sélectif de la racine C7 controlatérale pour la prise en charge des avulsions complètes post- traumatiques du plexus brachial
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Communications écrites
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Congrès Nationaux
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- Autophagy: a new therapeutic target in osteoporosis ?
Club Francophone d’étude de l’Autophagy, Lille, Octobre 2015 - Autophagic activity in osteosarcoma cancer stem cells
Groupe Francophone d’étude des Cellules Souches Cancéreuses, Marseille, Decembre 2015 - Autophagy: a new therapeutic target in osteoporosis ?
Société Francaise de Rhumatologie, Paris, Decembre 2015 - Rôle de l’autophagie dans les cellules souches tumorales d’ostéosarcome ?
Club Francophone d’étude de l’Autophagy, Paris, Octobre 2018 - Rôle de l’autophagie dans le micro environnement de l’ostéosarcome ?
Groupe Francophone d’étude des Cellules Souches Cancéreuses, Montpellier, Decembre 2017
- Autophagy: a new therapeutic target in osteoporosis ?
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Congrès Internationaux
- Implication of autophagy in a preclinical mouse model of bone ageing and of osteoporosis
European Calcified Tissue Society Congress, Rome, Mai 2016 - Feasability and results of surgery with free flap coverage after isolated limb perfusion for soft tissue sarcoma
Connective Tissue Oncology Society, Lisbon, Novembre 2016
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